HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing between carcinomas of prostatic and urothelial origin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Justine Varinot, Olivier Cussenot, Morgan Roupret, Pierre Conort, Marc-Olivier Bitker, Emmanuel Chartier-Kastler, Liang Cheng, Eva Compérat

ABSTRACT

The origin of a primary or metastatic carcinoma in the pelvic area is sometimes difficult to establish, in particular the distinction between those originating in the bladder and the prostate. A candidate marker is the HOXB13 gene, essential for prostate development. Some studies have shown expression of HOXB13 protein by immunohistochemistry in the nuclear compartment of benign prostate luminal epithelium and prostate carcinoma. Forty-two cases of biopsies and resection specimens of the prostate and urinary bladder, metastatic lymph nodes, and pelvic masses were retrieved from our databases. In all cases, doubt persisted regarding prostatic versus urothelial origin. All cases were stained for CK7, p63, p504s, PSA, CK20, and HOXB13. Chromogranin A, CD56, and synaptophysin were used when neuroendocrine differentiation was suspected. HOXB13 staining was negative or only weakly positive in all carcinomas of urothelial origin. Three of four carcinomas with neuroendocrine differentiation did not express HOXB13. The fourth carcinoma, in a patient with a history of prostate carcinoma, was positive. In two cases with a synchronous prostatic and urothelial carcinoma, HOXB13 was exclusively expressed in the prostatic carcinoma. Our results demonstrate that HOXB13 expression identifies prostatic origin of a carcinoma with good sensitivity (89 %) and very good specificity (100 %). HOXB13 is a specific and sensitive marker for prostate cells and a valuable diagnostic tool, especially when poorly differentiated or neuroendocrine tumors are encountered. These results justify testing of HOXB13 as a prostate-specific carcinoma marker in larger cohorts for a more thorough evaluation of its sensitivity and specificity. More... »

PAGES

803-809

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-013-1495-0

DOI

http://dx.doi.org/10.1007/s00428-013-1495-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015228523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24146108


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Transitional Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Laboratoire Oncotype Urologie\u2014GRC UPMC-05, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France", 
            "Service de pathologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varinot", 
        "givenName": "Justine", 
        "id": "sg:person.0712561146.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712561146.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Laboratoire Oncotype Urologie\u2014GRC UPMC-05, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cussenot", 
        "givenName": "Olivier", 
        "id": "sg:person.013241233644.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241233644.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service d\u2019urologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roupret", 
        "givenName": "Morgan", 
        "id": "sg:person.0740171455.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740171455.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service d\u2019urologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conort", 
        "givenName": "Pierre", 
        "id": "sg:person.01116276566.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116276566.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service d\u2019urologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bitker", 
        "givenName": "Marc-Olivier", 
        "id": "sg:person.01173307220.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173307220.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service d\u2019urologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chartier-Kastler", 
        "givenName": "Emmanuel", 
        "id": "sg:person.01075107345.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107345.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Room 4044, 46202-4108, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Liang", 
        "id": "sg:person.01365601531.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365601531.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de pathologie, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Comp\u00e9rat", 
        "givenName": "Eva", 
        "id": "sg:person.0640702012.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640702012.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/pai.0b013e3181e04816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001043990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e3181e04816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001043990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e3181e04816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001043990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e3181e04816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001043990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2007.11.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001647402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/v1ry91nkx5arw2q5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009768975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-005-0092-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014168007", 
          "https://doi.org/10.1007/s00428-005-0092-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-005-0092-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014168007", 
          "https://doi.org/10.1007/s00428-005-0092-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2012.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014489654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64814-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016219929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200111000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030003560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200111000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030003560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318260cde7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036577827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318260cde7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036577827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039256166", 
          "https://doi.org/10.1186/1476-4598-9-124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e3283511c73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039873501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e3283511c73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039873501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1110000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043805171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047821732", 
          "https://doi.org/10.1038/modpathol.3880220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047821732", 
          "https://doi.org/10.1038/modpathol.3880220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/pyqc-17cb-063t-q07j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048761867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181e6cbf3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050427175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181e6cbf3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050427175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181e6cbf3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050427175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305100813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051545908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305100813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051545908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0377-4929.77326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051654801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075034097", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076607150", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "The origin of a primary or metastatic carcinoma in the pelvic area is sometimes difficult to establish, in particular the distinction between those originating in the bladder and the prostate. A candidate marker is the HOXB13 gene, essential for prostate development. Some studies have shown expression of HOXB13 protein by immunohistochemistry in the nuclear compartment of benign prostate luminal epithelium and prostate carcinoma. Forty-two cases of biopsies and resection specimens of the prostate and urinary bladder, metastatic lymph nodes, and pelvic masses were retrieved from our databases. In all cases, doubt persisted regarding prostatic versus urothelial origin. All cases were stained for CK7, p63, p504s, PSA, CK20, and HOXB13. Chromogranin A, CD56, and synaptophysin were used when neuroendocrine differentiation was suspected. HOXB13 staining was negative or only weakly positive in all carcinomas of urothelial origin. Three of four carcinomas with neuroendocrine differentiation did not express HOXB13. The fourth carcinoma, in a patient with a history of prostate carcinoma, was positive. In two cases with a synchronous prostatic and urothelial carcinoma, HOXB13 was exclusively expressed in the prostatic carcinoma. Our results demonstrate that HOXB13 expression identifies prostatic origin of a carcinoma with good sensitivity (89 %) and very good specificity (100 %). HOXB13 is a specific and sensitive marker for prostate cells and a valuable diagnostic tool, especially when poorly differentiated or neuroendocrine tumors are encountered. These results justify testing of HOXB13 as a prostate-specific carcinoma marker in larger cohorts for a more thorough evaluation of its sensitivity and specificity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-013-1495-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "463"
      }
    ], 
    "name": "HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing between carcinomas of prostatic and urothelial origin", 
    "pagination": "803-809", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "488de3abd8241f62b470ef5c584c5c4088182ad810e6a41d90103a37883d7bc6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24146108"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-013-1495-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015228523"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-013-1495-0", 
      "https://app.dimensions.ai/details/publication/pub.1015228523"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-013-1495-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1495-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1495-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1495-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1495-0'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      62 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-013-1495-0 schema:about N183f0ef544f04555ac583de36cc5c6f7
2 N3989003d95a749ff86443353126dc3a8
3 N5443e134a4dc4e5cb495e21dc06bd43f
4 N719c544051cb471f901c8c60cd766012
5 N7f671382f4a64f0084c8e0a0d9e89560
6 N8adb63619f1e4e2ab2ca28b1fc08e10e
7 N915a08b5e8b5466f8580d9d5f4f59198
8 N927ae408306c4875a3d990e50542423b
9 N93b3cde5043f436d9422ce200a01fcde
10 N941cef997132478c9560dac263765039
11 N96f792d4d7fa4b58af5f45c9a8313876
12 N97effad63000490188a7db8a98fe92ee
13 N99dba718d8744785b87362030bd4a181
14 Nc3b686ae9c474eb19ee0e57d63aa46bf
15 Nf9b33ad3ae474079927b6b5ca24f2b4b
16 anzsrc-for:10
17 anzsrc-for:1004
18 schema:author N8e354d1ddae046e39e10af1d0f373c7c
19 schema:citation sg:pub.10.1007/s00428-005-0092-2
20 sg:pub.10.1038/modpathol.3880220
21 sg:pub.10.1186/1476-4598-9-124
22 https://app.dimensions.ai/details/publication/pub.1075034097
23 https://app.dimensions.ai/details/publication/pub.1076607150
24 https://doi.org/10.1016/j.humpath.2012.02.011
25 https://doi.org/10.1016/j.urology.2007.11.128
26 https://doi.org/10.1016/s0002-9440(10)64814-6
27 https://doi.org/10.1056/nejmoa1110000
28 https://doi.org/10.1097/00000478-200111000-00007
29 https://doi.org/10.1097/pai.0b013e3181e04816
30 https://doi.org/10.1097/pas.0b013e3181e6cbf3
31 https://doi.org/10.1097/pas.0b013e318260cde7
32 https://doi.org/10.1097/pat.0b013e3283511c73
33 https://doi.org/10.1177/002215540305100813
34 https://doi.org/10.1309/pyqc-17cb-063t-q07j
35 https://doi.org/10.1309/v1ry91nkx5arw2q5
36 https://doi.org/10.4103/0377-4929.77326
37 schema:datePublished 2013-12
38 schema:datePublishedReg 2013-12-01
39 schema:description The origin of a primary or metastatic carcinoma in the pelvic area is sometimes difficult to establish, in particular the distinction between those originating in the bladder and the prostate. A candidate marker is the HOXB13 gene, essential for prostate development. Some studies have shown expression of HOXB13 protein by immunohistochemistry in the nuclear compartment of benign prostate luminal epithelium and prostate carcinoma. Forty-two cases of biopsies and resection specimens of the prostate and urinary bladder, metastatic lymph nodes, and pelvic masses were retrieved from our databases. In all cases, doubt persisted regarding prostatic versus urothelial origin. All cases were stained for CK7, p63, p504s, PSA, CK20, and HOXB13. Chromogranin A, CD56, and synaptophysin were used when neuroendocrine differentiation was suspected. HOXB13 staining was negative or only weakly positive in all carcinomas of urothelial origin. Three of four carcinomas with neuroendocrine differentiation did not express HOXB13. The fourth carcinoma, in a patient with a history of prostate carcinoma, was positive. In two cases with a synchronous prostatic and urothelial carcinoma, HOXB13 was exclusively expressed in the prostatic carcinoma. Our results demonstrate that HOXB13 expression identifies prostatic origin of a carcinoma with good sensitivity (89 %) and very good specificity (100 %). HOXB13 is a specific and sensitive marker for prostate cells and a valuable diagnostic tool, especially when poorly differentiated or neuroendocrine tumors are encountered. These results justify testing of HOXB13 as a prostate-specific carcinoma marker in larger cohorts for a more thorough evaluation of its sensitivity and specificity.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf N0eb68ed6d6cf4ef4ba87e3d475d4cb15
44 N923724c1fa704252925999316810f308
45 sg:journal.1106235
46 schema:name HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing between carcinomas of prostatic and urothelial origin
47 schema:pagination 803-809
48 schema:productId N2b55be4443684262898d15d305ccba68
49 N699d4c9dc77c40d6a7c12dd4c56b5320
50 N75a128bcf3ce4799851d52ba0eb91bd8
51 N8eb8160e80934ca6bc0b52d62657e4f8
52 N9a9bbe41d16f4fac85dc7b9eba73d131
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015228523
54 https://doi.org/10.1007/s00428-013-1495-0
55 schema:sdDatePublished 2019-04-11T01:06
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N775a87669a9643a8af6fe77a9303053b
58 schema:url http://link.springer.com/10.1007%2Fs00428-013-1495-0
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N068f314fd0ff4870a7aa6a7db33af1fc rdf:first sg:person.01365601531.96
63 rdf:rest Nfbb607426c5b466590cdafd2405be813
64 N0eb68ed6d6cf4ef4ba87e3d475d4cb15 schema:issueNumber 6
65 rdf:type schema:PublicationIssue
66 N183f0ef544f04555ac583de36cc5c6f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Homeodomain Proteins
68 rdf:type schema:DefinedTerm
69 N24d5ef22158f4b5385351c31e8d0ef7a rdf:first sg:person.01173307220.15
70 rdf:rest N7c3e2f5354824c528cdaf01a9250fda9
71 N28e58505a7b54d1cb257c344c496b1ff rdf:first sg:person.013241233644.08
72 rdf:rest Nf1bae14e4a4d499a974614ade7bbb848
73 N2b55be4443684262898d15d305ccba68 schema:name dimensions_id
74 schema:value pub.1015228523
75 rdf:type schema:PropertyValue
76 N3989003d95a749ff86443353126dc3a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Tissue Array Analysis
78 rdf:type schema:DefinedTerm
79 N5443e134a4dc4e5cb495e21dc06bd43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Carcinoma, Transitional Cell
81 rdf:type schema:DefinedTerm
82 N699d4c9dc77c40d6a7c12dd4c56b5320 schema:name doi
83 schema:value 10.1007/s00428-013-1495-0
84 rdf:type schema:PropertyValue
85 N719c544051cb471f901c8c60cd766012 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Aged
87 rdf:type schema:DefinedTerm
88 N75a128bcf3ce4799851d52ba0eb91bd8 schema:name pubmed_id
89 schema:value 24146108
90 rdf:type schema:PropertyValue
91 N775a87669a9643a8af6fe77a9303053b schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N7c3e2f5354824c528cdaf01a9250fda9 rdf:first sg:person.01075107345.46
94 rdf:rest N068f314fd0ff4870a7aa6a7db33af1fc
95 N7f671382f4a64f0084c8e0a0d9e89560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Prostatic Neoplasms
97 rdf:type schema:DefinedTerm
98 N8adb63619f1e4e2ab2ca28b1fc08e10e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Middle Aged
100 rdf:type schema:DefinedTerm
101 N8e354d1ddae046e39e10af1d0f373c7c rdf:first sg:person.0712561146.73
102 rdf:rest N28e58505a7b54d1cb257c344c496b1ff
103 N8eb8160e80934ca6bc0b52d62657e4f8 schema:name readcube_id
104 schema:value 488de3abd8241f62b470ef5c584c5c4088182ad810e6a41d90103a37883d7bc6
105 rdf:type schema:PropertyValue
106 N915a08b5e8b5466f8580d9d5f4f59198 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Urinary Bladder Neoplasms
108 rdf:type schema:DefinedTerm
109 N923724c1fa704252925999316810f308 schema:volumeNumber 463
110 rdf:type schema:PublicationVolume
111 N927ae408306c4875a3d990e50542423b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Humans
113 rdf:type schema:DefinedTerm
114 N93b3cde5043f436d9422ce200a01fcde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Adult
116 rdf:type schema:DefinedTerm
117 N941cef997132478c9560dac263765039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Carcinoma
119 rdf:type schema:DefinedTerm
120 N96f792d4d7fa4b58af5f45c9a8313876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Sensitivity and Specificity
122 rdf:type schema:DefinedTerm
123 N97effad63000490188a7db8a98fe92ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Biomarkers, Tumor
125 rdf:type schema:DefinedTerm
126 N99dba718d8744785b87362030bd4a181 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N9a9bbe41d16f4fac85dc7b9eba73d131 schema:name nlm_unique_id
130 schema:value 9423843
131 rdf:type schema:PropertyValue
132 Nc1d7723c934c4640af181e040aac7189 rdf:first sg:person.01116276566.28
133 rdf:rest N24d5ef22158f4b5385351c31e8d0ef7a
134 Nc3b686ae9c474eb19ee0e57d63aa46bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Aged, 80 and over
136 rdf:type schema:DefinedTerm
137 Nf1bae14e4a4d499a974614ade7bbb848 rdf:first sg:person.0740171455.76
138 rdf:rest Nc1d7723c934c4640af181e040aac7189
139 Nf9b33ad3ae474079927b6b5ca24f2b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Diagnosis, Differential
141 rdf:type schema:DefinedTerm
142 Nfbb607426c5b466590cdafd2405be813 rdf:first sg:person.0640702012.02
143 rdf:rest rdf:nil
144 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
145 schema:name Technology
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical Biotechnology
149 rdf:type schema:DefinedTerm
150 sg:journal.1106235 schema:issn 0945-6317
151 1432-2307
152 schema:name Virchows Archiv
153 rdf:type schema:Periodical
154 sg:person.01075107345.46 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
155 schema:familyName Chartier-Kastler
156 schema:givenName Emmanuel
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107345.46
158 rdf:type schema:Person
159 sg:person.01116276566.28 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
160 schema:familyName Conort
161 schema:givenName Pierre
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116276566.28
163 rdf:type schema:Person
164 sg:person.01173307220.15 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
165 schema:familyName Bitker
166 schema:givenName Marc-Olivier
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173307220.15
168 rdf:type schema:Person
169 sg:person.013241233644.08 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
170 schema:familyName Cussenot
171 schema:givenName Olivier
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241233644.08
173 rdf:type schema:Person
174 sg:person.01365601531.96 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
175 schema:familyName Cheng
176 schema:givenName Liang
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365601531.96
178 rdf:type schema:Person
179 sg:person.0640702012.02 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
180 schema:familyName Compérat
181 schema:givenName Eva
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640702012.02
183 rdf:type schema:Person
184 sg:person.0712561146.73 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
185 schema:familyName Varinot
186 schema:givenName Justine
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712561146.73
188 rdf:type schema:Person
189 sg:person.0740171455.76 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
190 schema:familyName Roupret
191 schema:givenName Morgan
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740171455.76
193 rdf:type schema:Person
194 sg:pub.10.1007/s00428-005-0092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014168007
195 https://doi.org/10.1007/s00428-005-0092-2
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/modpathol.3880220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047821732
198 https://doi.org/10.1038/modpathol.3880220
199 rdf:type schema:CreativeWork
200 sg:pub.10.1186/1476-4598-9-124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039256166
201 https://doi.org/10.1186/1476-4598-9-124
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1075034097 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1076607150 schema:CreativeWork
205 https://doi.org/10.1016/j.humpath.2012.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014489654
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.urology.2007.11.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001647402
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0002-9440(10)64814-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016219929
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1056/nejmoa1110000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043805171
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/00000478-200111000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030003560
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/pai.0b013e3181e04816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001043990
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/pas.0b013e3181e6cbf3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050427175
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/pas.0b013e318260cde7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036577827
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/pat.0b013e3283511c73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039873501
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1177/002215540305100813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051545908
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1309/pyqc-17cb-063t-q07j schema:sameAs https://app.dimensions.ai/details/publication/pub.1048761867
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1309/v1ry91nkx5arw2q5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009768975
228 rdf:type schema:CreativeWork
229 https://doi.org/10.4103/0377-4929.77326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051654801
230 rdf:type schema:CreativeWork
231 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
232 schema:name Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Room 4044, 46202-4108, Indianapolis, IN, USA
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
235 schema:name Laboratoire Oncotype Urologie—GRC UPMC-05, Hôpital de la Pitié-Salpêtrière, Paris, France
236 Service de pathologie, Hôpital de la Pitié-Salpêtrière, Paris, France
237 Service d’urologie, Hôpital de la Pitié-Salpêtrière, 47-83, boulevard de l’Hôpital, 75013, Paris, France
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...