Burkholderia pseudomallei infection in chronic granulomatous disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12-03

AUTHORS

Raffaele Renella, Jean-Marie Perez, Sylvie Chollet-Martin, Sabine Sarnacki, Alain Fischer, Stéphane Blanche, Jean-Laurent Casanova, Capucine Picard

ABSTRACT

Melioidosis is a severe illness caused by Burkholderia pseudomallei, a sepsis-causing bacterial pathogen that is common in East Asia. We reexamined the underlying diagnosis in a 12-year-old boy who was diagnosed in the French West Indies with melioidosis when he was 4 years old. Our investigations led to the determination of chronic granulomatous disease (CGD), an inherited condition characterized by phagocytic cell dysfunction. This is the third reported case of melioidosis associated with CGD to be reported, lending support to an association between the two. The molecular determinants of the susceptibility of CGD patients to B. pseudomallei are still unknown. Our report suggests that CGD should be suspected in children with melioidosis, both in the Americas and probably in other regions world-wide. More... »

PAGES

175-177

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00431-005-0022-y

DOI

http://dx.doi.org/10.1007/s00431-005-0022-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032101685

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16328364


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179 grid-institutes:grid.412134.1 schema:alternateName Service de Chirurgie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
180 Unité d’Immunologie et Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
181 schema:name Service de Chirurgie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
182 Unité d’Immunologie et Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
183 rdf:type schema:Organization
184 grid-institutes:grid.463939.2 schema:alternateName Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM Unité 550 Faculté Necker, 156, rue Vaugirard, 75015, Paris, France
185 schema:name Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM Unité 550 Faculté Necker, 156, rue Vaugirard, 75015, Paris, France
186 Unité d’Immunologie et Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
187 rdf:type schema:Organization
 




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