Chronic inflammation in urothelial bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08-12

AUTHORS

Gabriella Nesi, Stefania Nobili, Tommaso Cai, Saverio Caini, Raffaella Santi

ABSTRACT

The association between inflammation and cancer has been pointed out in epidemiological and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in various malignancies. However, the molecular events leading to malignant transformation in a chronically inflamed environment are not fully understood. In urothelial carcinoma of the urinary bladder, inflammation plays a dual role. On the one hand, chronic inflammation is a well-established risk factor for the development of bladder cancer (BC), as seen in Schistosoma haematobium infection. On the other, intravesical therapy by bacillus Calmette-Guérin (BCG), which induces inflammation, offers protection against cancer recurrence. The large variety of pro-inflammatory mediators expressed by BC and immune cells binds to specific receptors which control signalling pathways. These activate transcription of a plethora of downstream factors. This review summarizes recent data regarding inflammation and urothelial carcinoma, with special emphasis on the role the inflammatory response plays in BC recurrence risk and progression. More... »

PAGES

623-633

References to SciGraph publications

  • 2011-07-19. Crosstalk in NF-κB signaling pathways in NATURE IMMUNOLOGY
  • 2012-06-13. Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer in BMC UROLOGY
  • 2009-01-27. Urinary tract infections and reduced risk of bladder cancer in Los Angeles in BRITISH JOURNAL OF CANCER
  • 2013-07-01. Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers in BMC CANCER
  • 2014-11-27. Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study in BRITISH JOURNAL OF CANCER
  • 2011-12-16. Identification and manipulation of tumor associated macrophages in human cancers in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2011-04-11. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer in MOLECULAR CANCER
  • 2008-07-01. Cancer-related inflammation in NATURE
  • 2005-12-13. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-09-15. Bladder cancer in spinal cord injury patients in SPINAL CORD
  • 2014-01-22. High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study in WORLD JOURNAL OF UROLOGY
  • 2012-06-08. p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma in MODERN PATHOLOGY
  • 2015-01-30. The route to personalized medicine in bladder cancer: where do we stand? in TARGETED ONCOLOGY
  • 2012-01-19. Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2014-02-04. The mechanism of action of BCG therapy for bladder cancer—a current perspective in NATURE REVIEWS UROLOGY
  • 2011-07-19. Inflammation meets cancer, with NF-κB as the matchmaker in NATURE IMMUNOLOGY
  • 2014-02-12. The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells in TUMOR BIOLOGY
  • 2008-01-10. Clinical significance of nuclear factor (NF)-κB levels in urothelial carcinoma of the urinary bladder in VIRCHOWS ARCHIV
  • 2012-11-05. Lower cyclooxygenase-2 expression is associated with recurrence of solitary non-muscle invasive bladder carcinoma in DIAGNOSTIC PATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-015-1820-x

    DOI

    http://dx.doi.org/10.1007/s00428-015-1820-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052009213

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26263854


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8404.8", 
              "name": [
                "Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nesi", 
            "givenName": "Gabriella", 
            "id": "sg:person.01264434603.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264434603.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8404.8", 
              "name": [
                "Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nobili", 
            "givenName": "Stefania", 
            "id": "sg:person.0626300165.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626300165.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d\u2019Oro 9, 50011, Trento, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d\u2019Oro 9, 50011, Trento, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cai", 
            "givenName": "Tommaso", 
            "id": "sg:person.0621104663.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621104663.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention (ISPO), Via delle Oblate 2, 50139, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417623.5", 
              "name": [
                "Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention (ISPO), Via delle Oblate 2, 50139, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caini", 
            "givenName": "Saverio", 
            "id": "sg:person.01161605365.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161605365.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8404.8", 
              "name": [
                "Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santi", 
            "givenName": "Raffaella", 
            "id": "sg:person.0636671044.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636671044.27"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sc.2009.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042922749", 
              "https://doi.org/10.1038/sc.2009.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2490-12-18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020468718", 
              "https://doi.org/10.1186/1471-2490-12-18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11523-015-0357-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021992503", 
              "https://doi.org/10.1007/s11523-015-0357-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-13-322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033986606", 
              "https://doi.org/10.1186/1471-2407-13-322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045118814", 
              "https://doi.org/10.1038/ni.2060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020376387", 
              "https://doi.org/10.1038/sj.bjc.6604889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-005-9121-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031450132", 
              "https://doi.org/10.1007/s10549-005-9121-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006965315", 
              "https://doi.org/10.1038/ni.2065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-10-36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025341208", 
              "https://doi.org/10.1186/1476-4598-10-36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-9-216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029858253", 
              "https://doi.org/10.1186/1479-5876-9-216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-007-0560-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017110605", 
              "https://doi.org/10.1007/s00428-007-0560-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-014-1237-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033125746", 
              "https://doi.org/10.1007/s00345-014-1237-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1746-1596-7-152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044253616", 
              "https://doi.org/10.1186/1746-1596-7-152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrurol.2014.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002890025", 
              "https://doi.org/10.1038/nrurol.2014.15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2012.103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025768033", 
              "https://doi.org/10.1038/modpathol.2012.103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-1704-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031574210", 
              "https://doi.org/10.1007/s13277-014-1704-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025039868", 
              "https://doi.org/10.1038/bjc.2014.601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1136-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018779941", 
              "https://doi.org/10.1007/s00432-011-1136-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-08-12", 
        "datePublishedReg": "2015-08-12", 
        "description": "The association between inflammation and cancer has been pointed out in epidemiological and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in various malignancies. However, the molecular events leading to malignant transformation in a chronically inflamed environment are not fully understood. In urothelial carcinoma of the urinary bladder, inflammation plays a dual role. On the one hand, chronic inflammation is a well-established risk factor for the development of bladder cancer (BC), as seen in Schistosoma haematobium infection. On the other, intravesical therapy by bacillus Calmette-Gu\u00e9rin (BCG), which induces inflammation, offers protection against cancer recurrence. The large variety of pro-inflammatory mediators expressed by BC and immune cells binds to specific receptors which control signalling pathways. These activate transcription of a plethora of downstream factors. This review summarizes recent data regarding inflammation and urothelial carcinoma, with special emphasis on the role the inflammatory response plays in BC recurrence risk and progression.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00428-015-1820-x", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1106235", 
            "issn": [
              "0945-6317", 
              "1432-2307"
            ], 
            "name": "Virchows Archiv", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "467"
          }
        ], 
        "keywords": [
          "bacillus Calmette-Gu\u00e9rin", 
          "bladder cancer", 
          "chronic inflammation", 
          "urothelial carcinoma", 
          "pro-inflammatory mediators", 
          "Schistosoma haematobium infection", 
          "urothelial bladder cancer", 
          "Calmette-Gu\u00e9rin", 
          "haematobium infection", 
          "intravesical therapy", 
          "risk factors", 
          "cancer recurrence", 
          "urinary bladder", 
          "inflammatory response", 
          "clinical studies", 
          "inflammation", 
          "recurrence risk", 
          "malignant transformation", 
          "specific receptors", 
          "cancer", 
          "carcinoma", 
          "recent data", 
          "downstream factors", 
          "molecular events", 
          "cells binds", 
          "recurrence", 
          "malignancy", 
          "bladder", 
          "therapy", 
          "infection", 
          "progression", 
          "carcinogenesis", 
          "receptors", 
          "dual role", 
          "factors", 
          "risk", 
          "mediators", 
          "role", 
          "association", 
          "review", 
          "response", 
          "pathway", 
          "activate transcription", 
          "special emphasis", 
          "study", 
          "events", 
          "protection", 
          "transcription", 
          "development", 
          "data", 
          "binds", 
          "hand", 
          "plethora", 
          "variety", 
          "emphasis", 
          "large variety", 
          "transformation", 
          "environment", 
          "immune cells binds", 
          "BC recurrence risk"
        ], 
        "name": "Chronic inflammation in urothelial bladder cancer", 
        "pagination": "623-633", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1052009213"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00428-015-1820-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26263854"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00428-015-1820-x", 
          "https://app.dimensions.ai/details/publication/pub.1052009213"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_677.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00428-015-1820-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1820-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1820-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1820-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1820-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    238 TRIPLES      22 PREDICATES      106 URIs      78 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00428-015-1820-x schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 anzsrc-for:1112
    4 schema:author N20aeae875fc5496990000fdd9c4a98da
    5 schema:citation sg:pub.10.1007/s00345-014-1237-1
    6 sg:pub.10.1007/s00428-007-0560-y
    7 sg:pub.10.1007/s00432-011-1136-4
    8 sg:pub.10.1007/s10549-005-9121-8
    9 sg:pub.10.1007/s11523-015-0357-x
    10 sg:pub.10.1007/s13277-014-1704-8
    11 sg:pub.10.1038/bjc.2014.601
    12 sg:pub.10.1038/modpathol.2012.103
    13 sg:pub.10.1038/nature07205
    14 sg:pub.10.1038/ni.2060
    15 sg:pub.10.1038/ni.2065
    16 sg:pub.10.1038/nrurol.2014.15
    17 sg:pub.10.1038/sc.2009.118
    18 sg:pub.10.1038/sj.bjc.6604889
    19 sg:pub.10.1186/1471-2407-13-322
    20 sg:pub.10.1186/1471-2490-12-18
    21 sg:pub.10.1186/1476-4598-10-36
    22 sg:pub.10.1186/1479-5876-9-216
    23 sg:pub.10.1186/1746-1596-7-152
    24 schema:datePublished 2015-08-12
    25 schema:datePublishedReg 2015-08-12
    26 schema:description The association between inflammation and cancer has been pointed out in epidemiological and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in various malignancies. However, the molecular events leading to malignant transformation in a chronically inflamed environment are not fully understood. In urothelial carcinoma of the urinary bladder, inflammation plays a dual role. On the one hand, chronic inflammation is a well-established risk factor for the development of bladder cancer (BC), as seen in Schistosoma haematobium infection. On the other, intravesical therapy by bacillus Calmette-Guérin (BCG), which induces inflammation, offers protection against cancer recurrence. The large variety of pro-inflammatory mediators expressed by BC and immune cells binds to specific receptors which control signalling pathways. These activate transcription of a plethora of downstream factors. This review summarizes recent data regarding inflammation and urothelial carcinoma, with special emphasis on the role the inflammatory response plays in BC recurrence risk and progression.
    27 schema:genre article
    28 schema:inLanguage en
    29 schema:isAccessibleForFree false
    30 schema:isPartOf N42cd265d65814191ac07478f5780a771
    31 Nb6e37f8841e8485aa43df03080fca39b
    32 sg:journal.1106235
    33 schema:keywords BC recurrence risk
    34 Calmette-Guérin
    35 Schistosoma haematobium infection
    36 activate transcription
    37 association
    38 bacillus Calmette-Guérin
    39 binds
    40 bladder
    41 bladder cancer
    42 cancer
    43 cancer recurrence
    44 carcinogenesis
    45 carcinoma
    46 cells binds
    47 chronic inflammation
    48 clinical studies
    49 data
    50 development
    51 downstream factors
    52 dual role
    53 emphasis
    54 environment
    55 events
    56 factors
    57 haematobium infection
    58 hand
    59 immune cells binds
    60 infection
    61 inflammation
    62 inflammatory response
    63 intravesical therapy
    64 large variety
    65 malignancy
    66 malignant transformation
    67 mediators
    68 molecular events
    69 pathway
    70 plethora
    71 pro-inflammatory mediators
    72 progression
    73 protection
    74 recent data
    75 receptors
    76 recurrence
    77 recurrence risk
    78 response
    79 review
    80 risk
    81 risk factors
    82 role
    83 special emphasis
    84 specific receptors
    85 study
    86 therapy
    87 transcription
    88 transformation
    89 urinary bladder
    90 urothelial bladder cancer
    91 urothelial carcinoma
    92 variety
    93 schema:name Chronic inflammation in urothelial bladder cancer
    94 schema:pagination 623-633
    95 schema:productId N2dd0fef90e1c450d97748aebea5a682b
    96 N35f9ebec8b81491d89a32e1b019a1224
    97 N5cc1ed4dfe7c4c298449cff13f160014
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052009213
    99 https://doi.org/10.1007/s00428-015-1820-x
    100 schema:sdDatePublished 2022-01-01T18:37
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N931e0d9cbc5f42f1bc84c13c156e3035
    103 schema:url https://doi.org/10.1007/s00428-015-1820-x
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N08f513bcb2374609a73e7dffa7f3388f rdf:first sg:person.0636671044.27
    108 rdf:rest rdf:nil
    109 N18741e70872c423b8dec2f7a1a446082 rdf:first sg:person.0626300165.20
    110 rdf:rest Nbf676ff39430442684ce30cfe8eb4133
    111 N20aeae875fc5496990000fdd9c4a98da rdf:first sg:person.01264434603.87
    112 rdf:rest N18741e70872c423b8dec2f7a1a446082
    113 N2dd0fef90e1c450d97748aebea5a682b schema:name dimensions_id
    114 schema:value pub.1052009213
    115 rdf:type schema:PropertyValue
    116 N35f9ebec8b81491d89a32e1b019a1224 schema:name pubmed_id
    117 schema:value 26263854
    118 rdf:type schema:PropertyValue
    119 N42cd265d65814191ac07478f5780a771 schema:volumeNumber 467
    120 rdf:type schema:PublicationVolume
    121 N5cc1ed4dfe7c4c298449cff13f160014 schema:name doi
    122 schema:value 10.1007/s00428-015-1820-x
    123 rdf:type schema:PropertyValue
    124 N6062e07c95c045198cc60d5353794494 rdf:first sg:person.01161605365.07
    125 rdf:rest N08f513bcb2374609a73e7dffa7f3388f
    126 N931e0d9cbc5f42f1bc84c13c156e3035 schema:name Springer Nature - SN SciGraph project
    127 rdf:type schema:Organization
    128 Nb6e37f8841e8485aa43df03080fca39b schema:issueNumber 6
    129 rdf:type schema:PublicationIssue
    130 Nbf676ff39430442684ce30cfe8eb4133 rdf:first sg:person.0621104663.55
    131 rdf:rest N6062e07c95c045198cc60d5353794494
    132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    133 schema:name Medical and Health Sciences
    134 rdf:type schema:DefinedTerm
    135 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Immunology
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Oncology and Carcinogenesis
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1106235 schema:issn 0945-6317
    142 1432-2307
    143 schema:name Virchows Archiv
    144 schema:publisher Springer Nature
    145 rdf:type schema:Periodical
    146 sg:person.01161605365.07 schema:affiliation grid-institutes:grid.417623.5
    147 schema:familyName Caini
    148 schema:givenName Saverio
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161605365.07
    150 rdf:type schema:Person
    151 sg:person.01264434603.87 schema:affiliation grid-institutes:grid.8404.8
    152 schema:familyName Nesi
    153 schema:givenName Gabriella
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264434603.87
    155 rdf:type schema:Person
    156 sg:person.0621104663.55 schema:affiliation grid-institutes:None
    157 schema:familyName Cai
    158 schema:givenName Tommaso
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621104663.55
    160 rdf:type schema:Person
    161 sg:person.0626300165.20 schema:affiliation grid-institutes:grid.8404.8
    162 schema:familyName Nobili
    163 schema:givenName Stefania
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626300165.20
    165 rdf:type schema:Person
    166 sg:person.0636671044.27 schema:affiliation grid-institutes:grid.8404.8
    167 schema:familyName Santi
    168 schema:givenName Raffaella
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636671044.27
    170 rdf:type schema:Person
    171 sg:pub.10.1007/s00345-014-1237-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033125746
    172 https://doi.org/10.1007/s00345-014-1237-1
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1007/s00428-007-0560-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017110605
    175 https://doi.org/10.1007/s00428-007-0560-y
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s00432-011-1136-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018779941
    178 https://doi.org/10.1007/s00432-011-1136-4
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s10549-005-9121-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031450132
    181 https://doi.org/10.1007/s10549-005-9121-8
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s11523-015-0357-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021992503
    184 https://doi.org/10.1007/s11523-015-0357-x
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s13277-014-1704-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031574210
    187 https://doi.org/10.1007/s13277-014-1704-8
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/bjc.2014.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025039868
    190 https://doi.org/10.1038/bjc.2014.601
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/modpathol.2012.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025768033
    193 https://doi.org/10.1038/modpathol.2012.103
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    196 https://doi.org/10.1038/nature07205
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/ni.2060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045118814
    199 https://doi.org/10.1038/ni.2060
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/ni.2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006965315
    202 https://doi.org/10.1038/ni.2065
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nrurol.2014.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002890025
    205 https://doi.org/10.1038/nrurol.2014.15
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/sc.2009.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042922749
    208 https://doi.org/10.1038/sc.2009.118
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/sj.bjc.6604889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376387
    211 https://doi.org/10.1038/sj.bjc.6604889
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1186/1471-2407-13-322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033986606
    214 https://doi.org/10.1186/1471-2407-13-322
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1186/1471-2490-12-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020468718
    217 https://doi.org/10.1186/1471-2490-12-18
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1186/1476-4598-10-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025341208
    220 https://doi.org/10.1186/1476-4598-10-36
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1186/1479-5876-9-216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029858253
    223 https://doi.org/10.1186/1479-5876-9-216
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1186/1746-1596-7-152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044253616
    226 https://doi.org/10.1186/1746-1596-7-152
    227 rdf:type schema:CreativeWork
    228 grid-institutes:None schema:alternateName Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro 9, 50011, Trento, Italy
    229 schema:name Department of Urology, Santa Chiara Regional Hospital, Largo Medaglie d’Oro 9, 50011, Trento, Italy
    230 rdf:type schema:Organization
    231 grid-institutes:grid.417623.5 schema:alternateName Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention (ISPO), Via delle Oblate 2, 50139, Florence, Italy
    232 schema:name Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention (ISPO), Via delle Oblate 2, 50139, Florence, Italy
    233 rdf:type schema:Organization
    234 grid-institutes:grid.8404.8 schema:alternateName Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    235 Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    236 schema:name Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    237 Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    238 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...