Morphological and immunological changes in the skin of autopsied women with AIDS View Full Text


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Article Info

DATE

2012-08-16

AUTHORS

Renata Beatriz Silva, Laura Penna Rocha, Laís Resende Cardoso de Souza, Humberto Aparecido Faria, Janaínna Grazielle Pacheco Olegário, Maria Helena Soares, Mara Lúcia Fonseca Ferraz, Rosana Rosa Miranda Corrêa, Vicente de Paula Antunes Teixeira, Camila Lourencini Cavellani

ABSTRACT

Acquired immunodeficiency syndrome (AIDS) is characterized by decreased immunity, making a patient more susceptible to opportunistic infections which can have cutaneous manifestations. The aim of this study was to evaluate the local immunity of the skin through morphological and immunohistochemical analysis. Skin samples of 52 women, 27 without AIDS and 25 with AIDS, autopsied in an academic referral hospital in Brazil were evaluated. The autopsy reports and medical records were reviewed, and histochemical Hematoxylin–eosin, Picrosirius red, and Verhoeff stains as well as morphometric (Image J and KS-300 Kontron-Zeiss) and immunohistochemical (S-100 and anti-IgA) analyses of the skin were performed. Women with AIDS presented a thinner epidermis than women without AIDS (33.33 [12.00–317.66] vs 67.42 [12.00–530.02] μm; p < 0.001), with a lower number of epithelial cell layers (4.00 [2.00–11.00] vs 4.00 [2.00–16.00]; p < 0.001), a smaller cell diameter (12.92 [6.00–28.87] vs 24.32 [6.00–33.12] μm; p < 0.001), and a lower number of Langerhans cells (LC) (12.58 [0.00–81.74] vs 31.44 [0.00–169.77] LC/mm2; p < 0.001). The dermis contained more collagen fibers (8.20 % [2.40–19.40] vs 6.30 % [0.40–13.90]; p < 0.001). Some of these parameters were negatively correlated with viral load and positively correlated with the number of CD4+ T-lymphocytes. We conclude that a decrease of the local skin immunity in women with AIDS may contribute to the development of skin lesions. More... »

PAGES

449-455

References to SciGraph publications

  • 1996-06. HIV viral load markers in clinical practice in NATURE MEDICINE
  • 1991-10. Mucosal transmission of HIV in NATURE
  • 1996. Humoral Immunity to HIV-1: in IMMUNOLOGY OF HIV INFECTION
  • 2008-09-29. Molecular architecture of the fruit fly's airway epithelial immune system in BMC GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00428-012-1297-9

    DOI

    http://dx.doi.org/10.1007/s00428-012-1297-9

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22895865


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    27 schema:description Acquired immunodeficiency syndrome (AIDS) is characterized by decreased immunity, making a patient more susceptible to opportunistic infections which can have cutaneous manifestations. The aim of this study was to evaluate the local immunity of the skin through morphological and immunohistochemical analysis. Skin samples of 52 women, 27 without AIDS and 25 with AIDS, autopsied in an academic referral hospital in Brazil were evaluated. The autopsy reports and medical records were reviewed, and histochemical Hematoxylin–eosin, Picrosirius red, and Verhoeff stains as well as morphometric (Image J and KS-300 Kontron-Zeiss) and immunohistochemical (S-100 and anti-IgA) analyses of the skin were performed. Women with AIDS presented a thinner epidermis than women without AIDS (33.33 [12.00–317.66] vs 67.42 [12.00–530.02] μm; p < 0.001), with a lower number of epithelial cell layers (4.00 [2.00–11.00] vs 4.00 [2.00–16.00]; p < 0.001), a smaller cell diameter (12.92 [6.00–28.87] vs 24.32 [6.00–33.12] μm; p < 0.001), and a lower number of Langerhans cells (LC) (12.58 [0.00–81.74] vs 31.44 [0.00–169.77] LC/mm2; p < 0.001). The dermis contained more collagen fibers (8.20 % [2.40–19.40] vs 6.30 % [0.40–13.90]; p < 0.001). Some of these parameters were negatively correlated with viral load and positively correlated with the number of CD4+ T-lymphocytes. We conclude that a decrease of the local skin immunity in women with AIDS may contribute to the development of skin lesions.
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