Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-06

AUTHORS

R. Moll, Ingrid Moll

ABSTRACT

Intraepidermal and dermal-epidermal cohesion are of paramount importance for the integrity of the skin. Some constituent molecules of keratinocyte adhesion complexes and basement membrane-associated structures are the targets of antibody-mediated autoimmune reactions that give rise to various (muco-)cutaneous blistering diseases. The current state of our knowledge about these molecules – along with the main clinical, histological, and immunohistochemical features of the corresponding autoimmune diseases and their pathogenetic mechanisms – comprise the subjects surveyed in this review. Among the desmosomal cadherins (desmogleins and desmocollins) that mediate epidermal cell–cell adhesion, it has been demonstrated that desmoglein 1 and desmoglein 3 are the autoantigens of pemphigus foliaceus and pemphigus vulgaris, respectively, both diseases that result in intraepidermal blistering. Further, desmocollin autoantibodies may be involved in IgA pemphigus. Paraneoplastic pemphigus is associated with autoantibodies directed against the desmosomal plaque protein, desmoplakin. Of the constituents of hemidesmosomes, the plaque protein, BP230 (BPAG1), and the collagen-like transmembrane protein, BP180 (BPAG2), are the autoantigens of bullous pemphigoid and pemphigoid gestationis, the manifestations of both of which include subepidermal blistering. Several diseases arise from autoimmune reactions against certain proteins associated with the basement membrane located beneath hemidesmosomes, for example laminin 5 (cicatricial pemphigoid), ladinin (LAD-1; linear IgA disease), uncein, and collagen VII (epidermolysis bullosa acquisita), the last of which is the constituent protein of the anchoring fibrils. Such recent advances in the elucidation of the molecular nature of autoantigens may serve as the basis for the development of novel molecule-based therapeutic strategies. More... »

PAGES

487-504

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280050197

DOI

http://dx.doi.org/10.1007/s004280050197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026373784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9672190


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basement Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadherins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Desmosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pemphigus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Diseases, Vesiculobullous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Pathology, Martin Luther University of Halle-Wittenberg, D-06097 Halle, Germany Tel.: +49-345-557 1882, Fax: +49-345-557 1295, DE", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Institute of Pathology, Martin Luther University of Halle-Wittenberg, D-06097 Halle, Germany Tel.: +49-345-557 1882, Fax: +49-345-557 1295, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moll", 
        "givenName": "R.", 
        "id": "sg:person.0724513345.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724513345.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Universit\u00e4tskrankenhaus Eppendorf, University of Hamburg, D-20246 Hamburg, Germany, DE", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Dermatology, Universit\u00e4tskrankenhaus Eppendorf, University of Hamburg, D-20246 Hamburg, Germany, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moll", 
        "givenName": "Ingrid", 
        "id": "sg:person.01107343130.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107343130.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02507101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034201065", 
          "https://doi.org/10.1007/bf02507101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004030050081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000930732", 
          "https://doi.org/10.1007/s004030050081"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-06", 
    "datePublishedReg": "1998-06-01", 
    "description": "Abstract\u2002Intraepidermal and dermal-epidermal cohesion are of paramount importance for the integrity of the skin. Some constituent molecules of keratinocyte adhesion complexes and basement membrane-associated structures are the targets of antibody-mediated autoimmune reactions that give rise to various (muco-)cutaneous blistering diseases. The current state of our knowledge about these molecules \u2013 along with the main clinical, histological, and immunohistochemical features of the corresponding autoimmune diseases and their pathogenetic mechanisms \u2013 comprise the subjects surveyed in this review. Among the desmosomal cadherins (desmogleins and desmocollins) that mediate epidermal cell\u2013cell adhesion, it has been demonstrated that desmoglein 1 and desmoglein 3 are the autoantigens of pemphigus foliaceus and pemphigus vulgaris, respectively, both diseases that result in intraepidermal blistering. Further, desmocollin autoantibodies may be involved in IgA pemphigus. Paraneoplastic pemphigus is associated with autoantibodies directed against the desmosomal plaque protein, desmoplakin. Of the constituents of hemidesmosomes, the plaque protein, BP230 (BPAG1), and the collagen-like transmembrane protein, BP180 (BPAG2), are the autoantigens of bullous pemphigoid and pemphigoid gestationis, the manifestations of both of which include subepidermal blistering. Several diseases arise from autoimmune reactions against certain proteins associated with the basement membrane located beneath hemidesmosomes, for example laminin 5 (cicatricial pemphigoid), ladinin (LAD-1; linear IgA disease), uncein, and collagen VII (epidermolysis bullosa acquisita), the last of which is the constituent protein of the anchoring fibrils. Such recent advances in the elucidation of the molecular nature of autoantigens may serve as the basis for the development of novel molecule-based therapeutic strategies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004280050197", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "432"
      }
    ], 
    "keywords": [
      "plaque proteins", 
      "epidermal cell-cell adhesion", 
      "cell-cell adhesion", 
      "constituents of hemidesmosomes", 
      "membrane-associated structures", 
      "desmosomal plaque proteins", 
      "dermal-epidermal cohesion", 
      "adhesion complexes", 
      "transmembrane protein", 
      "desmosomal cadherins", 
      "constituent proteins", 
      "certain proteins", 
      "basement membrane components", 
      "membrane components", 
      "molecular nature", 
      "such recent advances", 
      "protein", 
      "adhesion molecules", 
      "laminin 5", 
      "collagen VII", 
      "basement membrane", 
      "intraepidermal blistering", 
      "corresponding autoimmune diseases", 
      "recent advances", 
      "hemidesmosomes", 
      "desmoglein 1", 
      "therapeutic strategies", 
      "desmoplakin", 
      "molecules", 
      "epidermal adhesion molecules", 
      "cadherin", 
      "elucidation", 
      "desmoglein 3", 
      "membrane", 
      "vulgaris", 
      "adhesion", 
      "complexes", 
      "autoantigens", 
      "target", 
      "constituent molecules", 
      "integrity", 
      "disease", 
      "autoimmune diseases", 
      "structure", 
      "fibrils", 
      "paramount importance", 
      "target structures", 
      "advances", 
      "current state", 
      "development", 
      "constituents", 
      "components", 
      "basis", 
      "importance", 
      "blistering", 
      "autoimmunity", 
      "BP230", 
      "autoimmune reactions", 
      "review", 
      "reaction", 
      "uncein", 
      "knowledge", 
      "strategies", 
      "BP180", 
      "cohesion", 
      "rise", 
      "subepidermal blistering", 
      "features", 
      "nature", 
      "skin", 
      "foliaceus", 
      "pemphigus foliaceus", 
      "autoantibodies", 
      "state", 
      "pemphigus vulgaris", 
      "pemphigus", 
      "manifestations", 
      "pemphigoid gestationis", 
      "gestationis", 
      "bullous pemphigoid", 
      "intraepidermal", 
      "pemphigoid", 
      "subjects", 
      "immunohistochemical features", 
      "paraneoplastic pemphigus", 
      "IgA pemphigus", 
      "keratinocyte adhesion complexes", 
      "basement membrane-associated structures", 
      "antibody-mediated autoimmune reactions", 
      "desmocollin autoantibodies", 
      "collagen-like transmembrane protein", 
      "example laminin 5", 
      "ladinin", 
      "novel molecule-based therapeutic strategies", 
      "molecule-based therapeutic strategies"
    ], 
    "name": "Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity", 
    "pagination": "487-504", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026373784"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004280050197"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9672190"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004280050197", 
      "https://app.dimensions.ai/details/publication/pub.1026373784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_270.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004280050197"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004280050197'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004280050197'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004280050197'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004280050197'


 

This table displays all metadata directly associated to this object as RDF triples.

207 TRIPLES      22 PREDICATES      132 URIs      122 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004280050197 schema:about N07e65c108d014673a7b58cc27981ed9b
2 N2c476d41bf5b40ae91b5ffd525269144
3 N410bd6ad809c4371b0314b06d38ec9f4
4 N4c24f01555a2479380c9397707d7a47e
5 N4dd7a04c1ca4463e93e4a2c918c01390
6 N979b6ba6ed184565b1c431de89018409
7 Na0dcffdc51ad46f8bd48739345d63ef6
8 Nb13b90d0a3534986aaacf84a2cc6b065
9 anzsrc-for:11
10 anzsrc-for:1103
11 schema:author Nfb29259f5503435bb58221d3e60df5e6
12 schema:citation sg:pub.10.1007/bf02507101
13 sg:pub.10.1007/s004030050081
14 schema:datePublished 1998-06
15 schema:datePublishedReg 1998-06-01
16 schema:description Abstract Intraepidermal and dermal-epidermal cohesion are of paramount importance for the integrity of the skin. Some constituent molecules of keratinocyte adhesion complexes and basement membrane-associated structures are the targets of antibody-mediated autoimmune reactions that give rise to various (muco-)cutaneous blistering diseases. The current state of our knowledge about these molecules – along with the main clinical, histological, and immunohistochemical features of the corresponding autoimmune diseases and their pathogenetic mechanisms – comprise the subjects surveyed in this review. Among the desmosomal cadherins (desmogleins and desmocollins) that mediate epidermal cell–cell adhesion, it has been demonstrated that desmoglein 1 and desmoglein 3 are the autoantigens of pemphigus foliaceus and pemphigus vulgaris, respectively, both diseases that result in intraepidermal blistering. Further, desmocollin autoantibodies may be involved in IgA pemphigus. Paraneoplastic pemphigus is associated with autoantibodies directed against the desmosomal plaque protein, desmoplakin. Of the constituents of hemidesmosomes, the plaque protein, BP230 (BPAG1), and the collagen-like transmembrane protein, BP180 (BPAG2), are the autoantigens of bullous pemphigoid and pemphigoid gestationis, the manifestations of both of which include subepidermal blistering. Several diseases arise from autoimmune reactions against certain proteins associated with the basement membrane located beneath hemidesmosomes, for example laminin 5 (cicatricial pemphigoid), ladinin (LAD-1; linear IgA disease), uncein, and collagen VII (epidermolysis bullosa acquisita), the last of which is the constituent protein of the anchoring fibrils. Such recent advances in the elucidation of the molecular nature of autoantigens may serve as the basis for the development of novel molecule-based therapeutic strategies.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N1da88b8ba827485fbcee5e21f2aea37b
21 Nbcb8b7207e7443e6baea44f6acfed267
22 sg:journal.1106235
23 schema:keywords BP180
24 BP230
25 IgA pemphigus
26 adhesion
27 adhesion complexes
28 adhesion molecules
29 advances
30 antibody-mediated autoimmune reactions
31 autoantibodies
32 autoantigens
33 autoimmune diseases
34 autoimmune reactions
35 autoimmunity
36 basement membrane
37 basement membrane components
38 basement membrane-associated structures
39 basis
40 blistering
41 bullous pemphigoid
42 cadherin
43 cell-cell adhesion
44 certain proteins
45 cohesion
46 collagen VII
47 collagen-like transmembrane protein
48 complexes
49 components
50 constituent molecules
51 constituent proteins
52 constituents
53 constituents of hemidesmosomes
54 corresponding autoimmune diseases
55 current state
56 dermal-epidermal cohesion
57 desmocollin autoantibodies
58 desmoglein 1
59 desmoglein 3
60 desmoplakin
61 desmosomal cadherins
62 desmosomal plaque proteins
63 development
64 disease
65 elucidation
66 epidermal adhesion molecules
67 epidermal cell-cell adhesion
68 example laminin 5
69 features
70 fibrils
71 foliaceus
72 gestationis
73 hemidesmosomes
74 immunohistochemical features
75 importance
76 integrity
77 intraepidermal
78 intraepidermal blistering
79 keratinocyte adhesion complexes
80 knowledge
81 ladinin
82 laminin 5
83 manifestations
84 membrane
85 membrane components
86 membrane-associated structures
87 molecular nature
88 molecule-based therapeutic strategies
89 molecules
90 nature
91 novel molecule-based therapeutic strategies
92 paramount importance
93 paraneoplastic pemphigus
94 pemphigoid
95 pemphigoid gestationis
96 pemphigus
97 pemphigus foliaceus
98 pemphigus vulgaris
99 plaque proteins
100 protein
101 reaction
102 recent advances
103 review
104 rise
105 skin
106 state
107 strategies
108 structure
109 subepidermal blistering
110 subjects
111 such recent advances
112 target
113 target structures
114 therapeutic strategies
115 transmembrane protein
116 uncein
117 vulgaris
118 schema:name Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity
119 schema:pagination 487-504
120 schema:productId N0ea822afed7c468cbb1d18e469890635
121 Nc41b162b21934fbdb5775de8c4103798
122 Ndddc5e0cd69648bf8ecf7bd3587da121
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026373784
124 https://doi.org/10.1007/s004280050197
125 schema:sdDatePublished 2021-11-01T18:01
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher Na6761935c87f4e19b75fb03bd5e1949d
128 schema:url https://doi.org/10.1007/s004280050197
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N07e65c108d014673a7b58cc27981ed9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Basement Membrane
134 rdf:type schema:DefinedTerm
135 N0ea822afed7c468cbb1d18e469890635 schema:name dimensions_id
136 schema:value pub.1026373784
137 rdf:type schema:PropertyValue
138 N1da88b8ba827485fbcee5e21f2aea37b schema:issueNumber 6
139 rdf:type schema:PublicationIssue
140 N2c476d41bf5b40ae91b5ffd525269144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Desmosomes
142 rdf:type schema:DefinedTerm
143 N410bd6ad809c4371b0314b06d38ec9f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cadherins
145 rdf:type schema:DefinedTerm
146 N4c24f01555a2479380c9397707d7a47e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Epidermis
148 rdf:type schema:DefinedTerm
149 N4dd7a04c1ca4463e93e4a2c918c01390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Extracellular Matrix Proteins
151 rdf:type schema:DefinedTerm
152 N4df7722211e5493794dab7c4ccd600ac rdf:first sg:person.01107343130.17
153 rdf:rest rdf:nil
154 N979b6ba6ed184565b1c431de89018409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Skin Diseases, Vesiculobullous
156 rdf:type schema:DefinedTerm
157 Na0dcffdc51ad46f8bd48739345d63ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Na6761935c87f4e19b75fb03bd5e1949d schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Nb13b90d0a3534986aaacf84a2cc6b065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Pemphigus
164 rdf:type schema:DefinedTerm
165 Nbcb8b7207e7443e6baea44f6acfed267 schema:volumeNumber 432
166 rdf:type schema:PublicationVolume
167 Nc41b162b21934fbdb5775de8c4103798 schema:name doi
168 schema:value 10.1007/s004280050197
169 rdf:type schema:PropertyValue
170 Ndddc5e0cd69648bf8ecf7bd3587da121 schema:name pubmed_id
171 schema:value 9672190
172 rdf:type schema:PropertyValue
173 Nfb29259f5503435bb58221d3e60df5e6 rdf:first sg:person.0724513345.37
174 rdf:rest N4df7722211e5493794dab7c4ccd600ac
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
179 schema:name Clinical Sciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1106235 schema:issn 0945-6317
182 1432-2307
183 schema:name Virchows Archiv
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01107343130.17 schema:affiliation grid-institutes:grid.13648.38
187 schema:familyName Moll
188 schema:givenName Ingrid
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107343130.17
190 rdf:type schema:Person
191 sg:person.0724513345.37 schema:affiliation grid-institutes:grid.9018.0
192 schema:familyName Moll
193 schema:givenName R.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724513345.37
195 rdf:type schema:Person
196 sg:pub.10.1007/bf02507101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034201065
197 https://doi.org/10.1007/bf02507101
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s004030050081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000930732
200 https://doi.org/10.1007/s004030050081
201 rdf:type schema:CreativeWork
202 grid-institutes:grid.13648.38 schema:alternateName Department of Dermatology, Universitätskrankenhaus Eppendorf, University of Hamburg, D-20246 Hamburg, Germany, DE
203 schema:name Department of Dermatology, Universitätskrankenhaus Eppendorf, University of Hamburg, D-20246 Hamburg, Germany, DE
204 rdf:type schema:Organization
205 grid-institutes:grid.9018.0 schema:alternateName Institute of Pathology, Martin Luther University of Halle-Wittenberg, D-06097 Halle, Germany Tel.: +49-345-557 1882, Fax: +49-345-557 1295, DE
206 schema:name Institute of Pathology, Martin Luther University of Halle-Wittenberg, D-06097 Halle, Germany Tel.: +49-345-557 1882, Fax: +49-345-557 1295, DE
207 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...