Immune response to a recombinant fragment of the CagA protein of Helicobacter pylori in blood donors and patients with gastric ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-05

AUTHORS

Kersti Klaamas, O. Kurtenkov, Antonello Covacci, Agu Lipping, Torkel Wadström

ABSTRACT

IgG immune response to CagA was evaluated by enzyme-linked imunosorbent assay (ELISA) using a recombinant fragment of CagA as antigen in 171 patients with gastric cancer and 298 blood donors to determine whether it could be related to the ABO(H) blood group phenotype, stage of cancer or tumor morphology. The CagA-ELISA showed a good specificity (93.5%) and sensitivity (88.5%) as compared with immunoblotting for blot CagA-negative and -positive donors. The Helicobacter pylori seropositive blood group A donors revealed the lowest proportion (37.6%) of strong responders to CagA: A More... »

PAGES

227-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004300050097

DOI

http://dx.doi.org/10.1007/s004300050097

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004156918

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10363680


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