The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

Tatsuro Shimokama, Seij Haraoka, Hisashi Horiguchi, Fumihiro Sugiyama, Kazuo Murakami, T. Watanabe

ABSTRACT

The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also ”onion skinning”, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension. More... »

PAGES

169-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280050152

DOI

http://dx.doi.org/10.1007/s004280050152

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033736377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9504863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arteritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulosclerosis, Focal Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Juxtaglomerular Apparatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renin-Angiotensin System", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimokama", 
        "givenName": "Tatsuro", 
        "id": "sg:person.01271015273.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271015273.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haraoka", 
        "givenName": "Seij", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiguchi", 
        "givenName": "Hisashi", 
        "id": "sg:person.01007120102.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007120102.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiyama", 
        "givenName": "Fumihiro", 
        "id": "sg:person.01224412777.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224412777.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Kazuo", 
        "id": "sg:person.01305710302.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305710302.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "T.", 
        "id": "sg:person.012664624074.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012664624074.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-642-66954-5_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016777843", 
          "https://doi.org/10.1007/978-3-642-66954-5_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/226551a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018877976", 
          "https://doi.org/10.1038/226551a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024869059", 
          "https://doi.org/10.1007/bf00585940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02915101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046528613", 
          "https://doi.org/10.1007/bf02915101"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "Abstract\u2002The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also \u201donion skinning\u201d, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004280050152", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "432"
      }
    ], 
    "keywords": [
      "Tsukuba hypertensive mice", 
      "human malignant hypertension", 
      "renin-angiotensin system", 
      "glomerular sclerosis index", 
      "hypertensive mice", 
      "malignant hypertension", 
      "sclerosis index", 
      "juxtaglomerular apparatus", 
      "body weight ratio", 
      "smooth muscle cells", 
      "development of lesions", 
      "fibrinoid arteritis", 
      "onion skinning", 
      "malignant nephrosclerosis", 
      "blood pressure", 
      "renal lesions", 
      "control mice", 
      "vascular lesions", 
      "pathologic conditions", 
      "hypertension", 
      "muscle cells", 
      "mice", 
      "lesions", 
      "human renin", 
      "epithelial cells", 
      "kidney", 
      "arteritis", 
      "renin", 
      "ultrastructural methods", 
      "morphometrical analysis", 
      "further examination", 
      "pivotal role", 
      "morphometric analysis", 
      "nephrosclerosis", 
      "cells", 
      "mmHg", 
      "glomeruli", 
      "excellent model", 
      "months", 
      "birth", 
      "index", 
      "sclerotic", 
      "control", 
      "examination", 
      "weight ratio", 
      "same tendency", 
      "grade", 
      "years", 
      "development", 
      "role", 
      "analysis", 
      "pressure", 
      "frequency", 
      "ratio", 
      "tendency", 
      "model", 
      "variety", 
      "apparatus", 
      "system", 
      "electron microscopy", 
      "conditions", 
      "method", 
      "skinning", 
      "microscopy", 
      "light", 
      "THM"
    ], 
    "name": "The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis", 
    "pagination": "169-175", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033736377"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004280050152"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9504863"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004280050152", 
      "https://app.dimensions.ai/details/publication/pub.1033736377"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_276.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004280050152"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004280050152'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      21 PREDICATES      112 URIs      100 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004280050152 schema:about N07a2f623c93b434f9e7fb4e48e32f57c
2 N14f9f0e3c6444457b2fb51cc8c5b891c
3 N153d5c850b7a4bc7aa0600f3121e5701
4 N4d4848792b3d44fc82ead2499a30fd8d
5 N53ccc6218c9a4e6ab9f2341bbe1776d8
6 N789fd4c8cef4479b83a36ff809a0166e
7 N8b4782448712400da333120dde503901
8 N93c4cee2345d4a32b440a48338fcf110
9 N9ac809a5f93d402c91c4e98509f81e3c
10 Nbf705d52fafa49478fac8ebbc2a59e52
11 Nca2ca0b0ce80408a8c1443d59b112a4b
12 Ncb26f73c7df64280ada858551562d41b
13 Nd8b19b110e774efba2965aace25b15d8
14 Nda39c18be9e645fe842c1a72290b53ad
15 Ne0a3c7c26d4a4f6592f702134c4b974c
16 Nf8b54ae4c31d45f69fe4ee5f8f825156
17 anzsrc-for:11
18 anzsrc-for:1116
19 schema:author Nfa835e4c4fe142edb339d217048a2e31
20 schema:citation sg:pub.10.1007/978-3-642-66954-5_16
21 sg:pub.10.1007/bf00585940
22 sg:pub.10.1007/bf02915101
23 sg:pub.10.1038/226551a0
24 schema:datePublished 1998-02
25 schema:datePublishedReg 1998-02-01
26 schema:description Abstract The renin-angiotensin system has a pivotal role in hypertension. The Tsukuba hypertensive mouse (THM; a transgenic mouse carrying human genes for both renin and angiotensinogen) was generated to allow further examination of the renin-angiotensin system in a variety of pathologic conditions. We evaluated the development of renal lesions in these mice and in controls by morphometric, immunohistochemical and ultrastructural methods. Blood pressure was significantly higher in THM than in control mice; 1 year after birth, it was approximately 40 mmHg higher. The kidney-to-body weight ratio was also higher in THM than in control. Morphometrical analysis revealed that the glomerular sclerosis index was significantly elevated in THM with 10% of the glomeruli sclerotic at 18 months. The grade of vascular lesion and the frequency of fibronoid arteritis of the kidney exhibited the same tendency as the glomerular sclerosis index. Murine renin was located exclusively in the juxtaglomerular apparatus, whereas human renin was expressed not only in the juxtaglomerular apparatus, but also in periarteriolar smooth muscle cells and in mesangial and epithelial cells of the glomeruli. Light and electron microscopy revealed significant fibrinoid arteritis of the kidney in THM and also ”onion skinning”, both pathognomonic for malignant nephrosclerosis. THM may be an excellent model of human malignant hypertension.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N182537b873744a5abfc4fd412ad87166
30 N56fbd3cf9ad641108cfe9daff31995c4
31 sg:journal.1106235
32 schema:keywords THM
33 Tsukuba hypertensive mice
34 analysis
35 apparatus
36 arteritis
37 birth
38 blood pressure
39 body weight ratio
40 cells
41 conditions
42 control
43 control mice
44 development
45 development of lesions
46 electron microscopy
47 epithelial cells
48 examination
49 excellent model
50 fibrinoid arteritis
51 frequency
52 further examination
53 glomerular sclerosis index
54 glomeruli
55 grade
56 human malignant hypertension
57 human renin
58 hypertension
59 hypertensive mice
60 index
61 juxtaglomerular apparatus
62 kidney
63 lesions
64 light
65 malignant hypertension
66 malignant nephrosclerosis
67 method
68 mice
69 microscopy
70 mmHg
71 model
72 months
73 morphometric analysis
74 morphometrical analysis
75 muscle cells
76 nephrosclerosis
77 onion skinning
78 pathologic conditions
79 pivotal role
80 pressure
81 ratio
82 renal lesions
83 renin
84 renin-angiotensin system
85 role
86 same tendency
87 sclerosis index
88 sclerotic
89 skinning
90 smooth muscle cells
91 system
92 tendency
93 ultrastructural methods
94 variety
95 vascular lesions
96 weight ratio
97 years
98 schema:name The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis
99 schema:pagination 169-175
100 schema:productId N67f582a298e042fe8ac708b2d0eb78a0
101 Ndb2c1f709d8445e88be3101131e73a0a
102 Ndd2f95a3a6844eeb9b914f5c658ed6eb
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033736377
104 https://doi.org/10.1007/s004280050152
105 schema:sdDatePublished 2022-08-04T16:53
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Na91bc2e46ad248149efde933685fd4ef
108 schema:url https://doi.org/10.1007/s004280050152
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N07a2f623c93b434f9e7fb4e48e32f57c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Renin-Angiotensin System
114 rdf:type schema:DefinedTerm
115 N14f9f0e3c6444457b2fb51cc8c5b891c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kidney Glomerulus
117 rdf:type schema:DefinedTerm
118 N153d5c850b7a4bc7aa0600f3121e5701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice
120 rdf:type schema:DefinedTerm
121 N182537b873744a5abfc4fd412ad87166 schema:volumeNumber 432
122 rdf:type schema:PublicationVolume
123 N1ceee2b35a3944c59c5a5e5f813278bd rdf:first sg:person.01007120102.31
124 rdf:rest N2e04b091c1df4408b77a84266314f7ef
125 N1d09104177484993b52b257ea0f8be03 schema:affiliation grid-institutes:grid.20515.33
126 schema:familyName Haraoka
127 schema:givenName Seij
128 rdf:type schema:Person
129 N2e04b091c1df4408b77a84266314f7ef rdf:first sg:person.01224412777.86
130 rdf:rest N79e85fe11d844bb7b396b9ef7461c44a
131 N4d4848792b3d44fc82ead2499a30fd8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice, Transgenic
133 rdf:type schema:DefinedTerm
134 N53ccc6218c9a4e6ab9f2341bbe1776d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Blood Pressure
136 rdf:type schema:DefinedTerm
137 N56fbd3cf9ad641108cfe9daff31995c4 schema:issueNumber 2
138 rdf:type schema:PublicationIssue
139 N67f582a298e042fe8ac708b2d0eb78a0 schema:name doi
140 schema:value 10.1007/s004280050152
141 rdf:type schema:PropertyValue
142 N70246474b455417e8267e18b05b03cb0 rdf:first N1d09104177484993b52b257ea0f8be03
143 rdf:rest N1ceee2b35a3944c59c5a5e5f813278bd
144 N789fd4c8cef4479b83a36ff809a0166e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 N79e85fe11d844bb7b396b9ef7461c44a rdf:first sg:person.01305710302.41
148 rdf:rest Nb17a887539354f87be2e2f6d1ddc9cb0
149 N8b4782448712400da333120dde503901 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 N93c4cee2345d4a32b440a48338fcf110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Juxtaglomerular Apparatus
154 rdf:type schema:DefinedTerm
155 N9ac809a5f93d402c91c4e98509f81e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 Na91bc2e46ad248149efde933685fd4ef schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Nb17a887539354f87be2e2f6d1ddc9cb0 rdf:first sg:person.012664624074.29
161 rdf:rest rdf:nil
162 Nbf705d52fafa49478fac8ebbc2a59e52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Animals
164 rdf:type schema:DefinedTerm
165 Nca2ca0b0ce80408a8c1443d59b112a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Endothelium
167 rdf:type schema:DefinedTerm
168 Ncb26f73c7df64280ada858551562d41b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hypertension
170 rdf:type schema:DefinedTerm
171 Nd8b19b110e774efba2965aace25b15d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Muscle, Smooth, Vascular
173 rdf:type schema:DefinedTerm
174 Nda39c18be9e645fe842c1a72290b53ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Glomerulosclerosis, Focal Segmental
176 rdf:type schema:DefinedTerm
177 Ndb2c1f709d8445e88be3101131e73a0a schema:name pubmed_id
178 schema:value 9504863
179 rdf:type schema:PropertyValue
180 Ndd2f95a3a6844eeb9b914f5c658ed6eb schema:name dimensions_id
181 schema:value pub.1033736377
182 rdf:type schema:PropertyValue
183 Ne0a3c7c26d4a4f6592f702134c4b974c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Arteritis
185 rdf:type schema:DefinedTerm
186 Nf8b54ae4c31d45f69fe4ee5f8f825156 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Disease Models, Animal
188 rdf:type schema:DefinedTerm
189 Nfa835e4c4fe142edb339d217048a2e31 rdf:first sg:person.01271015273.11
190 rdf:rest N70246474b455417e8267e18b05b03cb0
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical Physiology
196 rdf:type schema:DefinedTerm
197 sg:journal.1106235 schema:issn 0945-6317
198 1432-2307
199 schema:name Virchows Archiv
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01007120102.31 schema:affiliation grid-institutes:grid.20515.33
203 schema:familyName Horiguchi
204 schema:givenName Hisashi
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007120102.31
206 rdf:type schema:Person
207 sg:person.01224412777.86 schema:affiliation grid-institutes:grid.20515.33
208 schema:familyName Sugiyama
209 schema:givenName Fumihiro
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224412777.86
211 rdf:type schema:Person
212 sg:person.012664624074.29 schema:affiliation grid-institutes:grid.20515.33
213 schema:familyName Watanabe
214 schema:givenName T.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012664624074.29
216 rdf:type schema:Person
217 sg:person.01271015273.11 schema:affiliation grid-institutes:grid.20515.33
218 schema:familyName Shimokama
219 schema:givenName Tatsuro
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271015273.11
221 rdf:type schema:Person
222 sg:person.01305710302.41 schema:affiliation grid-institutes:grid.20515.33
223 schema:familyName Murakami
224 schema:givenName Kazuo
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305710302.41
226 rdf:type schema:Person
227 sg:pub.10.1007/978-3-642-66954-5_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016777843
228 https://doi.org/10.1007/978-3-642-66954-5_16
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/bf00585940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024869059
231 https://doi.org/10.1007/bf00585940
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/bf02915101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046528613
234 https://doi.org/10.1007/bf02915101
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/226551a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018877976
237 https://doi.org/10.1038/226551a0
238 rdf:type schema:CreativeWork
239 grid-institutes:grid.20515.33 schema:alternateName Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP
240 Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP
241 Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP
242 schema:name Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Tel.: (+81) 298-53-3160, Fax: (+81) 298-53-3160 E-mail: nabeteru@md. tuskuba.ac.jp, JP
243 Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan, JP
244 Laboratory Animal Research Centre, University of Tsukuba, Tsukuba, Ibaraki 305, Japan, JP
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...