Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca2+ reuptake View Full Text


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Article Info

DATE

2014-11-21

AUTHORS

Hyoung Kyu Kim, Jae Boum Youm, Seung Hun Jeong, Sung Ryul Lee, In-Sung Song, Tae Hee Ko, Julius Ryan Pronto, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Bernd Nilius, Natalia P. Mischchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han

ABSTRACT

Echinochrome A (Ech A), a marine bio-product isolated from sea urchin eggs, is known to have cardioprotective effects through its strong antioxidant and ATP-sparing capabilities. However, the effects of Ech A on cardiac excitation–contraction (E-C) are not known. In this study, we investigated the effects of Ech A on cardiac contractility and Ca2+ handling in the rat heart. In ex vivo Langendorff hearts, Ech A (3 μM) decreased left ventricular developing pressure to 77.7 ± 6.5 % of basal level. In isolated ventricular myocytes, Ech A reduced the fractional cell shortening from 3.4 % at baseline to 2.1 %. Ech A increased both diastolic and peak systolic intracellular Ca2+ ([Ca2+]i). However, the ratio of peak [Ca]i to resting [Ca]i was significantly decreased. Ech A did not affect the L-type Ca2+ current. Inhibiting the Na+/Ca2+ exchanger with either NiCl2 or SEA400 did not affect the Ech A-dependent changes in Ca2+ handling. Our data demonstrate that treatment with Ech A results in a significant reduction in the phosphorylation of phospholamban at both serine 16 and threonine 17 leading to a significant inhibition of SR Ca2+-ATPase 2A (SERCA2A) and subsequent reduced Ca2+ uptake into the intracellular Ca2+ store. Taken together, our data show that Ech A negatively regulates cardiac contractility by inhibiting SERCA2A activity, which leads to a reduction in internal Ca2+ stores. More... »

PAGES

2151-2163

References to SciGraph publications

  • 2013-11-27. Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1988-02. Patch-clamp techniques for time-resolved capacitance measurements in single cells in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2010-09-30. Imaging Calcium Sparks in Cardiac Myocytes in LIGHT MICROSCOPY
  • 1993-08. Effect of lacidipine on ischaemic and reperfused isolated rabbit hearts in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2012-10-17. The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2008-07-29. The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases in NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
  • 1997-12. ATP-sparing effect of histochrome in acute myocardial ischemia in patients with coronary heart disease in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 2008-04-16. The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2000-08-26. Differential lusitropic responsiveness to β-adrenergic stimulation in rat atrial and ventricular cardiac myocytes in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1991-04. Distribution of naturally occurring quinones in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
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    http://scigraph.springernature.com/pub.10.1007/s00424-014-1648-2

    DOI

    http://dx.doi.org/10.1007/s00424-014-1648-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045666440

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25410495


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    339 grid-institutes:grid.417808.2 schema:alternateName G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022, Vladivostok, Russia
    340 schema:name G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022, Vladivostok, Russia
    341 rdf:type schema:Organization
    342 grid-institutes:grid.5596.f schema:alternateName Department Cell Molecular Medicine, Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven, Leuven, Belgium
    343 schema:name Department Cell Molecular Medicine, Laboratory Ion Channel Research, Campus Gasthuisberg, KU Leuven, Leuven, Belgium
    344 rdf:type schema:Organization
     




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