A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

Paolo Monti, Federica Marchesi, Michele Reni, Alessia Mercalli, Valeria Sordi, Alessandro Zerbi, Giampaolo Balzano, Valerio Di Carlo, Paola Allavena, Lorenzo Piemonti

ABSTRACT

There are a large number of stable pancreatic ductal carcinoma cell lines (PDCL) that are used by researchers worldwide. Detailed data about their differentiation status and genetic alterations are present in the literature, but a systematic correlation with cell biological behavior is often lacking. PDCL ( n=12) were clustered by source of tumor cell (ascites, primary tumor, metastasis), and the data of functional cell biology were correlated with the reported structural and genetic profiles. Major histocompatibility complex expression, chemosensitivity and aneuploidia appeared to be related to the source of PDCL, and proliferative capacity appeared to be related to the grade of differentiation. No correlation between genetic/structural features of PDCL and biological behavior was found. All the cell lines appeared generally insensitive to in vitro treatment with 5-fluorouracil and showed variable degrees of susceptibility to gemcitabine, raltitrexed and oxaliplatin. All the PDCL showed resistance to Fas-mediated apoptosis but were significantly sensitive to the pro-apoptotic effect of inflammatory cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)alpha and interferon gamma]. PDCL were characterized for the secretion of several factors relevant to the tumor-immune cross talk. Vascular endothelial growth factor, CCL2, CCL5 and transforming growth factor beta were the factors most frequently released; less frequent was the secretion of CXCL8, CCL22, IL-6 and sporadically CXCL12, IL-10 and hepatocyte growth factor. The cytokines IL-1beta and TNFalpha were always undetectable. In conclusion, a clear correlation between structural/genetic features and function could not be detected, suggesting the weakness of a "morphological" classification for the in vitro studies of pancreatic cancer. More... »

PAGES

236-247

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-004-1053-x

DOI

http://dx.doi.org/10.1007/s00428-004-1053-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005328795

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15258755


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monti", 
        "givenName": "Paolo", 
        "id": "sg:person.01104217261.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104217261.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department Immunology and Cell Biology \u201cMario Negri\u201d Institute, Via Eritrea 62, 20157, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchesi", 
        "givenName": "Federica", 
        "id": "sg:person.01017276032.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017276032.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reni", 
        "givenName": "Michele", 
        "id": "sg:person.01164712517.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164712517.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mercalli", 
        "givenName": "Alessia", 
        "id": "sg:person.01155641070.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155641070.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sordi", 
        "givenName": "Valeria", 
        "id": "sg:person.01340202670.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340202670.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zerbi", 
        "givenName": "Alessandro", 
        "id": "sg:person.0736672032.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736672032.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balzano", 
        "givenName": "Giampaolo", 
        "id": "sg:person.016310752144.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016310752144.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Carlo", 
        "givenName": "Valerio", 
        "id": "sg:person.0613402062.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613402062.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department Immunology and Cell Biology \u201cMario Negri\u201d Institute, Via Eritrea 62, 20157, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allavena", 
        "givenName": "Paola", 
        "id": "sg:person.01330404013.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330404013.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piemonti", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01176471410.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176471410.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1572-0241.2000.01699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000974633", 
          "https://doi.org/10.1111/j.1572-0241.2000.01699.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3835(96)04384-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001753063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02796382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003786719", 
          "https://doi.org/10.1007/bf02796382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02796382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003786719", 
          "https://doi.org/10.1007/bf02796382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1996.tb02649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004490148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004861017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(98)01349-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006190683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02915113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006951471", 
          "https://doi.org/10.1007/bf02915113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02915113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006951471", 
          "https://doi.org/10.1007/bf02915113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007194767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280100474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007423504", 
          "https://doi.org/10.1007/s004280100474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910580207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008237406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009614296", 
          "https://doi.org/10.1038/nrc949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009614296", 
          "https://doi.org/10.1038/nrc949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90029-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011322714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90029-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011322714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1985.tb02870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011779751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1985.tb02870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011779751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910190118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012396524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1102-991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013709887", 
          "https://doi.org/10.1038/ni1102-991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1102-991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013709887", 
          "https://doi.org/10.1038/ni1102-991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200210000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200210000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200210000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.9.4443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014604274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200003000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016530766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200003000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016530766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1746.2001.02583.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018665249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00199769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020408930", 
          "https://doi.org/10.1007/bf00199769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00199769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020408930", 
          "https://doi.org/10.1007/bf00199769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000055854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.10.4012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024094478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00012085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025857578", 
          "https://doi.org/10.1007/pl00012085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65149-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027868697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028953540", 
          "https://doi.org/10.1007/bf02624187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028953540", 
          "https://doi.org/10.1007/bf02624187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(98)01340-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030160678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8613012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030984426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032072537", 
          "https://doi.org/10.1038/bjc.1991.467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032072537", 
          "https://doi.org/10.1038/bjc.1991.467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032072537", 
          "https://doi.org/10.1038/bjc.1991.467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200007000-00049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033469333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200007000-00049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033469333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-5890(02)00013-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035012391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(85)80140-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036231089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64986-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036342030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036573066", 
          "https://doi.org/10.1038/sj.onc.1206128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036573066", 
          "https://doi.org/10.1038/sj.onc.1206128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1996.tb02572.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038004818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb09529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038848556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb09529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038848556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<580::aid-cncr38>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040668701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(88)80116-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041017970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-0039.2002.600401.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043793230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-5890(00)00079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045203928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19830215)51:4<662::aid-cncr2820510419>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045885292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002620050503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047087142", 
          "https://doi.org/10.1007/s002620050503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-2-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049010021", 
          "https://doi.org/10.1186/1476-4598-2-14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.47.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049586839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1520-6866(2001)21:1<27::aid-tcm4>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050980771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200203000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051205052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200203000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051205052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006383831045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052682147", 
          "https://doi.org/10.1023/a:1006383831045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910150505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053636143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.1999.14.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059242424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.8.1.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071536357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074559881", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074701726", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074798842", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074993574", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075003247", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.5.2756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075112145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-003-0784-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075268809", 
          "https://doi.org/10.1007/s00428-003-0784-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076595666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/56.4.843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077447920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081658261", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02774699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081894787", 
          "https://doi.org/10.1007/bf02774699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/67.3.563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082056551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082114245", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082479991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/58.2.209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082764071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082802227", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895713", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083309541", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-09", 
    "datePublishedReg": "2004-09-01", 
    "description": "There are a large number of stable pancreatic ductal carcinoma cell lines (PDCL) that are used by researchers worldwide. Detailed data about their differentiation status and genetic alterations are present in the literature, but a systematic correlation with cell biological behavior is often lacking. PDCL ( n=12) were clustered by source of tumor cell (ascites, primary tumor, metastasis), and the data of functional cell biology were correlated with the reported structural and genetic profiles. Major histocompatibility complex expression, chemosensitivity and aneuploidia appeared to be related to the source of PDCL, and proliferative capacity appeared to be related to the grade of differentiation. No correlation between genetic/structural features of PDCL and biological behavior was found. All the cell lines appeared generally insensitive to in vitro treatment with 5-fluorouracil and showed variable degrees of susceptibility to gemcitabine, raltitrexed and oxaliplatin. All the PDCL showed resistance to Fas-mediated apoptosis but were significantly sensitive to the pro-apoptotic effect of inflammatory cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)alpha and interferon gamma]. PDCL were characterized for the secretion of several factors relevant to the tumor-immune cross talk. Vascular endothelial growth factor, CCL2, CCL5 and transforming growth factor beta were the factors most frequently released; less frequent was the secretion of CXCL8, CCL22, IL-6 and sporadically CXCL12, IL-10 and hepatocyte growth factor. The cytokines IL-1beta and TNFalpha were always undetectable. In conclusion, a clear correlation between structural/genetic features and function could not be detected, suggesting the weakness of a \"morphological\" classification for the in vitro studies of pancreatic cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-004-1053-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "445"
      }
    ], 
    "name": "A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile", 
    "pagination": "236-247", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "19635379a00b2a461033d55b3170c80bd4f0725cc2c5773b416c1c6f757e038a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15258755"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-004-1053-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005328795"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-004-1053-x", 
      "https://app.dimensions.ai/details/publication/pub.1005328795"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-004-1053-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-004-1053-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-004-1053-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-004-1053-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-004-1053-x'


 

This table displays all metadata directly associated to this object as RDF triples.

390 TRIPLES      21 PREDICATES      108 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-004-1053-x schema:about N07a5a67d6691469c8ca40a29d40e79b0
2 N145ac279de6f4a8a89cb75f52d63dc59
3 N40146c9546fc45c8a59d5eebf8bb0023
4 N4eadcd25377344c997a8b5026092817b
5 N5808ebf3887c41b89d458a7ae46f0cfb
6 Na04747a182fd45179cb3304f53032abd
7 Nb3b1609e66fc4c68a088f4ae8031d9f0
8 Nc0391eaf0dec47d8aaf6982dbe38a6fe
9 Nd70b82e85cc949109318529fe4a75b6d
10 Neb14c2cd2b54493f90cdf742e5f0f74e
11 Nec52e91801c2474c84c945b7eb5be718
12 Neda90b5b9c254b229f71fc5b0afe132e
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N0431e4fa6d574a02ac131408d4f23b8a
16 schema:citation sg:pub.10.1007/bf00199769
17 sg:pub.10.1007/bf02624187
18 sg:pub.10.1007/bf02774699
19 sg:pub.10.1007/bf02796382
20 sg:pub.10.1007/bf02915113
21 sg:pub.10.1007/pl00012085
22 sg:pub.10.1007/s002620050503
23 sg:pub.10.1007/s00428-003-0784-4
24 sg:pub.10.1007/s004280100474
25 sg:pub.10.1023/a:1006383831045
26 sg:pub.10.1038/bjc.1991.467
27 sg:pub.10.1038/ni1102-991
28 sg:pub.10.1038/nrc949
29 sg:pub.10.1038/sj.onc.1206128
30 sg:pub.10.1111/j.1572-0241.2000.01699.x
31 sg:pub.10.1186/1476-4598-2-14
32 https://app.dimensions.ai/details/publication/pub.1074559881
33 https://app.dimensions.ai/details/publication/pub.1074701726
34 https://app.dimensions.ai/details/publication/pub.1074798842
35 https://app.dimensions.ai/details/publication/pub.1074993574
36 https://app.dimensions.ai/details/publication/pub.1075003247
37 https://app.dimensions.ai/details/publication/pub.1076595666
38 https://app.dimensions.ai/details/publication/pub.1081658261
39 https://app.dimensions.ai/details/publication/pub.1082114245
40 https://app.dimensions.ai/details/publication/pub.1082479991
41 https://app.dimensions.ai/details/publication/pub.1082802227
42 https://app.dimensions.ai/details/publication/pub.1082895713
43 https://app.dimensions.ai/details/publication/pub.1083309541
44 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<580::aid-cncr38>3.0.co;2-t
45 https://doi.org/10.1002/1097-0142(19830215)51:4<662::aid-cncr2820510419>3.0.co;2-x
46 https://doi.org/10.1002/1520-6866(2001)21:1<27::aid-tcm4>3.0.co;2-9
47 https://doi.org/10.1002/cncr.10753
48 https://doi.org/10.1002/ijc.2910150505
49 https://doi.org/10.1002/ijc.2910190118
50 https://doi.org/10.1002/ijc.2910580207
51 https://doi.org/10.1016/0022-1759(94)90029-9
52 https://doi.org/10.1016/0304-3835(96)04384-4
53 https://doi.org/10.1016/s0002-9343(88)80116-5
54 https://doi.org/10.1016/s0002-9440(10)64986-3
55 https://doi.org/10.1016/s0002-9440(10)65149-8
56 https://doi.org/10.1016/s0006-291x(85)80140-6
57 https://doi.org/10.1016/s0161-5890(00)00079-1
58 https://doi.org/10.1016/s0161-5890(02)00013-5
59 https://doi.org/10.1016/s0167-5699(98)01340-1
60 https://doi.org/10.1016/s0167-5699(98)01349-8
61 https://doi.org/10.1034/j.1399-0039.2002.600401.x
62 https://doi.org/10.1046/j.1440-1746.2001.02583.x
63 https://doi.org/10.1053/gast.1996.v110.pm8613012
64 https://doi.org/10.1073/pnas.87.10.4012
65 https://doi.org/10.1089/cbr.1999.14.49
66 https://doi.org/10.1093/jnci/56.4.843
67 https://doi.org/10.1093/jnci/58.2.209
68 https://doi.org/10.1093/jnci/67.3.563
69 https://doi.org/10.1097/00000658-200003000-00010
70 https://doi.org/10.1097/00006676-200007000-00049
71 https://doi.org/10.1097/00006676-200203000-00007
72 https://doi.org/10.1097/00006676-200210000-00019
73 https://doi.org/10.1111/j.1365-2559.1985.tb02870.x
74 https://doi.org/10.1111/j.1399-0039.1996.tb02572.x
75 https://doi.org/10.1111/j.1399-0039.1996.tb02649.x
76 https://doi.org/10.1111/j.1749-6632.1999.tb09529.x
77 https://doi.org/10.1146/annurev.immunol.21.120601.141135
78 https://doi.org/10.1159/000055854
79 https://doi.org/10.3322/canjclin.47.1.5
80 https://doi.org/10.3892/or.8.1.89
81 https://doi.org/10.4049/jimmunol.164.9.4443
82 https://doi.org/10.4049/jimmunol.169.5.2756
83 schema:datePublished 2004-09
84 schema:datePublishedReg 2004-09-01
85 schema:description There are a large number of stable pancreatic ductal carcinoma cell lines (PDCL) that are used by researchers worldwide. Detailed data about their differentiation status and genetic alterations are present in the literature, but a systematic correlation with cell biological behavior is often lacking. PDCL ( n=12) were clustered by source of tumor cell (ascites, primary tumor, metastasis), and the data of functional cell biology were correlated with the reported structural and genetic profiles. Major histocompatibility complex expression, chemosensitivity and aneuploidia appeared to be related to the source of PDCL, and proliferative capacity appeared to be related to the grade of differentiation. No correlation between genetic/structural features of PDCL and biological behavior was found. All the cell lines appeared generally insensitive to in vitro treatment with 5-fluorouracil and showed variable degrees of susceptibility to gemcitabine, raltitrexed and oxaliplatin. All the PDCL showed resistance to Fas-mediated apoptosis but were significantly sensitive to the pro-apoptotic effect of inflammatory cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)alpha and interferon gamma]. PDCL were characterized for the secretion of several factors relevant to the tumor-immune cross talk. Vascular endothelial growth factor, CCL2, CCL5 and transforming growth factor beta were the factors most frequently released; less frequent was the secretion of CXCL8, CCL22, IL-6 and sporadically CXCL12, IL-10 and hepatocyte growth factor. The cytokines IL-1beta and TNFalpha were always undetectable. In conclusion, a clear correlation between structural/genetic features and function could not be detected, suggesting the weakness of a "morphological" classification for the in vitro studies of pancreatic cancer.
86 schema:genre research_article
87 schema:inLanguage en
88 schema:isAccessibleForFree false
89 schema:isPartOf N625c374f5e1f471e90d70725fe1e160f
90 N6dedc6474aec486ba6e4df4c0fe42905
91 sg:journal.1106235
92 schema:name A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile
93 schema:pagination 236-247
94 schema:productId N21303bda7b994c27937b1f05e75fb047
95 N26c80abf7cb24ddfb64ab98273448ddf
96 N7eae3e037b3043999c5f4db24c56bcbc
97 Nd4f9dea79fc04471b6d57dd66ac26390
98 Nf18881e709f14e428b4acee303299e9d
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005328795
100 https://doi.org/10.1007/s00428-004-1053-x
101 schema:sdDatePublished 2019-04-11T01:06
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher N24567c8b5755419cab01677fdb43ee17
104 schema:url http://link.springer.com/10.1007%2Fs00428-004-1053-x
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N0027435be4984075af5053724d8d1d0d rdf:first sg:person.01176471410.58
109 rdf:rest rdf:nil
110 N0431e4fa6d574a02ac131408d4f23b8a rdf:first sg:person.01104217261.66
111 rdf:rest N989955ef7e304021b28032b01aef22b3
112 N07a5a67d6691469c8ca40a29d40e79b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Antineoplastic Agents
114 rdf:type schema:DefinedTerm
115 N145ac279de6f4a8a89cb75f52d63dc59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Division
117 rdf:type schema:DefinedTerm
118 N1c34e048e2d24bfdabec833561e62c72 rdf:first sg:person.016310752144.18
119 rdf:rest Nf389579cbb9d47aa98c8034c65b05910
120 N21303bda7b994c27937b1f05e75fb047 schema:name dimensions_id
121 schema:value pub.1005328795
122 rdf:type schema:PropertyValue
123 N24567c8b5755419cab01677fdb43ee17 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N26a1c043a7e74f0d90a3ca5932faf69d rdf:first sg:person.01164712517.20
126 rdf:rest Nb00c0c6fb1c347d3b150574b83556fcd
127 N26c80abf7cb24ddfb64ab98273448ddf schema:name doi
128 schema:value 10.1007/s00428-004-1053-x
129 rdf:type schema:PropertyValue
130 N336022da5edf4445b5b5438828afc25f schema:name Department Immunology and Cell Biology “Mario Negri” Institute, Via Eritrea 62, 20157, Milan, Italy
131 rdf:type schema:Organization
132 N40146c9546fc45c8a59d5eebf8bb0023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Phenotype
134 rdf:type schema:DefinedTerm
135 N4eadcd25377344c997a8b5026092817b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Enzyme-Linked Immunosorbent Assay
137 rdf:type schema:DefinedTerm
138 N5808ebf3887c41b89d458a7ae46f0cfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Line, Tumor
140 rdf:type schema:DefinedTerm
141 N625c374f5e1f471e90d70725fe1e160f schema:volumeNumber 445
142 rdf:type schema:PublicationVolume
143 N6dedc6474aec486ba6e4df4c0fe42905 schema:issueNumber 3
144 rdf:type schema:PublicationIssue
145 N7eae3e037b3043999c5f4db24c56bcbc schema:name nlm_unique_id
146 schema:value 9423843
147 rdf:type schema:PropertyValue
148 N935f672d73a945bea7423b99566257d2 schema:name Department Immunology and Cell Biology “Mario Negri” Institute, Via Eritrea 62, 20157, Milan, Italy
149 rdf:type schema:Organization
150 N9770bf210852420483bd6aa4029693a6 rdf:first sg:person.01340202670.67
151 rdf:rest Nb91c1736b8b54821a98a049868ab9026
152 N989955ef7e304021b28032b01aef22b3 rdf:first sg:person.01017276032.99
153 rdf:rest N26a1c043a7e74f0d90a3ca5932faf69d
154 Na04747a182fd45179cb3304f53032abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Pancreatic Neoplasms
156 rdf:type schema:DefinedTerm
157 Nb00c0c6fb1c347d3b150574b83556fcd rdf:first sg:person.01155641070.23
158 rdf:rest N9770bf210852420483bd6aa4029693a6
159 Nb3b1609e66fc4c68a088f4ae8031d9f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Carcinoma, Pancreatic Ductal
161 rdf:type schema:DefinedTerm
162 Nb91c1736b8b54821a98a049868ab9026 rdf:first sg:person.0736672032.67
163 rdf:rest N1c34e048e2d24bfdabec833561e62c72
164 Nc0391eaf0dec47d8aaf6982dbe38a6fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cytokines
166 rdf:type schema:DefinedTerm
167 Nd4f9dea79fc04471b6d57dd66ac26390 schema:name readcube_id
168 schema:value 19635379a00b2a461033d55b3170c80bd4f0725cc2c5773b416c1c6f757e038a
169 rdf:type schema:PropertyValue
170 Nd70b82e85cc949109318529fe4a75b6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name In Vitro Techniques
172 rdf:type schema:DefinedTerm
173 Neb14c2cd2b54493f90cdf742e5f0f74e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Humans
175 rdf:type schema:DefinedTerm
176 Nec52e91801c2474c84c945b7eb5be718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Flow Cytometry
178 rdf:type schema:DefinedTerm
179 Neda90b5b9c254b229f71fc5b0afe132e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Apoptosis
181 rdf:type schema:DefinedTerm
182 Nf18881e709f14e428b4acee303299e9d schema:name pubmed_id
183 schema:value 15258755
184 rdf:type schema:PropertyValue
185 Nf389579cbb9d47aa98c8034c65b05910 rdf:first sg:person.0613402062.26
186 rdf:rest Nfb3686fd92ed448abb60a862eb9a58b9
187 Nfb3686fd92ed448abb60a862eb9a58b9 rdf:first sg:person.01330404013.43
188 rdf:rest N0027435be4984075af5053724d8d1d0d
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
193 schema:name Immunology
194 rdf:type schema:DefinedTerm
195 sg:journal.1106235 schema:issn 0945-6317
196 1432-2307
197 schema:name Virchows Archiv
198 rdf:type schema:Periodical
199 sg:person.01017276032.99 schema:affiliation N935f672d73a945bea7423b99566257d2
200 schema:familyName Marchesi
201 schema:givenName Federica
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017276032.99
203 rdf:type schema:Person
204 sg:person.01104217261.66 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
205 schema:familyName Monti
206 schema:givenName Paolo
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104217261.66
208 rdf:type schema:Person
209 sg:person.01155641070.23 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
210 schema:familyName Mercalli
211 schema:givenName Alessia
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155641070.23
213 rdf:type schema:Person
214 sg:person.01164712517.20 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
215 schema:familyName Reni
216 schema:givenName Michele
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164712517.20
218 rdf:type schema:Person
219 sg:person.01176471410.58 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
220 schema:familyName Piemonti
221 schema:givenName Lorenzo
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176471410.58
223 rdf:type schema:Person
224 sg:person.01330404013.43 schema:affiliation N336022da5edf4445b5b5438828afc25f
225 schema:familyName Allavena
226 schema:givenName Paola
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330404013.43
228 rdf:type schema:Person
229 sg:person.01340202670.67 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
230 schema:familyName Sordi
231 schema:givenName Valeria
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340202670.67
233 rdf:type schema:Person
234 sg:person.016310752144.18 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
235 schema:familyName Balzano
236 schema:givenName Giampaolo
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016310752144.18
238 rdf:type schema:Person
239 sg:person.0613402062.26 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
240 schema:familyName Di Carlo
241 schema:givenName Valerio
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613402062.26
243 rdf:type schema:Person
244 sg:person.0736672032.67 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
245 schema:familyName Zerbi
246 schema:givenName Alessandro
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736672032.67
248 rdf:type schema:Person
249 sg:pub.10.1007/bf00199769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020408930
250 https://doi.org/10.1007/bf00199769
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/bf02624187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028953540
253 https://doi.org/10.1007/bf02624187
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/bf02774699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081894787
256 https://doi.org/10.1007/bf02774699
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/bf02796382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003786719
259 https://doi.org/10.1007/bf02796382
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/bf02915113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006951471
262 https://doi.org/10.1007/bf02915113
263 rdf:type schema:CreativeWork
264 sg:pub.10.1007/pl00012085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025857578
265 https://doi.org/10.1007/pl00012085
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s002620050503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047087142
268 https://doi.org/10.1007/s002620050503
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00428-003-0784-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075268809
271 https://doi.org/10.1007/s00428-003-0784-4
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s004280100474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007423504
274 https://doi.org/10.1007/s004280100474
275 rdf:type schema:CreativeWork
276 sg:pub.10.1023/a:1006383831045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052682147
277 https://doi.org/10.1023/a:1006383831045
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/bjc.1991.467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032072537
280 https://doi.org/10.1038/bjc.1991.467
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/ni1102-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709887
283 https://doi.org/10.1038/ni1102-991
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nrc949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009614296
286 https://doi.org/10.1038/nrc949
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/sj.onc.1206128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036573066
289 https://doi.org/10.1038/sj.onc.1206128
290 rdf:type schema:CreativeWork
291 sg:pub.10.1111/j.1572-0241.2000.01699.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000974633
292 https://doi.org/10.1111/j.1572-0241.2000.01699.x
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/1476-4598-2-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049010021
295 https://doi.org/10.1186/1476-4598-2-14
296 rdf:type schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074559881 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1074701726 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1074798842 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1074993574 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1075003247 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1076595666 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1081658261 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1082114245 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1082479991 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1082802227 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1082895713 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1083309541 schema:CreativeWork
309 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<580::aid-cncr38>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1040668701
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/1097-0142(19830215)51:4<662::aid-cncr2820510419>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045885292
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/1520-6866(2001)21:1<27::aid-tcm4>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050980771
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/cncr.10753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004861017
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1002/ijc.2910150505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053636143
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/ijc.2910190118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012396524
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1002/ijc.2910580207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008237406
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/0022-1759(94)90029-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011322714
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/0304-3835(96)04384-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001753063
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0002-9343(88)80116-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041017970
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0002-9440(10)64986-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036342030
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0002-9440(10)65149-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027868697
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0006-291x(85)80140-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036231089
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s0161-5890(00)00079-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045203928
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0161-5890(02)00013-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035012391
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s0167-5699(98)01340-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030160678
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0167-5699(98)01349-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006190683
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1034/j.1399-0039.2002.600401.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043793230
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1046/j.1440-1746.2001.02583.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018665249
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1053/gast.1996.v110.pm8613012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030984426
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1073/pnas.87.10.4012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024094478
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1089/cbr.1999.14.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059242424
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1093/jnci/56.4.843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077447920
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/jnci/58.2.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082764071
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/jnci/67.3.563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082056551
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/00000658-200003000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016530766
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1097/00006676-200007000-00049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033469333
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/00006676-200203000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051205052
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1097/00006676-200210000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013769328
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1365-2559.1985.tb02870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011779751
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/j.1399-0039.1996.tb02572.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038004818
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1111/j.1399-0039.1996.tb02649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004490148
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1111/j.1749-6632.1999.tb09529.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038848556
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1146/annurev.immunol.21.120601.141135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007194767
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1159/000055854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023936129
378 rdf:type schema:CreativeWork
379 https://doi.org/10.3322/canjclin.47.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049586839
380 rdf:type schema:CreativeWork
381 https://doi.org/10.3892/or.8.1.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071536357
382 rdf:type schema:CreativeWork
383 https://doi.org/10.4049/jimmunol.164.9.4443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014604274
384 rdf:type schema:CreativeWork
385 https://doi.org/10.4049/jimmunol.169.5.2756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075112145
386 rdf:type schema:CreativeWork
387 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
388 schema:name Department of Oncology, S. Raffaele Scientific Institute, Milan, Italy
389 Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S. Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
390 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...