ACE2, angiotensin-(1–7), and Mas: the other side of the coin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01

AUTHORS

Michael Bader

ABSTRACT

The renin–angiotensin system (RAS) has recently been extended by the addition of a novel axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide angiotensin (1–7) (Ang-(1–7)), and the G protein-coupled receptor Mas. ACE2 converts the vasoconstrictive and pro-oxidative peptide angiotensin II (Ang II) into Ang-(1–7) which exerts vasodilatory and antioxidative effects via its receptor Mas. Thereby, ACE2 regulates the local actions of the RAS in cardiovascular tissues and the ACE2/Ang-(1–7)/Mas axis exerts protective actions in hypertension, diabetes, and other cardiovascular disorders. Consequently, this novel RAS axis represents a promising therapeutic target for cardiovascular and metabolic diseases. More... »

PAGES

79-85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-012-1120-0

DOI

http://dx.doi.org/10.1007/s00424-012-1120-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007595320

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23463883


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