Testing for ROS1 in non-small cell lung cancer: a review with recommendations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Lukas Bubendorf, Reinhard Büttner, Fouad Al-Dayel, Manfred Dietel, Göran Elmberger, Keith Kerr, Fernando López-Ríos, Antonio Marchetti, Büge Öz, Patrick Pauwels, Frédérique Penault-Llorca, Giulio Rossi, Aleš Ryška, Erik Thunnissen

ABSTRACT

Rearrangements of the ROS1 gene occur in 1-2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laboratories currently rely on fluorescence in situ hybridisation (FISH) assays using a dual-colour break-apart probe to detect ROS1 rearrangements. Given the rarity of these rearrangements in NSCLC, detection of elevated ROS1 protein levels by immunohistochemistry may provide cost-effective screening prior to confirmatory FISH testing. Non-in situ testing approaches also hold potential as stand-alone methods or complementary tests, including multiplex real-time PCR assays and next-generation sequencing (NGS) platforms which include commercial test kits covering a range of fusion genes. In order to ensure high-quality biomarker testing, appropriate tissue handling, adequate control materials and participation in external quality assessment programmes are essential, irrespective of the testing technique employed. ROS1 testing is often only considered after negative tests for EGFR mutation and ALK gene rearrangement, based on the assumption that these oncogenic driver events tend to be exclusive. However, as the use of ROS1 inhibitors becomes routine, accurate and timely detection of ROS1 gene rearrangements will be critical for the optimal treatment of patients with NSCLC. As NGS techniques are introduced into routine diagnostic practice, ROS1 fusion gene testing will be provided as part of the initial testing package. More... »

PAGES

489-503

References to SciGraph publications

  • 2015-01. ROS1 gene rearrangement and copy number gain in non-small cell lung cancer in VIRCHOWS ARCHIV
  • 2012-03. RET, ROS1 and ALK fusions in lung cancer in NATURE MEDICINE
  • 2016-06. Bronchoscopic Re-biopsy for Mutational Analysis of Non-small Cell Lung Cancer in LUNG
  • 2014-12. Anchored multiplex PCR for targeted next-generation sequencing in NATURE MEDICINE
  • 2014-07-09. Comprehensive molecular profiling of lung adenocarcinoma in NATURE
  • 2015. The Pre-analytical Phase in Surgical Pathology in PRE-ANALYTICS OF PATHOLOGICAL SPECIMENS IN ONCOLOGY
  • 2015-02. Biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2007-04. Expression of the cytoskeleton linker protein ezrin in human cancers in CLINICAL & EXPERIMENTAL METASTASIS
  • 2007-12. RNA extraction from ten year old formalin-fixed paraffin-embedded breast cancer samples: a comparison of column purification and magnetic bead-based technologies in BMC MOLECULAR BIOLOGY
  • 2015-04. Comprehensive analysis of RET and ROS1 rearrangement in lung adenocarcinoma in MODERN PATHOLOGY
  • 2014-03. Prognostic and predictive biomarkers in lung cancer. A review in VIRCHOWS ARCHIV
  • 2016-03. Combined analysis of rearrangement of ALK, ROS1, somatic mutation of EGFR, KRAS, BRAF, PIK3CA, and mRNA expression of ERCC1, TYMS, RRM1, TUBB3, EGFR in patients with non-small cell lung cancer and their clinical significance in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2014-05. Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers in MODERN PATHOLOGY
  • 2015-07. Erratum to: ROS1 gene rearrangement and copy number gain in non-small cell lung cancer in VIRCHOWS ARCHIV
  • 2012-09. EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations in VIRCHOWS ARCHIV
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-016-2000-3

    DOI

    http://dx.doi.org/10.1007/s00428-016-2000-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022838465

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27535289


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