Serum cytokine and chemokine changes during Toscana virus meningitis. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-11

AUTHORS

Jessica Rauch, Lorenzo Zammarchi, Giampaolo Corti, Alessandro Bartoloni, Alexander Schlaphof, Jonas Schmidt-Chanasit, Dennis Tappe

ABSTRACT

Toscana virus is an important arbovirus causing meningitis and meningoencephalitis in countries around the Mediterranean Sea. While the clinical syndrome and laboratory diagnostic procedures have been well described, less is known about the immune response in Toscana virus meningitis and a possible use of cytokine and chemokine changes for the clinical follow-up of patients. We here characterized serum cytokine and chemokine profiles from 37 patients during the acute and convalescent phase of the infection. Only few serum cytokine/chemokine changes were detected during Toscana virus meningitis. Markedly increased concentrations of IP-10, interferon-α, IL-22, and eotaxin were found in the acute phase. Levels of interferon-α, IL-22, and eotaxin remained elevated in the convalescent phase, but decreased concentrations of GM-CSF were detected. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00430-019-00611-y

DOI

http://dx.doi.org/10.1007/s00430-019-00611-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113378508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30976912


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