Genetic profile of 22 pancreatic carcinoma cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

Patrick S. Moore, Bence Sipos, Simonetta Orlandini, Claudio Sorio, Francisco X. Real, Nicholas R. Lemoine, Thomas Gress, Claudio Bassi, Günter Klöppel, Holger Kalthoff, Hendrik Ungefroren, Matthias Löhr, Aldo Scarpa

ABSTRACT

. The K-ras, p53, p16 and DPC4 genes are among those most frequently altered in pancreatic ductal carcinoma. We analyzed 22 cell lines for alterations in these genes by direct sequence analysis and methylation-specific polymerase chain reaction. These cell lines showed mutations in K-ras and p53 at frequencies of 91% and 95%, respectively. Alterations in p16INK4a were found in all cases and included nine homozygous deletions, seven mutations and promoter methylation in six cases. Eight cell lines (36%) had an alteration of DPC4, including one mutation and seven homozygous deletions. The most typical mutational profile involved K-ras, p53, and p16INK4a, concurrently aberrated in 20 cases (91%). Eight cell lines had alterations in all four genes. Inactivation of DPC4 was always accompanied by alteration of all of the other three genes. This comprehensive data regarding the cumulative genetic alterations in pancreatic carcinoma cell lines will be of great value for studies involving drug sensitivity or resistance that may be associated with inactivation of a particular gene or molecular pathway. More... »

PAGES

798-802

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280100474

DOI

http://dx.doi.org/10.1007/s004280100474

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007423504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11787853


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