Helicobacter pylori infection produces expression of a secretory component in gastric mucous cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

Taimei Kaneko, Hiroyoshi Ota, Masayoshi Hayama, Taiji Akamatsu, Tsutomu Katsuyama

ABSTRACT

Helicobacter pylori infection induces the expression of a secretory component (SC) in gastric epithelial cells. We investigated the cell lineage of the SC- and immunoglobulin (Ig) A-expressing epithelial cells in H. pylori-infected gastric mucosa. Materials were obtained by means of gastric biopsy from H. pylori-infected patients (24 cases) before and after the eradication of H. pylori, from five normal uninfected volunteers, and from three gastrectomy cases. Acetic acid-ethanol-fixed and paraffin-embedded specimens were examined using histochemical staining for gastric mucins (periodic acid oxidation-thionine Schiff reaction-concanavalin A-horse radish peroxidase staining) by means of immunostaining for gastric mucins (45M1 and HIK1083), intestinal cells (MUC2 and CD10), Ki67, H. pylori, SC, and IgA. The SC and IgA were not found in normal gastric mucosa. The expressions of the SC and IgA in gastric surface mucous cells and mucous neck cells in the generating zone of the gastric mucosa of H. pylori-infected patients were significantly higher before eradication of H. pylori than after the eradication. These mucous cells have the potential for SC-mediated translocation of IgA into the gastric lumen, and this may act as part of the antibacterial defense system against H. pylori infection in the gastric generating zone. More... »

PAGES

514-520

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004280000285

DOI

http://dx.doi.org/10.1007/s004280000285

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016336679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11147172


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