Propranolol is more effective than pulsed dye laser and cryosurgery for infantile hemangiomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-29

AUTHORS

Shinji Kagami, Yoshihiro Kuwano, Sayaka Shibata, Yuta Uwajima, Daisuke Yamada, Akie Miyamoto, Takuya Miyagawa, Mayuko Araki, Kohji Takahashi, Sayako Isomura, Naohiko Aozasa, Yuri Masui, Mizuho Yamamoto, Ryo Inuzuka, Tatsuo Katori, Shinichi Sato

ABSTRACT

Propranolol hydrochloride is a nonselective β-blocker that is used for the treatment of hypertension, arrhythmia, and angina pectoris. In Japan, it was recently approved for the treatment of childhood arrhythmia. It has been observed to produce drastic involution of infantile hemangiomas. The aim of this prospective study was to examine propranolol’s superiority to classical therapy with pulsed dye laser and/or cryosurgery in treating proliferating infantile hemangiomas. Fifteen patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received grinded propranolol tablets 2 mg/kg per day divided in three doses. Twelve patients with proliferating infantile hemangiomas receiving pulsed dye laser and/or cryosurgery were enrolled as controls. Baseline electrocardiogram, echocardiogram, and chest x-ray were performed. Monitoring of heart rate, blood pressure, and blood glucose was performed every 2 weeks. Efficacy was assessed by performing blinded volume measurements and taking photographs at every visit. Propranolol induced significantly earlier involution and redness reduction of infantile hemangiomas, compared to pulsed dye laser and cryosurgery. Adverse effects such as hypoglycemia, hypotension, or bradycardia did not occur. Conclusion: The dramatic response of infantile hemangiomas to propranolol and few side effects suggest that early treatment of infantile hemangiomas could result in decreased disfigurement. Propranolol should be considered as a first-line treatment of infantile hemangiomas. More... »

PAGES

1521-1526

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-013-2075-7

DOI

http://dx.doi.org/10.1007/s00431-013-2075-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050810728

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23812512


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23 schema:description Propranolol hydrochloride is a nonselective β-blocker that is used for the treatment of hypertension, arrhythmia, and angina pectoris. In Japan, it was recently approved for the treatment of childhood arrhythmia. It has been observed to produce drastic involution of infantile hemangiomas. The aim of this prospective study was to examine propranolol’s superiority to classical therapy with pulsed dye laser and/or cryosurgery in treating proliferating infantile hemangiomas. Fifteen patients between the ages of 1 and 4 months with proliferating infantile hemangiomas received grinded propranolol tablets 2 mg/kg per day divided in three doses. Twelve patients with proliferating infantile hemangiomas receiving pulsed dye laser and/or cryosurgery were enrolled as controls. Baseline electrocardiogram, echocardiogram, and chest x-ray were performed. Monitoring of heart rate, blood pressure, and blood glucose was performed every 2 weeks. Efficacy was assessed by performing blinded volume measurements and taking photographs at every visit. Propranolol induced significantly earlier involution and redness reduction of infantile hemangiomas, compared to pulsed dye laser and cryosurgery. Adverse effects such as hypoglycemia, hypotension, or bradycardia did not occur. Conclusion: The dramatic response of infantile hemangiomas to propranolol and few side effects suggest that early treatment of infantile hemangiomas could result in decreased disfigurement. Propranolol should be considered as a first-line treatment of infantile hemangiomas.
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31 adverse effects
32 age
33 aim
34 angina pectoris
35 arrhythmias
36 baseline electrocardiogram
37 blinded volume measurements
38 blockers
39 blood glucose
40 blood pressure
41 bradycardia
42 chest X
43 childhood arrhythmias
44 classical therapies
45 control
46 cryosurgery
47 days
48 disfigurement
49 doses
50 dramatic response
51 drastic involution
52 dye laser
53 early involution
54 early treatment
55 echocardiogram
56 effect
57 efficacy
58 electrocardiogram
59 first-line treatment
60 glucose
61 grinded propranolol tablets 2
62 heart rate
63 hemangioma
64 hydrochloride
65 hypertension
66 hypoglycemia
67 hypotension
68 infantile hemangiomas
69 involution
70 laser
71 measurements
72 monitoring
73 months
74 patients
75 pectoris
76 photographs
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