KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11

AUTHORS

J. H. J. M. van Krieken, A. Jung, T. Kirchner, F. Carneiro, R. Seruca, F. T. Bosman, P. Quirke, J. F. Fléjou, T. Plato Hansen, G. de Hertogh, P. Jares, C. Langner, G. Hoefler, M. Ligtenberg, D. Tiniakos, S. Tejpar, G. Bevilacqua, A. Ensari

ABSTRACT

Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these therapies are effective only in a subset of patients. Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. Thus, KRAS mutation status can predict which patient may or may not benefit from anti-EGFR therapy. Although many diagnostic tools have been developed for KRAS mutation analysis, validated methods and standardized testing procedures are lacking. This poses a challenge for the optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Here we review the molecular basis of EGFR-targeted therapies and the resistance to treatment conferred by KRAS mutations. We also present guideline recommendations and a proposal for a European quality assurance program to help ensure accuracy and proficiency in KRAS mutation testing across the European Union. More... »

PAGES

417-431

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-008-0665-y

DOI

http://dx.doi.org/10.1007/s00428-008-0665-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013450881

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18802721


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality Assurance, Health Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500, Nijmegen, HB, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Krieken", 
        "givenName": "J. H. J. M.", 
        "id": "sg:person.013245604437.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Pathology, Ludwig-Maximilians Universit\u00e4t, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "A.", 
        "id": "sg:person.01211136300.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211136300.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Pathology, Ludwig-Maximilians Universit\u00e4t, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirchner", 
        "givenName": "T.", 
        "id": "sg:person.07551705102.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07551705102.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital de S\u00e3o Jo\u00e3o", 
          "id": "https://www.grid.ac/institutes/grid.414556.7", 
          "name": [
            "Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal", 
            "Medical Faculty of the of Porto, Porto, Portugal", 
            "Department of Pathology, Hospital S. Jo\u00e3o, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carneiro", 
        "givenName": "F.", 
        "id": "sg:person.016175710642.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016175710642.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Porto", 
          "id": "https://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal", 
            "Medical Faculty of the of Porto, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seruca", 
        "givenName": "R.", 
        "id": "sg:person.01277361713.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277361713.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "University Institute of Pathology, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosman", 
        "givenName": "F. T.", 
        "id": "sg:person.01064765425.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064765425.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Pathology and Tumour Biology, University of Leeds, Leeds, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quirke", 
        "givenName": "P.", 
        "id": "sg:person.014471504424.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014471504424.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Saint-Antoine Hospital, University Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fl\u00e9jou", 
        "givenName": "J. F.", 
        "id": "sg:person.01064715771.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064715771.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Pathology, Odense University Hospital, Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plato Hansen", 
        "givenName": "T.", 
        "id": "sg:person.01051124052.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051124052.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Department of Pathology, University Hospitals KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Hertogh", 
        "givenName": "G.", 
        "id": "sg:person.01033744500.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033744500.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Clinic of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.410458.c", 
          "name": [
            "Department of Pathology, Hospital Clinic, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jares", 
        "givenName": "P.", 
        "id": "sg:person.01074023250.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074023250.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Pathology, Medical University Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langner", 
        "givenName": "C.", 
        "id": "sg:person.01077027525.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077027525.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Pathology, Medical University Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoefler", 
        "givenName": "G.", 
        "id": "sg:person.0755631152.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755631152.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500, Nijmegen, HB, The Netherlands", 
            "Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ligtenberg", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Laboratory of Histology and Embryology, Medical School University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiniakos", 
        "givenName": "D.", 
        "id": "sg:person.0706654657.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706654657.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tejpar", 
        "givenName": "S.", 
        "id": "sg:person.0644246455.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644246455.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bevilacqua", 
        "givenName": "G.", 
        "id": "sg:person.0670266240.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670266240.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ankara University", 
          "id": "https://www.grid.ac/institutes/grid.7256.6", 
          "name": [
            "Department of Pathology, Ankara University Medical School, Ankara, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ensari", 
        "givenName": "A.", 
        "id": "sg:person.0657737241.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657737241.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1470-2045(05)70102-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000497060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0405220101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000546271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(97)10111-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001133027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9667-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001854286", 
          "https://doi.org/10.1245/s10434-007-9667-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002676081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002676081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prp.2007.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002980736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/ccc.2006.n.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003051395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdj920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003658974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004677902", 
          "https://doi.org/10.1038/bjc.1998.212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004677902", 
          "https://doi.org/10.1038/bjc.1998.212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2004.n.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005968207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011068113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011213819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011213819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011246506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-0646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012023614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b700071e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012995846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.11.8984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013167699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0707704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013325677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013645791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014358338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015471130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2004.022707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015488856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000703500403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015630105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000703500403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015630105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2007.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016407909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017230694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017860490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621721", 
          "https://doi.org/10.1054/bjoc.2001.1964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-7404(92)90062-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020754436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021264669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022065648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.082933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022556294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.5437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024397161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024434749", 
          "https://doi.org/10.1038/sj.bjc.6604053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/14622416.9.4.463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026405562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026719751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1040-8428(94)00144-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027064147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-1578(10)60571-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030068693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030082966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030493697", 
          "https://doi.org/10.1038/sj.onc.1207061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030493697", 
          "https://doi.org/10.1038/sj.onc.1207061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bmc.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031113077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930510304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031507490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.7116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031599680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033538744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-007-0644-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033577087", 
          "https://doi.org/10.1007/s00280-007-0644-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-007-0644-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033577087", 
          "https://doi.org/10.1007/s00280-007-0644-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152373", 
          "https://doi.org/10.1038/modpathol.3800774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152373", 
          "https://doi.org/10.1038/modpathol.3800774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035161767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2004.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035518953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2004.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035518953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.10310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035541469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bios.2007.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037308418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037639061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1037>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038126495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038401526", 
          "https://doi.org/10.1038/sj.bjc.6604009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-4158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038632088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038822007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2004.025551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038925742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039902479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039902479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020801911512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041730135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020801911512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041730135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418934a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042017236", 
          "https://doi.org/10.1038/418934a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418934a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042017236", 
          "https://doi.org/10.1038/418934a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800771211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042628204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.08.1620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043055498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043702992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044563589", 
          "https://doi.org/10.1038/sj.onc.1202291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044563589", 
          "https://doi.org/10.1038/sj.onc.1202291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045547866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)03752-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046424585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)03752-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046424585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048862205", 
          "https://doi.org/10.1038/sj.bjc.6603685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049190387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049419586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/ca.2007.0010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052065817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.08.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052650563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdl037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053206624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.5906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053434927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.10.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053488821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053566497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930415)71:8<2454::aid-cncr2820710805>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053679057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac701702t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055069383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac701702t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055069383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja034716g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055833218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja034716g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055833218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.29.5.1159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071516185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.16.6.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071530228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.5.8.3251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072294236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074733352", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077395580", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480701400313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077442025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480701400313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077442025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082722342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347341", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these therapies are effective only in a subset of patients. Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. Thus, KRAS mutation status can predict which patient may or may not benefit from anti-EGFR therapy. Although many diagnostic tools have been developed for KRAS mutation analysis, validated methods and standardized testing procedures are lacking. This poses a challenge for the optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Here we review the molecular basis of EGFR-targeted therapies and the resistance to treatment conferred by KRAS mutations. We also present guideline recommendations and a proposal for a European quality assurance program to help ensure accuracy and proficiency in KRAS mutation testing across the European Union.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-008-0665-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "453"
      }
    ], 
    "name": "KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program", 
    "pagination": "417-431", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "40139242060d2d888dd912a7e2338c9d957482c666c1406f1bf6851cb5872997"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18802721"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-008-0665-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013450881"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-008-0665-y", 
      "https://app.dimensions.ai/details/publication/pub.1013450881"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-008-0665-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0665-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0665-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0665-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0665-y'


 

This table displays all metadata directly associated to this object as RDF triples.

534 TRIPLES      21 PREDICATES      124 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-008-0665-y schema:about N17c827052f8b44de8ae1e2964371a5a9
2 N27ac414e02924970a170a23ad041cbb5
3 N2a7afd26e77c4d4c9a3598efddf9e9a0
4 N428842cfd5d04af6a68a5190b6304b1e
5 N51788ddca9fa49089841570aa7ccb72c
6 N5faec05f4b91415dbb52f3b705b6e2de
7 N7931f501162941c0a55e2a4aa5f1f7bc
8 N93c838c420664a6ebe949de9303fa329
9 Na09ac76b24a947839a431ee9d3ea1944
10 Nacfd94cbfded4da7bcad28e09f7fb1d3
11 Nc89b65ca38b6431b9f1508643f758474
12 Nd9ee5e3ef32b46a38acccba4430d2fde
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N89c259c45ee24e4996385bfc8292574c
16 schema:citation sg:pub.10.1007/s00280-007-0644-z
17 sg:pub.10.1038/418934a
18 sg:pub.10.1038/bjc.1998.212
19 sg:pub.10.1038/modpathol.3800774
20 sg:pub.10.1038/sj.bjc.6603685
21 sg:pub.10.1038/sj.bjc.6604009
22 sg:pub.10.1038/sj.bjc.6604053
23 sg:pub.10.1038/sj.onc.1202291
24 sg:pub.10.1038/sj.onc.1207061
25 sg:pub.10.1054/bjoc.2001.1964
26 sg:pub.10.1245/s10434-007-9667-2
27 https://app.dimensions.ai/details/publication/pub.1074733352
28 https://app.dimensions.ai/details/publication/pub.1077395580
29 https://app.dimensions.ai/details/publication/pub.1082722342
30 https://app.dimensions.ai/details/publication/pub.1083347341
31 https://doi.org/10.1002/1097-0142(19930415)71:8<2454::aid-cncr2820710805>3.0.co;2-2
32 https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1037>3.0.co;2-f
33 https://doi.org/10.1002/bjs.1800771211
34 https://doi.org/10.1002/bmc.353
35 https://doi.org/10.1002/cncr.21558
36 https://doi.org/10.1002/gcc.10310
37 https://doi.org/10.1002/ijc.23388
38 https://doi.org/10.1002/jcp.20310
39 https://doi.org/10.1002/jcp.20898
40 https://doi.org/10.1002/jso.2930510304
41 https://doi.org/10.1002/path.2295
42 https://doi.org/10.1016/0960-7404(92)90062-p
43 https://doi.org/10.1016/1040-8428(94)00144-i
44 https://doi.org/10.1016/j.bbcan.2005.06.003
45 https://doi.org/10.1016/j.bios.2007.12.011
46 https://doi.org/10.1016/j.ejca.2005.04.022
47 https://doi.org/10.1016/j.humpath.2007.10.027
48 https://doi.org/10.1016/j.prp.2007.06.001
49 https://doi.org/10.1016/s0360-3016(02)03752-5
50 https://doi.org/10.1016/s0959-8049(97)10111-3
51 https://doi.org/10.1016/s1470-2045(05)70102-9
52 https://doi.org/10.1016/s1525-1578(10)60571-5
53 https://doi.org/10.1021/ac701702t
54 https://doi.org/10.1021/ja034716g
55 https://doi.org/10.1039/b700071e
56 https://doi.org/10.1053/j.seminoncol.2004.09.036
57 https://doi.org/10.1056/nejmoa033025
58 https://doi.org/10.1056/nejmoa071834
59 https://doi.org/10.1056/nejmra0707704
60 https://doi.org/10.1073/pnas.0405220101
61 https://doi.org/10.1080/00313020801911512
62 https://doi.org/10.1093/annonc/mdi006
63 https://doi.org/10.1093/annonc/mdi907
64 https://doi.org/10.1093/annonc/mdj920
65 https://doi.org/10.1093/annonc/mdl037
66 https://doi.org/10.1093/annonc/mdm496
67 https://doi.org/10.1093/hmg/ddh238
68 https://doi.org/10.1093/jnci/dji112
69 https://doi.org/10.1093/jnci/dji174
70 https://doi.org/10.1093/nar/gkm809
71 https://doi.org/10.1126/science.1099314
72 https://doi.org/10.1136/gut.2005.082933
73 https://doi.org/10.1136/jcp.2004.022707
74 https://doi.org/10.1136/jcp.2004.025551
75 https://doi.org/10.1158/0008-5472.can-04-2818
76 https://doi.org/10.1158/0008-5472.can-06-0191
77 https://doi.org/10.1158/0008-5472.can-06-4158
78 https://doi.org/10.1158/0008-5472.can-07-5659
79 https://doi.org/10.1158/1078-0432.ccr-05-0738
80 https://doi.org/10.1158/1078-0432.ccr-06-0646
81 https://doi.org/10.1158/1078-0432.ccr-07-0332
82 https://doi.org/10.1177/107327480701400313
83 https://doi.org/10.1177/147323000703500403
84 https://doi.org/10.1200/jco.2004.10.182
85 https://doi.org/10.1200/jco.2005.08.037
86 https://doi.org/10.1200/jco.2006.08.1620
87 https://doi.org/10.1200/jco.2006.09.2775
88 https://doi.org/10.1200/jco.2006.10.5437
89 https://doi.org/10.1200/jco.2007.11.8984
90 https://doi.org/10.1200/jco.2007.12.5906
91 https://doi.org/10.1200/jco.2007.14.7116
92 https://doi.org/10.2217/14622416.9.4.463
93 https://doi.org/10.3322/ca.2007.0010
94 https://doi.org/10.3816/cbc.2004.n.011
95 https://doi.org/10.3816/ccc.2006.n.01
96 https://doi.org/10.3892/ijo.29.5.1159
97 https://doi.org/10.3892/or.16.6.1245
98 https://doi.org/10.4161/cbt.5.8.3251
99 schema:datePublished 2008-11
100 schema:datePublishedReg 2008-11-01
101 schema:description Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these therapies are effective only in a subset of patients. Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. Thus, KRAS mutation status can predict which patient may or may not benefit from anti-EGFR therapy. Although many diagnostic tools have been developed for KRAS mutation analysis, validated methods and standardized testing procedures are lacking. This poses a challenge for the optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Here we review the molecular basis of EGFR-targeted therapies and the resistance to treatment conferred by KRAS mutations. We also present guideline recommendations and a proposal for a European quality assurance program to help ensure accuracy and proficiency in KRAS mutation testing across the European Union.
102 schema:genre research_article
103 schema:inLanguage en
104 schema:isAccessibleForFree true
105 schema:isPartOf N192aa0c9c6e14e15904faaae13591ef9
106 Nda68d6184eb34132a317e7cff0de6785
107 sg:journal.1106235
108 schema:name KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program
109 schema:pagination 417-431
110 schema:productId N2d9a8de96e06446a8b6c7afed0ead720
111 N30adb12ab72c478a8de42fae294b4d67
112 N4f8db9f31bec48e0886b0b7b291ddb12
113 N6668e816e5134c5c94062ffb6ad6f238
114 N926b1d78874e408099c43f2027cb9159
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013450881
116 https://doi.org/10.1007/s00428-008-0665-y
117 schema:sdDatePublished 2019-04-10T15:00
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher Ndeef67a766a74a559d9a6b167c67830a
120 schema:url http://link.springer.com/10.1007%2Fs00428-008-0665-y
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N17c827052f8b44de8ae1e2964371a5a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Proto-Oncogene Proteins p21(ras)
126 rdf:type schema:DefinedTerm
127 N1913f5d2d27a452590f64f62db69ce3e rdf:first sg:person.01064715771.30
128 rdf:rest N3fad1bfa03404512998f0849b6929a5f
129 N192aa0c9c6e14e15904faaae13591ef9 schema:issueNumber 5
130 rdf:type schema:PublicationIssue
131 N1f52300d54684eaaaa647d3d07fa1add rdf:first sg:person.0706654657.10
132 rdf:rest N5fac1d77f43b4e218d1d06c2701c9481
133 N27ac414e02924970a170a23ad041cbb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Receptor, Epidermal Growth Factor
135 rdf:type schema:DefinedTerm
136 N2a7afd26e77c4d4c9a3598efddf9e9a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Colorectal Neoplasms
138 rdf:type schema:DefinedTerm
139 N2c612451cc8f46c69c068cc0122344e8 rdf:first sg:person.01277361713.77
140 rdf:rest Na4bb6d82bfbb47e090ca40ce1b875d71
141 N2d9a8de96e06446a8b6c7afed0ead720 schema:name pubmed_id
142 schema:value 18802721
143 rdf:type schema:PropertyValue
144 N30adb12ab72c478a8de42fae294b4d67 schema:name doi
145 schema:value 10.1007/s00428-008-0665-y
146 rdf:type schema:PropertyValue
147 N3e133285ad8248f099efbb4f967366ae rdf:first sg:person.0657737241.29
148 rdf:rest rdf:nil
149 N3fad1bfa03404512998f0849b6929a5f rdf:first sg:person.01051124052.85
150 rdf:rest N556eca48714d46d1b741732b604dcc5c
151 N428842cfd5d04af6a68a5190b6304b1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Genetic Testing
153 rdf:type schema:DefinedTerm
154 N4654b6dcec794418b3262a2152e302b4 rdf:first sg:person.0755631152.57
155 rdf:rest N9f8ad905e37d477a92cf6347073d393c
156 N4f8db9f31bec48e0886b0b7b291ddb12 schema:name readcube_id
157 schema:value 40139242060d2d888dd912a7e2338c9d957482c666c1406f1bf6851cb5872997
158 rdf:type schema:PropertyValue
159 N50425a342e54456988f317af1dff36d4 rdf:first sg:person.01074023250.99
160 rdf:rest N692da41227d84edd85f25744e644d7d1
161 N51788ddca9fa49089841570aa7ccb72c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 N556eca48714d46d1b741732b604dcc5c rdf:first sg:person.01033744500.36
165 rdf:rest N50425a342e54456988f317af1dff36d4
166 N5fac1d77f43b4e218d1d06c2701c9481 rdf:first sg:person.0644246455.12
167 rdf:rest N79e0651b92d443e589e199d3a58ccfb1
168 N5faec05f4b91415dbb52f3b705b6e2de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Proto-Oncogene Proteins
170 rdf:type schema:DefinedTerm
171 N6668e816e5134c5c94062ffb6ad6f238 schema:name dimensions_id
172 schema:value pub.1013450881
173 rdf:type schema:PropertyValue
174 N692da41227d84edd85f25744e644d7d1 rdf:first sg:person.01077027525.65
175 rdf:rest N4654b6dcec794418b3262a2152e302b4
176 N7931f501162941c0a55e2a4aa5f1f7bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Antibodies
178 rdf:type schema:DefinedTerm
179 N79e0651b92d443e589e199d3a58ccfb1 rdf:first sg:person.0670266240.47
180 rdf:rest N3e133285ad8248f099efbb4f967366ae
181 N85226d6530b84456a1a134bf2fb699d3 rdf:first sg:person.07551705102.14
182 rdf:rest Nc17f2841364f4bddbd81ca56ad900551
183 N89c259c45ee24e4996385bfc8292574c rdf:first sg:person.013245604437.70
184 rdf:rest Ne9cea148e8924f2ab687b7a0d0decf03
185 N926b1d78874e408099c43f2027cb9159 schema:name nlm_unique_id
186 schema:value 9423843
187 rdf:type schema:PropertyValue
188 N93c838c420664a6ebe949de9303fa329 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Europe
190 rdf:type schema:DefinedTerm
191 N9f8ad905e37d477a92cf6347073d393c rdf:first Ndf9031be6cb14a3b81c21b84b8935281
192 rdf:rest N1f52300d54684eaaaa647d3d07fa1add
193 Na09ac76b24a947839a431ee9d3ea1944 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Point Mutation
195 rdf:type schema:DefinedTerm
196 Na4bb6d82bfbb47e090ca40ce1b875d71 rdf:first sg:person.01064765425.88
197 rdf:rest Nc5e86ed45cbc489290dc3def4dc63135
198 Nacfd94cbfded4da7bcad28e09f7fb1d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Predictive Value of Tests
200 rdf:type schema:DefinedTerm
201 Nc17f2841364f4bddbd81ca56ad900551 rdf:first sg:person.016175710642.57
202 rdf:rest N2c612451cc8f46c69c068cc0122344e8
203 Nc5e86ed45cbc489290dc3def4dc63135 rdf:first sg:person.014471504424.70
204 rdf:rest N1913f5d2d27a452590f64f62db69ce3e
205 Nc89b65ca38b6431b9f1508643f758474 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Quality Assurance, Health Care
207 rdf:type schema:DefinedTerm
208 Nd9ee5e3ef32b46a38acccba4430d2fde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name ras Proteins
210 rdf:type schema:DefinedTerm
211 Nda68d6184eb34132a317e7cff0de6785 schema:volumeNumber 453
212 rdf:type schema:PublicationVolume
213 Ndeef67a766a74a559d9a6b167c67830a schema:name Springer Nature - SN SciGraph project
214 rdf:type schema:Organization
215 Ndf9031be6cb14a3b81c21b84b8935281 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
216 schema:familyName Ligtenberg
217 schema:givenName M.
218 rdf:type schema:Person
219 Ne9cea148e8924f2ab687b7a0d0decf03 rdf:first sg:person.01211136300.00
220 rdf:rest N85226d6530b84456a1a134bf2fb699d3
221 Nfbf05c1d9f974a24be10fa5404bcf28e schema:name Department of Pathology, Saint-Antoine Hospital, University Paris 6, Paris, France
222 rdf:type schema:Organization
223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
224 schema:name Medical and Health Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
227 schema:name Oncology and Carcinogenesis
228 rdf:type schema:DefinedTerm
229 sg:journal.1106235 schema:issn 0945-6317
230 1432-2307
231 schema:name Virchows Archiv
232 rdf:type schema:Periodical
233 sg:person.01033744500.36 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
234 schema:familyName de Hertogh
235 schema:givenName G.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033744500.36
237 rdf:type schema:Person
238 sg:person.01051124052.85 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
239 schema:familyName Plato Hansen
240 schema:givenName T.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051124052.85
242 rdf:type schema:Person
243 sg:person.01064715771.30 schema:affiliation Nfbf05c1d9f974a24be10fa5404bcf28e
244 schema:familyName Fléjou
245 schema:givenName J. F.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064715771.30
247 rdf:type schema:Person
248 sg:person.01064765425.88 schema:affiliation https://www.grid.ac/institutes/grid.9851.5
249 schema:familyName Bosman
250 schema:givenName F. T.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064765425.88
252 rdf:type schema:Person
253 sg:person.01074023250.99 schema:affiliation https://www.grid.ac/institutes/grid.410458.c
254 schema:familyName Jares
255 schema:givenName P.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074023250.99
257 rdf:type schema:Person
258 sg:person.01077027525.65 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
259 schema:familyName Langner
260 schema:givenName C.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077027525.65
262 rdf:type schema:Person
263 sg:person.01211136300.00 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
264 schema:familyName Jung
265 schema:givenName A.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211136300.00
267 rdf:type schema:Person
268 sg:person.01277361713.77 schema:affiliation https://www.grid.ac/institutes/grid.5808.5
269 schema:familyName Seruca
270 schema:givenName R.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277361713.77
272 rdf:type schema:Person
273 sg:person.013245604437.70 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
274 schema:familyName van Krieken
275 schema:givenName J. H. J. M.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70
277 rdf:type schema:Person
278 sg:person.014471504424.70 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
279 schema:familyName Quirke
280 schema:givenName P.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014471504424.70
282 rdf:type schema:Person
283 sg:person.016175710642.57 schema:affiliation https://www.grid.ac/institutes/grid.414556.7
284 schema:familyName Carneiro
285 schema:givenName F.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016175710642.57
287 rdf:type schema:Person
288 sg:person.0644246455.12 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
289 schema:familyName Tejpar
290 schema:givenName S.
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644246455.12
292 rdf:type schema:Person
293 sg:person.0657737241.29 schema:affiliation https://www.grid.ac/institutes/grid.7256.6
294 schema:familyName Ensari
295 schema:givenName A.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657737241.29
297 rdf:type schema:Person
298 sg:person.0670266240.47 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
299 schema:familyName Bevilacqua
300 schema:givenName G.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670266240.47
302 rdf:type schema:Person
303 sg:person.0706654657.10 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
304 schema:familyName Tiniakos
305 schema:givenName D.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706654657.10
307 rdf:type schema:Person
308 sg:person.07551705102.14 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
309 schema:familyName Kirchner
310 schema:givenName T.
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07551705102.14
312 rdf:type schema:Person
313 sg:person.0755631152.57 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
314 schema:familyName Hoefler
315 schema:givenName G.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755631152.57
317 rdf:type schema:Person
318 sg:pub.10.1007/s00280-007-0644-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033577087
319 https://doi.org/10.1007/s00280-007-0644-z
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/418934a schema:sameAs https://app.dimensions.ai/details/publication/pub.1042017236
322 https://doi.org/10.1038/418934a
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/bjc.1998.212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004677902
325 https://doi.org/10.1038/bjc.1998.212
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/modpathol.3800774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152373
328 https://doi.org/10.1038/modpathol.3800774
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/sj.bjc.6603685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048862205
331 https://doi.org/10.1038/sj.bjc.6603685
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/sj.bjc.6604009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038401526
334 https://doi.org/10.1038/sj.bjc.6604009
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/sj.bjc.6604053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024434749
337 https://doi.org/10.1038/sj.bjc.6604053
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/sj.onc.1202291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044563589
340 https://doi.org/10.1038/sj.onc.1202291
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/sj.onc.1207061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030493697
343 https://doi.org/10.1038/sj.onc.1207061
344 rdf:type schema:CreativeWork
345 sg:pub.10.1054/bjoc.2001.1964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020621721
346 https://doi.org/10.1054/bjoc.2001.1964
347 rdf:type schema:CreativeWork
348 sg:pub.10.1245/s10434-007-9667-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001854286
349 https://doi.org/10.1245/s10434-007-9667-2
350 rdf:type schema:CreativeWork
351 https://app.dimensions.ai/details/publication/pub.1074733352 schema:CreativeWork
352 https://app.dimensions.ai/details/publication/pub.1077395580 schema:CreativeWork
353 https://app.dimensions.ai/details/publication/pub.1082722342 schema:CreativeWork
354 https://app.dimensions.ai/details/publication/pub.1083347341 schema:CreativeWork
355 https://doi.org/10.1002/1097-0142(19930415)71:8<2454::aid-cncr2820710805>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053679057
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1037>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1038126495
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1002/bjs.1800771211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042628204
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1002/bmc.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031113077
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1002/cncr.21558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002676081
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1002/gcc.10310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035541469
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1002/ijc.23388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022065648
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1002/jcp.20310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014358338
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1002/jcp.20898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015471130
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1002/jso.2930510304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031507490
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1002/path.2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030082966
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1016/0960-7404(92)90062-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1020754436
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1016/1040-8428(94)00144-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1027064147
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1016/j.bbcan.2005.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039902479
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/j.bios.2007.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037308418
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1016/j.ejca.2005.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011213819
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1016/j.humpath.2007.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016407909
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/j.prp.2007.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002980736
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1016/s0360-3016(02)03752-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046424585
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/s0959-8049(97)10111-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001133027
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/s1470-2045(05)70102-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000497060
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/s1525-1578(10)60571-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030068693
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1021/ac701702t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055069383
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1021/ja034716g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055833218
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1039/b700071e schema:sameAs https://app.dimensions.ai/details/publication/pub.1012995846
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1053/j.seminoncol.2004.09.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035518953
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1056/nejmoa033025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035161767
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1056/nejmoa071834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038822007
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1056/nejmra0707704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013325677
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1073/pnas.0405220101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546271
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1080/00313020801911512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041730135
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1093/annonc/mdi006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011068113
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1093/annonc/mdi907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011246506
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1093/annonc/mdj920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003658974
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1093/annonc/mdl037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053206624
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1093/annonc/mdm496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045547866
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1093/hmg/ddh238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017230694
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1093/jnci/dji112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043702992
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1093/jnci/dji174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037639061
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1093/nar/gkm809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021264669
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1126/science.1099314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033538744
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1136/gut.2005.082933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022556294
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1136/jcp.2004.022707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015488856
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1136/jcp.2004.025551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038925742
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1158/0008-5472.can-04-2818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049419586
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1158/0008-5472.can-06-0191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013645791
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1158/0008-5472.can-06-4158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038632088
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1158/0008-5472.can-07-5659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017860490
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1158/1078-0432.ccr-05-0738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049190387
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1158/1078-0432.ccr-06-0646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012023614
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1158/1078-0432.ccr-07-0332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053566497
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1177/107327480701400313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077442025
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1177/147323000703500403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015630105
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1200/jco.2004.10.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053488821
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1200/jco.2005.08.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052650563
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1200/jco.2006.08.1620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043055498
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1200/jco.2006.10.5437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024397161
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1200/jco.2007.11.8984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013167699
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1200/jco.2007.12.5906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053434927
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1200/jco.2007.14.7116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031599680
476 rdf:type schema:CreativeWork
477 https://doi.org/10.2217/14622416.9.4.463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026405562
478 rdf:type schema:CreativeWork
479 https://doi.org/10.3322/ca.2007.0010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052065817
480 rdf:type schema:CreativeWork
481 https://doi.org/10.3816/cbc.2004.n.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005968207
482 rdf:type schema:CreativeWork
483 https://doi.org/10.3816/ccc.2006.n.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003051395
484 rdf:type schema:CreativeWork
485 https://doi.org/10.3892/ijo.29.5.1159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071516185
486 rdf:type schema:CreativeWork
487 https://doi.org/10.3892/or.16.6.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071530228
488 rdf:type schema:CreativeWork
489 https://doi.org/10.4161/cbt.5.8.3251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294236
490 rdf:type schema:CreativeWork
491 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
492 schema:name Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
493 Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500, Nijmegen, HB, The Netherlands
494 rdf:type schema:Organization
495 https://www.grid.ac/institutes/grid.11598.34 schema:alternateName Medical University of Graz
496 schema:name Institute of Pathology, Medical University Graz, Graz, Austria
497 rdf:type schema:Organization
498 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
499 schema:name Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy
500 rdf:type schema:Organization
501 https://www.grid.ac/institutes/grid.410458.c schema:alternateName Hospital Clinic of Barcelona
502 schema:name Department of Pathology, Hospital Clinic, Barcelona, Spain
503 rdf:type schema:Organization
504 https://www.grid.ac/institutes/grid.410569.f schema:alternateName Universitaire Ziekenhuizen Leuven
505 schema:name Department of Pathology, University Hospitals KU Leuven, Leuven, Belgium
506 Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium
507 rdf:type schema:Organization
508 https://www.grid.ac/institutes/grid.414556.7 schema:alternateName Hospital de São João
509 schema:name Department of Pathology, Hospital S. João, Porto, Portugal
510 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
511 Medical Faculty of the of Porto, Porto, Portugal
512 rdf:type schema:Organization
513 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
514 schema:name Laboratory of Histology and Embryology, Medical School University of Athens, Athens, Greece
515 rdf:type schema:Organization
516 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
517 schema:name Department of Pathology, Ludwig-Maximilians Universität, Munich, Germany
518 rdf:type schema:Organization
519 https://www.grid.ac/institutes/grid.5808.5 schema:alternateName University of Porto
520 schema:name Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
521 Medical Faculty of the of Porto, Porto, Portugal
522 rdf:type schema:Organization
523 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
524 schema:name Department of Pathology, Odense University Hospital, Odense, Denmark
525 rdf:type schema:Organization
526 https://www.grid.ac/institutes/grid.7256.6 schema:alternateName Ankara University
527 schema:name Department of Pathology, Ankara University Medical School, Ankara, Turkey
528 rdf:type schema:Organization
529 https://www.grid.ac/institutes/grid.9851.5 schema:alternateName University of Lausanne
530 schema:name University Institute of Pathology, Lausanne, Switzerland
531 rdf:type schema:Organization
532 https://www.grid.ac/institutes/grid.9909.9 schema:alternateName University of Leeds
533 schema:name Pathology and Tumour Biology, University of Leeds, Leeds, England
534 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...