Focal segmental glomerulosclerosis; why does it occur segmentally? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-29

AUTHORS

Michio Nagata, Namiko Kobayashi, Satoshi Hara

ABSTRACT

Podocyte loss is the fundamental basis of glomerulosclerosis. Focal segmental glomerulosclerosis (FSGS) is a progressive glomerular disease, and its glomerular features are a prototype of podocyte loss-driven glomerulosclerosis. The glomerular pathology of FSGS is characterized by a focal and segmental location of the sclerotic lesions in human FSGS; segmental sclerosis often shows simultaneous intra- and extra-capillary changes, including parietal cell migration, capillary collapse, hyaline deposition, and intra-capillary thrombi and occasional hypercellularity. This suggests that local cellular events, initiated by podocyte loss, are the basis of the segmental lesions in FSGS. Using podocyte-specific injury by toxin administration, a series of recent works has identified the cellular basis of the glomerular response to podocyte loss. This review discusses the molecular pathway of the local response to podocyte loss and its progression to sclerosis. Recent results suggest that segmental sclerosis is a physiological tissue response aimed at halting protein leakage from a disrupted filtration barrier. More... »

PAGES

983-988

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-017-2023-x

DOI

http://dx.doi.org/10.1007/s00424-017-2023-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090301211

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28664408


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