The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

Tatsuro Shimokama, Seij Haraoka, Hisashi Horiguchi, Fumihiro Sugiyama, Kazuo Murakami, T. Watanabe

ABSTRACT

The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also ”onion skinning”, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension. More... »

PAGES

169-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280050152

DOI

http://dx.doi.org/10.1007/s004280050152

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033736377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9504863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arteritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulosclerosis, Focal Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Juxtaglomerular Apparatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin-Angiotensin System", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimokama", 
        "givenName": "Tatsuro", 
        "id": "sg:person.01271015273.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271015273.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haraoka", 
        "givenName": "Seij", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiguchi", 
        "givenName": "Hisashi", 
        "id": "sg:person.01007120102.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007120102.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiyama", 
        "givenName": "Fumihiro", 
        "id": "sg:person.01224412777.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224412777.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Kazuo", 
        "id": "sg:person.01305710302.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305710302.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "T.", 
        "id": "sg:person.012664624074.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012664624074.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/226551a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018877976", 
          "https://doi.org/10.1038/226551a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-66954-5_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016777843", 
          "https://doi.org/10.1007/978-3-642-66954-5_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024869059", 
          "https://doi.org/10.1007/bf00585940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02915101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046528613", 
          "https://doi.org/10.1007/bf02915101"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "Abstract\u2002The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also \u201donion skinning\u201d, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004280050152", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "432"
      }
    ], 
    "keywords": [
      "Tsukuba hypertensive mice", 
      "human malignant hypertension", 
      "renin-angiotensin system", 
      "glomerular sclerosis index", 
      "hypertensive mice", 
      "malignant hypertension", 
      "sclerosis index", 
      "juxtaglomerular apparatus", 
      "body weight ratio", 
      "smooth muscle cells", 
      "development of lesions", 
      "fibrinoid arteritis", 
      "onion skinning", 
      "malignant nephrosclerosis", 
      "blood pressure", 
      "renal lesions", 
      "control mice", 
      "vascular lesions", 
      "pathologic conditions", 
      "hypertension", 
      "muscle cells", 
      "mice", 
      "lesions", 
      "human renin", 
      "kidney", 
      "epithelial cells", 
      "arteritis", 
      "renin", 
      "ultrastructural methods", 
      "morphometrical analysis", 
      "pivotal role", 
      "further examination", 
      "morphometric analysis", 
      "nephrosclerosis", 
      "cells", 
      "mmHg", 
      "excellent model", 
      "glomeruli", 
      "months", 
      "index", 
      "sclerotic", 
      "birth", 
      "control", 
      "examination", 
      "weight ratio", 
      "same tendency", 
      "grade", 
      "years", 
      "development", 
      "role", 
      "analysis", 
      "pressure", 
      "frequency", 
      "ratio", 
      "tendency", 
      "model", 
      "variety", 
      "apparatus", 
      "electron microscopy", 
      "system", 
      "conditions", 
      "method", 
      "skinning", 
      "microscopy", 
      "light", 
      "THM"
    ], 
    "name": "The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis", 
    "pagination": "169-175", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033736377"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004280050152"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9504863"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004280050152", 
      "https://app.dimensions.ai/details/publication/pub.1033736377"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_290.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004280050152"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      22 PREDICATES      113 URIs      101 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004280050152 schema:about N2a6d19158eb1420f9825f8ab585ad5ba
2 N4447ccf0c53e4ed787dfc4c010e75f50
3 N4639ab9305c940e0855d4a5301b93c2d
4 N4c673fc7a1704a089cf8b0d5dee3b9ef
5 N4fc641bad1b04842a19df4ac3d5b58f9
6 N6756849ca09f477b8b14e4fc0cdf02b3
7 N703b2a2b81a542db97d293646d6d3219
8 N790079efbea84bd9b694bc1699d4324d
9 N89078d45a587452eba74e69cf5fd49f9
10 N93daeee5cfd246919275100f9f3c3910
11 Nb8914cd68921476785df5ae14cd47a55
12 Nc06c53b78fed4463a8e484c5a46966f1
13 Nd45d1574264e48cf8e6f95356f635fe9
14 Ne336a8c5e529498aa738abef7877d2e6
15 Ne78f962f4fb14416baa26aa04ceb3311
16 Ne7fe418978384777958991057ece04d7
17 anzsrc-for:11
18 anzsrc-for:1116
19 schema:author Ne2e3204174f544b89b4c38b5b58188a0
20 schema:citation sg:pub.10.1007/978-3-642-66954-5_16
21 sg:pub.10.1007/bf00585940
22 sg:pub.10.1007/bf02915101
23 sg:pub.10.1038/226551a0
24 schema:datePublished 1998-02
25 schema:datePublishedReg 1998-02-01
26 schema:description Abstract The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also ”onion skinning”, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N0edc341974084d4f95d8e96fbcb5017d
31 N4a68f4687a1745fdaf3e7b8c4339ed6b
32 sg:journal.1106235
33 schema:keywords THM
34 Tsukuba hypertensive mice
35 analysis
36 apparatus
37 arteritis
38 birth
39 blood pressure
40 body weight ratio
41 cells
42 conditions
43 control
44 control mice
45 development
46 development of lesions
47 electron microscopy
48 epithelial cells
49 examination
50 excellent model
51 fibrinoid arteritis
52 frequency
53 further examination
54 glomerular sclerosis index
55 glomeruli
56 grade
57 human malignant hypertension
58 human renin
59 hypertension
60 hypertensive mice
61 index
62 juxtaglomerular apparatus
63 kidney
64 lesions
65 light
66 malignant hypertension
67 malignant nephrosclerosis
68 method
69 mice
70 microscopy
71 mmHg
72 model
73 months
74 morphometric analysis
75 morphometrical analysis
76 muscle cells
77 nephrosclerosis
78 onion skinning
79 pathologic conditions
80 pivotal role
81 pressure
82 ratio
83 renal lesions
84 renin
85 renin-angiotensin system
86 role
87 same tendency
88 sclerosis index
89 sclerotic
90 skinning
91 smooth muscle cells
92 system
93 tendency
94 ultrastructural methods
95 variety
96 vascular lesions
97 weight ratio
98 years
99 schema:name The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis
100 schema:pagination 169-175
101 schema:productId N5f86136a87bc4790b4dc3ad9b3379528
102 N61b835ca9cda4ddcacaa30157bb4eee6
103 Nd138ea105b6444f9b39073334b1424c2
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033736377
105 https://doi.org/10.1007/s004280050152
106 schema:sdDatePublished 2022-06-01T22:03
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N337ef21cc3634df6892ee819eb48a0ef
109 schema:url https://doi.org/10.1007/s004280050152
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N0edc341974084d4f95d8e96fbcb5017d schema:issueNumber 2
114 rdf:type schema:PublicationIssue
115 N19e422b0e5c2442695cb07b885db1e48 rdf:first sg:person.01224412777.86
116 rdf:rest N811edf0ae5f84d3cbef0eb1cc77945d6
117 N2a6d19158eb1420f9825f8ab585ad5ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Kidney Glomerulus
119 rdf:type schema:DefinedTerm
120 N337ef21cc3634df6892ee819eb48a0ef schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N3a192e6aebf147fbbb55e95c14ea9226 rdf:first Ne78c67a7ae0348bd8191fe45d2bff5ba
123 rdf:rest N7288ba15560e417eb8984c7916d24839
124 N4447ccf0c53e4ed787dfc4c010e75f50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Female
126 rdf:type schema:DefinedTerm
127 N4639ab9305c940e0855d4a5301b93c2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Disease Models, Animal
129 rdf:type schema:DefinedTerm
130 N4a68f4687a1745fdaf3e7b8c4339ed6b schema:volumeNumber 432
131 rdf:type schema:PublicationVolume
132 N4c673fc7a1704a089cf8b0d5dee3b9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Juxtaglomerular Apparatus
134 rdf:type schema:DefinedTerm
135 N4fc641bad1b04842a19df4ac3d5b58f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Blood Pressure
137 rdf:type schema:DefinedTerm
138 N518919f3a84d4c18b2f5ed94fd844980 rdf:first sg:person.012664624074.29
139 rdf:rest rdf:nil
140 N5f86136a87bc4790b4dc3ad9b3379528 schema:name doi
141 schema:value 10.1007/s004280050152
142 rdf:type schema:PropertyValue
143 N61b835ca9cda4ddcacaa30157bb4eee6 schema:name dimensions_id
144 schema:value pub.1033736377
145 rdf:type schema:PropertyValue
146 N6756849ca09f477b8b14e4fc0cdf02b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice, Transgenic
148 rdf:type schema:DefinedTerm
149 N703b2a2b81a542db97d293646d6d3219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 N7288ba15560e417eb8984c7916d24839 rdf:first sg:person.01007120102.31
153 rdf:rest N19e422b0e5c2442695cb07b885db1e48
154 N790079efbea84bd9b694bc1699d4324d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice
156 rdf:type schema:DefinedTerm
157 N811edf0ae5f84d3cbef0eb1cc77945d6 rdf:first sg:person.01305710302.41
158 rdf:rest N518919f3a84d4c18b2f5ed94fd844980
159 N89078d45a587452eba74e69cf5fd49f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Hypertension
161 rdf:type schema:DefinedTerm
162 N93daeee5cfd246919275100f9f3c3910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Glomerulosclerosis, Focal Segmental
164 rdf:type schema:DefinedTerm
165 Nb8914cd68921476785df5ae14cd47a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 Nc06c53b78fed4463a8e484c5a46966f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Arteritis
170 rdf:type schema:DefinedTerm
171 Nd138ea105b6444f9b39073334b1424c2 schema:name pubmed_id
172 schema:value 9504863
173 rdf:type schema:PropertyValue
174 Nd45d1574264e48cf8e6f95356f635fe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Muscle, Smooth, Vascular
176 rdf:type schema:DefinedTerm
177 Ne2e3204174f544b89b4c38b5b58188a0 rdf:first sg:person.01271015273.11
178 rdf:rest N3a192e6aebf147fbbb55e95c14ea9226
179 Ne336a8c5e529498aa738abef7877d2e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Endothelium
181 rdf:type schema:DefinedTerm
182 Ne78c67a7ae0348bd8191fe45d2bff5ba schema:affiliation grid-institutes:grid.20515.33
183 schema:familyName Haraoka
184 schema:givenName Seij
185 rdf:type schema:Person
186 Ne78f962f4fb14416baa26aa04ceb3311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Male
188 rdf:type schema:DefinedTerm
189 Ne7fe418978384777958991057ece04d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Renin-Angiotensin System
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical Physiology
197 rdf:type schema:DefinedTerm
198 sg:journal.1106235 schema:issn 0945-6317
199 1432-2307
200 schema:name Virchows Archiv
201 schema:publisher Springer Nature
202 rdf:type schema:Periodical
203 sg:person.01007120102.31 schema:affiliation grid-institutes:grid.20515.33
204 schema:familyName Horiguchi
205 schema:givenName Hisashi
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007120102.31
207 rdf:type schema:Person
208 sg:person.01224412777.86 schema:affiliation grid-institutes:grid.20515.33
209 schema:familyName Sugiyama
210 schema:givenName Fumihiro
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224412777.86
212 rdf:type schema:Person
213 sg:person.012664624074.29 schema:affiliation grid-institutes:grid.20515.33
214 schema:familyName Watanabe
215 schema:givenName T.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012664624074.29
217 rdf:type schema:Person
218 sg:person.01271015273.11 schema:affiliation grid-institutes:grid.20515.33
219 schema:familyName Shimokama
220 schema:givenName Tatsuro
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271015273.11
222 rdf:type schema:Person
223 sg:person.01305710302.41 schema:affiliation grid-institutes:grid.20515.33
224 schema:familyName Murakami
225 schema:givenName Kazuo
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305710302.41
227 rdf:type schema:Person
228 sg:pub.10.1007/978-3-642-66954-5_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016777843
229 https://doi.org/10.1007/978-3-642-66954-5_16
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/bf00585940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024869059
232 https://doi.org/10.1007/bf00585940
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/bf02915101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046528613
235 https://doi.org/10.1007/bf02915101
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/226551a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018877976
238 https://doi.org/10.1038/226551a0
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.20515.33 schema:alternateName Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP
241 Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP
242 Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP
243 schema:name Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP
244 Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP
245 Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...