Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-11

AUTHORS

H. Pandit, M. Vlychou, D. Whitwell, D. Crook, R. Luqmani, S. Ostlere, D. W. Murray, N. A. Athanasou

ABSTRACT

Clinical, radiological and histological findings were analysed in four patients who developed bilateral pseudotumours following metal-on-metal (MoM) resurfacing arthroplasties of both hips. Using a panel of monoclonal antibodies directed against HLA-DR, macrophages (CD14, CD68), dendritic cells (DC-SIGN, S100, CD11c), B cells (CD20), and T cells (CD3, CD4, CD8), the nature of the heavy inflammatory response seen in these cases was examined. Bilateral masses developed in periprosthetic soft tissues following the second MoM arthroplasty; these were characterised histologically by extensive coagulative necrosis, a heavy macrophage infiltrate and the presence of granulomas containing macrophages and giant cells; there was also a diffuse lymphocyte and variable plasma cell and eosinophil polymorph infiltrate. Immunohistochemistry showed strong expression of HLA-DR, CD14 and CD68 in both granulomatous and necrotic areas; lymphocytes were predominantly CD3+/CD4+ T cells. The clinical, morphological and immunophenotypic features of these necrotic granulomatous pseudotumours, which in all cases develop following a second resurfacing hip arthroplasty, is suggestive of a type IV immune response, possibly to MoM metal alloy components. More... »

PAGES

529

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-008-0659-9

DOI

http://dx.doi.org/10.1007/s00428-008-0659-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014366103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18769936


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthroplasty, Replacement, Hip", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granuloma, Plasma Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypersensitivity, Delayed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pandit", 
        "givenName": "H.", 
        "id": "sg:person.01231462311.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231462311.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vlychou", 
        "givenName": "M.", 
        "id": "sg:person.01070763043.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070763043.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whitwell", 
        "givenName": "D.", 
        "id": "sg:person.0670420011.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670420011.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crook", 
        "givenName": "D.", 
        "id": "sg:person.013745315422.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013745315422.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luqmani", 
        "givenName": "R.", 
        "id": "sg:person.0740410612.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740410612.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ostlere", 
        "givenName": "S.", 
        "id": "sg:person.01070233741.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070233741.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murray", 
        "givenName": "D. W.", 
        "id": "sg:person.012633757262.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012633757262.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Athanasou", 
        "givenName": "N. A.", 
        "id": "sg:person.013046236517.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/bmj.4.5993.374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006521902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-200402000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006984727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-200402000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006984727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-200402000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006984727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.89b5.18903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009589861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.88b3.16748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012280601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.00453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012371712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.00453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012371712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00367764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013025542", 
          "https://doi.org/10.1007/bf00367764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.30856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014329673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.90b7.20213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022755186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0536.2002.470107.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039201640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0536.1997.tb02435.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050307258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199608001-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060166502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199608001-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060166502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199608001-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060166502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-199072020-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068890365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-200501000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068896560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.a.02039pp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.a.02039pp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.a.02039pp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.c.00949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.c.00949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.c.00949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068898659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077478950", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.72b2.2312557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078643653"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "Clinical, radiological and histological findings were analysed in four patients who developed bilateral pseudotumours following metal-on-metal (MoM) resurfacing arthroplasties of both hips. Using a panel of monoclonal antibodies directed against HLA-DR, macrophages (CD14, CD68), dendritic cells (DC-SIGN, S100, CD11c), B cells (CD20), and T cells (CD3, CD4, CD8), the nature of the heavy inflammatory response seen in these cases was examined. Bilateral masses developed in periprosthetic soft tissues following the second MoM arthroplasty; these were characterised histologically by extensive coagulative necrosis, a heavy macrophage infiltrate and the presence of granulomas containing macrophages and giant cells; there was also a diffuse lymphocyte and variable plasma cell and eosinophil polymorph infiltrate. Immunohistochemistry showed strong expression of HLA-DR, CD14 and CD68 in both granulomatous and necrotic areas; lymphocytes were predominantly CD3+/CD4+ T cells. The clinical, morphological and immunophenotypic features of these necrotic granulomatous pseudotumours, which in all cases develop following a second resurfacing hip arthroplasty, is suggestive of a type IV immune response, possibly to MoM metal alloy components.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-008-0659-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "453"
      }
    ], 
    "name": "Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response", 
    "pagination": "529", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4470443a2c565a61725e6f31bc83a9c803c34b6ab75af9bac6d3dfb702a43381"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18769936"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-008-0659-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014366103"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-008-0659-9", 
      "https://app.dimensions.ai/details/publication/pub.1014366103"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13102_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-008-0659-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0659-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0659-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0659-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0659-9'


 

This table displays all metadata directly associated to this object as RDF triples.

212 TRIPLES      21 PREDICATES      57 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-008-0659-9 schema:about N061dc9e9fcb34709a113e0af97a59083
2 N174a7736e3e6426c8db808bbbc187d81
3 N1c81144deafc418983c81f02d23f8d76
4 N2f2e27a7a3c44c7b9f5f696ce632613f
5 N3f4d37f316044c29aaa30701de485b60
6 N4642d0f9960d4a34ad463f9bdf85b0d2
7 N57987d475dee44e49cdb555f9dd07204
8 N715d0e48df00405f86545b0007a34ea6
9 N81c1b588253a4ed7a467410f9bd2e599
10 Nd5a443fe95864f859fca95e1fb32b5e6
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author Nd676787e36b84a2096704b8ef4077eaa
14 schema:citation sg:pub.10.1007/bf00367764
15 https://app.dimensions.ai/details/publication/pub.1077478950
16 https://doi.org/10.1002/jbm.a.30856
17 https://doi.org/10.1034/j.1600-0536.2002.470107.x
18 https://doi.org/10.1097/00000372-200402000-00008
19 https://doi.org/10.1097/00003086-199608001-00017
20 https://doi.org/10.1111/j.1600-0536.1997.tb02435.x
21 https://doi.org/10.1136/bmj.4.5993.374
22 https://doi.org/10.1302/0301-620x.72b2.2312557
23 https://doi.org/10.1302/0301-620x.88b3.16748
24 https://doi.org/10.1302/0301-620x.89b5.18903
25 https://doi.org/10.1302/0301-620x.90b7.20213
26 https://doi.org/10.2106/00004623-199072020-00014
27 https://doi.org/10.2106/00004623-200501000-00005
28 https://doi.org/10.2106/jbjs.a.02039pp
29 https://doi.org/10.2106/jbjs.c.00949
30 https://doi.org/10.2106/jbjs.d.02916
31 https://doi.org/10.2106/jbjs.f.00453
32 schema:datePublished 2008-11
33 schema:datePublishedReg 2008-11-01
34 schema:description Clinical, radiological and histological findings were analysed in four patients who developed bilateral pseudotumours following metal-on-metal (MoM) resurfacing arthroplasties of both hips. Using a panel of monoclonal antibodies directed against HLA-DR, macrophages (CD14, CD68), dendritic cells (DC-SIGN, S100, CD11c), B cells (CD20), and T cells (CD3, CD4, CD8), the nature of the heavy inflammatory response seen in these cases was examined. Bilateral masses developed in periprosthetic soft tissues following the second MoM arthroplasty; these were characterised histologically by extensive coagulative necrosis, a heavy macrophage infiltrate and the presence of granulomas containing macrophages and giant cells; there was also a diffuse lymphocyte and variable plasma cell and eosinophil polymorph infiltrate. Immunohistochemistry showed strong expression of HLA-DR, CD14 and CD68 in both granulomatous and necrotic areas; lymphocytes were predominantly CD3+/CD4+ T cells. The clinical, morphological and immunophenotypic features of these necrotic granulomatous pseudotumours, which in all cases develop following a second resurfacing hip arthroplasty, is suggestive of a type IV immune response, possibly to MoM metal alloy components.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N79fc02be1d934ecaaf611bf82f2a776f
39 N8b49fd30c43f4cf380cb2e06f8db1171
40 sg:journal.1106235
41 schema:name Necrotic granulomatous pseudotumours in bilateral resurfacing hip arthoplasties: evidence for a type IV immune response
42 schema:pagination 529
43 schema:productId N26e8a9c1684e4bd08a7f355ee3522b03
44 N775a8cf07e6a4610a35e589bc1b63492
45 Nb6c651094b6e4e16af6403f210d10e6d
46 Ne13a6a8a7174497cbff7e1b48bcbe5af
47 Nf532091da0d34686bab2ab8f06977b42
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014366103
49 https://doi.org/10.1007/s00428-008-0659-9
50 schema:sdDatePublished 2019-04-11T14:32
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher Nd972c279511847f3af81b95a4c4337cc
53 schema:url http://link.springer.com/10.1007%2Fs00428-008-0659-9
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N02a391d19aae42549b3beb229c1c6e31 rdf:first sg:person.012633757262.69
58 rdf:rest Nfe720dd5defa4e559dd5ef9b96b92032
59 N061dc9e9fcb34709a113e0af97a59083 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Granuloma, Plasma Cell
61 rdf:type schema:DefinedTerm
62 N174a7736e3e6426c8db808bbbc187d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Metals
64 rdf:type schema:DefinedTerm
65 N1c81144deafc418983c81f02d23f8d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Middle Aged
67 rdf:type schema:DefinedTerm
68 N1cadab06bc7c4589a0c228370c446b18 rdf:first sg:person.013745315422.71
69 rdf:rest N6977a0fabc2f4e0089a9ce75c030df57
70 N1de3f7ee31724834b5f8fe2785a41d36 rdf:first sg:person.01070233741.25
71 rdf:rest N02a391d19aae42549b3beb229c1c6e31
72 N26e8a9c1684e4bd08a7f355ee3522b03 schema:name doi
73 schema:value 10.1007/s00428-008-0659-9
74 rdf:type schema:PropertyValue
75 N2f2e27a7a3c44c7b9f5f696ce632613f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Humans
77 rdf:type schema:DefinedTerm
78 N3f4d37f316044c29aaa30701de485b60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Hypersensitivity, Delayed
80 rdf:type schema:DefinedTerm
81 N4642d0f9960d4a34ad463f9bdf85b0d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Aged
83 rdf:type schema:DefinedTerm
84 N57987d475dee44e49cdb555f9dd07204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Female
86 rdf:type schema:DefinedTerm
87 N6977a0fabc2f4e0089a9ce75c030df57 rdf:first sg:person.0740410612.82
88 rdf:rest N1de3f7ee31724834b5f8fe2785a41d36
89 N715d0e48df00405f86545b0007a34ea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Bone Neoplasms
91 rdf:type schema:DefinedTerm
92 N775a8cf07e6a4610a35e589bc1b63492 schema:name pubmed_id
93 schema:value 18769936
94 rdf:type schema:PropertyValue
95 N79e8a4494c9a4e8db2bb4016610a79fc rdf:first sg:person.01070763043.09
96 rdf:rest Nadde07d60f4640d394bad8d3e3f7e0d5
97 N79fc02be1d934ecaaf611bf82f2a776f schema:volumeNumber 453
98 rdf:type schema:PublicationVolume
99 N81c1b588253a4ed7a467410f9bd2e599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Arthroplasty, Replacement, Hip
101 rdf:type schema:DefinedTerm
102 N8b49fd30c43f4cf380cb2e06f8db1171 schema:issueNumber 5
103 rdf:type schema:PublicationIssue
104 Nadde07d60f4640d394bad8d3e3f7e0d5 rdf:first sg:person.0670420011.72
105 rdf:rest N1cadab06bc7c4589a0c228370c446b18
106 Nb6c651094b6e4e16af6403f210d10e6d schema:name readcube_id
107 schema:value 4470443a2c565a61725e6f31bc83a9c803c34b6ab75af9bac6d3dfb702a43381
108 rdf:type schema:PropertyValue
109 Nd5a443fe95864f859fca95e1fb32b5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Necrosis
111 rdf:type schema:DefinedTerm
112 Nd676787e36b84a2096704b8ef4077eaa rdf:first sg:person.01231462311.63
113 rdf:rest N79e8a4494c9a4e8db2bb4016610a79fc
114 Nd972c279511847f3af81b95a4c4337cc schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 Ne13a6a8a7174497cbff7e1b48bcbe5af schema:name dimensions_id
117 schema:value pub.1014366103
118 rdf:type schema:PropertyValue
119 Nf532091da0d34686bab2ab8f06977b42 schema:name nlm_unique_id
120 schema:value 9423843
121 rdf:type schema:PropertyValue
122 Nfe720dd5defa4e559dd5ef9b96b92032 rdf:first sg:person.013046236517.87
123 rdf:rest rdf:nil
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
128 schema:name Immunology
129 rdf:type schema:DefinedTerm
130 sg:journal.1106235 schema:issn 0945-6317
131 1432-2307
132 schema:name Virchows Archiv
133 rdf:type schema:Periodical
134 sg:person.01070233741.25 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
135 schema:familyName Ostlere
136 schema:givenName S.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070233741.25
138 rdf:type schema:Person
139 sg:person.01070763043.09 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
140 schema:familyName Vlychou
141 schema:givenName M.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070763043.09
143 rdf:type schema:Person
144 sg:person.01231462311.63 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
145 schema:familyName Pandit
146 schema:givenName H.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231462311.63
148 rdf:type schema:Person
149 sg:person.012633757262.69 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
150 schema:familyName Murray
151 schema:givenName D. W.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012633757262.69
153 rdf:type schema:Person
154 sg:person.013046236517.87 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
155 schema:familyName Athanasou
156 schema:givenName N. A.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87
158 rdf:type schema:Person
159 sg:person.013745315422.71 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
160 schema:familyName Crook
161 schema:givenName D.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013745315422.71
163 rdf:type schema:Person
164 sg:person.0670420011.72 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
165 schema:familyName Whitwell
166 schema:givenName D.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670420011.72
168 rdf:type schema:Person
169 sg:person.0740410612.82 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
170 schema:familyName Luqmani
171 schema:givenName R.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740410612.82
173 rdf:type schema:Person
174 sg:pub.10.1007/bf00367764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013025542
175 https://doi.org/10.1007/bf00367764
176 rdf:type schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1077478950 schema:CreativeWork
178 https://doi.org/10.1002/jbm.a.30856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014329673
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1034/j.1600-0536.2002.470107.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039201640
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1097/00000372-200402000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006984727
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1097/00003086-199608001-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060166502
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/j.1600-0536.1997.tb02435.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050307258
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1136/bmj.4.5993.374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006521902
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1302/0301-620x.72b2.2312557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078643653
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1302/0301-620x.88b3.16748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012280601
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1302/0301-620x.89b5.18903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009589861
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1302/0301-620x.90b7.20213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022755186
197 rdf:type schema:CreativeWork
198 https://doi.org/10.2106/00004623-199072020-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068890365
199 rdf:type schema:CreativeWork
200 https://doi.org/10.2106/00004623-200501000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068896560
201 rdf:type schema:CreativeWork
202 https://doi.org/10.2106/jbjs.a.02039pp schema:sameAs https://app.dimensions.ai/details/publication/pub.1068898643
203 rdf:type schema:CreativeWork
204 https://doi.org/10.2106/jbjs.c.00949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068898659
205 rdf:type schema:CreativeWork
206 https://doi.org/10.2106/jbjs.d.02916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068899550
207 rdf:type schema:CreativeWork
208 https://doi.org/10.2106/jbjs.f.00453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012371712
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
211 schema:name Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Headington, OX3 7LD, Oxford, UK
212 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...