Involvement of FcɛR1β gene polymorphisms in susceptibility to atopy in Korean children with asthma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03-14

AUTHORS

Eun Soo Kim, Seung-Hyun Kim, Kyung Won Kim, Hae-Sim Park, Eun Soon Shin, Jong Eun Lee, Myung Hyun Sohn, Kyu-Earn Kim

ABSTRACT

IntroductionIgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcɛR1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma.Materials and methodsWe genotyped 650 children for allelic determinants at two polymorphic sites, −109T/C and E237G, in the FcɛR1β gene by SNP-IT™ assays using the SNP stream 25K™ system.ResultsDistributions of the genotype and allele frequencies of FcɛR1β −109T/C and E237G polymorphisms were significantly associated with atopy (P < 0.05) and elevated serum IgE levels. However, differences in the E237G polymorphism did not reach statistical significance after adjustment for multiple comparisons. The genotypes TC or CC at −109T/C were associated with decreased forced expiratory flow25–75% in children with asthma (P < 0.05), but this did not reach statistical significance after correction for multiple comparisons. In addition, haplotype 1 (T-A) was associated with atopy susceptibility (P = 0.0069). Analysis of genotype distributions of haplotypes demonstrated a significantly lower PC20 for homozygous −/− diploids compared with homozygous Ht1/Ht1 (P = 0.0261).ConclusionPolymorphisms in the FcɛR1β gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways of asthmatic patients. More... »

PAGES

1483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-009-0960-x

DOI

http://dx.doi.org/10.1007/s00431-009-0960-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047257240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19288130


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