Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-02

AUTHORS

Fumiyoshi Fushimi, Kenichi Taguchi, Hiroto Izumi, Kimitoshi Kohno, Michihiko Kuwano, Mayumi Ono, Yutaka Nakashima, Tetsuro Takesue, Seiji Naito, Yoshinao Oda

ABSTRACT

Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC. More... »

PAGES

553-562

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-013-1460-y

DOI

http://dx.doi.org/10.1007/s00428-013-1460-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015161367

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23907567


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxiredoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Dialysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thioredoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Y-Box-Binding Protein 1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fushimi", 
        "givenName": "Fumiyoshi", 
        "id": "sg:person.010317524155.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010317524155.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Pathology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taguchi", 
        "givenName": "Kenichi", 
        "id": "sg:person.013732377402.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732377402.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izumi", 
        "givenName": "Hiroto", 
        "id": "sg:person.01007122017.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Kimitoshi", 
        "id": "sg:person.0745037146.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwano", 
        "givenName": "Michihiko", 
        "id": "sg:person.0615256535.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256535.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ono", 
        "givenName": "Mayumi", 
        "id": "sg:person.013120526702.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013120526702.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415148.d", 
          "name": [
            "Department of Pathology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Yutaka", 
        "id": "sg:person.07456121032.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456121032.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415148.d", 
          "name": [
            "Department of Urology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takesue", 
        "givenName": "Tetsuro", 
        "id": "sg:person.01105633603.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105633603.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naito", 
        "givenName": "Seiji", 
        "id": "sg:person.01261127150.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261127150.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oda", 
        "givenName": "Yoshinao", 
        "id": "sg:person.0730707143.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730707143.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00408-007-9066-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020364420", 
          "https://doi.org/10.1007/s00408-007-9066-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003300000601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045562294", 
          "https://doi.org/10.1007/s003300000601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047829746", 
          "https://doi.org/10.1038/modpathol.3800604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003104569", 
          "https://doi.org/10.1038/sj.onc.1210084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-28-93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030026212", 
          "https://doi.org/10.1186/1756-9966-28-93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2010.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003912984", 
          "https://doi.org/10.1038/cr.2010.178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042071125", 
          "https://doi.org/10.1038/onc.2009.321"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08-02", 
    "datePublishedReg": "2013-08-02", 
    "description": "Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00428-013-1460-y", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6086722", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6092069", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "463"
      }
    ], 
    "keywords": [
      "renal cell carcinoma", 
      "sporadic renal cell carcinoma", 
      "cell carcinoma", 
      "epithelial hyperplasia", 
      "cystic disease", 
      "oxidative stress", 
      "Y-box-binding protein 1", 
      "end-stage renal disease", 
      "duration of dialysis", 
      "protein 1", 
      "Fuhrman nuclear grade", 
      "renal disease", 
      "nuclear grade", 
      "antioxidant activity", 
      "cellular defense mechanisms", 
      "control group", 
      "tumor progression", 
      "nuclear expression", 
      "Prx-3", 
      "disease", 
      "peroxiredoxin 1", 
      "progression", 
      "antioxidant mechanisms", 
      "carcinoma", 
      "hyperplasia", 
      "antioxidant proteins", 
      "immunoreactivity", 
      "stimulating effect", 
      "kidney", 
      "dialysis", 
      "carcinogenesis", 
      "defense mechanisms", 
      "expression", 
      "patients", 
      "pathogenesis", 
      "immunohistochemistry", 
      "cancer", 
      "impairment", 
      "cases", 
      "activity", 
      "duration", 
      "effect", 
      "grade", 
      "group", 
      "stress", 
      "mechanism", 
      "protein", 
      "thioredoxin", 
      "data", 
      "peroxiredoxins", 
      "Prx", 
      "insights", 
      "terms"
    ], 
    "name": "Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma", 
    "pagination": "553-562", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015161367"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-013-1460-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23907567"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-013-1460-y", 
      "https://app.dimensions.ai/details/publication/pub.1015161367"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00428-013-1460-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1460-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1460-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1460-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-013-1460-y'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      102 URIs      87 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-013-1460-y schema:about N041cc08896a742398d5ef1b8298deba8
2 N0d8ae9d92d254721b430f702c55b2f01
3 N193d5fb52467448fb504acec1bbfefb1
4 N1a04c207e7c3411185ce2c2037a05aee
5 N3264f2201ac743688a2a72f0f0226bab
6 N535a8311306241edac0c3436b4245f48
7 N55feba862b1c4f40ae2a43bf026c3a28
8 N716e075999b14d6f8bdb16e65b80c48b
9 N78c1e53b37f14fcd9d6d4b4f973d725b
10 N7fb51acdcdf448c09aaf386b071654bb
11 N8dd5cfe869d8483a95aad5f9af448609
12 Nc90984f686694cef884277127dae1d42
13 Nd661f48783234a0e92449f3b42ff4a4c
14 Nd6f145d5cedd4dc6b17be13d114443c4
15 Ndfeb451850d14a7b997dbc5560dba6f5
16 Neda86cb6d03b4b1bbcdbb3d3eec21d63
17 Nf5620036dfe54a50891040fec1d56f09
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N8d99bb8cecb647078d2db08dd664a23f
21 schema:citation sg:pub.10.1007/s003300000601
22 sg:pub.10.1007/s00408-007-9066-2
23 sg:pub.10.1038/cr.2010.178
24 sg:pub.10.1038/modpathol.3800604
25 sg:pub.10.1038/onc.2009.321
26 sg:pub.10.1038/sj.onc.1210084
27 sg:pub.10.1186/1756-9966-28-93
28 schema:datePublished 2013-08-02
29 schema:datePublishedReg 2013-08-02
30 schema:description Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N47925826442c49b385a2a9337b25f77e
34 Nda4a0c20f7184747ab163bef408290e2
35 sg:journal.1106235
36 schema:keywords Fuhrman nuclear grade
37 Prx
38 Prx-3
39 Y-box-binding protein 1
40 activity
41 antioxidant activity
42 antioxidant mechanisms
43 antioxidant proteins
44 cancer
45 carcinogenesis
46 carcinoma
47 cases
48 cell carcinoma
49 cellular defense mechanisms
50 control group
51 cystic disease
52 data
53 defense mechanisms
54 dialysis
55 disease
56 duration
57 duration of dialysis
58 effect
59 end-stage renal disease
60 epithelial hyperplasia
61 expression
62 grade
63 group
64 hyperplasia
65 immunohistochemistry
66 immunoreactivity
67 impairment
68 insights
69 kidney
70 mechanism
71 nuclear expression
72 nuclear grade
73 oxidative stress
74 pathogenesis
75 patients
76 peroxiredoxin 1
77 peroxiredoxins
78 progression
79 protein
80 protein 1
81 renal cell carcinoma
82 renal disease
83 sporadic renal cell carcinoma
84 stimulating effect
85 stress
86 terms
87 thioredoxin
88 tumor progression
89 schema:name Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma
90 schema:pagination 553-562
91 schema:productId N289f1b35ba654f4ba82c7046988cbe71
92 N51aac92bbb624463b06012a1b58d4aca
93 N6bf1e0d921ba4b969c3a242d8a56ced8
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015161367
95 https://doi.org/10.1007/s00428-013-1460-y
96 schema:sdDatePublished 2022-09-02T15:56
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N42eef444f07b4548ba186fa6328876a4
99 schema:url https://doi.org/10.1007/s00428-013-1460-y
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N041cc08896a742398d5ef1b8298deba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aged, 80 and over
105 rdf:type schema:DefinedTerm
106 N0d8ae9d92d254721b430f702c55b2f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Thioredoxins
108 rdf:type schema:DefinedTerm
109 N108e5ba1556f49dc9e9f201a44de27ff rdf:first sg:person.0745037146.34
110 rdf:rest Nce3f242d8da5456d91680bd1bbe480b3
111 N18bd44721f71431f9297e0b9c30bcbe0 rdf:first sg:person.013120526702.99
112 rdf:rest N2eb93631482e496ab036e152e230d1e8
113 N193d5fb52467448fb504acec1bbfefb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Middle Aged
115 rdf:type schema:DefinedTerm
116 N1a04c207e7c3411185ce2c2037a05aee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Peroxiredoxins
118 rdf:type schema:DefinedTerm
119 N289f1b35ba654f4ba82c7046988cbe71 schema:name dimensions_id
120 schema:value pub.1015161367
121 rdf:type schema:PropertyValue
122 N2eb93631482e496ab036e152e230d1e8 rdf:first sg:person.07456121032.01
123 rdf:rest Nacb7bb6b244746968373b29cf1528f08
124 N3264f2201ac743688a2a72f0f0226bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N42eef444f07b4548ba186fa6328876a4 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N47925826442c49b385a2a9337b25f77e schema:issueNumber 4
130 rdf:type schema:PublicationIssue
131 N51aac92bbb624463b06012a1b58d4aca schema:name doi
132 schema:value 10.1007/s00428-013-1460-y
133 rdf:type schema:PropertyValue
134 N535a8311306241edac0c3436b4245f48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adult
136 rdf:type schema:DefinedTerm
137 N55feba862b1c4f40ae2a43bf026c3a28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Carcinoma, Renal Cell
139 rdf:type schema:DefinedTerm
140 N6bf1e0d921ba4b969c3a242d8a56ced8 schema:name pubmed_id
141 schema:value 23907567
142 rdf:type schema:PropertyValue
143 N716e075999b14d6f8bdb16e65b80c48b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Renal Dialysis
145 rdf:type schema:DefinedTerm
146 N78c1e53b37f14fcd9d6d4b4f973d725b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N7fb51acdcdf448c09aaf386b071654bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Retrospective Studies
151 rdf:type schema:DefinedTerm
152 N8d99bb8cecb647078d2db08dd664a23f rdf:first sg:person.010317524155.38
153 rdf:rest Nb00ca9057cd945a783c5d1cf27f222f9
154 N8dd5cfe869d8483a95aad5f9af448609 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N9d155db3f435475482b4d71862eae669 rdf:first sg:person.01261127150.29
158 rdf:rest Ne5be7a3042764ba6912487df29d8853f
159 Nacb7bb6b244746968373b29cf1528f08 rdf:first sg:person.01105633603.08
160 rdf:rest N9d155db3f435475482b4d71862eae669
161 Nb00ca9057cd945a783c5d1cf27f222f9 rdf:first sg:person.013732377402.33
162 rdf:rest Nbe982890017c48e1b53dea5cf5d8364c
163 Nbe982890017c48e1b53dea5cf5d8364c rdf:first sg:person.01007122017.64
164 rdf:rest N108e5ba1556f49dc9e9f201a44de27ff
165 Nc90984f686694cef884277127dae1d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Kidney Neoplasms
167 rdf:type schema:DefinedTerm
168 Nce3f242d8da5456d91680bd1bbe480b3 rdf:first sg:person.0615256535.33
169 rdf:rest N18bd44721f71431f9297e0b9c30bcbe0
170 Nd661f48783234a0e92449f3b42ff4a4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Oxidative Stress
172 rdf:type schema:DefinedTerm
173 Nd6f145d5cedd4dc6b17be13d114443c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Aged
175 rdf:type schema:DefinedTerm
176 Nda4a0c20f7184747ab163bef408290e2 schema:volumeNumber 463
177 rdf:type schema:PublicationVolume
178 Ndfeb451850d14a7b997dbc5560dba6f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Immunohistochemistry
180 rdf:type schema:DefinedTerm
181 Ne5be7a3042764ba6912487df29d8853f rdf:first sg:person.0730707143.99
182 rdf:rest rdf:nil
183 Neda86cb6d03b4b1bbcdbb3d3eec21d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Disease Progression
185 rdf:type schema:DefinedTerm
186 Nf5620036dfe54a50891040fec1d56f09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Y-Box-Binding Protein 1
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:grant.6086722 http://pending.schema.org/fundedItem sg:pub.10.1007/s00428-013-1460-y
196 rdf:type schema:MonetaryGrant
197 sg:grant.6092069 http://pending.schema.org/fundedItem sg:pub.10.1007/s00428-013-1460-y
198 rdf:type schema:MonetaryGrant
199 sg:journal.1106235 schema:issn 0945-6317
200 1432-2307
201 schema:name Virchows Archiv
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01007122017.64 schema:affiliation grid-institutes:grid.271052.3
205 schema:familyName Izumi
206 schema:givenName Hiroto
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007122017.64
208 rdf:type schema:Person
209 sg:person.010317524155.38 schema:affiliation grid-institutes:grid.177174.3
210 schema:familyName Fushimi
211 schema:givenName Fumiyoshi
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010317524155.38
213 rdf:type schema:Person
214 sg:person.01105633603.08 schema:affiliation grid-institutes:grid.415148.d
215 schema:familyName Takesue
216 schema:givenName Tetsuro
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105633603.08
218 rdf:type schema:Person
219 sg:person.01261127150.29 schema:affiliation grid-institutes:grid.177174.3
220 schema:familyName Naito
221 schema:givenName Seiji
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261127150.29
223 rdf:type schema:Person
224 sg:person.013120526702.99 schema:affiliation grid-institutes:grid.177174.3
225 schema:familyName Ono
226 schema:givenName Mayumi
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013120526702.99
228 rdf:type schema:Person
229 sg:person.013732377402.33 schema:affiliation grid-institutes:None
230 schema:familyName Taguchi
231 schema:givenName Kenichi
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732377402.33
233 rdf:type schema:Person
234 sg:person.0615256535.33 schema:affiliation grid-institutes:grid.177174.3
235 schema:familyName Kuwano
236 schema:givenName Michihiko
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615256535.33
238 rdf:type schema:Person
239 sg:person.0730707143.99 schema:affiliation grid-institutes:grid.177174.3
240 schema:familyName Oda
241 schema:givenName Yoshinao
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730707143.99
243 rdf:type schema:Person
244 sg:person.0745037146.34 schema:affiliation grid-institutes:grid.271052.3
245 schema:familyName Kohno
246 schema:givenName Kimitoshi
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745037146.34
248 rdf:type schema:Person
249 sg:person.07456121032.01 schema:affiliation grid-institutes:grid.415148.d
250 schema:familyName Nakashima
251 schema:givenName Yutaka
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456121032.01
253 rdf:type schema:Person
254 sg:pub.10.1007/s003300000601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045562294
255 https://doi.org/10.1007/s003300000601
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s00408-007-9066-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020364420
258 https://doi.org/10.1007/s00408-007-9066-2
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/cr.2010.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003912984
261 https://doi.org/10.1038/cr.2010.178
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/modpathol.3800604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047829746
264 https://doi.org/10.1038/modpathol.3800604
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/onc.2009.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042071125
267 https://doi.org/10.1038/onc.2009.321
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sj.onc.1210084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003104569
270 https://doi.org/10.1038/sj.onc.1210084
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1756-9966-28-93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030026212
273 https://doi.org/10.1186/1756-9966-28-93
274 rdf:type schema:CreativeWork
275 grid-institutes:None schema:alternateName Department of Pathology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan
276 schema:name Department of Pathology, National Kyushu Cancer Center, Minami-ku, Fukuoka, Japan
277 rdf:type schema:Organization
278 grid-institutes:grid.177174.3 schema:alternateName Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan
279 Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
280 Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
281 schema:name Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan
282 Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
283 Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
284 rdf:type schema:Organization
285 grid-institutes:grid.271052.3 schema:alternateName Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
286 schema:name Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.415148.d schema:alternateName Department of Pathology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan
289 Department of Urology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan
290 schema:name Department of Pathology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan
291 Department of Urology, Fukuoka Red Cross Hospital, Minami-ku, Fukuoka, Japan
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...