Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

Mustafa Mohamed, David Gonzalez, Karen J. Fritchie, John Swansbury, Dorte Wren, Charlotte Benson, Robin L. Jones, Cyril Fisher, Khin Thway

ABSTRACT

Desmoplastic small round cell tumor (DSRCT) is a rare, biologically aggressive soft tissue neoplasm of uncertain differentiation, most often arising in the abdominal and pelvic cavities of adolescents and young adults with a striking male predominance. Histologically, it is characterized by islands of uniform small round cells in prominent desmoplastic stroma, and it has a polyimmunophenotypic profile, typically expressing WT1 and cytokeratin, desmin, and neural/neuroendocrine differentiation markers to varying degrees. Tumors at other sites and with variant morphology are more rarely described. DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion. Fluorescence in situ hybridization (FISH), to detect EWSR1 rearrangement, and reverse transcription-polymerase chain reaction (RT-PCR) to assess for EWSR1-WT1 fusion transcripts are routine diagnostic ancillary tools. We present a large institutional comparative series of FISH and RT-PCR for DSRCT diagnosis. Twenty-six specimens (from 25 patients) histologically diagnosed as DSRCT were assessed for EWSR1 rearrangement and EWSR1-WT1 fusion transcripts. Of these 26 specimens, 24 yielded positive results with either FISH or RT-PCR or both. FISH was performed in 23 samples, with EWSR1 rearrangement seen in 21 (91.3%). RT-PCR was performed in 18 samples, of which 13 (72.2%) harbored EWSR1-WT1 fusion transcripts. The sensitivity of FISH in detecting DSRCT was 91.3%, and that of RT-PCR was 92.8% following omission of four technical failures. Therefore, both methods are comparable in terms of sensitivity. FISH is more sensitive if technical failures for RT-PCR are taken into account, and RT-PCR is more specific in confirming DSRCT. Both methods complement each other by confirming cases that the other method may not. In isolation, FISH is a relatively non-specific diagnostic adjunct due to the number of different neoplasms that can harbor EWSR1 rearrangement, such as Ewing sarcoma. However, in cases with appropriate morphology and a typical pattern of immunostaining, FISH is confirmatory of the diagnosis. More... »

PAGES

631-640

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-017-2207-y

DOI

http://dx.doi.org/10.1007/s00428-017-2207-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090898147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28748349


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calmodulin-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Desmoplastic Small Round Cell Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Protein EWS", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohamed", 
        "givenName": "Mustafa", 
        "id": "sg:person.011464634065.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464634065.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Molecular Diagnostics, Royal Marsden Hospital, Surrey, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "David", 
        "id": "sg:person.01233421047.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233421047.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Divisions of Anatomic Pathology and Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fritchie", 
        "givenName": "Karen J.", 
        "id": "sg:person.0771203335.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771203335.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Clinical Cytogenetics, Royal Marsden Hospital, Surrey, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swansbury", 
        "givenName": "John", 
        "id": "sg:person.01252652123.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252652123.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Molecular Diagnostics, Royal Marsden Hospital, Surrey, Sutton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wren", 
        "givenName": "Dorte", 
        "id": "sg:person.01101260631.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101260631.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benson", 
        "givenName": "Charlotte", 
        "id": "sg:person.01316126434.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316126434.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Robin L.", 
        "id": "sg:person.01110361365.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110361365.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fisher", 
        "givenName": "Cyril", 
        "id": "sg:person.0650371415.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650371415.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thway", 
        "givenName": "Khin", 
        "id": "sg:person.01023745035.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023745035.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00000478-199106000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000398294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199106000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000398294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199106000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000398294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000539582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002173575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199506000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002346308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199506000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002346308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2045-3329-2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003332979", 
          "https://doi.org/10.1186/2045-3329-2-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2010.076133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003505559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(99)90119-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004615936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.1997.d01-620.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005082800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.1997.d01-620.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005082800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1827.2006.02003.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008669227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31825485c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009596018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31825485c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009596018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.mp.0000056630.76035.f3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010634839", 
          "https://doi.org/10.1097/01.mp.0000056630.76035.f3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2004.025502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012043041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2006.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015533176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100249900108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016532886", 
          "https://doi.org/10.1007/s100249900108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(95)90303-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018533006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018651500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018651500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2015-203380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020436798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15513818909022347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020750401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2008.04.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020842236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(93)90105-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024955853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(92)90094-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028270063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-007-0488-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028481851", 
          "https://doi.org/10.1007/s00405-007-0488-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-007-0488-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028481851", 
          "https://doi.org/10.1007/s00405-007-0488-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1197-309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032380305", 
          "https://doi.org/10.1038/ng1197-309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-199802000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032566918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-199802000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032566918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033061234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033061234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000213432.14740.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035653406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000213432.14740.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035653406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200006000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037765600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200006000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037765600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199204000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038633576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199204000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038633576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2016-203691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039491253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2005.026245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042799970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200207000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043185484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200207000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043185484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anndiagpath.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045888064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000128676.64288.0f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049135478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000128676.64288.0f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049135478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(98)00062-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049341252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199507000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051148685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199507000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051148685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2014.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052415450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199601000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060121965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199604000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199702000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199702000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199702000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199811000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199911000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199911000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199911000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/114.3.345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074698772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074701724", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082385761", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082463128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082692480", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082789265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082953417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.9.3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083316825"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11", 
    "datePublishedReg": "2017-11-01", 
    "description": "Desmoplastic small round cell tumor (DSRCT) is a rare, biologically aggressive soft tissue neoplasm of uncertain differentiation, most often arising in the abdominal and pelvic cavities of adolescents and young adults with a striking male predominance. Histologically, it is characterized by islands of uniform small round cells in prominent desmoplastic stroma, and it has a polyimmunophenotypic profile, typically expressing WT1 and cytokeratin, desmin, and neural/neuroendocrine differentiation markers to varying degrees. Tumors at other sites and with variant morphology are more rarely described. DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion. Fluorescence in situ hybridization (FISH), to detect EWSR1 rearrangement, and reverse transcription-polymerase chain reaction (RT-PCR) to assess for EWSR1-WT1 fusion transcripts are routine diagnostic ancillary tools. We present a large institutional comparative series of FISH and RT-PCR for DSRCT diagnosis. Twenty-six specimens (from 25 patients) histologically diagnosed as DSRCT were assessed for EWSR1 rearrangement and EWSR1-WT1 fusion transcripts. Of these 26 specimens, 24 yielded positive results with either FISH or RT-PCR or both. FISH was performed in 23 samples, with EWSR1 rearrangement seen in 21 (91.3%). RT-PCR was performed in 18 samples, of which 13 (72.2%) harbored EWSR1-WT1 fusion transcripts. The sensitivity of FISH in detecting DSRCT was 91.3%, and that of RT-PCR was 92.8% following omission of four technical failures. Therefore, both methods are comparable in terms of sensitivity. FISH is more sensitive if technical failures for RT-PCR are taken into account, and RT-PCR is more specific in confirming DSRCT. Both methods complement each other by confirming cases that the other method may not. In isolation, FISH is a relatively non-specific diagnostic adjunct due to the number of different neoplasms that can harbor EWSR1 rearrangement, such as Ewing sarcoma. However, in cases with appropriate morphology and a typical pattern of immunostaining, FISH is confirmatory of the diagnosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-017-2207-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "471"
      }
    ], 
    "name": "Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques", 
    "pagination": "631-640", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "88cfee86f1ec2957ab5d01f69e85db993b5ab3ab78950399bd659029699c558d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28748349"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-017-2207-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090898147"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-017-2207-y", 
      "https://app.dimensions.ai/details/publication/pub.1090898147"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113677_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00428-017-2207-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-017-2207-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-017-2207-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-017-2207-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-017-2207-y'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      94 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-017-2207-y schema:about N01e13a6adba74536a6eb11e7b611fd4c
2 N08b9e519d9c146eca3ecd47052a0bae9
3 N361a4413cbfa48b7b0713e1b85406fa0
4 N37096bcfac464944809507588e607465
5 N39bb3feeaaa04275834f7783fd17e06c
6 N5b339ef2e3e24a0285b31739706bdcaa
7 N5c8bb7547a524b3cac0a1677dd8e7dd3
8 N7721612dde7942c6813f3e1bf8bd3e38
9 N893e3e1991be4a4d966af6a5108689bf
10 N9806c07570444942a94994c40d779d4a
11 N9f77936519ab4ae6936c25ab85f89d85
12 Na6dc6a5cbeb9458a99fae3a1b7339cc0
13 Na9c14796c87c4e91b15a308eaebb8a08
14 Nb71c3500028947a0a3a11804ef81dc74
15 Ndeabc7ab784f4e5291ab68cd94e5ba5e
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N9753bef32b534b6bad38852b980c6ba7
19 schema:citation sg:pub.10.1007/s00405-007-0488-5
20 sg:pub.10.1007/s100249900108
21 sg:pub.10.1038/ng1197-309
22 sg:pub.10.1097/01.mp.0000056630.76035.f3
23 sg:pub.10.1186/2045-3329-2-3
24 https://app.dimensions.ai/details/publication/pub.1074701724
25 https://app.dimensions.ai/details/publication/pub.1082385761
26 https://app.dimensions.ai/details/publication/pub.1082463128
27 https://app.dimensions.ai/details/publication/pub.1082692480
28 https://app.dimensions.ai/details/publication/pub.1082789265
29 https://app.dimensions.ai/details/publication/pub.1082953417
30 https://doi.org/10.1002/cncr.21282
31 https://doi.org/10.1016/0046-8177(92)90094-j
32 https://doi.org/10.1016/0046-8177(95)90303-8
33 https://doi.org/10.1016/0165-4608(93)90105-u
34 https://doi.org/10.1016/j.anndiagpath.2015.03.004
35 https://doi.org/10.1016/j.canlet.2006.03.027
36 https://doi.org/10.1016/j.humpath.2008.04.019
37 https://doi.org/10.1016/j.humpath.2014.09.015
38 https://doi.org/10.1016/s0046-8177(99)90119-3
39 https://doi.org/10.1016/s0165-4608(98)00062-4
40 https://doi.org/10.1046/j.1365-2559.1997.d01-620.x
41 https://doi.org/10.1093/ajcp/114.3.345
42 https://doi.org/10.1097/00000478-199106000-00001
43 https://doi.org/10.1097/00000478-199204000-00010
44 https://doi.org/10.1097/00000478-199506000-00006
45 https://doi.org/10.1097/00000478-199601000-00013
46 https://doi.org/10.1097/00000478-199604000-00002
47 https://doi.org/10.1097/00000478-199702000-00013
48 https://doi.org/10.1097/00000478-199811000-00001
49 https://doi.org/10.1097/00000478-199811000-00002
50 https://doi.org/10.1097/00000478-199911000-00012
51 https://doi.org/10.1097/00000478-200006000-00008
52 https://doi.org/10.1097/00000478-200207000-00001
53 https://doi.org/10.1097/00004347-199507000-00011
54 https://doi.org/10.1097/00019606-199802000-00005
55 https://doi.org/10.1097/01.pas.0000128676.64288.0f
56 https://doi.org/10.1097/01.pas.0000213432.14740.14
57 https://doi.org/10.1097/pas.0000000000000231
58 https://doi.org/10.1097/pas.0b013e31825485c5
59 https://doi.org/10.1111/his.12269
60 https://doi.org/10.1111/j.1440-1827.2006.02003.x
61 https://doi.org/10.1136/jclinpath-2015-203380
62 https://doi.org/10.1136/jclinpath-2016-203691
63 https://doi.org/10.1136/jcp.2004.025502
64 https://doi.org/10.1136/jcp.2005.026245
65 https://doi.org/10.1136/jcp.2010.076133
66 https://doi.org/10.1158/0008-5472.can-08-4041
67 https://doi.org/10.1200/jco.1998.16.9.3028
68 https://doi.org/10.3109/15513818909022347
69 schema:datePublished 2017-11
70 schema:datePublishedReg 2017-11-01
71 schema:description Desmoplastic small round cell tumor (DSRCT) is a rare, biologically aggressive soft tissue neoplasm of uncertain differentiation, most often arising in the abdominal and pelvic cavities of adolescents and young adults with a striking male predominance. Histologically, it is characterized by islands of uniform small round cells in prominent desmoplastic stroma, and it has a polyimmunophenotypic profile, typically expressing WT1 and cytokeratin, desmin, and neural/neuroendocrine differentiation markers to varying degrees. Tumors at other sites and with variant morphology are more rarely described. DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion. Fluorescence in situ hybridization (FISH), to detect EWSR1 rearrangement, and reverse transcription-polymerase chain reaction (RT-PCR) to assess for EWSR1-WT1 fusion transcripts are routine diagnostic ancillary tools. We present a large institutional comparative series of FISH and RT-PCR for DSRCT diagnosis. Twenty-six specimens (from 25 patients) histologically diagnosed as DSRCT were assessed for EWSR1 rearrangement and EWSR1-WT1 fusion transcripts. Of these 26 specimens, 24 yielded positive results with either FISH or RT-PCR or both. FISH was performed in 23 samples, with EWSR1 rearrangement seen in 21 (91.3%). RT-PCR was performed in 18 samples, of which 13 (72.2%) harbored EWSR1-WT1 fusion transcripts. The sensitivity of FISH in detecting DSRCT was 91.3%, and that of RT-PCR was 92.8% following omission of four technical failures. Therefore, both methods are comparable in terms of sensitivity. FISH is more sensitive if technical failures for RT-PCR are taken into account, and RT-PCR is more specific in confirming DSRCT. Both methods complement each other by confirming cases that the other method may not. In isolation, FISH is a relatively non-specific diagnostic adjunct due to the number of different neoplasms that can harbor EWSR1 rearrangement, such as Ewing sarcoma. However, in cases with appropriate morphology and a typical pattern of immunostaining, FISH is confirmatory of the diagnosis.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree false
75 schema:isPartOf N7d9592bb1eae4031b969ebec3e032571
76 N90d2eac478964dca9e4ce6d23b20556e
77 sg:journal.1106235
78 schema:name Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques
79 schema:pagination 631-640
80 schema:productId N0f1f4e9ca45b4923b72b00d88cee8d1f
81 N275cb68a1e1e431fa31498a28e6f361f
82 N3f185fdaa7e54c5f80eb4b38a7521f17
83 N5520218164ae42d4a567b1acb7bb91ce
84 Nd7e76c35a3974c0bbdcdd0cf387be8ce
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090898147
86 https://doi.org/10.1007/s00428-017-2207-y
87 schema:sdDatePublished 2019-04-11T10:38
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N22039a0665ea4a35b50fafe6aedd1a51
90 schema:url https://link.springer.com/10.1007%2Fs00428-017-2207-y
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0107b984fe424b6a8f90ff409388a85d rdf:first sg:person.0771203335.01
95 rdf:rest Ned102ec4838748fd906f2500271a8ef4
96 N01e13a6adba74536a6eb11e7b611fd4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Female
98 rdf:type schema:DefinedTerm
99 N08b9e519d9c146eca3ecd47052a0bae9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Desmoplastic Small Round Cell Tumor
101 rdf:type schema:DefinedTerm
102 N0f1f4e9ca45b4923b72b00d88cee8d1f schema:name dimensions_id
103 schema:value pub.1090898147
104 rdf:type schema:PropertyValue
105 N1341bfe9548a46c0b33c47c0e1ae1cce rdf:first sg:person.01316126434.16
106 rdf:rest N4b02999fba6c4d1d9d0940c0f578aed9
107 N22039a0665ea4a35b50fafe6aedd1a51 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N275cb68a1e1e431fa31498a28e6f361f schema:name doi
110 schema:value 10.1007/s00428-017-2207-y
111 rdf:type schema:PropertyValue
112 N361a4413cbfa48b7b0713e1b85406fa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name RNA-Binding Protein EWS
114 rdf:type schema:DefinedTerm
115 N37096bcfac464944809507588e607465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 N39bb3feeaaa04275834f7783fd17e06c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Calmodulin-Binding Proteins
120 rdf:type schema:DefinedTerm
121 N3b27ea7a46d64794a348cdcc92e48015 rdf:first sg:person.0650371415.92
122 rdf:rest N6447a2516053456590edee7e65b38f91
123 N3f185fdaa7e54c5f80eb4b38a7521f17 schema:name pubmed_id
124 schema:value 28748349
125 rdf:type schema:PropertyValue
126 N4b02999fba6c4d1d9d0940c0f578aed9 rdf:first sg:person.01110361365.31
127 rdf:rest N3b27ea7a46d64794a348cdcc92e48015
128 N5520218164ae42d4a567b1acb7bb91ce schema:name readcube_id
129 schema:value 88cfee86f1ec2957ab5d01f69e85db993b5ab3ab78950399bd659029699c558d
130 rdf:type schema:PropertyValue
131 N5b339ef2e3e24a0285b31739706bdcaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adolescent
133 rdf:type schema:DefinedTerm
134 N5c8bb7547a524b3cac0a1677dd8e7dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name RNA-Binding Proteins
136 rdf:type schema:DefinedTerm
137 N6447a2516053456590edee7e65b38f91 rdf:first sg:person.01023745035.11
138 rdf:rest rdf:nil
139 N64997c784f65467e82633841f8c7da87 rdf:first sg:person.01233421047.98
140 rdf:rest N0107b984fe424b6a8f90ff409388a85d
141 N7721612dde7942c6813f3e1bf8bd3e38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 N7d9592bb1eae4031b969ebec3e032571 schema:issueNumber 5
145 rdf:type schema:PublicationIssue
146 N893e3e1991be4a4d966af6a5108689bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Adult
148 rdf:type schema:DefinedTerm
149 N90d2eac478964dca9e4ce6d23b20556e schema:volumeNumber 471
150 rdf:type schema:PublicationVolume
151 N9753bef32b534b6bad38852b980c6ba7 rdf:first sg:person.011464634065.66
152 rdf:rest N64997c784f65467e82633841f8c7da87
153 N9806c07570444942a94994c40d779d4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name In Situ Hybridization, Fluorescence
155 rdf:type schema:DefinedTerm
156 N9e03c0055c1a4e4f9dd3d4520f9764ae rdf:first sg:person.01101260631.44
157 rdf:rest N1341bfe9548a46c0b33c47c0e1ae1cce
158 N9f77936519ab4ae6936c25ab85f89d85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Child
160 rdf:type schema:DefinedTerm
161 Na6dc6a5cbeb9458a99fae3a1b7339cc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Middle Aged
163 rdf:type schema:DefinedTerm
164 Na9c14796c87c4e91b15a308eaebb8a08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Young Adult
166 rdf:type schema:DefinedTerm
167 Nb71c3500028947a0a3a11804ef81dc74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Oncogene Proteins, Fusion
169 rdf:type schema:DefinedTerm
170 Nd7e76c35a3974c0bbdcdd0cf387be8ce schema:name nlm_unique_id
171 schema:value 9423843
172 rdf:type schema:PropertyValue
173 Ndeabc7ab784f4e5291ab68cd94e5ba5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Reverse Transcriptase Polymerase Chain Reaction
175 rdf:type schema:DefinedTerm
176 Ned102ec4838748fd906f2500271a8ef4 rdf:first sg:person.01252652123.38
177 rdf:rest N9e03c0055c1a4e4f9dd3d4520f9764ae
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
182 schema:name Oncology and Carcinogenesis
183 rdf:type schema:DefinedTerm
184 sg:journal.1106235 schema:issn 0945-6317
185 1432-2307
186 schema:name Virchows Archiv
187 rdf:type schema:Periodical
188 sg:person.01023745035.11 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
189 schema:familyName Thway
190 schema:givenName Khin
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023745035.11
192 rdf:type schema:Person
193 sg:person.01101260631.44 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
194 schema:familyName Wren
195 schema:givenName Dorte
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101260631.44
197 rdf:type schema:Person
198 sg:person.01110361365.31 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
199 schema:familyName Jones
200 schema:givenName Robin L.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110361365.31
202 rdf:type schema:Person
203 sg:person.011464634065.66 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
204 schema:familyName Mohamed
205 schema:givenName Mustafa
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464634065.66
207 rdf:type schema:Person
208 sg:person.01233421047.98 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
209 schema:familyName Gonzalez
210 schema:givenName David
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233421047.98
212 rdf:type schema:Person
213 sg:person.01252652123.38 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
214 schema:familyName Swansbury
215 schema:givenName John
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252652123.38
217 rdf:type schema:Person
218 sg:person.01316126434.16 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
219 schema:familyName Benson
220 schema:givenName Charlotte
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316126434.16
222 rdf:type schema:Person
223 sg:person.0650371415.92 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
224 schema:familyName Fisher
225 schema:givenName Cyril
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650371415.92
227 rdf:type schema:Person
228 sg:person.0771203335.01 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
229 schema:familyName Fritchie
230 schema:givenName Karen J.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771203335.01
232 rdf:type schema:Person
233 sg:pub.10.1007/s00405-007-0488-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028481851
234 https://doi.org/10.1007/s00405-007-0488-5
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s100249900108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016532886
237 https://doi.org/10.1007/s100249900108
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/ng1197-309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032380305
240 https://doi.org/10.1038/ng1197-309
241 rdf:type schema:CreativeWork
242 sg:pub.10.1097/01.mp.0000056630.76035.f3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010634839
243 https://doi.org/10.1097/01.mp.0000056630.76035.f3
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/2045-3329-2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003332979
246 https://doi.org/10.1186/2045-3329-2-3
247 rdf:type schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1074701724 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1082385761 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1082463128 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082692480 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082789265 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082953417 schema:CreativeWork
254 https://doi.org/10.1002/cncr.21282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018651500
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/0046-8177(92)90094-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1028270063
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0046-8177(95)90303-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018533006
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/0165-4608(93)90105-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1024955853
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.anndiagpath.2015.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045888064
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.canlet.2006.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015533176
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.humpath.2008.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020842236
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.humpath.2014.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052415450
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0046-8177(99)90119-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004615936
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0165-4608(98)00062-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049341252
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1046/j.1365-2559.1997.d01-620.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005082800
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/ajcp/114.3.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074698772
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/00000478-199106000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000398294
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1097/00000478-199204000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038633576
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1097/00000478-199506000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002346308
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1097/00000478-199601000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060121965
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1097/00000478-199604000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122026
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1097/00000478-199702000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122256
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1097/00000478-199811000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122707
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00000478-199811000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122708
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00000478-199911000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122996
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/00000478-200006000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037765600
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/00000478-200207000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043185484
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/00004347-199507000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051148685
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/00019606-199802000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032566918
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/01.pas.0000128676.64288.0f schema:sameAs https://app.dimensions.ai/details/publication/pub.1049135478
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1097/01.pas.0000213432.14740.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035653406
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1097/pas.0000000000000231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033061234
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1097/pas.0b013e31825485c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009596018
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/his.12269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000539582
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1440-1827.2006.02003.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008669227
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1136/jclinpath-2015-203380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020436798
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1136/jclinpath-2016-203691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039491253
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1136/jcp.2004.025502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012043041
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1136/jcp.2005.026245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042799970
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1136/jcp.2010.076133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003505559
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/0008-5472.can-08-4041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002173575
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1200/jco.1998.16.9.3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083316825
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3109/15513818909022347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020750401
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.424926.f schema:alternateName Royal Marsden Hospital
333 schema:name Clinical Cytogenetics, Royal Marsden Hospital, Surrey, Sutton, UK
334 Molecular Diagnostics, Royal Marsden Hospital, Surrey, Sutton, UK
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.5072.0 schema:alternateName Royal Marsden NHS Foundation Trust
337 schema:name Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, London, UK
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
340 schema:name Divisions of Anatomic Pathology and Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...