Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-04

AUTHORS

Kosuke Miyai, Yuiko Yonekura, Keiichi Ito, Susumu Matsukuma, Hitoshi Tsuda

ABSTRACT

We previously demonstrated a genetic evidence of the progression from seminoma to embryonal carcinoma in mixed testicular germ cell tumors (TGCTs). This process, the “reprogramming” of seminoma cells, is crucial for pathological tumorigenesis and should be kept in mind while designing clinical therapeutic strategies. We hypothesized that a comparison between pure-type seminomas and seminoma components in mixed tumors (mixed-type seminomas) could reveal early changes in the reprogramming process. In the present study, we performed gene expression microarray analysis of six pure-type and six mixed-type seminomas. Hierarchical clustering analysis properly grouped each type of seminomas into a separated cluster. Supervised analysis between pure-type and mixed-type seminomas revealed 154 significantly dysregulated genes (Storey-adjusted q < 0.05). The genes with the highest overexpression in mixed-type seminomas compared with the pure-type seminomas included MT1 isoforms, PRSS8, TSC22D1, and SLC39A4; downregulated genes included DEFB123, LMTK2, and MYRF. Functional annotation analysis of the differentially expressed genes revealed that the top-ranked functional categories were related to cellular zinc metabolism and consisted of MT1 isoforms and SLC39A4, the results of which were validated using quantitative polymerase chain reaction and immunohistochemical analysis. In conclusion, this research provides further evidence that pure and mixed types of seminomas are molecularly different, which may contribute to elucidate the reprogramming mechanism in the progression of TGCTs. More... »

PAGES

1177-1186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-021-03168-5

DOI

http://dx.doi.org/10.1007/s00428-021-03168-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140184623

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34347114


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Complex and Mixed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Germ Cell and Embryonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Seminoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testicular Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
            "Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyai", 
        "givenName": "Kosuke", 
        "id": "sg:person.01307144321.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307144321.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yonekura", 
        "givenName": "Yuiko", 
        "id": "sg:person.016307414251.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016307414251.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Urology, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Keiichi", 
        "id": "sg:person.0742101353.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742101353.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsukuma", 
        "givenName": "Susumu", 
        "id": "sg:person.01042572065.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042572065.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuda", 
        "givenName": "Hitoshi", 
        "id": "sg:person.07547136242.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547136242.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1385/bter:104:1:057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009150743", 
          "https://doi.org/10.1385/bter:104:1:057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-015-2702-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050030762", 
          "https://doi.org/10.1007/s00280-015-2702-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2015.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046017855", 
          "https://doi.org/10.1038/labinvest.2015.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-8-142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023588367", 
          "https://doi.org/10.1186/1471-2105-8-142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042707059", 
          "https://doi.org/10.1038/modpathol.2008.127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-009-0307-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208112", 
          "https://doi.org/10.1007/s11010-009-0307-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-019-02560-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112781528", 
          "https://doi.org/10.1007/s00428-019-02560-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017986774", 
          "https://doi.org/10.1038/ncomms6973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sigtrans.2017.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090915478", 
          "https://doi.org/10.1038/sigtrans.2017.29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026684135", 
          "https://doi.org/10.1038/bjc.2015.408"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-08-04", 
    "datePublishedReg": "2021-08-04", 
    "description": "We previously demonstrated a genetic evidence of the progression from seminoma to embryonal carcinoma in mixed testicular germ cell tumors (TGCTs). This process, the \u201creprogramming\u201d of seminoma cells, is crucial for pathological tumorigenesis and should be kept in mind while designing clinical therapeutic strategies. We hypothesized that a comparison between pure-type seminomas and seminoma components in mixed tumors (mixed-type seminomas) could reveal early changes in the reprogramming process. In the present study, we performed gene expression microarray analysis of six pure-type and six mixed-type seminomas. Hierarchical clustering analysis properly grouped each type of seminomas into a separated cluster. Supervised analysis between pure-type and mixed-type seminomas revealed 154 significantly dysregulated genes (Storey-adjusted q\u2009<\u20090.05). The genes with the highest overexpression in mixed-type seminomas compared with the pure-type seminomas included MT1 isoforms, PRSS8, TSC22D1, and SLC39A4; downregulated genes included DEFB123, LMTK2, and MYRF. Functional annotation analysis of the differentially expressed genes revealed that the top-ranked functional categories were related to cellular zinc metabolism and consisted of MT1 isoforms and SLC39A4, the results of which were validated using quantitative polymerase chain reaction and immunohistochemical analysis. In conclusion, this research provides further evidence that pure and mixed types of seminomas are molecularly different, which may contribute to elucidate the reprogramming mechanism in the progression of TGCTs.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00428-021-03168-5", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8420090", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "479"
      }
    ], 
    "keywords": [
      "testicular germ cell tumors", 
      "germ cell tumors", 
      "seminoma component", 
      "cell tumors", 
      "gene expression microarray analysis", 
      "mixed tumor", 
      "mixed testicular germ cell tumor", 
      "expression microarray analysis", 
      "adult testicular germ cell tumors", 
      "MT1 isoforms", 
      "types of seminomas", 
      "progression of TGCTs", 
      "clinical therapeutic strategies", 
      "microarray analysis", 
      "quantitative polymerase chain reaction", 
      "polymerase chain reaction", 
      "therapeutic strategies", 
      "immunohistochemical analysis", 
      "embryonal carcinoma", 
      "seminoma", 
      "early changes", 
      "seminoma cells", 
      "zinc metabolism", 
      "tumors", 
      "chain reaction", 
      "high overexpression", 
      "functional annotation analysis", 
      "cellular zinc metabolism", 
      "progression", 
      "present study", 
      "supervised analysis", 
      "further evidence", 
      "mixed type", 
      "carcinoma", 
      "isoforms", 
      "SLC39A4", 
      "genes", 
      "evidence", 
      "annotation analysis", 
      "tumorigenesis", 
      "genetic evidence", 
      "PRSS8", 
      "metabolism", 
      "overexpression", 
      "conclusion", 
      "cells", 
      "MYRF", 
      "LMTK2", 
      "analysis", 
      "reprogramming", 
      "study", 
      "types", 
      "comparison", 
      "changes", 
      "mechanism", 
      "functional categories", 
      "categories", 
      "strategies", 
      "components", 
      "results", 
      "research", 
      "reaction", 
      "mind", 
      "process", 
      "clusters"
    ], 
    "name": "Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors", 
    "pagination": "1177-1186", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1140184623"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-021-03168-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34347114"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-021-03168-5", 
      "https://app.dimensions.ai/details/publication/pub.1140184623"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_911.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00428-021-03168-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-021-03168-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-021-03168-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-021-03168-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-021-03168-5'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      120 URIs      102 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-021-03168-5 schema:about N08c38d41a4714fbd904dca49a705b9f5
2 N0c89cefa94714e52a0989ea62432046a
3 N1080d07c46dd4422b5a4ed568265b95f
4 N2a86b9c5c5394b3e9723ca4e8607b73d
5 N324a97100cea4b4999efcc5a5f9bfb96
6 N564f6a20de1641f0981c2a0d29fed1d0
7 N5baf1b37889e48ad81e1780a390d610f
8 N5f7bb10ea0e74166b1b5bea5e6247da4
9 N66a662b9487e4b72b59382455b92e4f1
10 N76c09b4e282344568c8f728bd61478da
11 N7a463168d0cc4fc6bd0bfee3e7fc4787
12 N8730127ab0ba484eac5449c5c3011b2a
13 N92c9c4969097463190d8a614169731f0
14 Na586383aa0cb497fa0075d5148036e16
15 Nd95923ee94134111859b864eb820ea00
16 Ndacd877d1a1640c7833cc10a3877c749
17 Ne414597482214522b2eda71900c62f59
18 Nf34aed2462bf4f61b8656488d710b8d5
19 Nf72489471be44bb9bffc1e3c7b6a7c8e
20 Nff6f988c09834981b2d360fa75709c29
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N317bbec5375f49df8c48c165924fca67
24 schema:citation sg:pub.10.1007/s00280-015-2702-2
25 sg:pub.10.1007/s00428-019-02560-6
26 sg:pub.10.1007/s11010-009-0307-y
27 sg:pub.10.1038/bjc.2015.408
28 sg:pub.10.1038/labinvest.2015.12
29 sg:pub.10.1038/modpathol.2008.127
30 sg:pub.10.1038/ncomms6973
31 sg:pub.10.1038/sigtrans.2017.29
32 sg:pub.10.1186/1471-2105-8-142
33 sg:pub.10.1385/bter:104:1:057
34 schema:datePublished 2021-08-04
35 schema:datePublishedReg 2021-08-04
36 schema:description We previously demonstrated a genetic evidence of the progression from seminoma to embryonal carcinoma in mixed testicular germ cell tumors (TGCTs). This process, the “reprogramming” of seminoma cells, is crucial for pathological tumorigenesis and should be kept in mind while designing clinical therapeutic strategies. We hypothesized that a comparison between pure-type seminomas and seminoma components in mixed tumors (mixed-type seminomas) could reveal early changes in the reprogramming process. In the present study, we performed gene expression microarray analysis of six pure-type and six mixed-type seminomas. Hierarchical clustering analysis properly grouped each type of seminomas into a separated cluster. Supervised analysis between pure-type and mixed-type seminomas revealed 154 significantly dysregulated genes (Storey-adjusted q < 0.05). The genes with the highest overexpression in mixed-type seminomas compared with the pure-type seminomas included MT1 isoforms, PRSS8, TSC22D1, and SLC39A4; downregulated genes included DEFB123, LMTK2, and MYRF. Functional annotation analysis of the differentially expressed genes revealed that the top-ranked functional categories were related to cellular zinc metabolism and consisted of MT1 isoforms and SLC39A4, the results of which were validated using quantitative polymerase chain reaction and immunohistochemical analysis. In conclusion, this research provides further evidence that pure and mixed types of seminomas are molecularly different, which may contribute to elucidate the reprogramming mechanism in the progression of TGCTs.
37 schema:genre article
38 schema:isAccessibleForFree false
39 schema:isPartOf Nd156d416c3bd4d4cace31edc6a0fe38c
40 Nd428e9a04ee84bf2a8aacc2ff09a891d
41 sg:journal.1106235
42 schema:keywords LMTK2
43 MT1 isoforms
44 MYRF
45 PRSS8
46 SLC39A4
47 adult testicular germ cell tumors
48 analysis
49 annotation analysis
50 carcinoma
51 categories
52 cell tumors
53 cells
54 cellular zinc metabolism
55 chain reaction
56 changes
57 clinical therapeutic strategies
58 clusters
59 comparison
60 components
61 conclusion
62 early changes
63 embryonal carcinoma
64 evidence
65 expression microarray analysis
66 functional annotation analysis
67 functional categories
68 further evidence
69 gene expression microarray analysis
70 genes
71 genetic evidence
72 germ cell tumors
73 high overexpression
74 immunohistochemical analysis
75 isoforms
76 mechanism
77 metabolism
78 microarray analysis
79 mind
80 mixed testicular germ cell tumor
81 mixed tumor
82 mixed type
83 overexpression
84 polymerase chain reaction
85 present study
86 process
87 progression
88 progression of TGCTs
89 quantitative polymerase chain reaction
90 reaction
91 reprogramming
92 research
93 results
94 seminoma
95 seminoma cells
96 seminoma component
97 strategies
98 study
99 supervised analysis
100 testicular germ cell tumors
101 therapeutic strategies
102 tumorigenesis
103 tumors
104 types
105 types of seminomas
106 zinc metabolism
107 schema:name Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors
108 schema:pagination 1177-1186
109 schema:productId N14c3a7e0cfbc4b72b508b82bbd5275c4
110 N19a87494a1d84fa488c71a0faafeca28
111 N6edc6a8342244337877db441df5a8ce6
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140184623
113 https://doi.org/10.1007/s00428-021-03168-5
114 schema:sdDatePublished 2022-11-24T21:08
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N65c0439fcae74e588030eeae5bde63af
117 schema:url https://doi.org/10.1007/s00428-021-03168-5
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N08c38d41a4714fbd904dca49a705b9f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Reverse Transcriptase Polymerase Chain Reaction
123 rdf:type schema:DefinedTerm
124 N0c89cefa94714e52a0989ea62432046a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Testicular Neoplasms
126 rdf:type schema:DefinedTerm
127 N1080d07c46dd4422b5a4ed568265b95f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Adult
129 rdf:type schema:DefinedTerm
130 N14c3a7e0cfbc4b72b508b82bbd5275c4 schema:name pubmed_id
131 schema:value 34347114
132 rdf:type schema:PropertyValue
133 N15b38a8138414cf7a41ea5a6b7ba0357 rdf:first sg:person.01042572065.02
134 rdf:rest N39edf8651db748b1996bc40744011f98
135 N19a87494a1d84fa488c71a0faafeca28 schema:name dimensions_id
136 schema:value pub.1140184623
137 rdf:type schema:PropertyValue
138 N2a86b9c5c5394b3e9723ca4e8607b73d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Transcriptome
140 rdf:type schema:DefinedTerm
141 N317bbec5375f49df8c48c165924fca67 rdf:first sg:person.01307144321.06
142 rdf:rest N6c53dd58d4004069ae476968aae160e4
143 N324a97100cea4b4999efcc5a5f9bfb96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation, Neoplastic
145 rdf:type schema:DefinedTerm
146 N39edf8651db748b1996bc40744011f98 rdf:first sg:person.07547136242.70
147 rdf:rest rdf:nil
148 N564f6a20de1641f0981c2a0d29fed1d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Immunohistochemistry
150 rdf:type schema:DefinedTerm
151 N5baf1b37889e48ad81e1780a390d610f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Neoplasms, Germ Cell and Embryonal
153 rdf:type schema:DefinedTerm
154 N5f7bb10ea0e74166b1b5bea5e6247da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Gene Expression Profiling
156 rdf:type schema:DefinedTerm
157 N65c0439fcae74e588030eeae5bde63af schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N66a662b9487e4b72b59382455b92e4f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Humans
161 rdf:type schema:DefinedTerm
162 N6c53dd58d4004069ae476968aae160e4 rdf:first sg:person.016307414251.40
163 rdf:rest N729ca0b39d964f5c87d284bc581275de
164 N6edc6a8342244337877db441df5a8ce6 schema:name doi
165 schema:value 10.1007/s00428-021-03168-5
166 rdf:type schema:PropertyValue
167 N729ca0b39d964f5c87d284bc581275de rdf:first sg:person.0742101353.31
168 rdf:rest N15b38a8138414cf7a41ea5a6b7ba0357
169 N76c09b4e282344568c8f728bd61478da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Biomarkers, Tumor
171 rdf:type schema:DefinedTerm
172 N7a463168d0cc4fc6bd0bfee3e7fc4787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Middle Aged
174 rdf:type schema:DefinedTerm
175 N8730127ab0ba484eac5449c5c3011b2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Real-Time Polymerase Chain Reaction
177 rdf:type schema:DefinedTerm
178 N92c9c4969097463190d8a614169731f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Young Adult
180 rdf:type schema:DefinedTerm
181 Na586383aa0cb497fa0075d5148036e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Disease Progression
183 rdf:type schema:DefinedTerm
184 Nd156d416c3bd4d4cace31edc6a0fe38c schema:volumeNumber 479
185 rdf:type schema:PublicationVolume
186 Nd428e9a04ee84bf2a8aacc2ff09a891d schema:issueNumber 6
187 rdf:type schema:PublicationIssue
188 Nd95923ee94134111859b864eb820ea00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Neoplasms, Complex and Mixed
190 rdf:type schema:DefinedTerm
191 Ndacd877d1a1640c7833cc10a3877c749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Male
193 rdf:type schema:DefinedTerm
194 Ne414597482214522b2eda71900c62f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Seminoma
196 rdf:type schema:DefinedTerm
197 Nf34aed2462bf4f61b8656488d710b8d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Oligonucleotide Array Sequence Analysis
199 rdf:type schema:DefinedTerm
200 Nf72489471be44bb9bffc1e3c7b6a7c8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Cellular Reprogramming
202 rdf:type schema:DefinedTerm
203 Nff6f988c09834981b2d360fa75709c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Adolescent
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
210 schema:name Clinical Sciences
211 rdf:type schema:DefinedTerm
212 sg:grant.8420090 http://pending.schema.org/fundedItem sg:pub.10.1007/s00428-021-03168-5
213 rdf:type schema:MonetaryGrant
214 sg:journal.1106235 schema:issn 0945-6317
215 1432-2307
216 schema:name Virchows Archiv
217 schema:publisher Springer Nature
218 rdf:type schema:Periodical
219 sg:person.01042572065.02 schema:affiliation grid-institutes:grid.416614.0
220 schema:familyName Matsukuma
221 schema:givenName Susumu
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042572065.02
223 rdf:type schema:Person
224 sg:person.01307144321.06 schema:affiliation grid-institutes:grid.416614.0
225 schema:familyName Miyai
226 schema:givenName Kosuke
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307144321.06
228 rdf:type schema:Person
229 sg:person.016307414251.40 schema:affiliation grid-institutes:grid.416614.0
230 schema:familyName Yonekura
231 schema:givenName Yuiko
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016307414251.40
233 rdf:type schema:Person
234 sg:person.0742101353.31 schema:affiliation grid-institutes:grid.416614.0
235 schema:familyName Ito
236 schema:givenName Keiichi
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742101353.31
238 rdf:type schema:Person
239 sg:person.07547136242.70 schema:affiliation grid-institutes:grid.416614.0
240 schema:familyName Tsuda
241 schema:givenName Hitoshi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547136242.70
243 rdf:type schema:Person
244 sg:pub.10.1007/s00280-015-2702-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050030762
245 https://doi.org/10.1007/s00280-015-2702-2
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s00428-019-02560-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112781528
248 https://doi.org/10.1007/s00428-019-02560-6
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s11010-009-0307-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1004208112
251 https://doi.org/10.1007/s11010-009-0307-y
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/bjc.2015.408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026684135
254 https://doi.org/10.1038/bjc.2015.408
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/labinvest.2015.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046017855
257 https://doi.org/10.1038/labinvest.2015.12
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/modpathol.2008.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042707059
260 https://doi.org/10.1038/modpathol.2008.127
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/ncomms6973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017986774
263 https://doi.org/10.1038/ncomms6973
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sigtrans.2017.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090915478
266 https://doi.org/10.1038/sigtrans.2017.29
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1471-2105-8-142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023588367
269 https://doi.org/10.1186/1471-2105-8-142
270 rdf:type schema:CreativeWork
271 sg:pub.10.1385/bter:104:1:057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009150743
272 https://doi.org/10.1385/bter:104:1:057
273 rdf:type schema:CreativeWork
274 grid-institutes:grid.416614.0 schema:alternateName Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
275 Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan
276 Department of Urology, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan
277 schema:name Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
278 Department of Laboratory Medicine, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan
279 Department of Urology, National Defense Medical College, 359-8513, Tokorozawa, Saitama, Japan
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...