Soluble tumor necrosis factor receptor I (sTNFRI) as a prognostic factor in melanoma patients in Slovene population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

Vesna Galvani, Katrina Pretnar Hartman, Ruth R. Rupreht, Srdjan Novaković, Borut Štabuc, Janja Ocvirk, Viktor Menart, Vladimira Gaberc Porekar, Anton Štalc, Primož Rožman, Vladka Čurin Šerbec

ABSTRACT

Tumor necrosis factor α (TNF-α) and its receptors (TNFRI and TNFRII) which exist in soluble form as a product of cleavage of the extracellular domain of membrane integrated receptors, still rise debate about their importance. It was reported that TNF-α has numerous actions in diseases such as inflammation, autoimmunity, infectious diseases, septic shock and many types of cancer [1, 2]. Several authors have reported the significance of sTNFRI level in serum of cancer patients [3, 4]. This study was performed in collaboration with the Institute of Oncology of Slovenia.At least two different mouse monoclonal antibodies (MAbs) against human sTNFRI have been prepared to obtain a sensitive and reliable sandwich ELISA. It was compared with commercially available R&D and Endogen ELISAs for the determination of sTNFRI. Groups of patients with different stages of melanoma and epithelial ovarian carcinoma were tested and their clinical records were reexamined. Levels of sTNFRI were measured and compared with the normal serum levels of sTNFRI. More... »

PAGES

r061-r063

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s004240000007

DOI

http://dx.doi.org/10.1007/s004240000007

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017120949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28008483


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