An international study comparing conventional versus mRNA level testing (TargetPrint) for ER, PR, and HER2 status of breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09

AUTHORS

Jelle Wesseling, Corrado Tinterri, Anna Sapino, Fabrizio Zanconati, Martijn Lutke-Holzik, Bichlien Nguyen, Kenneth B Deck, Patrizia Querzoli, Tiziana Perin, Carmela Giardina, Gerhard Seitz, Jean-Marc Guinebretière, Julie Barone, Laura Dekker, Femke de Snoo, Lisette Stork-Sloots, Paul Roepman, Toru Watanabe, Pino Cusumano

ABSTRACT

To compare results from messenger RNA (mRNA)-based TargetPrint testing with those from immunohistochemistry (IHC) and in situ hybridization (ISH) conducted according to local standard procedures at hospitals worldwide. Tumor samples were prospectively obtained from 806 patients at 22 hospitals. The mRNA level of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) was assessed by TargetPrint quantitative gene expression readouts. IHC/ISH assessments were performed according to local standards at the participating hospitals. TargetPrint readout showed a high concordance with IHC/ISH of 95 % (kappa 0.81) for ER, 81 % (kappa 0.56) for PR, and 94 % (kappa 0.76) for HER2. The positive/negative agreement between TargetPrint and IHC for ER, PR, and HER2 was 96 %/87 %, 84 %/74 %, and 74 %/98 %, respectively. The concordance rate in IHC/ISH results between hospitals varied: 88-100 % for ER (kappa 0.50-1.00); 50-100 % for PR (kappa 0.20-1.00); and 90-100 % for HER2 (kappa 0.59-1.00). mRNA readout of ER, PR, and HER2 status by TargetPrint was largely comparable to local IHC/ISH analysis. However, there was substantial discordance in IHC/ISH results between different hospitals. When results are discordant, the use of TargetPrint would improve the reliability of hormone receptor and HER2 results by prompting retesting in a reference laboratory. More... »

PAGES

297-304

References to SciGraph publications

  • 2007-04. The effects of fixation, processing and evaluation criteria on immunohistochemical detection of hormone receptors in breast cancer in BREAST CANCER
  • 2014-02. Central pathology laboratory review of HER2 and ER in early breast cancer: an ALTTO trial [BIG 2-06/NCCTG N063D (Alliance)] ring study in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-12. A gene expression profile for detection of sufficient tumour cells in breast tumour tissue: microarray diagnosis eligibility in BMC MEDICAL GENOMICS
  • 2008-12. Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen in BMC GENOMICS
  • 2012-04. ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer in BREAST CANCER RESEARCH
  • 2010-05. Issues and updates: evaluating estrogen receptor-α, progesterone receptor, and HER2 in breast cancer in MODERN PATHOLOGY
  • 2007-05. Standardization of HER2 testing: results of an international proficiency-testing ring study in MODERN PATHOLOGY
  • 2016-02. Discordant assessment of tumor biomarkers by histopathological and molecular assays in the EORTC randomized controlled 10041/BIG 03-04 MINDACT trial breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-12. HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens in BMC CANCER
  • 2012-10. Comparison of Molecular Subtyping with BluePrint, MammaPrint, and TargetPrint to Local Clinical Subtyping in Breast Cancer Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2010-01. Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patients in BREAST CANCER RESEARCH AND TREATMENT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-016-1979-9

    DOI

    http://dx.doi.org/10.1007/s00428-016-1979-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035083675

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27377889


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Estrogen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Progesterone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Antoni van Leeuwenhoek Hospital", 
              "id": "https://www.grid.ac/institutes/grid.430814.a", 
              "name": [
                "Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wesseling", 
            "givenName": "Jelle", 
            "id": "sg:person.0672321535.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672321535.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Humanitas Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417728.f", 
              "name": [
                "Breast Surgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tinterri", 
            "givenName": "Corrado", 
            "id": "sg:person.01156415557.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156415557.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Turin", 
              "id": "https://www.grid.ac/institutes/grid.7605.4", 
              "name": [
                "Department of Medical Sciences, Universit\u00e0 di Torino, Torino, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sapino", 
            "givenName": "Anna", 
            "id": "sg:person.01133265311.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133265311.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Trieste", 
              "id": "https://www.grid.ac/institutes/grid.5133.4", 
              "name": [
                "Anatomic Pathology Unit, Universit\u00e0 di Trieste, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zanconati", 
            "givenName": "Fabrizio", 
            "id": "sg:person.0707443145.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707443145.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medisch Spectrum Twente", 
              "id": "https://www.grid.ac/institutes/grid.415214.7", 
              "name": [
                "Department of Surgery, Medisch Spectrum Twente, Enschede and the Saxenburgh Group, Hardenberg, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lutke-Holzik", 
            "givenName": "Martijn", 
            "id": "sg:person.0640427203.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640427203.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Long Beach Memorial Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.415304.7", 
              "name": [
                "Department of Medicine, Todd Cancer Institute, Long Beach Memorial Medical Center, Long Beach, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "Bichlien", 
            "id": "sg:person.0761063635.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761063635.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Saddleback Memorial Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.416405.2", 
              "name": [
                "Memorial Care Breast Center, Saddleback Memorial Medical Center, Laguna Hills, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deck", 
            "givenName": "Kenneth B", 
            "id": "sg:person.01075312235.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075312235.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Ferrara", 
              "id": "https://www.grid.ac/institutes/grid.8484.0", 
              "name": [
                "Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, Universit\u00e0 di Ferrara, Ferrara, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Querzoli", 
            "givenName": "Patrizia", 
            "id": "sg:person.01117275052.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117275052.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centro di Riferimento Oncologico", 
              "id": "https://www.grid.ac/institutes/grid.418321.d", 
              "name": [
                "Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perin", 
            "givenName": "Tiziana", 
            "id": "sg:person.01161273346.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161273346.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bari Aldo Moro", 
              "id": "https://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Pathological Anatomy, Universit\u00e0 degli Studi di Bari, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giardina", 
            "givenName": "Carmela", 
            "id": "sg:person.0767233416.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767233416.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sozialstiftung Bamberg", 
              "id": "https://www.grid.ac/institutes/grid.419802.6", 
              "name": [
                "Institute of Pathology, Klinikum Bamberg, Bamberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seitz", 
            "givenName": "Gerhard", 
            "id": "sg:person.01053307516.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053307516.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Ren\u00e9 Huguenin", 
              "id": "https://www.grid.ac/institutes/grid.418205.a", 
              "name": [
                "Department of Pathology, Institut Curie, H\u00f4pital Ren\u00e9-Huguenin, Saint-Cloud, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guinebreti\u00e8re", 
            "givenName": "Jean-Marc", 
            "id": "sg:person.01244162220.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244162220.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sharp Memorial Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415655.6", 
              "name": [
                "Comprehensive Breast Care of San Diego and Sharp Memorial Hospital, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barone", 
            "givenName": "Julie", 
            "id": "sg:person.01257654035.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257654035.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Agendia (Netherlands)", 
              "id": "https://www.grid.ac/institutes/grid.423768.c", 
              "name": [
                "Agendia, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dekker", 
            "givenName": "Laura", 
            "id": "sg:person.013672455515.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672455515.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Agendia (Netherlands)", 
              "id": "https://www.grid.ac/institutes/grid.423768.c", 
              "name": [
                "Agendia, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Snoo", 
            "givenName": "Femke", 
            "id": "sg:person.01167175573.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167175573.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Agendia (Netherlands)", 
              "id": "https://www.grid.ac/institutes/grid.423768.c", 
              "name": [
                "Agendia, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stork-Sloots", 
            "givenName": "Lisette", 
            "id": "sg:person.0764724735.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764724735.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Agendia (Netherlands)", 
              "id": "https://www.grid.ac/institutes/grid.423768.c", 
              "name": [
                "Agendia, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roepman", 
            "givenName": "Paul", 
            "id": "sg:person.01335361547.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335361547.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Medicine, Hamamatsu Oncology Center, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Toru", 
            "id": "sg:person.016660357515.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016660357515.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre Hospitalier Chr\u00e9tien", 
              "id": "https://www.grid.ac/institutes/grid.433083.f", 
              "name": [
                "Gynecology Oncology Unit, Centre Hospitalier Chr\u00e9tien, Li\u00e8ge, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cusumano", 
            "givenName": "Pino", 
            "id": "sg:person.01033751672.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033751672.61"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1634/theoncologist.2008-0184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000312341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-0449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002055562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005342936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.36.2574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006957939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.03.4744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007072891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdr304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009166329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-9-239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010596045", 
              "https://doi.org/10.1186/1471-2164-9-239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djn200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011427122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pme.13.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011903621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.6529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016721540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-012-2561-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016994220", 
              "https://doi.org/10.1245/s10434-012-2561-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.9437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018919180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.53.2.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019542421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.10.6393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020707555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1755-8794-2-52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021337094", 
              "https://doi.org/10.1186/1755-8794-2-52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-1282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021940935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2012-0032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022301508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2010.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022350415", 
              "https://doi.org/10.1038/modpathol.2010.55"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2010.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022350415", 
              "https://doi.org/10.1038/modpathol.2010.55"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/4d1a04ncdk96wfy7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022759445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023808052", 
              "https://doi.org/10.1186/bcr3145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023809873", 
              "https://doi.org/10.1186/1471-2407-10-534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.8211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024504624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.09.2775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026719751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2325/jbcs.976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028729188", 
              "https://doi.org/10.2325/jbcs.976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2325/jbcs.976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028729188", 
              "https://doi.org/10.2325/jbcs.976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.11.9453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029462575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.pai.0000213135.16783.bc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030513246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.pai.0000213135.16783.bc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030513246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035152373", 
              "https://doi.org/10.1038/modpathol.3800774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035152373", 
              "https://doi.org/10.1038/modpathol.3800774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2827-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035490900", 
              "https://doi.org/10.1007/s10549-013-2827-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0318-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036794295", 
              "https://doi.org/10.1007/s10549-009-0318-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0318-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036794295", 
              "https://doi.org/10.1007/s10549-009-0318-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-3690-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038743376", 
              "https://doi.org/10.1007/s10549-016-3690-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-3690-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038743376", 
              "https://doi.org/10.1007/s10549-016-3690-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/001316446002000104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039619716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/001316446002000104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039619716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.34.7963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039783018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042228618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042592360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042592360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3816/cbc.2006.n.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043088315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/ajcp5uumfma5zkii", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043928777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/jmoldx.2009.080070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044572777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0036559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047525232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.14.2364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049142592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.25120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049287033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.25120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049287033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.06.6944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052926880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077263596", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1043/1543-2165-134.6.930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078171149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2011.0137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078483976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2011.0137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078483976"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-09", 
        "datePublishedReg": "2016-09-01", 
        "description": "To compare results from messenger RNA (mRNA)-based TargetPrint testing with those from immunohistochemistry (IHC) and in situ hybridization (ISH) conducted according to local standard procedures at hospitals worldwide. Tumor samples were prospectively obtained from 806 patients at 22 hospitals. The mRNA level of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) was assessed by TargetPrint quantitative gene expression readouts. IHC/ISH assessments were performed according to local standards at the participating hospitals. TargetPrint readout showed a high concordance with IHC/ISH of 95\u00a0% (kappa 0.81) for ER, 81\u00a0% (kappa 0.56) for PR, and 94\u00a0% (kappa 0.76) for HER2. The positive/negative agreement between TargetPrint and IHC for ER, PR, and HER2 was 96\u00a0%/87\u00a0%, 84\u00a0%/74\u00a0%, and 74\u00a0%/98\u00a0%, respectively. The concordance rate in IHC/ISH results between hospitals varied: 88-100\u00a0% for ER (kappa 0.50-1.00); 50-100\u00a0% for PR (kappa 0.20-1.00); and 90-100\u00a0% for HER2 (kappa 0.59-1.00). mRNA readout of ER, PR, and HER2 status by TargetPrint was largely comparable to local IHC/ISH analysis. However, there was substantial discordance in IHC/ISH results between different hospitals. When results are discordant, the use of TargetPrint would improve the reliability of hormone receptor and HER2 results by prompting retesting in a reference laboratory. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00428-016-1979-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1106235", 
            "issn": [
              "0945-6317", 
              "1432-2307"
            ], 
            "name": "Virchows Archiv", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "469"
          }
        ], 
        "name": "An international study comparing conventional versus mRNA level testing (TargetPrint) for ER, PR, and HER2 status of breast cancer", 
        "pagination": "297-304", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a7203d7991a92becdcb94d1e37cd17b7273d8bf34c0876b418fc3fc9f16ae1d3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27377889"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9423843"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00428-016-1979-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035083675"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00428-016-1979-9", 
          "https://app.dimensions.ai/details/publication/pub.1035083675"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70043_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00428-016-1979-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-016-1979-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-016-1979-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-016-1979-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-016-1979-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    441 TRIPLES      21 PREDICATES      88 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00428-016-1979-9 schema:about N016f38682878479c83ab98f7233b9215
    2 N0cb72131492146eebd0675afa8b7060c
    3 N5788466a14e647a99a506b1a695298ed
    4 N61fc931f73344c73a0886cb2edc73a4c
    5 N7a319286be324890ac0e0d9f94ef26f4
    6 N8d37e36636a3439398d50df2af3f3680
    7 N92cc07e1e3934d96acd48c8610f99ebf
    8 N9ee57bb9335a46dbb138aa8d0a2e1c2a
    9 Na741d442005646638634966bc0e85973
    10 Naa30ccbb5f834f60a0b623ef3d194633
    11 Nb0b91a9d75704e268e0430f24f6e9776
    12 Nbb8736c141db4c6db2a13bbbbd28ff0f
    13 Nbe42f8dd72904f98bd05a58efd5cd910
    14 Nea5ee29a368149bd9d07ded8613591a8
    15 Nf06b38e606784861ab40bcd2e153ef6c
    16 anzsrc-for:11
    17 anzsrc-for:1103
    18 schema:author N5babce43668045698b33bb069f659048
    19 schema:citation sg:pub.10.1007/s10549-009-0318-0
    20 sg:pub.10.1007/s10549-013-2827-0
    21 sg:pub.10.1007/s10549-016-3690-6
    22 sg:pub.10.1038/modpathol.2010.55
    23 sg:pub.10.1038/modpathol.3800774
    24 sg:pub.10.1186/1471-2164-9-239
    25 sg:pub.10.1186/1471-2407-10-534
    26 sg:pub.10.1186/1755-8794-2-52
    27 sg:pub.10.1186/bcr3145
    28 sg:pub.10.1245/s10434-012-2561-6
    29 sg:pub.10.2325/jbcs.976
    30 https://app.dimensions.ai/details/publication/pub.1077263596
    31 https://doi.org/10.1002/cncr.25120
    32 https://doi.org/10.1043/1543-2165-134.6.930
    33 https://doi.org/10.1093/annonc/mdp273
    34 https://doi.org/10.1093/annonc/mdp322
    35 https://doi.org/10.1093/annonc/mdr304
    36 https://doi.org/10.1093/annonc/mdu026
    37 https://doi.org/10.1093/jnci/djn200
    38 https://doi.org/10.1097/01.pai.0000213135.16783.bc
    39 https://doi.org/10.1136/jcp.53.2.125
    40 https://doi.org/10.1158/1078-0432.ccr-09-0449
    41 https://doi.org/10.1158/1078-0432.ccr-10-1282
    42 https://doi.org/10.1177/001316446002000104
    43 https://doi.org/10.1200/jco.2005.03.4744
    44 https://doi.org/10.1200/jco.2006.06.6944
    45 https://doi.org/10.1200/jco.2006.09.2775
    46 https://doi.org/10.1200/jco.2007.10.6393
    47 https://doi.org/10.1200/jco.2007.11.9453
    48 https://doi.org/10.1200/jco.2007.12.9437
    49 https://doi.org/10.1200/jco.2007.14.2364
    50 https://doi.org/10.1200/jco.2009.24.8211
    51 https://doi.org/10.1200/jco.2009.25.6529
    52 https://doi.org/10.1200/jco.2011.34.7963
    53 https://doi.org/10.1200/jco.2011.36.2574
    54 https://doi.org/10.1309/4d1a04ncdk96wfy7
    55 https://doi.org/10.1309/ajcp5uumfma5zkii
    56 https://doi.org/10.1371/journal.pone.0036559
    57 https://doi.org/10.1634/theoncologist.2008-0184
    58 https://doi.org/10.1634/theoncologist.2012-0032
    59 https://doi.org/10.2217/pme.13.88
    60 https://doi.org/10.2353/jmoldx.2009.080070
    61 https://doi.org/10.3816/cbc.2006.n.025
    62 https://doi.org/10.6004/jnccn.2011.0137
    63 schema:datePublished 2016-09
    64 schema:datePublishedReg 2016-09-01
    65 schema:description To compare results from messenger RNA (mRNA)-based TargetPrint testing with those from immunohistochemistry (IHC) and in situ hybridization (ISH) conducted according to local standard procedures at hospitals worldwide. Tumor samples were prospectively obtained from 806 patients at 22 hospitals. The mRNA level of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) was assessed by TargetPrint quantitative gene expression readouts. IHC/ISH assessments were performed according to local standards at the participating hospitals. TargetPrint readout showed a high concordance with IHC/ISH of 95 % (kappa 0.81) for ER, 81 % (kappa 0.56) for PR, and 94 % (kappa 0.76) for HER2. The positive/negative agreement between TargetPrint and IHC for ER, PR, and HER2 was 96 %/87 %, 84 %/74 %, and 74 %/98 %, respectively. The concordance rate in IHC/ISH results between hospitals varied: 88-100 % for ER (kappa 0.50-1.00); 50-100 % for PR (kappa 0.20-1.00); and 90-100 % for HER2 (kappa 0.59-1.00). mRNA readout of ER, PR, and HER2 status by TargetPrint was largely comparable to local IHC/ISH analysis. However, there was substantial discordance in IHC/ISH results between different hospitals. When results are discordant, the use of TargetPrint would improve the reliability of hormone receptor and HER2 results by prompting retesting in a reference laboratory.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N0cb35c8043284efe8dcbb578af953c20
    70 Nc9b29ad6525a4faf9039ce8a77e838b3
    71 sg:journal.1106235
    72 schema:name An international study comparing conventional versus mRNA level testing (TargetPrint) for ER, PR, and HER2 status of breast cancer
    73 schema:pagination 297-304
    74 schema:productId N0a55cc3b388749b89a2b354c27a0850c
    75 N2d7760eb991a41b1bd3a786e043e5204
    76 N5bb350ad25b14755bd6a803126faf73a
    77 N7db268745ed249febd43978f0326b5f7
    78 Ncc6fe55ef8d0459fab885d637d271c4e
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035083675
    80 https://doi.org/10.1007/s00428-016-1979-9
    81 schema:sdDatePublished 2019-04-11T12:39
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher N2984110f07d143f29bbce4dae8b0cab6
    84 schema:url https://link.springer.com/10.1007%2Fs00428-016-1979-9
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N016f38682878479c83ab98f7233b9215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Receptors, Estrogen
    90 rdf:type schema:DefinedTerm
    91 N04586b73cfc74f9ab3def498c0c55fb9 rdf:first sg:person.0761063635.15
    92 rdf:rest Nb224f76d25e44633960f5f9b6563102c
    93 N0a55cc3b388749b89a2b354c27a0850c schema:name doi
    94 schema:value 10.1007/s00428-016-1979-9
    95 rdf:type schema:PropertyValue
    96 N0cb35c8043284efe8dcbb578af953c20 schema:issueNumber 3
    97 rdf:type schema:PublicationIssue
    98 N0cb72131492146eebd0675afa8b7060c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Young Adult
    100 rdf:type schema:DefinedTerm
    101 N0e0657a868cd40ba9c6f38fee2bd68a8 rdf:first sg:person.01257654035.07
    102 rdf:rest Na1e06cb8f1b94cb4bbea39f04a6d1b6a
    103 N17fab10e9a124369afc0671fc531ac45 rdf:first sg:person.01167175573.05
    104 rdf:rest Ndf16c21ebe424e66ae8e79d320e95758
    105 N20fa731f337f4b54bf50f50b06758c59 rdf:first sg:person.01133265311.28
    106 rdf:rest Nf50a2eaa60854291902757967a9a375f
    107 N266ae172f6b54167ae4781f1b4072087 rdf:first sg:person.01244162220.06
    108 rdf:rest N0e0657a868cd40ba9c6f38fee2bd68a8
    109 N2984110f07d143f29bbce4dae8b0cab6 schema:name Springer Nature - SN SciGraph project
    110 rdf:type schema:Organization
    111 N2b791cbb5b454beea0edfd2b448b4192 rdf:first sg:person.016660357515.42
    112 rdf:rest N8869404450424a65982cd0da347d10a3
    113 N2d7760eb991a41b1bd3a786e043e5204 schema:name pubmed_id
    114 schema:value 27377889
    115 rdf:type schema:PropertyValue
    116 N5788466a14e647a99a506b1a695298ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Receptors, Progesterone
    118 rdf:type schema:DefinedTerm
    119 N5933b3ed70fd4994b0c103f303126711 rdf:first sg:person.0767233416.16
    120 rdf:rest N93344c215a0a4f29bb7b23f36e87eb1d
    121 N5babce43668045698b33bb069f659048 rdf:first sg:person.0672321535.45
    122 rdf:rest Nb8b18f5c55ca46759ceb393143e8abe4
    123 N5bb350ad25b14755bd6a803126faf73a schema:name nlm_unique_id
    124 schema:value 9423843
    125 rdf:type schema:PropertyValue
    126 N61fc931f73344c73a0886cb2edc73a4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Immunohistochemistry
    128 rdf:type schema:DefinedTerm
    129 N7a319286be324890ac0e0d9f94ef26f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N7db268745ed249febd43978f0326b5f7 schema:name dimensions_id
    133 schema:value pub.1035083675
    134 rdf:type schema:PropertyValue
    135 N8869404450424a65982cd0da347d10a3 rdf:first sg:person.01033751672.61
    136 rdf:rest rdf:nil
    137 N8aff460849d640668f3c1bae14efc920 rdf:first sg:person.0640427203.25
    138 rdf:rest N04586b73cfc74f9ab3def498c0c55fb9
    139 N8d37e36636a3439398d50df2af3f3680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Reproducibility of Results
    141 rdf:type schema:DefinedTerm
    142 N92cc07e1e3934d96acd48c8610f99ebf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Receptor, ErbB-2
    144 rdf:type schema:DefinedTerm
    145 N93344c215a0a4f29bb7b23f36e87eb1d rdf:first sg:person.01053307516.93
    146 rdf:rest N266ae172f6b54167ae4781f1b4072087
    147 N9ee57bb9335a46dbb138aa8d0a2e1c2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Aged, 80 and over
    149 rdf:type schema:DefinedTerm
    150 Na1e06cb8f1b94cb4bbea39f04a6d1b6a rdf:first sg:person.013672455515.57
    151 rdf:rest N17fab10e9a124369afc0671fc531ac45
    152 Na741d442005646638634966bc0e85973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Gene Expression Regulation, Neoplastic
    154 rdf:type schema:DefinedTerm
    155 Naa30ccbb5f834f60a0b623ef3d194633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Biomarkers, Tumor
    157 rdf:type schema:DefinedTerm
    158 Nb0b91a9d75704e268e0430f24f6e9776 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Adult
    160 rdf:type schema:DefinedTerm
    161 Nb224f76d25e44633960f5f9b6563102c rdf:first sg:person.01075312235.67
    162 rdf:rest Nfbcdd87dd776450db517dfc4b42ed92b
    163 Nb4ed5ea2bf864d498b37bdd713ad6a92 rdf:first sg:person.01335361547.47
    164 rdf:rest N2b791cbb5b454beea0edfd2b448b4192
    165 Nb54369f8d11648748296d8ad64402a2c rdf:first sg:person.01161273346.37
    166 rdf:rest N5933b3ed70fd4994b0c103f303126711
    167 Nb8b18f5c55ca46759ceb393143e8abe4 rdf:first sg:person.01156415557.01
    168 rdf:rest N20fa731f337f4b54bf50f50b06758c59
    169 Nbb8736c141db4c6db2a13bbbbd28ff0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Aged
    171 rdf:type schema:DefinedTerm
    172 Nbe42f8dd72904f98bd05a58efd5cd910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Breast Neoplasms
    174 rdf:type schema:DefinedTerm
    175 Nc9b29ad6525a4faf9039ce8a77e838b3 schema:volumeNumber 469
    176 rdf:type schema:PublicationVolume
    177 Ncc6fe55ef8d0459fab885d637d271c4e schema:name readcube_id
    178 schema:value a7203d7991a92becdcb94d1e37cd17b7273d8bf34c0876b418fc3fc9f16ae1d3
    179 rdf:type schema:PropertyValue
    180 Ndc253adc92cb4ec6af80f825f8484c88 schema:name Department of Medicine, Hamamatsu Oncology Center, Shizuoka, Japan
    181 rdf:type schema:Organization
    182 Ndf16c21ebe424e66ae8e79d320e95758 rdf:first sg:person.0764724735.42
    183 rdf:rest Nb4ed5ea2bf864d498b37bdd713ad6a92
    184 Nea5ee29a368149bd9d07ded8613591a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Middle Aged
    186 rdf:type schema:DefinedTerm
    187 Nf06b38e606784861ab40bcd2e153ef6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Female
    189 rdf:type schema:DefinedTerm
    190 Nf50a2eaa60854291902757967a9a375f rdf:first sg:person.0707443145.40
    191 rdf:rest N8aff460849d640668f3c1bae14efc920
    192 Nfbcdd87dd776450db517dfc4b42ed92b rdf:first sg:person.01117275052.75
    193 rdf:rest Nb54369f8d11648748296d8ad64402a2c
    194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Medical and Health Sciences
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Clinical Sciences
    199 rdf:type schema:DefinedTerm
    200 sg:journal.1106235 schema:issn 0945-6317
    201 1432-2307
    202 schema:name Virchows Archiv
    203 rdf:type schema:Periodical
    204 sg:person.01033751672.61 schema:affiliation https://www.grid.ac/institutes/grid.433083.f
    205 schema:familyName Cusumano
    206 schema:givenName Pino
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033751672.61
    208 rdf:type schema:Person
    209 sg:person.01053307516.93 schema:affiliation https://www.grid.ac/institutes/grid.419802.6
    210 schema:familyName Seitz
    211 schema:givenName Gerhard
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053307516.93
    213 rdf:type schema:Person
    214 sg:person.01075312235.67 schema:affiliation https://www.grid.ac/institutes/grid.416405.2
    215 schema:familyName Deck
    216 schema:givenName Kenneth B
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075312235.67
    218 rdf:type schema:Person
    219 sg:person.01117275052.75 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
    220 schema:familyName Querzoli
    221 schema:givenName Patrizia
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117275052.75
    223 rdf:type schema:Person
    224 sg:person.01133265311.28 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
    225 schema:familyName Sapino
    226 schema:givenName Anna
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133265311.28
    228 rdf:type schema:Person
    229 sg:person.01156415557.01 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
    230 schema:familyName Tinterri
    231 schema:givenName Corrado
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156415557.01
    233 rdf:type schema:Person
    234 sg:person.01161273346.37 schema:affiliation https://www.grid.ac/institutes/grid.418321.d
    235 schema:familyName Perin
    236 schema:givenName Tiziana
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161273346.37
    238 rdf:type schema:Person
    239 sg:person.01167175573.05 schema:affiliation https://www.grid.ac/institutes/grid.423768.c
    240 schema:familyName de Snoo
    241 schema:givenName Femke
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167175573.05
    243 rdf:type schema:Person
    244 sg:person.01244162220.06 schema:affiliation https://www.grid.ac/institutes/grid.418205.a
    245 schema:familyName Guinebretière
    246 schema:givenName Jean-Marc
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244162220.06
    248 rdf:type schema:Person
    249 sg:person.01257654035.07 schema:affiliation https://www.grid.ac/institutes/grid.415655.6
    250 schema:familyName Barone
    251 schema:givenName Julie
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257654035.07
    253 rdf:type schema:Person
    254 sg:person.01335361547.47 schema:affiliation https://www.grid.ac/institutes/grid.423768.c
    255 schema:familyName Roepman
    256 schema:givenName Paul
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335361547.47
    258 rdf:type schema:Person
    259 sg:person.013672455515.57 schema:affiliation https://www.grid.ac/institutes/grid.423768.c
    260 schema:familyName Dekker
    261 schema:givenName Laura
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672455515.57
    263 rdf:type schema:Person
    264 sg:person.016660357515.42 schema:affiliation Ndc253adc92cb4ec6af80f825f8484c88
    265 schema:familyName Watanabe
    266 schema:givenName Toru
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016660357515.42
    268 rdf:type schema:Person
    269 sg:person.0640427203.25 schema:affiliation https://www.grid.ac/institutes/grid.415214.7
    270 schema:familyName Lutke-Holzik
    271 schema:givenName Martijn
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640427203.25
    273 rdf:type schema:Person
    274 sg:person.0672321535.45 schema:affiliation https://www.grid.ac/institutes/grid.430814.a
    275 schema:familyName Wesseling
    276 schema:givenName Jelle
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672321535.45
    278 rdf:type schema:Person
    279 sg:person.0707443145.40 schema:affiliation https://www.grid.ac/institutes/grid.5133.4
    280 schema:familyName Zanconati
    281 schema:givenName Fabrizio
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707443145.40
    283 rdf:type schema:Person
    284 sg:person.0761063635.15 schema:affiliation https://www.grid.ac/institutes/grid.415304.7
    285 schema:familyName Nguyen
    286 schema:givenName Bichlien
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761063635.15
    288 rdf:type schema:Person
    289 sg:person.0764724735.42 schema:affiliation https://www.grid.ac/institutes/grid.423768.c
    290 schema:familyName Stork-Sloots
    291 schema:givenName Lisette
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764724735.42
    293 rdf:type schema:Person
    294 sg:person.0767233416.16 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
    295 schema:familyName Giardina
    296 schema:givenName Carmela
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767233416.16
    298 rdf:type schema:Person
    299 sg:pub.10.1007/s10549-009-0318-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036794295
    300 https://doi.org/10.1007/s10549-009-0318-0
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s10549-013-2827-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035490900
    303 https://doi.org/10.1007/s10549-013-2827-0
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s10549-016-3690-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038743376
    306 https://doi.org/10.1007/s10549-016-3690-6
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/modpathol.2010.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022350415
    309 https://doi.org/10.1038/modpathol.2010.55
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/modpathol.3800774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152373
    312 https://doi.org/10.1038/modpathol.3800774
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1186/1471-2164-9-239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010596045
    315 https://doi.org/10.1186/1471-2164-9-239
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1186/1471-2407-10-534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023809873
    318 https://doi.org/10.1186/1471-2407-10-534
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1186/1755-8794-2-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021337094
    321 https://doi.org/10.1186/1755-8794-2-52
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1186/bcr3145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023808052
    324 https://doi.org/10.1186/bcr3145
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1245/s10434-012-2561-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016994220
    327 https://doi.org/10.1245/s10434-012-2561-6
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.2325/jbcs.976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028729188
    330 https://doi.org/10.2325/jbcs.976
    331 rdf:type schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1077263596 schema:CreativeWork
    333 https://doi.org/10.1002/cncr.25120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049287033
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1043/1543-2165-134.6.930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078171149
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/annonc/mdp273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042228618
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/annonc/mdp322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042592360
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1093/annonc/mdr304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009166329
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1093/annonc/mdu026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005342936
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1093/jnci/djn200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011427122
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1097/01.pai.0000213135.16783.bc schema:sameAs https://app.dimensions.ai/details/publication/pub.1030513246
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1136/jcp.53.2.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019542421
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1158/1078-0432.ccr-09-0449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002055562
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1158/1078-0432.ccr-10-1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021940935
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1177/001316446002000104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039619716
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1200/jco.2005.03.4744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007072891
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1200/jco.2006.06.6944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052926880
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1200/jco.2007.10.6393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020707555
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1200/jco.2007.11.9453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029462575
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1200/jco.2007.12.9437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018919180
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1200/jco.2007.14.2364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049142592
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1200/jco.2009.24.8211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024504624
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1200/jco.2009.25.6529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016721540
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1200/jco.2011.34.7963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039783018
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1200/jco.2011.36.2574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006957939
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1309/4d1a04ncdk96wfy7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022759445
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1309/ajcp5uumfma5zkii schema:sameAs https://app.dimensions.ai/details/publication/pub.1043928777
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1371/journal.pone.0036559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047525232
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1634/theoncologist.2008-0184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000312341
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1634/theoncologist.2012-0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022301508
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.2217/pme.13.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011903621
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.2353/jmoldx.2009.080070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044572777
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.3816/cbc.2006.n.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043088315
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.6004/jnccn.2011.0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078483976
    396 rdf:type schema:CreativeWork
    397 https://www.grid.ac/institutes/grid.415214.7 schema:alternateName Medisch Spectrum Twente
    398 schema:name Department of Surgery, Medisch Spectrum Twente, Enschede and the Saxenburgh Group, Hardenberg, The Netherlands
    399 rdf:type schema:Organization
    400 https://www.grid.ac/institutes/grid.415304.7 schema:alternateName Long Beach Memorial Medical Center
    401 schema:name Department of Medicine, Todd Cancer Institute, Long Beach Memorial Medical Center, Long Beach, CA, USA
    402 rdf:type schema:Organization
    403 https://www.grid.ac/institutes/grid.415655.6 schema:alternateName Sharp Memorial Hospital
    404 schema:name Comprehensive Breast Care of San Diego and Sharp Memorial Hospital, San Diego, CA, USA
    405 rdf:type schema:Organization
    406 https://www.grid.ac/institutes/grid.416405.2 schema:alternateName Saddleback Memorial Medical Center
    407 schema:name Memorial Care Breast Center, Saddleback Memorial Medical Center, Laguna Hills, CA, USA
    408 rdf:type schema:Organization
    409 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
    410 schema:name Breast Surgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    411 rdf:type schema:Organization
    412 https://www.grid.ac/institutes/grid.418205.a schema:alternateName Hôpital René Huguenin
    413 schema:name Department of Pathology, Institut Curie, Hôpital René-Huguenin, Saint-Cloud, France
    414 rdf:type schema:Organization
    415 https://www.grid.ac/institutes/grid.418321.d schema:alternateName Centro di Riferimento Oncologico
    416 schema:name Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    417 rdf:type schema:Organization
    418 https://www.grid.ac/institutes/grid.419802.6 schema:alternateName Sozialstiftung Bamberg
    419 schema:name Institute of Pathology, Klinikum Bamberg, Bamberg, Germany
    420 rdf:type schema:Organization
    421 https://www.grid.ac/institutes/grid.423768.c schema:alternateName Agendia (Netherlands)
    422 schema:name Agendia, Amsterdam, The Netherlands
    423 rdf:type schema:Organization
    424 https://www.grid.ac/institutes/grid.430814.a schema:alternateName Antoni van Leeuwenhoek Hospital
    425 schema:name Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    426 rdf:type schema:Organization
    427 https://www.grid.ac/institutes/grid.433083.f schema:alternateName Centre Hospitalier Chrétien
    428 schema:name Gynecology Oncology Unit, Centre Hospitalier Chrétien, Liège, Belgium
    429 rdf:type schema:Organization
    430 https://www.grid.ac/institutes/grid.5133.4 schema:alternateName University of Trieste
    431 schema:name Anatomic Pathology Unit, Università di Trieste, Trieste, Italy
    432 rdf:type schema:Organization
    433 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
    434 schema:name Department of Medical Sciences, Università di Torino, Torino, Italy
    435 rdf:type schema:Organization
    436 https://www.grid.ac/institutes/grid.7644.1 schema:alternateName University of Bari Aldo Moro
    437 schema:name Department of Pathological Anatomy, Università degli Studi di Bari, Bari, Italy
    438 rdf:type schema:Organization
    439 https://www.grid.ac/institutes/grid.8484.0 schema:alternateName University of Ferrara
    440 schema:name Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, Università di Ferrara, Ferrara, Italy
    441 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...