In a cohort of breast cancer screened patients the proportion of HER2 positive cases is lower than that earlier reported ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04-21

AUTHORS

Silvia Giuliani, Chiara Maura Ciniselli, Elena Leonardi, Enzo Polla, Nicola Decarli, Claudio Luchini, Chiara Cantaloni, Fabio Gasperetti, Daniela Cazzolli, Gabriella Berlanda, Daniela Bernardi, Marco Pellegrini, Renza Triolo, Antonella Ferro, Paolo Verderio, Mattia Barbareschi

ABSTRACT

Human epithelial growth factor receptor 2 (HER2) overexpression and/or amplification is of predictive and prognostic value in infiltrating breast carcinoma (IBC). We evaluated the proportion of HER2-positive cases (score 3 overexpression/score 2 plus fluorescence in situ hybridization (FISH) amplification) in a consecutive series of 2163 patients. According to immunohistochemical analysis of HER2 expression, using Herceptest and FDA criteria, 839 cases had score 0, 476 score 1+, 699 score 2+, and 149 score 3+. Of the 699 scoring 2+ cases, 160 (22.88 %) showed Her2 gene amplification by FISH analysis, making a total of 309 (14.28 %) HER2-positive cases. Grade 1 ductal and special type IBC were never HER2 positive, while only three infiltrating lobular carcinomas but a relevant percentage of small IBC were HER2 positive. Of HER2-positive cases, 52.1 % was pT1 and of these, 38.5 % was pT1b or smaller. Logistic regression analysis revealed that estrogen receptor (ER), progesterone receptor (PgR), grade, and pT were significantly associated with HER2 positivity and that HER2 3+ cases were more frequently of higher grade and pT than HER2 2+/Her2 amplified cases. In addition, HER2 3+ cases were more frequently in ER and PgR negative than HER2 2+/Her2 amplified cases. We conclude that the proportion of HER2 positive cases is lower than that reported in older literature and that pathological characteristics differ between HER2 3+ and HER2 2+/Her2 amplified cases. More... »

PAGES

45-50

References to SciGraph publications

  • 2001-02. Untangling the ErbB signalling network in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-09-22. Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival in BRITISH JOURNAL OF CANCER
  • 2010-08-27. HER2-ASCO-Guidelines in DIE PATHOLOGIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-016-1940-y

    DOI

    http://dx.doi.org/10.1007/s00428-016-1940-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005592412

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27097809


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    25 schema:description Human epithelial growth factor receptor 2 (HER2) overexpression and/or amplification is of predictive and prognostic value in infiltrating breast carcinoma (IBC). We evaluated the proportion of HER2-positive cases (score 3 overexpression/score 2 plus fluorescence in situ hybridization (FISH) amplification) in a consecutive series of 2163 patients. According to immunohistochemical analysis of HER2 expression, using Herceptest and FDA criteria, 839 cases had score 0, 476 score 1+, 699 score 2+, and 149 score 3+. Of the 699 scoring 2+ cases, 160 (22.88 %) showed Her2 gene amplification by FISH analysis, making a total of 309 (14.28 %) HER2-positive cases. Grade 1 ductal and special type IBC were never HER2 positive, while only three infiltrating lobular carcinomas but a relevant percentage of small IBC were HER2 positive. Of HER2-positive cases, 52.1 % was pT1 and of these, 38.5 % was pT1b or smaller. Logistic regression analysis revealed that estrogen receptor (ER), progesterone receptor (PgR), grade, and pT were significantly associated with HER2 positivity and that HER2 3+ cases were more frequently of higher grade and pT than HER2 2+/Her2 amplified cases. In addition, HER2 3+ cases were more frequently in ER and PgR negative than HER2 2+/Her2 amplified cases. We conclude that the proportion of HER2 positive cases is lower than that reported in older literature and that pathological characteristics differ between HER2 3+ and HER2 2+/Her2 amplified cases.
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    36 HER2 gene amplification
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