In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Serena Bonin, Danae Pracella, Renzo Barbazza, Sandro Sulfaro, Giorgio Stanta

ABSTRACT

Axillary lymph node status is one of the most important prognostic variables for breast cancer (BC). To investigate and understand the clinical, histopathological and biological factors that affect prognosis in node-positive young breast cancer patients, we compared the phenotype of 100 primary tumours with their corresponding loco-regional lymph node (LN) metastases using conventional immunohistochemistry (IHC) markers currently in use for molecular classification of breast cancer. By comparing the expression of ER, PR, HER-2, Ki67, K8, K5/6 and vimentin, we found that expression of HER-2, Ki67, K8 and vimentin is frequently lost in lymph node metastases. Between the primary tumour and corresponding lymph node metastases, expression of keratins K8 and K5/6 significantly changed. Expression of K8 in lymph node metastases, but not in primary tumours, segregates patients in two sub-groups with different outcomes. Survival of patients with K8-positive LN metastases at 5 years in comparison with patients with K8-negative LN metastases was 75 vs 48 %, at 10 years 62 vs 22 % and at 20 years 53 vs 14 % (p < 0.001). K8 immunostaining of tissue from the lymph node metastasis allows defining a sub-group of lymph node-positive BC patients with a highly unfavourable outcome, for whom therapeutic options might have to be reconsidered. More... »

PAGES

571-580

References to SciGraph publications

  • 2011-02. Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-12. St Gallen molecular subtypes in primary breast cancer and matched lymph node metastases - aspects on distribution and prognosis for patients with luminal A tumours: results from a prospective randomised trial in BMC CANCER
  • 2008-02. Basal cytokeratins in breast tumours among BRCA1, BRCA2and mutation-negative breast cancer families in BREAST CANCER RESEARCH
  • 2010-05. Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2013-07. Metronomic chemotherapy for cancer treatment: a decade of clinical studies in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2012-07. Stem cell-related markers in primary breast cancers and associated metastatic lesions in MODERN PATHOLOGY
  • 2005-01. Predictors of positive axillary lymph nodes in breast cancer patients with metastatic sentinel lymph node in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2010-07. Does Analysis of Biomarkers in Tumor Cells in Lymph Node Metastases Give Additional Prognostic Information in Primary Breast Cancer? in WORLD JOURNAL OF SURGERY
  • 2014-01. Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis in MEDICAL ONCOLOGY
  • 2014-10. Breast cancer in young women: have the prognostic implications of breast cancer subtypes changed over time? in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-12. Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness in MOLECULAR CANCER
  • 2007-07. Ki-67 expression in primary breast carcinomas and their axillary lymph node metastases: clinical implications in VIRCHOWS ARCHIV
  • 2011-05-19. Rapid Protein Extraction from Formalin-Fixed Paraffin-Embedded Tissue Samples in GUIDELINES FOR MOLECULAR ANALYSIS IN ARCHIVE TISSUES
  • 2014-01. Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer in MEDICAL ONCOLOGY
  • 2011-12. Evaluation of ER, PgR, HER-2, Ki-67, cyclin D1, and nm23-H1 as predictors of pathological complete response to neoadjuvant chemotherapy for locally advanced breast cancer in MEDICAL ONCOLOGY
  • 2006-03. New trends of immunohistochemistry for making differential diagnosis of breast lesions in MEDICAL MOLECULAR MORPHOLOGY
  • 2012-09. Keratin expression in breast cancers in VIRCHOWS ARCHIV
  • 2009-12. Does vimentin help to delineate the so-called 'basal type breast cancer'? in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2012-12. Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer in JOURNAL OF TRANSLATIONAL MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-015-1748-1

    DOI

    http://dx.doi.org/10.1007/s00428-015-1748-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026756082

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25724181


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Keratin-8", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proportional Hazards Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Array Analysis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonin", 
            "givenName": "Serena", 
            "id": "sg:person.01125307154.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125307154.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pracella", 
            "givenName": "Danae", 
            "id": "sg:person.01207462724.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207462724.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbazza", 
            "givenName": "Renzo", 
            "id": "sg:person.0603512365.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603512365.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Santa Maria Degli Angeli", 
              "id": "https://www.grid.ac/institutes/grid.415199.1", 
              "name": [
                "Department of Laboratory Medicine, S.C. Pathology, Santa Maria degli Angeli Hospital, 33170, Pordenone, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulfaro", 
            "givenName": "Sandro", 
            "id": "sg:person.01207513565.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207513565.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stanta", 
            "givenName": "Giorgio", 
            "id": "sg:person.0111107245.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111107245.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.2147/ott.s65294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000313725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-013-0798-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001424934", 
              "https://doi.org/10.1007/s12032-013-0798-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(11)61539-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003140514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci57088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003733464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-28-118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004957771", 
              "https://doi.org/10.1186/1756-9966-28-118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdr304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009166329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2012.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009456656", 
              "https://doi.org/10.1038/modpathol.2012.37"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-3125-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009528638", 
              "https://doi.org/10.1007/s10549-014-3125-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0499-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009529309", 
              "https://doi.org/10.1007/s00268-010-0499-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0499-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009529309", 
              "https://doi.org/10.1007/s00268-010-0499-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.breast.2011.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009695561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010222506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010222506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011430625", 
              "https://doi.org/10.1038/ejhg.2009.230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02710021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011714585", 
              "https://doi.org/10.1007/bf02710021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02710021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011714585", 
              "https://doi.org/10.1007/bf02710021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(82)90400-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012378105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9776(11)70309-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013531014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31804c7283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014021497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31804c7283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014021497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e31804c7283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014021497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-007-0435-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014094832", 
              "https://doi.org/10.1007/s00428-007-0435-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-007-0435-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014094832", 
              "https://doi.org/10.1007/s00428-007-0435-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-010-9676-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014769318", 
              "https://doi.org/10.1007/s12032-010-9676-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/erm.09.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016180143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-10-226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018030630", 
              "https://doi.org/10.1186/1479-5876-10-226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djp082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020655992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1066896906293054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020835906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1066896906293054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020835906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-013-0801-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021350530", 
              "https://doi.org/10.1007/s12032-013-0801-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0053532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021524715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pdm.0b013e3181e3630c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pdm.0b013e3181e3630c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4137/bcbcr.s10701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024619622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pdm.0b013e31818d107b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026246468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pdm.0b013e31818d107b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026246468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pdm.0b013e31818d107b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026246468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr1863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028053059", 
              "https://doi.org/10.1186/bcr1863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr1863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028053059", 
              "https://doi.org/10.1186/bcr1863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.50.9984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028197158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029792500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0020297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030831943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-012-1289-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033437196", 
              "https://doi.org/10.1007/s00428-012-1289-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.191367098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034333528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034572531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034572531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-2191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037544941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.breast.2005.08.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037579869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.breast.2005.08.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037579869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-8-88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038455624", 
              "https://doi.org/10.1186/1476-4598-8-88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.1748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042281410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042797955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-1113-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044008565", 
              "https://doi.org/10.1007/s10549-010-1113-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2013/347073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045556108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-13-558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047114795", 
              "https://doi.org/10.1186/1471-2407-13-558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17890-0_38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047873716", 
              "https://doi.org/10.1007/978-3-642-17890-0_38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17890-0_38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047873716", 
              "https://doi.org/10.1007/978-3-642-17890-0_38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-013-2125-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048027899", 
              "https://doi.org/10.1007/s00280-013-2125-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2006.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048696033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050374658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00795-006-0309-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051656319", 
              "https://doi.org/10.1007/s00795-006-0309-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00795-006-0309-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051656319", 
              "https://doi.org/10.1007/s00795-006-0309-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077343632", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078172257", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078615490", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/cbm-120293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078688018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083046002", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083073983", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-05", 
        "datePublishedReg": "2015-05-01", 
        "description": "Axillary lymph node status is one of the most important prognostic variables for breast cancer (BC). To investigate and understand the clinical, histopathological and biological factors that affect prognosis in node-positive young breast cancer patients, we compared the phenotype of 100 primary tumours with their corresponding loco-regional lymph node (LN) metastases using conventional immunohistochemistry (IHC) markers currently in use for molecular classification of breast cancer. By comparing the expression of ER, PR, HER-2, Ki67, K8, K5/6 and vimentin, we found that expression of HER-2, Ki67, K8 and vimentin is frequently lost in lymph node metastases. Between the primary tumour and corresponding lymph node metastases, expression of keratins K8 and K5/6 significantly changed. Expression of K8 in lymph node metastases, but not in primary tumours, segregates patients in two sub-groups with different outcomes. Survival of patients with K8-positive LN metastases at 5 years in comparison with patients with K8-negative LN metastases was 75 vs 48 %, at 10 years 62 vs 22 % and at 20 years 53 vs 14 % (p\u2009<\u20090.001). K8 immunostaining of tissue from the lymph node metastasis allows defining a sub-group of lymph node-positive BC patients with a highly unfavourable outcome, for whom therapeutic options might have to be reconsidered.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00428-015-1748-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1106235", 
            "issn": [
              "0945-6317", 
              "1432-2307"
            ], 
            "name": "Virchows Archiv", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "466"
          }
        ], 
        "name": "In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumour is an indicator of better survival", 
        "pagination": "571-580", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7f7691458722fb250e44433a0a5025f2b520ceea63ebc20978f3b88e332b7162"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25724181"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9423843"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00428-015-1748-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026756082"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00428-015-1748-1", 
          "https://app.dimensions.ai/details/publication/pub.1026756082"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:47", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000513.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00428-015-1748-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1748-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1748-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1748-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-015-1748-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    334 TRIPLES      21 PREDICATES      96 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00428-015-1748-1 schema:about N2d7122d28b0a4a14bb138d22cd638b6e
    2 N2d98b7ed58ed479783984cb15518ef4f
    3 N2fdf752f1b184d64aabf836adc1af374
    4 N466f86dd6ad54b958eeeeeb756101a22
    5 N66940e131e6348e4bbcfc2d2c3d016d9
    6 N7322a104c9044c668185fefd2c607886
    7 N7c04bec53bb847cc89a18a0792b660e8
    8 N918af044bbce4edba050589894fa7821
    9 N986b38baa942419fa476e1a1d7805000
    10 Nba3ed659f843460d98609f7a003e915b
    11 Nc704cda626144502839abb7b5951e33d
    12 Nd09894542ace45819aa38a29ceac59ab
    13 Nd93db2fb769d49ceb0a796e04d977353
    14 Nfb58e30ad2b24a67b5950350ab4b7057
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author Ndbb45079e96c4b21b47f3ae6941ac7bd
    18 schema:citation sg:pub.10.1007/978-3-642-17890-0_38
    19 sg:pub.10.1007/bf02710021
    20 sg:pub.10.1007/s00268-010-0499-z
    21 sg:pub.10.1007/s00280-013-2125-x
    22 sg:pub.10.1007/s00428-007-0435-2
    23 sg:pub.10.1007/s00428-012-1289-9
    24 sg:pub.10.1007/s00795-006-0309-8
    25 sg:pub.10.1007/s10549-010-1113-7
    26 sg:pub.10.1007/s10549-014-3125-1
    27 sg:pub.10.1007/s12032-010-9676-z
    28 sg:pub.10.1007/s12032-013-0798-y
    29 sg:pub.10.1007/s12032-013-0801-7
    30 sg:pub.10.1038/ejhg.2009.230
    31 sg:pub.10.1038/modpathol.2012.37
    32 sg:pub.10.1186/1471-2407-13-558
    33 sg:pub.10.1186/1476-4598-8-88
    34 sg:pub.10.1186/1479-5876-10-226
    35 sg:pub.10.1186/1756-9966-28-118
    36 sg:pub.10.1186/bcr1863
    37 https://app.dimensions.ai/details/publication/pub.1077343632
    38 https://app.dimensions.ai/details/publication/pub.1078172257
    39 https://app.dimensions.ai/details/publication/pub.1078615490
    40 https://app.dimensions.ai/details/publication/pub.1083046002
    41 https://app.dimensions.ai/details/publication/pub.1083073983
    42 https://doi.org/10.1002/path.2648
    43 https://doi.org/10.1002/path.4288
    44 https://doi.org/10.1016/0092-8674(82)90400-7
    45 https://doi.org/10.1016/j.breast.2005.08.023
    46 https://doi.org/10.1016/j.breast.2011.07.008
    47 https://doi.org/10.1016/j.ejso.2006.09.003
    48 https://doi.org/10.1016/s0140-6736(11)61539-0
    49 https://doi.org/10.1016/s0960-9776(11)70309-5
    50 https://doi.org/10.1073/pnas.191367098
    51 https://doi.org/10.1093/annonc/mdp427
    52 https://doi.org/10.1093/annonc/mdp579
    53 https://doi.org/10.1093/annonc/mdr304
    54 https://doi.org/10.1093/jnci/djp082
    55 https://doi.org/10.1097/pai.0b013e31804c7283
    56 https://doi.org/10.1097/pdm.0b013e31818d107b
    57 https://doi.org/10.1097/pdm.0b013e3181e3630c
    58 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
    59 https://doi.org/10.1155/2013/347073
    60 https://doi.org/10.1158/1078-0432.ccr-04-2191
    61 https://doi.org/10.1172/jci57088
    62 https://doi.org/10.1177/1066896906293054
    63 https://doi.org/10.1200/jco.2007.13.1748
    64 https://doi.org/10.1200/jco.2013.50.9984
    65 https://doi.org/10.1371/journal.pone.0020297
    66 https://doi.org/10.1371/journal.pone.0053532
    67 https://doi.org/10.1586/erm.09.30
    68 https://doi.org/10.2147/ott.s65294
    69 https://doi.org/10.3233/cbm-120293
    70 https://doi.org/10.4137/bcbcr.s10701
    71 schema:datePublished 2015-05
    72 schema:datePublishedReg 2015-05-01
    73 schema:description Axillary lymph node status is one of the most important prognostic variables for breast cancer (BC). To investigate and understand the clinical, histopathological and biological factors that affect prognosis in node-positive young breast cancer patients, we compared the phenotype of 100 primary tumours with their corresponding loco-regional lymph node (LN) metastases using conventional immunohistochemistry (IHC) markers currently in use for molecular classification of breast cancer. By comparing the expression of ER, PR, HER-2, Ki67, K8, K5/6 and vimentin, we found that expression of HER-2, Ki67, K8 and vimentin is frequently lost in lymph node metastases. Between the primary tumour and corresponding lymph node metastases, expression of keratins K8 and K5/6 significantly changed. Expression of K8 in lymph node metastases, but not in primary tumours, segregates patients in two sub-groups with different outcomes. Survival of patients with K8-positive LN metastases at 5 years in comparison with patients with K8-negative LN metastases was 75 vs 48 %, at 10 years 62 vs 22 % and at 20 years 53 vs 14 % (p < 0.001). K8 immunostaining of tissue from the lymph node metastasis allows defining a sub-group of lymph node-positive BC patients with a highly unfavourable outcome, for whom therapeutic options might have to be reconsidered.
    74 schema:genre research_article
    75 schema:inLanguage en
    76 schema:isAccessibleForFree false
    77 schema:isPartOf N91262ea7afff4ea88b933e5ad36f66d3
    78 Ne68881b8b9534e928a349d43a7dc3a74
    79 sg:journal.1106235
    80 schema:name In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumour is an indicator of better survival
    81 schema:pagination 571-580
    82 schema:productId N2d276b8b1c064ea79d5d9a3a2c47f195
    83 N52fce7037ef54114beacafc93fc789ab
    84 N63d07b098dd04915b7b27232b5f0d9bc
    85 N74690162a11e4834bfe6b46c9972b36f
    86 Ncafe49a0e22d49c1ac7f316a1464be69
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026756082
    88 https://doi.org/10.1007/s00428-015-1748-1
    89 schema:sdDatePublished 2019-04-10T20:47
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher N32dcbc3bda024ed8a76d7c65dcd7bacb
    92 schema:url http://link.springer.com/10.1007%2Fs00428-015-1748-1
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N06e5977ec39d4b61b7035088cdc7f138 schema:name Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy
    97 rdf:type schema:Organization
    98 N2d276b8b1c064ea79d5d9a3a2c47f195 schema:name pubmed_id
    99 schema:value 25724181
    100 rdf:type schema:PropertyValue
    101 N2d7122d28b0a4a14bb138d22cd638b6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Lymphatic Metastasis
    103 rdf:type schema:DefinedTerm
    104 N2d98b7ed58ed479783984cb15518ef4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Immunohistochemistry
    106 rdf:type schema:DefinedTerm
    107 N2fdf752f1b184d64aabf836adc1af374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 N32dcbc3bda024ed8a76d7c65dcd7bacb schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N3cd621a0de924fffae80df3e34aa7174 rdf:first sg:person.01207513565.38
    113 rdf:rest N5166788555b14a3098a78d12f289cf88
    114 N466f86dd6ad54b958eeeeeb756101a22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Biomarkers, Tumor
    116 rdf:type schema:DefinedTerm
    117 N4b5c6affc80a4477b0c4abdfed341ab7 schema:name Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy
    118 rdf:type schema:Organization
    119 N4d9893fc2f7344a3b53a5e7704f07b85 schema:name Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy
    120 rdf:type schema:Organization
    121 N5166788555b14a3098a78d12f289cf88 rdf:first sg:person.0111107245.10
    122 rdf:rest rdf:nil
    123 N52fce7037ef54114beacafc93fc789ab schema:name dimensions_id
    124 schema:value pub.1026756082
    125 rdf:type schema:PropertyValue
    126 N63d07b098dd04915b7b27232b5f0d9bc schema:name nlm_unique_id
    127 schema:value 9423843
    128 rdf:type schema:PropertyValue
    129 N66940e131e6348e4bbcfc2d2c3d016d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Middle Aged
    131 rdf:type schema:DefinedTerm
    132 N7322a104c9044c668185fefd2c607886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Breast Neoplasms
    134 rdf:type schema:DefinedTerm
    135 N74690162a11e4834bfe6b46c9972b36f schema:name doi
    136 schema:value 10.1007/s00428-015-1748-1
    137 rdf:type schema:PropertyValue
    138 N7c04bec53bb847cc89a18a0792b660e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Female
    140 rdf:type schema:DefinedTerm
    141 N91262ea7afff4ea88b933e5ad36f66d3 schema:volumeNumber 466
    142 rdf:type schema:PublicationVolume
    143 N918af044bbce4edba050589894fa7821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Tissue Array Analysis
    145 rdf:type schema:DefinedTerm
    146 N986b38baa942419fa476e1a1d7805000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Prognosis
    148 rdf:type schema:DefinedTerm
    149 Nba3ed659f843460d98609f7a003e915b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Keratin-8
    151 rdf:type schema:DefinedTerm
    152 Nc704cda626144502839abb7b5951e33d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Kaplan-Meier Estimate
    154 rdf:type schema:DefinedTerm
    155 Ncafe49a0e22d49c1ac7f316a1464be69 schema:name readcube_id
    156 schema:value 7f7691458722fb250e44433a0a5025f2b520ceea63ebc20978f3b88e332b7162
    157 rdf:type schema:PropertyValue
    158 Nd09894542ace45819aa38a29ceac59ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Neoplasm Staging
    160 rdf:type schema:DefinedTerm
    161 Nd1176305f62f45dd8474066837228cf0 rdf:first sg:person.01207462724.07
    162 rdf:rest Nfd0edffd3fea419491cfc85e1c41d5fe
    163 Nd93db2fb769d49ceb0a796e04d977353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Proportional Hazards Models
    165 rdf:type schema:DefinedTerm
    166 Ndbb45079e96c4b21b47f3ae6941ac7bd rdf:first sg:person.01125307154.15
    167 rdf:rest Nd1176305f62f45dd8474066837228cf0
    168 Ne68881b8b9534e928a349d43a7dc3a74 schema:issueNumber 5
    169 rdf:type schema:PublicationIssue
    170 Nf5304aa939bf437eb9c1255a589e4f05 schema:name Department of Medical Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, Trieste, Italy
    171 rdf:type schema:Organization
    172 Nfb58e30ad2b24a67b5950350ab4b7057 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Adult
    174 rdf:type schema:DefinedTerm
    175 Nfd0edffd3fea419491cfc85e1c41d5fe rdf:first sg:person.0603512365.60
    176 rdf:rest N3cd621a0de924fffae80df3e34aa7174
    177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Medical and Health Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Oncology and Carcinogenesis
    182 rdf:type schema:DefinedTerm
    183 sg:journal.1106235 schema:issn 0945-6317
    184 1432-2307
    185 schema:name Virchows Archiv
    186 rdf:type schema:Periodical
    187 sg:person.0111107245.10 schema:affiliation N4d9893fc2f7344a3b53a5e7704f07b85
    188 schema:familyName Stanta
    189 schema:givenName Giorgio
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111107245.10
    191 rdf:type schema:Person
    192 sg:person.01125307154.15 schema:affiliation N4b5c6affc80a4477b0c4abdfed341ab7
    193 schema:familyName Bonin
    194 schema:givenName Serena
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125307154.15
    196 rdf:type schema:Person
    197 sg:person.01207462724.07 schema:affiliation N06e5977ec39d4b61b7035088cdc7f138
    198 schema:familyName Pracella
    199 schema:givenName Danae
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207462724.07
    201 rdf:type schema:Person
    202 sg:person.01207513565.38 schema:affiliation https://www.grid.ac/institutes/grid.415199.1
    203 schema:familyName Sulfaro
    204 schema:givenName Sandro
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207513565.38
    206 rdf:type schema:Person
    207 sg:person.0603512365.60 schema:affiliation Nf5304aa939bf437eb9c1255a589e4f05
    208 schema:familyName Barbazza
    209 schema:givenName Renzo
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603512365.60
    211 rdf:type schema:Person
    212 sg:pub.10.1007/978-3-642-17890-0_38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047873716
    213 https://doi.org/10.1007/978-3-642-17890-0_38
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf02710021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011714585
    216 https://doi.org/10.1007/bf02710021
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00268-010-0499-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1009529309
    219 https://doi.org/10.1007/s00268-010-0499-z
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00280-013-2125-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048027899
    222 https://doi.org/10.1007/s00280-013-2125-x
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00428-007-0435-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014094832
    225 https://doi.org/10.1007/s00428-007-0435-2
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00428-012-1289-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033437196
    228 https://doi.org/10.1007/s00428-012-1289-9
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00795-006-0309-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051656319
    231 https://doi.org/10.1007/s00795-006-0309-8
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s10549-010-1113-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044008565
    234 https://doi.org/10.1007/s10549-010-1113-7
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s10549-014-3125-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009528638
    237 https://doi.org/10.1007/s10549-014-3125-1
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s12032-010-9676-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014769318
    240 https://doi.org/10.1007/s12032-010-9676-z
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s12032-013-0798-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001424934
    243 https://doi.org/10.1007/s12032-013-0798-y
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s12032-013-0801-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021350530
    246 https://doi.org/10.1007/s12032-013-0801-7
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ejhg.2009.230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430625
    249 https://doi.org/10.1038/ejhg.2009.230
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/modpathol.2012.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009456656
    252 https://doi.org/10.1038/modpathol.2012.37
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/1471-2407-13-558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047114795
    255 https://doi.org/10.1186/1471-2407-13-558
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/1476-4598-8-88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038455624
    258 https://doi.org/10.1186/1476-4598-8-88
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/1479-5876-10-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018030630
    261 https://doi.org/10.1186/1479-5876-10-226
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/1756-9966-28-118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004957771
    264 https://doi.org/10.1186/1756-9966-28-118
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1186/bcr1863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028053059
    267 https://doi.org/10.1186/bcr1863
    268 rdf:type schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1077343632 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1078172257 schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1078615490 schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1083046002 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1083073983 schema:CreativeWork
    274 https://doi.org/10.1002/path.2648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034572531
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/path.4288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029792500
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/0092-8674(82)90400-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012378105
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.breast.2005.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037579869
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.breast.2011.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009695561
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.ejso.2006.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048696033
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/s0140-6736(11)61539-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003140514
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/s0960-9776(11)70309-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013531014
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1073/pnas.191367098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034333528
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1093/annonc/mdp427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042797955
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/annonc/mdp579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050374658
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/annonc/mdr304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009166329
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/jnci/djp082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020655992
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1097/pai.0b013e31804c7283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014021497
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1097/pdm.0b013e31818d107b schema:sameAs https://app.dimensions.ai/details/publication/pub.1026246468
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1097/pdm.0b013e3181e3630c schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014222
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222506
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1155/2013/347073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045556108
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1158/1078-0432.ccr-04-2191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037544941
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1172/jci57088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003733464
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1177/1066896906293054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020835906
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1200/jco.2007.13.1748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042281410
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1200/jco.2013.50.9984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028197158
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1371/journal.pone.0020297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030831943
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1371/journal.pone.0053532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021524715
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1586/erm.09.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016180143
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.2147/ott.s65294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000313725
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.3233/cbm-120293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078688018
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.4137/bcbcr.s10701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024619622
    331 rdf:type schema:CreativeWork
    332 https://www.grid.ac/institutes/grid.415199.1 schema:alternateName Azienda Ospedaliera Santa Maria Degli Angeli
    333 schema:name Department of Laboratory Medicine, S.C. Pathology, Santa Maria degli Angeli Hospital, 33170, Pordenone, Italy
    334 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...