DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-12

AUTHORS

Ulrike Bockmühl, Iver Petersen

ABSTRACT

In head and neck squamous cell carcinomas (HNSCC) the prognostic factors that are routinely considered when deciding therapeutic strategies are still stage and site of the primary tumour, and the presence of nodal or distant metastases. However, it is recognised that these clinical predictors are limited since they do not satisfactorily reflect the biological behaviour of the individual tumour. With the evolving understanding of the genetic and molecular basis of human malignancies, there are an increasing number of factors being claimed to provide prognostic information even in HNSCC. Here we review own and published data on DNA ploidy, karyotyping and molecular cytogenetic changes and its relevance in HNSCC carcinogenesis. The survey suggests that the induction of aneuploidy is a very early event in tumour development being detectable already in non-dysplastic leukoplakia and highly predictive for the subsequent development of a carcinoma. Moreover, specific chromosomal imbalances are associated with different stages of cancer progression and patient's survival, which we have compiled into a progression model of HNSCC. More... »

PAGES

541-550

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00428-002-0729-3

DOI

http://dx.doi.org/10.1007/s00428-002-0729-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019840122

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12461610


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytogenetic Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ploidies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Klinikum Fulda", 
          "id": "https://www.grid.ac/institutes/grid.419818.d", 
          "name": [
            "Department of Otorhinolaryngology, Head and Neck and Facial Plastic Surgery, Klinikum Fulda, Teaching Hospital of the Philipps-University Marburg, Pacelliallee 4, 36043 Fulda, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bockm\u00fchl", 
        "givenName": "Ulrike", 
        "id": "sg:person.01316200643.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316200643.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Pathology, Charit\u00e9 Hospital, Humboldt-University Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petersen", 
        "givenName": "Iver", 
        "id": "sg:person.0744012632.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744012632.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/gcc.1209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000771482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348949710600919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001368132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348949710600919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001368132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002523394", 
          "https://doi.org/10.1038/bjc.1998.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002523394", 
          "https://doi.org/10.1038/bjc.1998.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1995.01890020019005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004721701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0347(199812)20:8<668::aid-hed2>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005555328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001622-199006000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009167979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001622-199006000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009167979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199902)24:2<144::aid-gcc7>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011996714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64549-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013125275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65571-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015962174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200109000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017605212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200109000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017605212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20001001)88:1<71::aid-ijc11>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018588669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mhn.2001.114794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018841533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mhn.2001.114794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018841533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mhn.2001.114794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018841533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.1.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019112160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1992.01880020067017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019226719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.241500798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00202476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022154976", 
          "https://doi.org/10.1007/bf00202476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00202476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022154976", 
          "https://doi.org/10.1007/bf00202476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0714.2000.290506.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023103917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1288/00005537-198209000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023585049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200003000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023589638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200003000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023589638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200003000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023589638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029314764", 
          "https://doi.org/10.1038/bjc.1996.92"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1996.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029314764", 
          "https://doi.org/10.1038/bjc.1996.92"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000024511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029989210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0022215100112940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031561377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81683-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031899717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348949510400903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032018971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348949510400903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032018971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.1.479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032091423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/98.3.296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033910389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000059072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034800887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1995.01890070076016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036077072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280000199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036211121", 
          "https://doi.org/10.1007/s004280000199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348940010900411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037148564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348940010900411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037148564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199808)22:4<312::aid-gcc7>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038958420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940101)73:1<187::aid-cncr2820730132>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038969759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1990.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039256830", 
          "https://doi.org/10.1038/bjc.1990.169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1990.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039256830", 
          "https://doi.org/10.1038/bjc.1990.169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.1986.03780110035003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040224427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950101)75:1+<147::aid-cncr2820751304>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041391741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2273.1987.tb00196.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041500995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0347(199803)20:2<145::aid-hed8>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041748765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930115)71:2<452::aid-cncr2820710228>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042819351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(90)90049-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042863779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280100393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042960650", 
          "https://doi.org/10.1007/s004280100393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870070208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044102921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200104263441702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044728660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1096-9896(200107)194:3<303::aid-path879>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045548828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200106000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045741072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200106000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045741072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2273.1991.tb02104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046659743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2273.1991.tb02104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046659743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0169(200010)47:2<81::aid-cm1>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047290895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0964-1955(92)90006-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047417055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950315)75:6<1343::aid-cncr2820750617>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048726608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280100405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048757494", 
          "https://doi.org/10.1007/s004280100405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65120-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050102123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0496-368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050243706", 
          "https://doi.org/10.1038/ng0496-368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-8375(00)00126-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050564881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051933133", 
          "https://doi.org/10.1038/bjc.1997.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051933133", 
          "https://doi.org/10.1038/bjc.1997.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950901)76:5<853::aid-cncr2820760520>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052255126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1359641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062477301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1957167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062514970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5274.494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5340.1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062558562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-002-0726-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075220413", 
          "https://doi.org/10.1007/s00428-002-0726-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.20.2.456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083941885"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-12", 
    "datePublishedReg": "2002-12-01", 
    "description": "In head and neck squamous cell carcinomas (HNSCC) the prognostic factors that are routinely considered when deciding therapeutic strategies are still stage and site of the primary tumour, and the presence of nodal or distant metastases. However, it is recognised that these clinical predictors are limited since they do not satisfactorily reflect the biological behaviour of the individual tumour. With the evolving understanding of the genetic and molecular basis of human malignancies, there are an increasing number of factors being claimed to provide prognostic information even in HNSCC. Here we review own and published data on DNA ploidy, karyotyping and molecular cytogenetic changes and its relevance in HNSCC carcinogenesis. The survey suggests that the induction of aneuploidy is a very early event in tumour development being detectable already in non-dysplastic leukoplakia and highly predictive for the subsequent development of a carcinoma. Moreover, specific chromosomal imbalances are associated with different stages of cancer progression and patient's survival, which we have compiled into a progression model of HNSCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00428-002-0729-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "441"
      }
    ], 
    "name": "DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma", 
    "pagination": "541-550", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e878293a0e76bb03961e465397049eaf813f74724ac68e82508baef3ff50592"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12461610"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423843"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00428-002-0729-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019840122"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00428-002-0729-3", 
      "https://app.dimensions.ai/details/publication/pub.1019840122"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000531.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00428-002-0729-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00428-002-0729-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00428-002-0729-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00428-002-0729-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00428-002-0729-3'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      99 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00428-002-0729-3 schema:about N05cd41035a234baabc03c0852df5c0a0
2 N0be80dc777a945f49d84d0db0c23f2ff
3 N0c323f9feb9a439f85b49d2986d08660
4 N2d4416bb8eea4b60bf6ea5c7e2b6cdbc
5 N96880226ca2e479daf97485f2a5bd8e1
6 N9f2001d0a983425db0ce777ad9a5265d
7 Nb84c6e47d1c74528a1cf877979b478c4
8 Nd5a1e6ecd07547769a161d719447a31f
9 Nda642ead26d34074b6e54469818a1b21
10 Ne60d5cbbe73e4b1cabab265dfc8cd000
11 anzsrc-for:11
12 anzsrc-for:1112
13 schema:author Ndae5ecebf1a94efaaa8720cdb32ceb9e
14 schema:citation sg:pub.10.1007/bf00202476
15 sg:pub.10.1007/s00428-002-0726-6
16 sg:pub.10.1007/s004280000199
17 sg:pub.10.1007/s004280100393
18 sg:pub.10.1007/s004280100405
19 sg:pub.10.1038/bjc.1990.169
20 sg:pub.10.1038/bjc.1996.92
21 sg:pub.10.1038/bjc.1997.13
22 sg:pub.10.1038/bjc.1998.43
23 sg:pub.10.1038/ng0496-368
24 https://doi.org/10.1001/archotol.1986.03780110035003
25 https://doi.org/10.1001/archotol.1992.01880020067017
26 https://doi.org/10.1001/archotol.1995.01890020019005
27 https://doi.org/10.1001/archotol.1995.01890070076016
28 https://doi.org/10.1002/(sici)1097-0347(199803)20:2<145::aid-hed8>3.0.co;2-2
29 https://doi.org/10.1002/(sici)1097-0347(199812)20:8<668::aid-hed2>3.0.co;2-9
30 https://doi.org/10.1002/(sici)1098-2264(199808)22:4<312::aid-gcc7>3.0.co;2-y
31 https://doi.org/10.1002/(sici)1098-2264(199902)24:2<144::aid-gcc7>3.0.co;2-9
32 https://doi.org/10.1002/1096-9896(200107)194:3<303::aid-path879>3.0.co;2-q
33 https://doi.org/10.1002/1097-0142(19930115)71:2<452::aid-cncr2820710228>3.0.co;2-b
34 https://doi.org/10.1002/1097-0142(19940101)73:1<187::aid-cncr2820730132>3.0.co;2-j
35 https://doi.org/10.1002/1097-0142(19950101)75:1+<147::aid-cncr2820751304>3.0.co;2-u
36 https://doi.org/10.1002/1097-0142(19950315)75:6<1343::aid-cncr2820750617>3.0.co;2-t
37 https://doi.org/10.1002/1097-0142(19950901)76:5<853::aid-cncr2820760520>3.0.co;2-6
38 https://doi.org/10.1002/1097-0169(200010)47:2<81::aid-cm1>3.0.co;2-#
39 https://doi.org/10.1002/1097-0215(20001001)88:1<71::aid-ijc11>3.0.co;2-x
40 https://doi.org/10.1002/gcc.1209
41 https://doi.org/10.1002/gcc.2870070208
42 https://doi.org/10.1016/0165-4608(90)90049-g
43 https://doi.org/10.1016/0964-1955(92)90006-m
44 https://doi.org/10.1016/s0002-9440(10)64549-x
45 https://doi.org/10.1016/s0002-9440(10)65120-6
46 https://doi.org/10.1016/s0002-9440(10)65571-x
47 https://doi.org/10.1016/s0092-8674(00)81683-9
48 https://doi.org/10.1016/s1368-8375(00)00126-3
49 https://doi.org/10.1017/s0022215100112940
50 https://doi.org/10.1034/j.1600-0714.2000.290506.x
51 https://doi.org/10.1056/nejm200104263441702
52 https://doi.org/10.1067/mhn.2001.114794
53 https://doi.org/10.1073/pnas.241500798
54 https://doi.org/10.1073/pnas.93.1.479
55 https://doi.org/10.1073/pnas.97.1.303
56 https://doi.org/10.1093/ajcp/98.3.296
57 https://doi.org/10.1097/00001622-199006000-00017
58 https://doi.org/10.1097/00005537-200003000-00008
59 https://doi.org/10.1097/00005537-200106000-00028
60 https://doi.org/10.1097/00005537-200109000-00010
61 https://doi.org/10.1111/j.1365-2273.1987.tb00196.x
62 https://doi.org/10.1111/j.1365-2273.1991.tb02104.x
63 https://doi.org/10.1126/science.1359641
64 https://doi.org/10.1126/science.1957167
65 https://doi.org/10.1126/science.273.5274.494
66 https://doi.org/10.1126/science.278.5340.1054
67 https://doi.org/10.1159/000024511
68 https://doi.org/10.1159/000059072
69 https://doi.org/10.1177/000348940010900411
70 https://doi.org/10.1177/000348949510400903
71 https://doi.org/10.1177/000348949710600919
72 https://doi.org/10.1200/jco.2002.20.2.456
73 https://doi.org/10.1288/00005537-198209000-00018
74 schema:datePublished 2002-12
75 schema:datePublishedReg 2002-12-01
76 schema:description In head and neck squamous cell carcinomas (HNSCC) the prognostic factors that are routinely considered when deciding therapeutic strategies are still stage and site of the primary tumour, and the presence of nodal or distant metastases. However, it is recognised that these clinical predictors are limited since they do not satisfactorily reflect the biological behaviour of the individual tumour. With the evolving understanding of the genetic and molecular basis of human malignancies, there are an increasing number of factors being claimed to provide prognostic information even in HNSCC. Here we review own and published data on DNA ploidy, karyotyping and molecular cytogenetic changes and its relevance in HNSCC carcinogenesis. The survey suggests that the induction of aneuploidy is a very early event in tumour development being detectable already in non-dysplastic leukoplakia and highly predictive for the subsequent development of a carcinoma. Moreover, specific chromosomal imbalances are associated with different stages of cancer progression and patient's survival, which we have compiled into a progression model of HNSCC.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree false
80 schema:isPartOf N24efb23798c34da9aba4fde55db5092d
81 Nacf041e3384242f387271e284474f12c
82 sg:journal.1106235
83 schema:name DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma
84 schema:pagination 541-550
85 schema:productId N00b652409d3c402793ea2a4b0c037f84
86 N03d9f1287c2942a7a9cddd4c90da1487
87 N80b404a40f5b4128817c8aeaf612fc80
88 N9daef960d548402892f2c0219dd0b0c7
89 Ncdd7e4d42e7846b9917078ca4e75941d
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019840122
91 https://doi.org/10.1007/s00428-002-0729-3
92 schema:sdDatePublished 2019-04-10T23:28
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Nbb02085541ef41b78528c5c06fb3c746
95 schema:url http://link.springer.com/10.1007%2Fs00428-002-0729-3
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N00b652409d3c402793ea2a4b0c037f84 schema:name dimensions_id
100 schema:value pub.1019840122
101 rdf:type schema:PropertyValue
102 N03d9f1287c2942a7a9cddd4c90da1487 schema:name nlm_unique_id
103 schema:value 9423843
104 rdf:type schema:PropertyValue
105 N05cd41035a234baabc03c0852df5c0a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name DNA, Neoplasm
107 rdf:type schema:DefinedTerm
108 N0be80dc777a945f49d84d0db0c23f2ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cytogenetic Analysis
110 rdf:type schema:DefinedTerm
111 N0c323f9feb9a439f85b49d2986d08660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Head and Neck Neoplasms
113 rdf:type schema:DefinedTerm
114 N24efb23798c34da9aba4fde55db5092d schema:volumeNumber 441
115 rdf:type schema:PublicationVolume
116 N2d4416bb8eea4b60bf6ea5c7e2b6cdbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Prognosis
118 rdf:type schema:DefinedTerm
119 N519ae52d3ff64e93ab6bd9dbff953650 schema:name Institute of Pathology, Charité Hospital, Humboldt-University Berlin, Germany
120 rdf:type schema:Organization
121 N7fafba04a12c4b3dbf024c0449589331 rdf:first sg:person.0744012632.18
122 rdf:rest rdf:nil
123 N80b404a40f5b4128817c8aeaf612fc80 schema:name doi
124 schema:value 10.1007/s00428-002-0729-3
125 rdf:type schema:PropertyValue
126 N96880226ca2e479daf97485f2a5bd8e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Ploidies
128 rdf:type schema:DefinedTerm
129 N9daef960d548402892f2c0219dd0b0c7 schema:name readcube_id
130 schema:value 5e878293a0e76bb03961e465397049eaf813f74724ac68e82508baef3ff50592
131 rdf:type schema:PropertyValue
132 N9f2001d0a983425db0ce777ad9a5265d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Models, Biological
134 rdf:type schema:DefinedTerm
135 Nacf041e3384242f387271e284474f12c schema:issueNumber 6
136 rdf:type schema:PublicationIssue
137 Nb84c6e47d1c74528a1cf877979b478c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 Nbb02085541ef41b78528c5c06fb3c746 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Ncdd7e4d42e7846b9917078ca4e75941d schema:name pubmed_id
143 schema:value 12461610
144 rdf:type schema:PropertyValue
145 Nd5a1e6ecd07547769a161d719447a31f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Chromosome Aberrations
147 rdf:type schema:DefinedTerm
148 Nda642ead26d34074b6e54469818a1b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Carcinoma, Squamous Cell
150 rdf:type schema:DefinedTerm
151 Ndae5ecebf1a94efaaa8720cdb32ceb9e rdf:first sg:person.01316200643.29
152 rdf:rest N7fafba04a12c4b3dbf024c0449589331
153 Ne60d5cbbe73e4b1cabab265dfc8cd000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Survival Rate
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
160 schema:name Oncology and Carcinogenesis
161 rdf:type schema:DefinedTerm
162 sg:journal.1106235 schema:issn 0945-6317
163 1432-2307
164 schema:name Virchows Archiv
165 rdf:type schema:Periodical
166 sg:person.01316200643.29 schema:affiliation https://www.grid.ac/institutes/grid.419818.d
167 schema:familyName Bockmühl
168 schema:givenName Ulrike
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316200643.29
170 rdf:type schema:Person
171 sg:person.0744012632.18 schema:affiliation N519ae52d3ff64e93ab6bd9dbff953650
172 schema:familyName Petersen
173 schema:givenName Iver
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744012632.18
175 rdf:type schema:Person
176 sg:pub.10.1007/bf00202476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022154976
177 https://doi.org/10.1007/bf00202476
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/s00428-002-0726-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075220413
180 https://doi.org/10.1007/s00428-002-0726-6
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s004280000199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036211121
183 https://doi.org/10.1007/s004280000199
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s004280100393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042960650
186 https://doi.org/10.1007/s004280100393
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s004280100405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048757494
189 https://doi.org/10.1007/s004280100405
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/bjc.1990.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039256830
192 https://doi.org/10.1038/bjc.1990.169
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/bjc.1996.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029314764
195 https://doi.org/10.1038/bjc.1996.92
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/bjc.1997.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051933133
198 https://doi.org/10.1038/bjc.1997.13
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/bjc.1998.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002523394
201 https://doi.org/10.1038/bjc.1998.43
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/ng0496-368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050243706
204 https://doi.org/10.1038/ng0496-368
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1001/archotol.1986.03780110035003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040224427
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1001/archotol.1992.01880020067017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019226719
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1001/archotol.1995.01890020019005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004721701
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1001/archotol.1995.01890070076016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036077072
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/(sici)1097-0347(199803)20:2<145::aid-hed8>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041748765
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/(sici)1097-0347(199812)20:8<668::aid-hed2>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005555328
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/(sici)1098-2264(199808)22:4<312::aid-gcc7>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038958420
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/(sici)1098-2264(199902)24:2<144::aid-gcc7>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011996714
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/1096-9896(200107)194:3<303::aid-path879>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1045548828
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/1097-0142(19930115)71:2<452::aid-cncr2820710228>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1042819351
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/1097-0142(19940101)73:1<187::aid-cncr2820730132>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1038969759
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/1097-0142(19950101)75:1+<147::aid-cncr2820751304>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1041391741
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/1097-0142(19950315)75:6<1343::aid-cncr2820750617>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1048726608
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/1097-0142(19950901)76:5<853::aid-cncr2820760520>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052255126
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/1097-0169(200010)47:2<81::aid-cm1>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1047290895
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/1097-0215(20001001)88:1<71::aid-ijc11>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018588669
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/gcc.1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000771482
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/gcc.2870070208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044102921
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0165-4608(90)90049-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1042863779
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0964-1955(92)90006-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1047417055
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0002-9440(10)64549-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013125275
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0002-9440(10)65120-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050102123
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0002-9440(10)65571-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015962174
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0092-8674(00)81683-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031899717
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s1368-8375(00)00126-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050564881
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1017/s0022215100112940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031561377
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1034/j.1600-0714.2000.290506.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023103917
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1056/nejm200104263441702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044728660
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1067/mhn.2001.114794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018841533
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1073/pnas.241500798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053203
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1073/pnas.93.1.479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032091423
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.97.1.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019112160
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/ajcp/98.3.296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033910389
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/00001622-199006000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009167979
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1097/00005537-200003000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023589638
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1097/00005537-200106000-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045741072
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/00005537-200109000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017605212
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1365-2273.1987.tb00196.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041500995
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1365-2273.1991.tb02104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046659743
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.1359641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477301
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.1957167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062514970
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/science.273.5274.494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553704
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1126/science.278.5340.1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558562
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1159/000024511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029989210
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1159/000059072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034800887
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1177/000348940010900411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037148564
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1177/000348949510400903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032018971
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1177/000348949710600919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001368132
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1200/jco.2002.20.2.456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083941885
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1288/00005537-198209000-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023585049
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.419818.d schema:alternateName Klinikum Fulda
307 schema:name Department of Otorhinolaryngology, Head and Neck and Facial Plastic Surgery, Klinikum Fulda, Teaching Hospital of the Philipps-University Marburg, Pacelliallee 4, 36043 Fulda, Germany
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...