suPAR and chronic kidney disease—a podocyte story View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Martin Zeier, Jochen Reiser

ABSTRACT

The soluble urokinase-type plasminogen activator receptor (suPAR) is a circulating signaling molecule derived from immature myeloid cells. Elevated levels of suPAR have been linked to the pathogenesis of the kidney disease focal and segmental glomerulosclerosis. Here, suPAR acts on podocytes by activating αvβ3 integrins. Large observational studies showed that suPAR also predicts chronic kidney disease incidence and progression by predating the disease by several years prior to any other known marker of renal dysfunction. suPAR is rapidly developing into a prime target for pharmacotherapy as its neutralization is forecasted to be feasible and safe. More... »

PAGES

1017-1020

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-017-2026-7

DOI

http://dx.doi.org/10.1007/s00424-017-2026-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090384523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28689240


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