Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-10

AUTHORS

Sebastian Hölters, Oybek Khalmurzaev, Alexey Pryalukhin, Philine Loertzer, Martin Janssen, Julia Heinzelbecker, Stefan Ueberdiek, Thorsten Pfuhl, Sigrun Smola, Abbas Agaimy, Carol Geppert, Hagen Loertzer, Xaver Krah, Heiko Wunderlich, Stefan Wagenpfeil, Rainer M Bohle, Michael Stöckle, Vsevolod Matveev, Arndt Hartmann, Kerstin Junker

ABSTRACT

The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. HPV genotyping and p16INK4a immunostaining were performed. The histological subtype and TNM were reclassified by two experienced uropathologists. Survival analyses were performed by Kaplan-Meier estimator and log-rank test. Uni- and multivariable analyses were performed by Cox proportional hazard model and Fisher's exact test for contingency analysis. HPV status was not found to be an independent prognostic factor. Histological subtypes differ in prognosis with the best outcome found in warty and the worst in basaloid carcinomas. Patients with pT1b defined by poor differentiation or lymphovascular invasion (LVI) had the shortest metastasis-free survival compared with pT1a (log-rank, p = 0.02). Lymph node metastasis and LVI were significantly associated with poor metastasis-free, cancer-specific and overall survival and could be identified as the only independent prognostic parameters. Prognostic value of TNM could not be improved using the 8th versus the 7th edition. In contrast to HPV status, histological subtypes are of prognostic value and should be an essential part of pathologic reports. The impact of the HPV status needs to be analysed in a subtype-specific manner. Parameters describing lymphatic dissemination have the highest impact on prognosis. Inclusion of tumour grade and LVI into a single T-category (pT1b) seems questionable. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-019-02566-0

DOI

http://dx.doi.org/10.1007/s00428-019-02566-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113356258

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30972551


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RDF/XML is a standard XML format for linked data.

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