Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-01

AUTHORS

Markku Miettinen, Jerzy Lasota

ABSTRACT

. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. They are defined here as KIT (CD117, stem cell factor receptor)-positive mesenchymal spindle cell or epithelioid neoplasms primary in the GI tract, omentum, and mesentery. GISTs typically present in older individuals and are most common in the stomach (60–70%), followed by small intestine (20–25%), colon and rectum (5%), and esophagus (<5%). Benign tumors outnumber the malignant ones by a wide margin. Approximately 70% of GISTs are positive for CD34, 20–30% are positive for smooth muscle actin (SMA), 10% are positive for S100 protein and <5% are positive for desmin. The expression of CD34 and SMA is often reciprocal. GISTs commonly have activating mutations in exon 11 (or rarely exon 9 and exon 13) of the KIT gene that encodes a tyrosine kinase receptor for the growth factor named stem cell factor or mast cell growth factor. Ligand-independent activation of KIT appears to be a strong candidate for molecular pathogenesis of GISTs, and it may be a target for future treatment for such tumors. Other genetic changes in GISTs discovered using comparative genomic hybridization include losses in 14q and 22q in both benign and malignant GISTs and occurrence in various gains predominantly in malignant GISTs. GISTs have phenotypic similarities with the interstitial cells of Cajal and, therefore, a histogenetic origin from these cells has been suggested. An alternative possibility, origin of pluripotential stem cells, is also possible; this is supported by the same origin of Cajal cells and smooth muscle and by the common SMA expression in GISTs. GISTs differ clinically and pathogenetically from true leiomyosarcomas (very rare in the GI tract) and leiomyomas. The latter occur in the GI tract, predominantly in the esophagus (intramural tumors) and the colon and rectum (muscularis mucosae tumors). They also differ from schwannomas that are benign S100-positive spindle cell tumors usually presenting in the stomach. GI autonomic nerve tumors (GANTs) are probably a subset of GIST. Other mesenchymal tumors that have to be separated from GISTs include inflammatory myofibroblastic tumors in children, desmoid, and dedifferentiated liposarcoma. Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs. More... »

PAGES

1-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280000338

DOI

http://dx.doi.org/10.1007/s004280000338

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027401391

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11213830


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leiomyoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurilemmoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA", 
          "id": "http://www.grid.ac/institutes/grid.496749.1", 
          "name": [
            "Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miettinen", 
        "givenName": "Markku", 
        "id": "sg:person.01053336254.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053336254.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA", 
          "id": "http://www.grid.ac/institutes/grid.496749.1", 
          "name": [
            "Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lasota", 
        "givenName": "Jerzy", 
        "id": "sg:person.01136611424.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136611424.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00197388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016177750", 
          "https://doi.org/10.1007/bf00197388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00193492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021035383", 
          "https://doi.org/10.1007/bf00193492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004166521", 
          "https://doi.org/10.1038/sj.onc.1202496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017956501", 
          "https://doi.org/10.1038/1209"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-01", 
    "datePublishedReg": "2001-01-01", 
    "description": "Abstract. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. They are defined here as KIT (CD117, stem cell factor receptor)-positive mesenchymal spindle cell or epithelioid neoplasms primary in the GI tract, omentum, and mesentery. GISTs typically present in older individuals and are most common in the stomach (60\u201370%), followed by small intestine (20\u201325%), colon and rectum (5%), and esophagus (<5%). Benign tumors outnumber the malignant ones by a wide margin. Approximately 70% of GISTs are positive for CD34, 20\u201330% are positive for smooth muscle actin (SMA), 10% are positive for S100 protein and <5% are positive for desmin. The expression of CD34 and SMA is often reciprocal. GISTs commonly have activating mutations in exon 11 (or rarely exon 9 and exon 13) of the KIT gene that encodes a tyrosine kinase receptor for the growth factor named stem cell factor or mast cell growth factor. Ligand-independent activation of KIT appears to be a strong candidate for molecular pathogenesis of GISTs, and it may be a target for future treatment for such tumors. Other genetic changes in GISTs discovered using comparative genomic hybridization include losses in 14q and 22q in both benign and malignant GISTs and occurrence in various gains predominantly in malignant GISTs. GISTs have phenotypic similarities with the interstitial cells of Cajal and, therefore, a histogenetic origin from these cells has been suggested. An alternative possibility, origin of pluripotential stem cells, is also possible; this is supported by the same origin of Cajal cells and smooth muscle and by the common SMA expression in GISTs. GISTs differ clinically and pathogenetically from true leiomyosarcomas (very rare in the GI tract) and leiomyomas. The latter occur in the GI tract, predominantly in the esophagus (intramural tumors) and the colon and rectum (muscularis mucosae tumors). They also differ from schwannomas that are benign S100-positive spindle cell tumors usually presenting in the stomach. GI autonomic nerve tumors (GANTs) are probably a subset of GIST. Other mesenchymal tumors that have to be separated from GISTs include inflammatory myofibroblastic tumors in children, desmoid, and dedifferentiated liposarcoma. Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s004280000338", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "438"
      }
    ], 
    "keywords": [
      "gastrointestinal stromal tumors", 
      "smooth muscle actin", 
      "malignant gastrointestinal stromal tumor", 
      "mesenchymal tumors", 
      "GI tract", 
      "stem cell factor", 
      "growth factor", 
      "inflammatory myofibroblastic tumor", 
      "common mesenchymal tumors", 
      "spindle cell tumors", 
      "mesenchymal spindle cells", 
      "cell factor", 
      "expression of CD34", 
      "subset of GISTs", 
      "molecular genetic features", 
      "cell growth factor", 
      "true leiomyosarcoma", 
      "nerve tumors", 
      "myofibroblastic tumor", 
      "Cajal cells", 
      "stromal tumors", 
      "tyrosine kinase receptors", 
      "cell tumors", 
      "epithelioid neoplasm", 
      "dedifferentiated liposarcoma", 
      "differential diagnosis", 
      "benign tumors", 
      "ligand-independent activation", 
      "such tumors", 
      "metastatic melanoma", 
      "smooth muscle", 
      "spindle cells", 
      "SMA expression", 
      "gastrointestinal tract", 
      "future treatment", 
      "pluripotential stem cells", 
      "muscle actin", 
      "molecular pathogenesis", 
      "interstitial cells", 
      "tumors", 
      "small intestine", 
      "histogenetic origin", 
      "older individuals", 
      "malignant ones", 
      "S100 protein", 
      "tract", 
      "genetic features", 
      "kinase receptors", 
      "mast cell growth factor", 
      "esophagus", 
      "rectum", 
      "colon", 
      "comparative genomic hybridization", 
      "stomach", 
      "CD34", 
      "exon 11", 
      "kit gene", 
      "stem cells", 
      "wide margin", 
      "cells", 
      "kit", 
      "genomic hybridization", 
      "genetic changes", 
      "angiosarcoma", 
      "leiomyosarcoma", 
      "factors", 
      "schwannoma", 
      "desmoids", 
      "leiomyoma", 
      "omentum", 
      "liposarcoma", 
      "neoplasms", 
      "CD117", 
      "pathogenesis", 
      "Cajal", 
      "mesentery", 
      "expression", 
      "melanoma", 
      "diagnosis", 
      "desmin", 
      "intestine", 
      "receptors", 
      "phenotypic similarity", 
      "muscle", 
      "treatment", 
      "children", 
      "activation", 
      "strong candidate", 
      "individuals", 
      "subset", 
      "mutations", 
      "target", 
      "actin", 
      "origin", 
      "protein", 
      "genes", 
      "occurrence", 
      "loss", 
      "changes", 
      "candidates", 
      "same origin", 
      "hybridization", 
      "margin", 
      "gain", 
      "features", 
      "alternative possibility", 
      "possibility", 
      "similarity", 
      "one", 
      "common SMA expression", 
      "benign S100-positive spindle cell tumors", 
      "S100-positive spindle cell tumors", 
      "GI autonomic nerve tumors", 
      "autonomic nerve tumors"
    ], 
    "name": "Gastrointestinal stromal tumors \u2013 definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis", 
    "pagination": "1-12", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027401391"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s004280000338"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11213830"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s004280000338", 
      "https://app.dimensions.ai/details/publication/pub.1027401391"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_327.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s004280000338"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s004280000338'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s004280000338'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s004280000338'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s004280000338'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      22 PREDICATES      156 URIs      144 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s004280000338 schema:about N0a45485474d549899f5020551cb6d2cd
2 N3bae8985cbdc4f11a851fc9733c5e8a0
3 N6ce9f691fdcd4a8a8052a7abedb97c6a
4 N87400b929f464d6992971742925ba2c0
5 N89e779a77339429d8277fc5a7770dee5
6 N97048f791fe64866a6231403f8d6a51d
7 N99accedd81e6420795331bbb62e1b12f
8 Na23c5c66f8854fdfb1fbd01ef5edd14d
9 Nb50e20d9c54f4efa9e5cde3b240d0ccd
10 Nfa4ba7bdc3f84a52a7670681edf7eef0
11 Nfb242861644a43edbefc32442cb68ec5
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N700b318c527e42bd949d0cd886cf98fc
15 schema:citation sg:pub.10.1007/bf00193492
16 sg:pub.10.1007/bf00197388
17 sg:pub.10.1038/1209
18 sg:pub.10.1038/sj.onc.1202496
19 schema:datePublished 2001-01
20 schema:datePublishedReg 2001-01-01
21 schema:description Abstract. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. They are defined here as KIT (CD117, stem cell factor receptor)-positive mesenchymal spindle cell or epithelioid neoplasms primary in the GI tract, omentum, and mesentery. GISTs typically present in older individuals and are most common in the stomach (60–70%), followed by small intestine (20–25%), colon and rectum (5%), and esophagus (<5%). Benign tumors outnumber the malignant ones by a wide margin. Approximately 70% of GISTs are positive for CD34, 20–30% are positive for smooth muscle actin (SMA), 10% are positive for S100 protein and <5% are positive for desmin. The expression of CD34 and SMA is often reciprocal. GISTs commonly have activating mutations in exon 11 (or rarely exon 9 and exon 13) of the KIT gene that encodes a tyrosine kinase receptor for the growth factor named stem cell factor or mast cell growth factor. Ligand-independent activation of KIT appears to be a strong candidate for molecular pathogenesis of GISTs, and it may be a target for future treatment for such tumors. Other genetic changes in GISTs discovered using comparative genomic hybridization include losses in 14q and 22q in both benign and malignant GISTs and occurrence in various gains predominantly in malignant GISTs. GISTs have phenotypic similarities with the interstitial cells of Cajal and, therefore, a histogenetic origin from these cells has been suggested. An alternative possibility, origin of pluripotential stem cells, is also possible; this is supported by the same origin of Cajal cells and smooth muscle and by the common SMA expression in GISTs. GISTs differ clinically and pathogenetically from true leiomyosarcomas (very rare in the GI tract) and leiomyomas. The latter occur in the GI tract, predominantly in the esophagus (intramural tumors) and the colon and rectum (muscularis mucosae tumors). They also differ from schwannomas that are benign S100-positive spindle cell tumors usually presenting in the stomach. GI autonomic nerve tumors (GANTs) are probably a subset of GIST. Other mesenchymal tumors that have to be separated from GISTs include inflammatory myofibroblastic tumors in children, desmoid, and dedifferentiated liposarcoma. Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N8c2cdacacc8347c081c927041f3f27f7
26 Ncbd39a7f66d3445c9cb2edb461881777
27 sg:journal.1106235
28 schema:keywords CD117
29 CD34
30 Cajal
31 Cajal cells
32 GI autonomic nerve tumors
33 GI tract
34 S100 protein
35 S100-positive spindle cell tumors
36 SMA expression
37 actin
38 activation
39 alternative possibility
40 angiosarcoma
41 autonomic nerve tumors
42 benign S100-positive spindle cell tumors
43 benign tumors
44 candidates
45 cell factor
46 cell growth factor
47 cell tumors
48 cells
49 changes
50 children
51 colon
52 common SMA expression
53 common mesenchymal tumors
54 comparative genomic hybridization
55 dedifferentiated liposarcoma
56 desmin
57 desmoids
58 diagnosis
59 differential diagnosis
60 epithelioid neoplasm
61 esophagus
62 exon 11
63 expression
64 expression of CD34
65 factors
66 features
67 future treatment
68 gain
69 gastrointestinal stromal tumors
70 gastrointestinal tract
71 genes
72 genetic changes
73 genetic features
74 genomic hybridization
75 growth factor
76 histogenetic origin
77 hybridization
78 individuals
79 inflammatory myofibroblastic tumor
80 interstitial cells
81 intestine
82 kinase receptors
83 kit
84 kit gene
85 leiomyoma
86 leiomyosarcoma
87 ligand-independent activation
88 liposarcoma
89 loss
90 malignant gastrointestinal stromal tumor
91 malignant ones
92 margin
93 mast cell growth factor
94 melanoma
95 mesenchymal spindle cells
96 mesenchymal tumors
97 mesentery
98 metastatic melanoma
99 molecular genetic features
100 molecular pathogenesis
101 muscle
102 muscle actin
103 mutations
104 myofibroblastic tumor
105 neoplasms
106 nerve tumors
107 occurrence
108 older individuals
109 omentum
110 one
111 origin
112 pathogenesis
113 phenotypic similarity
114 pluripotential stem cells
115 possibility
116 protein
117 receptors
118 rectum
119 same origin
120 schwannoma
121 similarity
122 small intestine
123 smooth muscle
124 smooth muscle actin
125 spindle cell tumors
126 spindle cells
127 stem cell factor
128 stem cells
129 stomach
130 stromal tumors
131 strong candidate
132 subset
133 subset of GISTs
134 such tumors
135 target
136 tract
137 treatment
138 true leiomyosarcoma
139 tumors
140 tyrosine kinase receptors
141 wide margin
142 schema:name Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
143 schema:pagination 1-12
144 schema:productId N90e259ce350f4a1fb70938987519e6b3
145 N9e83ca89d3ed4d0ab5e3040b7548e8d0
146 Nf8ad9f8497594dfbbd4f91f462435800
147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027401391
148 https://doi.org/10.1007/s004280000338
149 schema:sdDatePublished 2022-01-01T18:10
150 schema:sdLicense https://scigraph.springernature.com/explorer/license/
151 schema:sdPublisher N7a65c6d616e84e1a8228e1a526a99f2a
152 schema:url https://doi.org/10.1007/s004280000338
153 sgo:license sg:explorer/license/
154 sgo:sdDataset articles
155 rdf:type schema:ScholarlyArticle
156 N0a45485474d549899f5020551cb6d2cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Neurilemmoma
158 rdf:type schema:DefinedTerm
159 N32a7c429c6764d85a2d410159675f28f rdf:first sg:person.01136611424.97
160 rdf:rest rdf:nil
161 N3bae8985cbdc4f11a851fc9733c5e8a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Leiomyoma
163 rdf:type schema:DefinedTerm
164 N6ce9f691fdcd4a8a8052a7abedb97c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Gastrointestinal Neoplasms
166 rdf:type schema:DefinedTerm
167 N700b318c527e42bd949d0cd886cf98fc rdf:first sg:person.01053336254.60
168 rdf:rest N32a7c429c6764d85a2d410159675f28f
169 N7a65c6d616e84e1a8228e1a526a99f2a schema:name Springer Nature - SN SciGraph project
170 rdf:type schema:Organization
171 N87400b929f464d6992971742925ba2c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Immunohistochemistry
173 rdf:type schema:DefinedTerm
174 N89e779a77339429d8277fc5a7770dee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Molecular Sequence Data
176 rdf:type schema:DefinedTerm
177 N8c2cdacacc8347c081c927041f3f27f7 schema:issueNumber 1
178 rdf:type schema:PublicationIssue
179 N90e259ce350f4a1fb70938987519e6b3 schema:name dimensions_id
180 schema:value pub.1027401391
181 rdf:type schema:PropertyValue
182 N97048f791fe64866a6231403f8d6a51d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Oncogene Proteins
184 rdf:type schema:DefinedTerm
185 N99accedd81e6420795331bbb62e1b12f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Amino Acid Sequence
187 rdf:type schema:DefinedTerm
188 N9e83ca89d3ed4d0ab5e3040b7548e8d0 schema:name pubmed_id
189 schema:value 11213830
190 rdf:type schema:PropertyValue
191 Na23c5c66f8854fdfb1fbd01ef5edd14d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Diagnosis, Differential
193 rdf:type schema:DefinedTerm
194 Nb50e20d9c54f4efa9e5cde3b240d0ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Humans
196 rdf:type schema:DefinedTerm
197 Ncbd39a7f66d3445c9cb2edb461881777 schema:volumeNumber 438
198 rdf:type schema:PublicationVolume
199 Nf8ad9f8497594dfbbd4f91f462435800 schema:name doi
200 schema:value 10.1007/s004280000338
201 rdf:type schema:PropertyValue
202 Nfa4ba7bdc3f84a52a7670681edf7eef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mutation
204 rdf:type schema:DefinedTerm
205 Nfb242861644a43edbefc32442cb68ec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Proto-Oncogene Proteins c-kit
207 rdf:type schema:DefinedTerm
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
212 schema:name Clinical Sciences
213 rdf:type schema:DefinedTerm
214 sg:journal.1106235 schema:issn 0945-6317
215 1432-2307
216 schema:name Virchows Archiv
217 schema:publisher Springer Nature
218 rdf:type schema:Periodical
219 sg:person.01053336254.60 schema:affiliation grid-institutes:grid.496749.1
220 schema:familyName Miettinen
221 schema:givenName Markku
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053336254.60
223 rdf:type schema:Person
224 sg:person.01136611424.97 schema:affiliation grid-institutes:grid.496749.1
225 schema:familyName Lasota
226 schema:givenName Jerzy
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136611424.97
228 rdf:type schema:Person
229 sg:pub.10.1007/bf00193492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021035383
230 https://doi.org/10.1007/bf00193492
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/bf00197388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016177750
233 https://doi.org/10.1007/bf00197388
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017956501
236 https://doi.org/10.1038/1209
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/sj.onc.1202496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004166521
239 https://doi.org/10.1038/sj.onc.1202496
240 rdf:type schema:CreativeWork
241 grid-institutes:grid.496749.1 schema:alternateName Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA
242 schema:name Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue, N.W., Washington, DC 20306-6000, USA
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...