Strategies for optimizing pathologic staging of sentinel lymph nodes in breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Eva V. E. Madsen, Jan van Dalen, Joost van Gorp, Inne H. M. Borel Rinkes, Thijs van Dalen

ABSTRACT

Due to the extensive pathologic evaluation of the sentinel lymph node (SLN), micrometastases are frequently observed. If micrometastases are clinically relevant, the histopathologic examination of SLNs should be sensitive enough to detect them. The probability of detecting micrometastases was calculated when examining the SLN according to the current Dutch pathology protocol and strategies evaluated to optimize the chance of detection. The dimensions of 20 consecutive axillary SLNs in patients with cT1-2N0 breast cancer were measured. In a mathematical model, the probability of detecting micrometastases in a SLN was calculated. Similarly, strategies to optimize the probability of detecting micrometastases were explored. When applying the pathology guidelines, the calculated probability to detect a micrometastasis was 18% for a 200-microm micrometastasis and 69% for a 2.0-mm metastasis in a median sized SLN. To detect the smallest micrometastasis in a median-sized SLN with a 95% probability, the interval between the sections must be decreased to 200 microm, and 20 levels from both halves must be examined. Given a prognostic significance of micrometastases, our current pathology guidelines are not sensitive enough. The number of sections should be increased, while the interval between cuts should be no more than 200 microm. More... »

PAGES

17-24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-008-0601-1

DOI

http://dx.doi.org/10.1007/s00428-008-0601-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030010912

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18563440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guidelines as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Theoretical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Netherlands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sentinel Lymph Node Biopsy", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Diakonessenhuis hospital", 
          "id": "https://www.grid.ac/institutes/grid.413681.9", 
          "name": [
            "Department of Surgery, Diakonessenhuis, Bosboomstraat 1, 3582 KE, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madsen", 
        "givenName": "Eva V. E.", 
        "id": "sg:person.011570244642.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011570244642.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Rotterdam", 
          "id": "https://www.grid.ac/institutes/grid.6906.9", 
          "name": [
            "Department of Information and Decision Sciences, RSM Erasmus University Rotterdam, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dalen", 
        "givenName": "Jan", 
        "id": "sg:person.01342777465.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342777465.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diakonessenhuis hospital", 
          "id": "https://www.grid.ac/institutes/grid.413681.9", 
          "name": [
            "Department of Pathology, Diakonessenhuis, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gorp", 
        "givenName": "Joost", 
        "id": "sg:person.01255257102.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255257102.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borel Rinkes", 
        "givenName": "Inne H. M.", 
        "id": "sg:person.013100574355.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013100574355.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diakonessenhuis hospital", 
          "id": "https://www.grid.ac/institutes/grid.413681.9", 
          "name": [
            "Department of Surgery, Diakonessenhuis, Bosboomstraat 1, 3582 KE, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dalen", 
        "givenName": "Thijs", 
        "id": "sg:person.01244316273.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244316273.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/jcp.55.12.926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002378104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.4725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007786093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91386-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91386-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198111000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198111000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198111000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2006.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015444597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010915)92:6<1378::aid-cncr1460>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017329506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2003.013599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023034137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70947-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024239107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-005-0103-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024961951", 
          "https://doi.org/10.1007/s00428-005-0103-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-005-0103-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024961951", 
          "https://doi.org/10.1007/s00428-005-0103-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027727701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20001215)89:12<2527::aid-cncr3>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027752668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20001215)89:12<2527::aid-cncr3>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027752668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028388400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2003.014308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032793088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197101000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033347574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197101000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033347574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/v0vc-25af-09vy-t6q1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033677173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036222905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042557886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042557886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9084-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047572592", 
          "https://doi.org/10.1245/s10434-006-9084-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9098(199812)69:4<212::aid-jso4>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048998582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsre.1999.5629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050350799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9434-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052758598", 
          "https://doi.org/10.1007/s10549-006-9434-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9434-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052758598", 
          "https://doi.org/10.1007/s10549-006-9434-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-001-0008-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053137167", 
          "https://doi.org/10.1007/s00268-001-0008-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076808597", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082201012", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082876244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.6.2345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083106808"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "Due to the extensive pathologic evaluation of the sentinel lymph node (SLN), micrometastases are frequently observed. If micrometastases are clinically relevant, the histopathologic examination of SLNs should be sensitive enough to detect them. The probability of detecting micrometastases was calculated when examining the SLN according to the current Dutch pathology protocol and strategies evaluated to optimize the chance of detection. The dimensions of 20 consecutive axillary SLNs in patients with cT1-2N0 breast cancer were measured. In a mathematical model, the probability of detecting micrometastases in a SLN was calculated. Similarly, strategies to optimize the probability of detecting micrometastases were explored. When applying the pathology guidelines, the calculated probability to detect a micrometastasis was 18% for a 200-microm micrometastasis and 69% for a 2.0-mm metastasis in a median sized SLN. To detect the smallest micrometastasis in a median-sized SLN with a 95% probability, the interval between the sections must be decreased to 200 microm, and 20 levels from both halves must be examined. Given a prognostic significance of micrometastases, our current pathology guidelines are not sensitive enough. The number of sections should be increased, while the interval between cuts should be no more than 200 microm.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-008-0601-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "453"
      }
    ], 
    "name": "Strategies for optimizing pathologic staging of sentinel lymph nodes in breast cancer patients", 
    "pagination": "17-24", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8ef816b8b08d54006f844d95b50f70beba1d28a4b331bb217e3840f8886d0ab3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18563440"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-008-0601-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030010912"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-008-0601-1", 
      "https://app.dimensions.ai/details/publication/pub.1030010912"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-008-0601-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0601-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0601-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0601-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-008-0601-1'


 

This table displays all metadata directly associated to this object as RDF triples.

233 TRIPLES      21 PREDICATES      68 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-008-0601-1 schema:about N006a8d16c01a49e5b173990589752903
2 N0b30b893b06a4209b70a935592035a94
3 N32b841aa9c0a4a369dd8cdcf98f548dc
4 N4d2f9f41cb1149a4b5132046e63755e4
5 N629d6a62726746df892769e011f4696f
6 N63648c6f4fb74a46b2e99896283eb5ad
7 Nb40087e85c0047cf989be95207257a8c
8 Nb4d13ef5f79e4ff08d1a7dd4bd6388c3
9 Ncf07ebdd986f451f8d464a3e2ec51da7
10 Nd50101d6f97f4ccd8da28884db414af6
11 Ne9434db541f7495a8929ffffb42d2921
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N58a2a3bca3c54cc3903692af2c338090
15 schema:citation sg:pub.10.1007/s00268-001-0008-5
16 sg:pub.10.1007/s00428-005-0103-3
17 sg:pub.10.1007/s10549-006-9434-2
18 sg:pub.10.1245/s10434-006-9084-y
19 https://app.dimensions.ai/details/publication/pub.1076808597
20 https://app.dimensions.ai/details/publication/pub.1082201012
21 https://app.dimensions.ai/details/publication/pub.1082876244
22 https://doi.org/10.1002/(sici)1096-9098(199812)69:4<212::aid-jso4>3.0.co;2-v
23 https://doi.org/10.1002/1097-0142(20001215)89:12<2527::aid-cncr3>3.0.co;2-6
24 https://doi.org/10.1002/1097-0142(20010915)92:6<1378::aid-cncr1460>3.0.co;2-y
25 https://doi.org/10.1002/bjs.4725
26 https://doi.org/10.1002/cncr.22069
27 https://doi.org/10.1002/cncr.22112
28 https://doi.org/10.1006/jsre.1999.5629
29 https://doi.org/10.1016/0140-6736(90)91386-o
30 https://doi.org/10.1016/j.ejso.2006.01.003
31 https://doi.org/10.1016/s1470-2045(06)70947-0
32 https://doi.org/10.1097/00000658-197101000-00006
33 https://doi.org/10.1097/00000658-198111000-00006
34 https://doi.org/10.1097/00000658-199709000-00006
35 https://doi.org/10.1097/00000658-199805000-00005
36 https://doi.org/10.1136/jcp.2003.013599
37 https://doi.org/10.1136/jcp.2003.014308
38 https://doi.org/10.1136/jcp.55.12.926
39 https://doi.org/10.1200/jco.1997.15.6.2345
40 https://doi.org/10.1200/jco.2005.07.094
41 https://doi.org/10.1200/jco.2005.08.001
42 https://doi.org/10.1309/v0vc-25af-09vy-t6q1
43 schema:datePublished 2008-07
44 schema:datePublishedReg 2008-07-01
45 schema:description Due to the extensive pathologic evaluation of the sentinel lymph node (SLN), micrometastases are frequently observed. If micrometastases are clinically relevant, the histopathologic examination of SLNs should be sensitive enough to detect them. The probability of detecting micrometastases was calculated when examining the SLN according to the current Dutch pathology protocol and strategies evaluated to optimize the chance of detection. The dimensions of 20 consecutive axillary SLNs in patients with cT1-2N0 breast cancer were measured. In a mathematical model, the probability of detecting micrometastases in a SLN was calculated. Similarly, strategies to optimize the probability of detecting micrometastases were explored. When applying the pathology guidelines, the calculated probability to detect a micrometastasis was 18% for a 200-microm micrometastasis and 69% for a 2.0-mm metastasis in a median sized SLN. To detect the smallest micrometastasis in a median-sized SLN with a 95% probability, the interval between the sections must be decreased to 200 microm, and 20 levels from both halves must be examined. Given a prognostic significance of micrometastases, our current pathology guidelines are not sensitive enough. The number of sections should be increased, while the interval between cuts should be no more than 200 microm.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf Nce9b05727f1f4ef3a60466de4c6f2e3c
50 Ne0e49179a0a4474a8790c3990e5bc17e
51 sg:journal.1106235
52 schema:name Strategies for optimizing pathologic staging of sentinel lymph nodes in breast cancer patients
53 schema:pagination 17-24
54 schema:productId N68d9565c50e5449f9bc4a446ff4ca690
55 N9278a144604e4990a3623cd2bb1d255d
56 Na7c43f9011124bf59f29e623075d8e40
57 Nbb4b01ac56a049499c606fe9841a0d72
58 Nbf56935cd29845948389c9b5fa3198ee
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030010912
60 https://doi.org/10.1007/s00428-008-0601-1
61 schema:sdDatePublished 2019-04-10T19:09
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N34bd49a0fe78449ca7396dcf060bf20f
64 schema:url http://link.springer.com/10.1007%2Fs00428-008-0601-1
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N006a8d16c01a49e5b173990589752903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Breast Neoplasms
70 rdf:type schema:DefinedTerm
71 N0b30b893b06a4209b70a935592035a94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Prognosis
73 rdf:type schema:DefinedTerm
74 N32b841aa9c0a4a369dd8cdcf98f548dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Models, Theoretical
76 rdf:type schema:DefinedTerm
77 N34bd49a0fe78449ca7396dcf060bf20f schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N4d2f9f41cb1149a4b5132046e63755e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Models, Biological
81 rdf:type schema:DefinedTerm
82 N58a2a3bca3c54cc3903692af2c338090 rdf:first sg:person.011570244642.93
83 rdf:rest N7fa4a77d7dfc4f029cfa6f8a4b48c672
84 N629d6a62726746df892769e011f4696f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Humans
86 rdf:type schema:DefinedTerm
87 N63648c6f4fb74a46b2e99896283eb5ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Netherlands
89 rdf:type schema:DefinedTerm
90 N68d9565c50e5449f9bc4a446ff4ca690 schema:name dimensions_id
91 schema:value pub.1030010912
92 rdf:type schema:PropertyValue
93 N6bc6759cd2804b2ea604a50f7cd3ee19 rdf:first sg:person.01244316273.51
94 rdf:rest rdf:nil
95 N7fa4a77d7dfc4f029cfa6f8a4b48c672 rdf:first sg:person.01342777465.18
96 rdf:rest N93c7feb1c3994305a87553f6c04425c1
97 N9278a144604e4990a3623cd2bb1d255d schema:name doi
98 schema:value 10.1007/s00428-008-0601-1
99 rdf:type schema:PropertyValue
100 N93c7feb1c3994305a87553f6c04425c1 rdf:first sg:person.01255257102.03
101 rdf:rest Nf64eec7dbf10463ab340c81154f89030
102 Na7c43f9011124bf59f29e623075d8e40 schema:name readcube_id
103 schema:value 8ef816b8b08d54006f844d95b50f70beba1d28a4b331bb217e3840f8886d0ab3
104 rdf:type schema:PropertyValue
105 Nb40087e85c0047cf989be95207257a8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Guidelines as Topic
107 rdf:type schema:DefinedTerm
108 Nb4d13ef5f79e4ff08d1a7dd4bd6388c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Female
110 rdf:type schema:DefinedTerm
111 Nbb4b01ac56a049499c606fe9841a0d72 schema:name nlm_unique_id
112 schema:value 9423843
113 rdf:type schema:PropertyValue
114 Nbf56935cd29845948389c9b5fa3198ee schema:name pubmed_id
115 schema:value 18563440
116 rdf:type schema:PropertyValue
117 Nce9b05727f1f4ef3a60466de4c6f2e3c schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 Ncf07ebdd986f451f8d464a3e2ec51da7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Sentinel Lymph Node Biopsy
121 rdf:type schema:DefinedTerm
122 Nd50101d6f97f4ccd8da28884db414af6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neoplasm Staging
124 rdf:type schema:DefinedTerm
125 Ne0e49179a0a4474a8790c3990e5bc17e schema:volumeNumber 453
126 rdf:type schema:PublicationVolume
127 Ne9434db541f7495a8929ffffb42d2921 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Lymphatic Metastasis
129 rdf:type schema:DefinedTerm
130 Nf64eec7dbf10463ab340c81154f89030 rdf:first sg:person.013100574355.78
131 rdf:rest N6bc6759cd2804b2ea604a50f7cd3ee19
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
136 schema:name Oncology and Carcinogenesis
137 rdf:type schema:DefinedTerm
138 sg:journal.1106235 schema:issn 0945-6317
139 1432-2307
140 schema:name Virchows Archiv
141 rdf:type schema:Periodical
142 sg:person.011570244642.93 schema:affiliation https://www.grid.ac/institutes/grid.413681.9
143 schema:familyName Madsen
144 schema:givenName Eva V. E.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011570244642.93
146 rdf:type schema:Person
147 sg:person.01244316273.51 schema:affiliation https://www.grid.ac/institutes/grid.413681.9
148 schema:familyName van Dalen
149 schema:givenName Thijs
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244316273.51
151 rdf:type schema:Person
152 sg:person.01255257102.03 schema:affiliation https://www.grid.ac/institutes/grid.413681.9
153 schema:familyName van Gorp
154 schema:givenName Joost
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255257102.03
156 rdf:type schema:Person
157 sg:person.013100574355.78 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
158 schema:familyName Borel Rinkes
159 schema:givenName Inne H. M.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013100574355.78
161 rdf:type schema:Person
162 sg:person.01342777465.18 schema:affiliation https://www.grid.ac/institutes/grid.6906.9
163 schema:familyName van Dalen
164 schema:givenName Jan
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342777465.18
166 rdf:type schema:Person
167 sg:pub.10.1007/s00268-001-0008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053137167
168 https://doi.org/10.1007/s00268-001-0008-5
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s00428-005-0103-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024961951
171 https://doi.org/10.1007/s00428-005-0103-3
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/s10549-006-9434-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052758598
174 https://doi.org/10.1007/s10549-006-9434-2
175 rdf:type schema:CreativeWork
176 sg:pub.10.1245/s10434-006-9084-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047572592
177 https://doi.org/10.1245/s10434-006-9084-y
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1076808597 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1082201012 schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1082876244 schema:CreativeWork
182 https://doi.org/10.1002/(sici)1096-9098(199812)69:4<212::aid-jso4>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1048998582
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/1097-0142(20001215)89:12<2527::aid-cncr3>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027752668
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1002/1097-0142(20010915)92:6<1378::aid-cncr1460>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017329506
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1002/bjs.4725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007786093
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/cncr.22069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027727701
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/cncr.22112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036222905
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1006/jsre.1999.5629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050350799
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0140-6736(90)91386-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116988
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.ejso.2006.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015444597
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s1470-2045(06)70947-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024239107
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00000658-197101000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033347574
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00000658-198111000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010113107
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/00000658-199709000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134617
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/00000658-199805000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134779
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1136/jcp.2003.013599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023034137
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1136/jcp.2003.014308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032793088
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1136/jcp.55.12.926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002378104
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1200/jco.1997.15.6.2345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083106808
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1200/jco.2005.07.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028388400
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1200/jco.2005.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042557886
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1309/v0vc-25af-09vy-t6q1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033677173
223 rdf:type schema:CreativeWork
224 https://www.grid.ac/institutes/grid.413681.9 schema:alternateName Diakonessenhuis hospital
225 schema:name Department of Pathology, Diakonessenhuis, Utrecht, The Netherlands
226 Department of Surgery, Diakonessenhuis, Bosboomstraat 1, 3582 KE, Utrecht, The Netherlands
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.6906.9 schema:alternateName Erasmus University Rotterdam
229 schema:name Department of Information and Decision Sciences, RSM Erasmus University Rotterdam, Rotterdam, The Netherlands
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
232 schema:name Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
233 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...