Ontology type: schema:ScholarlyArticle
2006-08-31
AUTHORSMasanori Hisaoka, Yuji Takamatsu, Yutaka Hirano, Hironobu Maeda, Tetsuo Hamada
ABSTRACTSebaceous differentiation has been described in only limited examples of benign and malignant epithelial lesions of the breast. We report a rare case of mammary sebaceous carcinoma to further delineate its morphologic features. Microscopically, the tumor, arising in the right mammary gland of a 63-year-old woman, was composed of well-defined solid sheets or lobules of atypical epithelial cells including many large pale or clear cells with often scalloped nuclei and coarsely vacuolated cytoplasm, in which abundant lipid droplets were identified with oil-red-O staining. Immunohistochemical expressions of cytokeratin, epithelial membrane antigen, and receptors of estrogen and progesterone were detected, whereas GCDFP-15, S-100 protein, vimentin, α-smooth muscle actin, p63, androgen receptor, and the HER2/neu protein were not expressed. Besides, a subset of the tumor cells co-expressed synaptophysin, neurofilament, and PGP9.5, suggesting neuroendocrine differentiation that is a hitherto undescribed phenomenon in the mammary tumors with sebaceous features. This case would expand the morphologic diversity of carcinoma of the breast. More... »
PAGES484-488
http://scigraph.springernature.com/pub.10.1007/s00428-006-0264-8
DOIhttp://dx.doi.org/10.1007/s00428-006-0264-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1044657412
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16944238
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenocarcinoma, Sebaceous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azo Compounds",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coloring Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorescent Antibody Technique, Indirect",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Keratins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mammography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mastectomy, Modified Radical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mucin-1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Estrogen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Progesterone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sebaceous Gland Neoplasms",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.271052.3",
"name": [
"Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Hisaoka",
"givenName": "Masanori",
"id": "sg:person.0732533314.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732533314.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku800-0296, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.415645.7",
"name": [
"Department of Surgery, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku800-0296, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Takamatsu",
"givenName": "Yuji",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku800-0296, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.415645.7",
"name": [
"Department of Surgery, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku800-0296, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Hirano",
"givenName": "Yutaka",
"id": "sg:person.0607547217.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607547217.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku, 800-0296, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.415645.7",
"name": [
"Department of Radiology, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku, 800-0296, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Maeda",
"givenName": "Hironobu",
"id": "sg:person.01351362541.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351362541.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgical Pathology, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku, 800-0296, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.415645.7",
"name": [
"Department of Surgical Pathology, Kyushu Rosai Hospital, 1-3-1 Takamatsu, Kuzuhara, Kokuraminami-ku, 800-0296, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Hamada",
"givenName": "Tetsuo",
"id": "sg:person.01217112136.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217112136.17"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00427064",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013515824",
"https://doi.org/10.1007/bf00427064"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004280000366",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018254316",
"https://doi.org/10.1007/s004280000366"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-08-31",
"datePublishedReg": "2006-08-31",
"description": "Sebaceous differentiation has been described in only limited examples of benign and malignant epithelial lesions of the breast. We report a rare case of mammary sebaceous carcinoma to further delineate its morphologic features. Microscopically, the tumor, arising in the right mammary gland of a 63-year-old woman, was composed of well-defined solid sheets or lobules of atypical epithelial cells including many large pale or clear cells with often scalloped nuclei and coarsely vacuolated cytoplasm, in which abundant lipid droplets were identified with oil-red-O staining. Immunohistochemical expressions of cytokeratin, epithelial membrane antigen, and receptors of estrogen and progesterone were detected, whereas GCDFP-15, S-100 protein, vimentin, \u03b1-smooth muscle actin, p63, androgen receptor, and the HER2/neu protein were not expressed. Besides, a subset of the tumor cells co-expressed synaptophysin, neurofilament, and PGP9.5, suggesting neuroendocrine differentiation that is a hitherto undescribed phenomenon in the mammary tumors with sebaceous features. This case would expand the morphologic diversity of carcinoma of the breast.",
"genre": "article",
"id": "sg:pub.10.1007/s00428-006-0264-8",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1106235",
"issn": [
"0945-6317",
"1432-2307"
],
"name": "Virchows Archiv",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "449"
}
],
"keywords": [
"sebaceous carcinoma",
"HER2/neu protein",
"receptors of estrogen",
"right mammary gland",
"atypical epithelial cells",
"malignant epithelial lesions",
"epithelial membrane antigen",
"smooth muscle actin",
"hitherto undescribed phenomenon",
"GCDFP-15",
"neuroendocrine differentiation",
"case report",
"abundant lipid droplets",
"epithelial lesions",
"immunohistochemical expression",
"androgen receptor",
"mammary tumors",
"clear cells",
"sebaceous differentiation",
"rare case",
"membrane antigen",
"muscle actin",
"morphologic features",
"neu protein",
"carcinoma",
"mammary gland",
"epithelial cells",
"breast",
"solid sheets",
"lipid droplets",
"tumors",
"receptors",
"undescribed phenomenon",
"cells",
"morphologic diversity",
"synaptophysin",
"PGP9.5",
"estrogen",
"progesterone",
"lesions",
"antigen",
"neurofilaments",
"vimentin",
"women",
"lobule",
"differentiation",
"gland",
"staining",
"cases",
"protein",
"p63",
"report",
"review",
"expression",
"subset",
"cytoplasm",
"actin",
"nucleus",
"features",
"literature",
"limited examples",
"phenomenon",
"droplets",
"diversity",
"sheets",
"example"
],
"name": "Sebaceous carcinoma of the breast: case report and review of the literature",
"pagination": "484-488",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1044657412"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00428-006-0264-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16944238"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00428-006-0264-8",
"https://app.dimensions.ai/details/publication/pub.1044657412"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_417.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00428-006-0264-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-006-0264-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-006-0264-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-006-0264-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-006-0264-8'
This table displays all metadata directly associated to this object as RDF triples.
234 TRIPLES
22 PREDICATES
110 URIs
100 LITERALS
23 BLANK NODES