Ontology type: schema:ScholarlyArticle
2014-06
AUTHORSJim-Ray Chen, Tsan-Yu Hsieh, Huang-Yang Chen, Kun-Yan Yeh, Kuo-Su Chen, Yi-Che ChangChien, Mariann Pintye, Liang-Che Chang, Cheng-Cheng Hwang, Hui-Ping Chien, Yuan-Chun Hsu
ABSTRACTImmunohistochemical expression of ERα, encoded by the ESR1 (estrogen receptor 1) gene located at 6q25.1, is the most important determinant of responsiveness to endocrine therapy in breast cancer. The prevalence and significance of ESR1 amplification in breast cancer remain controversial. We set out to assess ESR1 status and its relevance in breast cancer in Taiwan. We tested tissue samples from 311 invasive carcinomas in a tissue microarray for ESR1 status by fluorescent in situ hybridization (FISH) and chromogenic in situ hybridization (CISH). In order to examine its association with ERα and ESR1 status, HER2 status was determined by FISH. Of the carcinomas, 58.8 % (183/311) was ERα positive. None of the carcinomas showed amplification of ESR1 by either method, whereas 24.1 % (75/311) of the carcinomas harbored HER2 amplification. Of the carcinomas, 9.6 % (26/301) showed ESR1 gain (1.3 ≤ ratio ESR1/chromosome 6 < 2) by FISH and 10 % (24/299) by CISH. FISH and CISH results showed a good correlation (κ-coefficient = 0.786). ESR1 gain by FISH and CISH was significantly associated with high-grade (P = 0.0294 and 0.0417, respectively) but not with ERα expression, HER2 status, or overall survival. ERα positivity was significantly associated with better overall survival (P = 0.039). HER2 amplification was significantly related with poor overall survival (P = 0.002). Our data confirm that in breast cancer, HER2 amplification is a frequent genetic aberration and a negative prognostic factor, and show that ESR1 amplification is not a key genetic abnormality in the tumorigenesis of breast cancer in Taiwan. More... »
PAGES689-699
http://scigraph.springernature.com/pub.10.1007/s00428-014-1576-8
DOIhttp://dx.doi.org/10.1007/s00428-014-1576-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24756215
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"description": "Immunohistochemical expression of ER\u03b1, encoded by the ESR1 (estrogen receptor 1) gene located at 6q25.1, is the most important determinant of responsiveness to endocrine therapy in breast cancer. The prevalence and significance of ESR1 amplification in breast cancer remain controversial. We set out to assess ESR1 status and its relevance in breast cancer in Taiwan. We tested tissue samples from 311 invasive carcinomas in a tissue microarray for ESR1 status by fluorescent in situ hybridization (FISH) and chromogenic in situ hybridization (CISH). In order to examine its association with ER\u03b1 and ESR1 status, HER2 status was determined by FISH. Of the carcinomas, 58.8\u00a0% (183/311) was ER\u03b1 positive. None of the carcinomas showed amplification of ESR1 by either method, whereas 24.1\u00a0% (75/311) of the carcinomas harbored HER2 amplification. Of the carcinomas, 9.6\u00a0% (26/301) showed ESR1 gain (1.3\u2009\u2264\u2009ratio ESR1/chromosome 6\u2009<\u20092) by FISH and 10\u00a0% (24/299) by CISH. FISH and CISH results showed a good correlation (\u03ba-coefficient\u2009=\u20090.786). ESR1 gain by FISH and CISH was significantly associated with high-grade (P\u2009=\u20090.0294 and 0.0417, respectively) but not with ER\u03b1 expression, HER2 status, or overall survival. ER\u03b1 positivity was significantly associated with better overall survival (P\u2009=\u20090.039). HER2 amplification was significantly related with poor overall survival (P\u2009=\u20090.002). Our data confirm that in breast cancer, HER2 amplification is a frequent genetic aberration and a negative prognostic factor, and show that ESR1 amplification is not a key genetic abnormality in the tumorigenesis of breast cancer in Taiwan. ",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-014-1576-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-014-1576-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-014-1576-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-014-1576-8'
This table displays all metadata directly associated to this object as RDF triples.
334 TRIPLES
21 PREDICATES
83 URIs
38 LITERALS
26 BLANK NODES