Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Ima Trempler, Ellen Binder, Nadiya El-Sourani, Patrick Schiffler, Jan-Gerd Tenberge, Anne-Marike Schiffer, Gereon R. Fink, Ricarda I. Schubotz

ABSTRACT

Parkinson's disease (PD), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. Since the phasic signal of dopamine neurons is proposed to guide learning by signifying mismatches between subjects' expectations and external events, we here investigated whether akinetic-rigid PD patients without mild cognitive impairment exhibit difficulties in dealing with either relevant (requiring flexibility) or irrelevant (requiring stability) prediction errors. Following our previous study on flexibility and stability in prediction (Trempler et al. J Cogn Neurosci 29(2):298-309, 2017), we then assessed whether deficits would correspond with specific structural alterations in dopaminergic regions as well as in inferior frontal cortex, medial prefrontal cortex, and the hippocampus. Twenty-one healthy controls and twenty-one akinetic-rigid PD patients on and off medication performed a task which required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press, whereas sequence omissions had to be ignored. Independent of the disease, midbrain volume was related to a general response bias to unexpected events, whereas right putamen volume correlated with the ability to discriminate between relevant and irrelevant prediction errors. However, patients compared with healthy participants showed deficits in stabilisation against irrelevant prediction errors, associated with thickness of right inferior frontal gyrus and left medial prefrontal cortex. Flexible updating due to relevant prediction errors was also affected in patients compared with controls and associated with right hippocampus volume. Dopaminergic medication influenced behavioural performance across, but not within the patients. Our exploratory study warrants further research on deficient prediction error processing and its structural correlates as a core of cognitive symptoms occurring already in early stages of the disease. More... »

PAGES

2097-2111

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00429-018-1616-2

DOI

http://dx.doi.org/10.1007/s00429-018-1616-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100671323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29374792


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428 Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, Westfälische Wilhelms-Universität, Fliednerstr. 21, 48149, Münster, Germany
429 rdf:type schema:Organization
430 https://www.grid.ac/institutes/grid.5949.1 schema:alternateName University of Münster
431 schema:name Department of Psychology, Westfälische Wilhelms-Universität, 48149, Münster, Germany
432 Institute of Neuroscience and Medicine (INM3), Cognitive Neuroscience, Research Centre Jülich, 52425, Jülich, Germany
433 Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, Westfälische Wilhelms-Universität, Fliednerstr. 21, 48149, Münster, Germany
434 rdf:type schema:Organization
435 https://www.grid.ac/institutes/grid.7728.a schema:alternateName Brunel University London
436 schema:name Department of Life Sciences, Division of Psychology, Brunel University, UB8 3PH, Uxbridge, UK
437 rdf:type schema:Organization
 




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