CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01

AUTHORS

Rita T. Lawlor, Valentina Daprà, Ilaria Girolami, Antonio Pea, Camilla Pilati, Alessia Nottegar, Paola Piccoli, Claudia Parolini, Nicola Sperandio, Paola Capelli, Aldo Scarpa, Claudio Luchini

ABSTRACT

CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities. More... »

PAGES

105-109

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-018-2437-7

DOI

http://dx.doi.org/10.1007/s00428-018-2437-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106255144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30132130


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