Anterior gradient protein 2 (AGR2) is an independent prognostic factor in ovarian high-grade serous carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

S. Darb-Esfahani, F. Fritzsche, G. Kristiansen, W. Weichert, J. Sehouli, I. Braicu, M. Dietel, C. Denkert

ABSTRACT

Ovarian high-grade serous carcinoma (HGSC, type 2 ovarian carcinoma) is a poor prognosis cancer with limited therapeutic options. We aimed to investigate the expression pattern and prognostic potential of the metastasis-promoting protein anterior gradient 2 (AGR2) in primary HGSC. Immunohistochemistry was applied to a cohort of 124 primary HGSCs using tissue microarrays. Additionally, in 48 type 1 carcinomas (low-grade serous (LGSC), endometrioid (EC), clear cell (CCC), and mucinous carcinoma (MC)), AGR2 expression was investigated in an exploratory approach. A strong expression of AGR2 was seen in 15 HGSCs (12.1 %) and was significantly linked to shortened overall survival (OS, p = 0.011) and also for progression-free survival (PFS, p = 0.001) in the setting of adjuvant platinum-based chemotherapy (CTX). Multivariate survival analysis including age, stage, and residual tumor after surgery revealed that AGR2 expression was an independent prognostic marker for OS (p = 0.001) and PFS (p = 0.001) in HGSC. In type 1 carcinomas, AGR2 was significantly increased as compared to HGSC (p = 0.001) and was seen in subsets of all histological types, low-grade serous LGSC, EC, CCC, and MC. In particular, strong diffuse staining was seen in LGSC and MC. There was no association between AGR2 and estrogen receptor expression in ovarian type 1 or type 2 carcinomas. AGR2 expression identifies highly aggressive HGSC with a compromised prognosis for which novel therapeutic options are needed. Our data strongly support the further evaluation of AGR2 as a therapeutic target and a potential marker for response to platinum-based CTX in this tumor entity. More... »

PAGES

109-116

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-012-1273-4

DOI

http://dx.doi.org/10.1007/s00428-012-1273-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036401667

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22752467


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-012-1273-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-012-1273-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-012-1273-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-012-1273-4'


 

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298 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
299 schema:name Department of Gynecology, Charité Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany
300 Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.9851.5 schema:alternateName University of Lausanne
303 schema:name Institute of Pathology Enge, Zürich, Switzerland
304 rdf:type schema:Organization
 




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