Educational Paper: Aspects of clinical pharmacology in children—pharmacovigilance and safety View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

Imti Choonara

ABSTRACT

Adverse drug reactions (ADRs) are a significant problem in children, affecting one in ten children in hospital. Within the community, one in 500 children will experience an adverse drug reaction each year. Pharmacovigilance has been useful in detecting suspected ADRs. However, most ADRs are unreported and often not suspected. Education of health professionals in relation to drug toxicity improves the reporting rate of suspected ADRs. Clinical trials are useful to evaluate the efficacy of drugs. They are, however, not the best way of looking at ADRs where surveillance following the widespread use of a drug is more appropriate. Alongside work by the regulatory agencies, independent investigators have helped collate data. This information has been useful in developing guidelines to prevent further cases of drug toxicity. Greater awareness and understanding of drug toxicity in children should result in more rational prescribing. More... »

PAGES

577-580

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-012-1871-9

DOI

http://dx.doi.org/10.1007/s00431-012-1871-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019657383

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23111760


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