TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08-08

AUTHORS

Sravan Mandadi, Takaaki Sokabe, Koji Shibasaki, Kimiaki Katanosaka, Atsuko Mizuno, Aziz Moqrich, Ardem Patapoutian, Tomoko Fukumi-Tominaga, Kazue Mizumura, Makoto Tominaga

ABSTRACT

Transient receptor potential V3 (TRPV3) and TRPV4 are heat-activated cation channels expressed in keratinocytes. It has been proposed that heat-activation of TRPV3 and/or TRPV4 in the skin may release diffusible molecules which would then activate termini of neighboring dorsal root ganglion (DRG) neurons. Here we show that adenosine triphosphate (ATP) is such a candidate molecule released from keratinocytes upon heating in the co-culture systems. Using TRPV1-deficient DRG neurons, we found that increase in cytosolic Ca(2+)-concentration in DRG neurons upon heating was observed only when neurons were co-cultured with keratinocytes, and this increase was blocked by P2 purinoreceptor antagonists, PPADS and suramin. In a co-culture of keratinocytes with HEK293 cells (transfected with P2X(2) cDNA to serve as a bio-sensor), we observed that heat-activated keratinocytes secretes ATP, and that ATP release is compromised in keratinocytes from TRPV3-deficient mice. This study provides evidence that ATP is a messenger molecule for mainly TRPV3-mediated thermotransduction in skin. More... »

PAGES

1093-1102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-009-0703-x

DOI

http://dx.doi.org/10.1007/s00424-009-0703-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008603661

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19669158


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