Renal cell carcinoma with t(X;17)(p11.2;q25) in a 6-year-old Taiwanese boy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

Chi-Kuan Chen, Chuen Hsueh, Jin-Yao Lai, Iou-Jih Hung, Jacqueline Whang-Peng, Wan-Ping Wang, Hsin-Yi Lai, Jim-Ray Chen

ABSTRACT

Pediatric renal cell carcinoma (RCC) associated with ASPL-TFE3 gene fusion resulting from balanced translocation, t(X;17)(p11.2;q25), is a distinctive tumor entity. It is uncommon, and most reported cases have exclusively come from Western societies. We report a case of t(X;17)(p11.2;q25) RCC in a 6-year-old Taiwanese boy. The patient presented with dysuria and intermittent hematuria for 1 year. Nonenhanced CT showed a well-defined homogeneous hyperdensity lesion in the upper pole of the left kidney. This patient refused to receive immediate surgical procedures but had routine follow-ups. After a 9-month follow-up, the patient underwent total nephrectomy with a favorable outcome. Final diagnosis is established based on the characteristic microscopic features, strong nuclear TFE-3 immunoreactivity, and the presence of type 1 TFE3-ASPL fusion gene detected by reverse transcriptasepolymerase chain reactions. No adjuvant therapy is given, and the patient is alive without evidence of disease for 1 year and 6 months. More... »

PAGES

215-219

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-006-0337-8

DOI

http://dx.doi.org/10.1007/s00428-006-0337-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041301808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17149613


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