Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04-12

AUTHORS

Masatoshi Akiyama, Haruo Ohtani, Eiichi Sato, Hiroshi Nagura, Koichi Tabayashi

ABSTRACT

The pathophysiological significance of matrix metalloproteinases (MMPs) in aortic dissection remains poorly understood. The purpose of the present study is to clarify the significance of MMPs in aortic dissection. The activities and distributions of MMP-2, membrane-type 1-MMP (MT1-MMP), and MMP-9 were evaluated by gelatin zymography, immunohistochemistry, and in situ hybridization in 29 patients and seven autopsy cases. To assess if these MMPs are related to a tissue remodeling process, we compared the expression of these MMPs with that of type I procollagen and platelet-derived growth factor receptor β chain (PDGF Rβ). Patients were divided into three groups based on histological findings: acute, intermediate, and healed groups. The most remarkable changes were observed in the intermediate group, in which MMP-2 activity peaked and tissue expression of mRNAs for MMP-2 and MT1-MMP were observed in spindle-shaped cells in the neointima, organizing thrombus, and the adventitia. These expression patterns were essentially coupled with those of type I procollagen mRNA and PDGF-Rβ protein. The association of MMP-2, MT1-MMP, type I procollagen, and PDGF-Rβ suggests that MMP-2 and MT1-MMP could be involved not only in the degradation of aortic tissue but also in tissue remodeling, which may be associated with the healing process. More... »

PAGES

811-821

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-006-0194-5

DOI

http://dx.doi.org/10.1007/s00428-006-0194-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041385120

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16609908


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