Ontology type: schema:ScholarlyArticle
2006-01-25
AUTHORSYoshio Jinno, Haruo Ohtani, Shiro Nakamura, Motoji Oki, Kiyoshi Maeda, Kohei Fukushima, Hiroshi Nagura, Nobuhide Oshitani, Takayuki Matsumoto, Tetsuo Arakawa
ABSTRACTAbnormalities in humoral immunity are implicated in the pathogenesis of ulcerative colitis. However, the detailed mechanisms of B-cell activation in the locale remain unaccounted for. We analyzed ulcerative colitis from the standpoint of lymphocytic expansion in the loco. Intestinal specimens obtained at surgery from 30 patients with ulcerative colitis treated with corticosteroids and 15 with Crohn’s disease were analyzed by immunohistochemistry and flow cytometry. Ulcerative colitis was characterized by a diffuse distribution of Ki-67+ small round cells particularly in the ulcer base (that were CD19+ and CD20–), with a significant number of them also CD138+. Immunoelectron microscopy for CD19 revealed an abundance of rough endoplasmic reticulum in the cytoplasm. These indicated that they are of immature plasma lineage cells. By contrast, plasma cells in Crohn’s disease were negative for CD19, and the labeling for Ki-67 was infrequent, showing mature phenotype. Flow cytometry revealed an occurrence of CD19+ and CD20– cells in ulcerative colitis but not in Crohn’s disease. The labeling index of Ki-67 among CD19+ plasma cells was positively correlated with the clinical activity of ulcerative colitis. High labeling of Ki-67 in CD19+ plasma cells is specific for active ulcerative colitis that was resistant to medical treatment by corticosteroids. More... »
PAGES412-421
http://scigraph.springernature.com/pub.10.1007/s00428-005-0136-7
DOIhttp://dx.doi.org/10.1007/s00428-005-0136-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1049453074
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16435133
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigens, CD19",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Lineage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colitis, Ulcerative",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crohn Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endoplasmic Reticulum",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Flow Cytometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucocorticoids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ki-67 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plasma Cells",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Division of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Japan",
"id": "http://www.grid.ac/institutes/grid.272264.7",
"name": [
"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"Department of Internal Medicine, Division of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Japan"
],
"type": "Organization"
},
"familyName": "Jinno",
"givenName": "Yoshio",
"id": "sg:person.0760717771.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760717771.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, National Hospital Organization Mito Medical Center, Ibaraki, Japan",
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Ohtani",
"givenName": "Haruo",
"id": "sg:person.01213261602.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213261602.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Shiro",
"id": "sg:person.010031712242.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010031712242.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Oki",
"givenName": "Motoji",
"id": "sg:person.0576743607.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576743607.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Maeda",
"givenName": "Kiyoshi",
"id": "sg:person.01013751772.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013751772.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Fukushima",
"givenName": "Kohei",
"id": "sg:person.015700171232.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015700171232.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Nagura",
"givenName": "Hiroshi",
"id": "sg:person.0723362470.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Oshitani",
"givenName": "Nobuhide",
"id": "sg:person.01022666631.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022666631.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Division of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Japan",
"id": "http://www.grid.ac/institutes/grid.272264.7",
"name": [
"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"Department of Internal Medicine, Division of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Japan"
],
"type": "Organization"
},
"familyName": "Matsumoto",
"givenName": "Takayuki",
"id": "sg:person.012162205442.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.261445.0",
"name": [
"Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Arakawa",
"givenName": "Tetsuo",
"id": "sg:person.010413206312.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010413206312.32"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s005350050021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019239223",
"https://doi.org/10.1007/s005350050021"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095573",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028418809",
"https://doi.org/10.1038/35095573"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-01-25",
"datePublishedReg": "2006-01-25",
"description": "Abnormalities in humoral immunity are implicated in the pathogenesis of ulcerative colitis. However, the detailed mechanisms of B-cell activation in the locale remain unaccounted for. We analyzed ulcerative colitis from the standpoint of lymphocytic expansion in the loco. Intestinal specimens obtained at surgery from 30 patients with ulcerative colitis treated with corticosteroids and 15 with Crohn\u2019s disease were analyzed by immunohistochemistry and flow cytometry. Ulcerative colitis was characterized by a diffuse distribution of Ki-67+ small round cells particularly in the ulcer base (that were CD19+ and CD20\u2013), with a significant number of them also CD138+. Immunoelectron microscopy for CD19 revealed an abundance of rough endoplasmic reticulum in the cytoplasm. These indicated that they are of immature plasma lineage cells. By contrast, plasma cells in Crohn\u2019s disease were negative for CD19, and the labeling for Ki-67 was infrequent, showing mature phenotype. Flow cytometry revealed an occurrence of CD19+ and CD20\u2013 cells in ulcerative colitis but not in Crohn\u2019s disease. The labeling index of Ki-67 among CD19+ plasma cells was positively correlated with the clinical activity of ulcerative colitis. High labeling of Ki-67 in CD19+ plasma cells is specific for active ulcerative colitis that was resistant to medical treatment by corticosteroids.",
"genre": "article",
"id": "sg:pub.10.1007/s00428-005-0136-7",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1106235",
"issn": [
"0945-6317",
"1432-2307"
],
"name": "Virchows Archiv",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "448"
}
],
"keywords": [
"active ulcerative colitis",
"ulcerative colitis",
"Ki-67",
"plasma cells",
"Crohn's disease",
"small round cells",
"B cell activation",
"CD20 cells",
"humoral immunity",
"ulcer base",
"intestinal specimens",
"clinical activity",
"colitis",
"CD19",
"medical treatment",
"labeling index",
"frequent labeling",
"flow cytometry",
"round cells",
"disease",
"mature phenotype",
"lineage cells",
"corticosteroids",
"high labeling",
"diffuse distribution",
"rough endoplasmic reticulum",
"cytometry",
"cells",
"significant number",
"CD138",
"surgery",
"patients",
"pathogenesis",
"immunohistochemistry",
"abnormalities",
"immunity",
"labeling",
"endoplasmic reticulum",
"infiltration",
"treatment",
"detailed mechanism",
"infrequent",
"activation",
"phenotype",
"index",
"cytoplasm",
"reticulum",
"activity",
"specimens",
"occurrence",
"loco",
"contrast",
"mechanism",
"number",
"base",
"microscopy",
"expansion",
"locales",
"standpoint",
"distribution",
"abundance"
],
"name": "Infiltration of CD19+ plasma cells with frequent labeling of Ki-67 in corticosteroid-resistant active ulcerative colitis",
"pagination": "412-421",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1049453074"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00428-005-0136-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16435133"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00428-005-0136-7",
"https://app.dimensions.ai/details/publication/pub.1049453074"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_429.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00428-005-0136-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-005-0136-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-005-0136-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-005-0136-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-005-0136-7'
This table displays all metadata directly associated to this object as RDF triples.
287 TRIPLES
21 PREDICATES
108 URIs
98 LITERALS
27 BLANK NODES