Effects of non-fatiguing respiratory muscle loading induced by expiratory flow limitation during strenuous incremental cycle exercise on metabolic stress and ... View Full Text


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Article Info

DATE

2017-12

AUTHORS

Camille Rolland-Debord, Capucine Morelot-Panzini, Thomas Similowski, Roberto Duranti, Pierantonio Laveneziana

ABSTRACT

Exercise induces release of cytokines and increase of circulating natural killers (NK) lymphocyte during strong activation of respiratory muscles. We hypothesised that non-fatiguing respiratory muscle loading during exercise causes an increase in NK cells and in metabolic stress indices. Heart rate (HR), ventilation (VE), oesophageal pressure (Pes), oxygen consumption (VO2), dyspnoea and leg effort were measured in eight healthy humans (five men and three women, average age of 31 ± 4 years and body weight of 68 ± 10 kg), performing an incremental exercise testing on a cycle ergometer under control condition and expiratory flow limitation (FL) achieved by putting a Starling resistor. Blood samples were obtained at baseline, at peak of exercise and at iso-workload corresponding to that reached at the peak of FL exercise during control exercise. Diaphragmatic fatigue was evaluated by measuring the tension time index of the diaphragm. Respiratory muscle overloading caused an earlier interruption of exercise. Diaphragmatic fatigue did not occur in the two conditions. At peak of flow-limited exercise compared to iso-workload, HR, peak inspiratory and expiratory Pes, NK cells and norepinephrine were significantly higher. The number of NK cells was significantly related to ΔPes (i.e. difference between the most and the less negative Pes) and plasmatic catecholamines. Loading of respiratory muscles is able to cause an increase of NK cells provided that activation of respiratory muscles is intense enough to induce a significant metabolic stress. More... »

PAGES

1533-1544

References to SciGraph publications

  • 2005-10. Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans in EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
  • 1988-12. The Leucocytosis of Exercise in SPORTS MEDICINE
  • 2000-10. Exercise and cytokines in IMMUNOLOGY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00424-017-2070-3

    DOI

    http://dx.doi.org/10.1007/s00424-017-2070-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091916975

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28948400


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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00424-017-2070-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00424-017-2070-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00424-017-2070-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00424-017-2070-3'


     

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    268 Sorbonne Universités, UPMC Université Paris 06, INSERM, UMRS_1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France
    269 rdf:type schema:Organization
    270 https://www.grid.ac/institutes/grid.8404.8 schema:alternateName University of Florence
    271 schema:name Department of Internal Medicine, Section of Clinical Immunology and Respiratory Diseases, University of Florence, Florence, Italy
    272 rdf:type schema:Organization
     




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