Peroxisome proliferator-activated receptor β activation promotes myonuclear accretion in skeletal muscle of adult and aged mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-09

AUTHORS

C. Giordano, A. S. Rousseau, N. Wagner, C. Gaudel, J. Murdaca, C. Jehl-Piétri, B. Sibille, P. A. Grimaldi, P. Lopez

ABSTRACT

We reported recently that peroxisome proliferator-activated receptor beta (PPARbeta) activation promotes a calcineurin-dependent exercise-like remodelling characterised by increased numbers of oxidative fibres and capillaries. As physical exercise also induces myonuclear accretion, we investigated whether PPARbeta activation alters myonuclear density. Transgenic muscle-specific PPARbeta over-expression induced 14% increase of myonuclear density. Pharmacological PPARbeta activation promoted rapid and massive myonuclear accretion (20% increase after 48 h), which is dependent upon calcineurin/nuclear factor of activated T cells signalling pathway. In vivo bromodeoxyuridine labelling and proliferating cell nuclear antigen immunodetection revealed that PPARbeta activation did not promote cell proliferation, suggesting that the PPARbeta-promoted myonuclear accretion involves fusion of pre-existing muscle precursor cells to myofibres rather than cell division. Finally, we showed that in skeletal muscle, ageing led to a down-regulation of PPARbeta accompanied by decrease of both oxidative fibre number and myonuclear density. PPARbeta pharmacological activation counteracts, at least in part, the ageing-driven muscle remodelling. More... »

PAGES

901-913

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9

DOI

http://dx.doi.org/10.1007/s00424-009-0676-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022899108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19415321


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcineurin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcineurin Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Citrate (si)-Synthase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclosporine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Fibers, Fast-Twitch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Fibers, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NFATC Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PPAR-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proliferating Cell Nuclear Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Satellite Cells, Skeletal Muscle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Succinate Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giordano", 
        "givenName": "C.", 
        "id": "sg:person.0666746036.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666746036.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rousseau", 
        "givenName": "A. S.", 
        "id": "sg:person.01240134742.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240134742.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "N.", 
        "id": "sg:person.01340322655.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340322655.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaudel", 
        "givenName": "C.", 
        "id": "sg:person.0637737663.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637737663.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murdaca", 
        "givenName": "J.", 
        "id": "sg:person.01306674653.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306674653.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jehl-Pi\u00e9tri", 
        "givenName": "C.", 
        "id": "sg:person.0765410632.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765410632.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sibille", 
        "givenName": "B.", 
        "id": "sg:person.01262116511.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262116511.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grimaldi", 
        "givenName": "P. A.", 
        "id": "sg:person.01263111703.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263111703.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nice Sophia Antipolis University", 
          "id": "https://www.grid.ac/institutes/grid.10737.32", 
          "name": [
            "INSERM U907, Universit\u00e9 de Nice-Sophia Antipolis, Facult\u00e9 de M\u00e9decine, 28 avenue de Valombrose, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "P.", 
        "id": "sg:person.01344236736.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344236736.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01554-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002098966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2007.06.091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002687554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000252790.70572.0c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004162314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000252790.70572.0c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004162314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2004.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004349661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2007.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005946233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.091021198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006226204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e05-01-0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007677840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(61)90450-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008777421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00532.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009514323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.9.2.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010893613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.01227.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010992692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-0004.2000.570103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012258360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/00005768-198910001-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013191294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2005.10.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013725097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00269-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014706912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00318695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015659644", 
          "https://doi.org/10.1007/bf00318695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00318695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015659644", 
          "https://doi.org/10.1007/bf00318695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017517525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.75.103004.142622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018598309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmrr.656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019133445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jemt.1070300504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020953383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.19.e27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022152428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.1993.tb00451.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022547491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-201x.1999.00619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023076372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0001-6772.2003.01238.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024726786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00913.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031153233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033912783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033912783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mus.880170607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034011343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01923439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038604665", 
          "https://doi.org/10.1007/bf01923439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-894x(03)00207-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038763252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-894x(03)00207-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038763252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00581.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045415755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/h96-014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045972121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme.1.01499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046520091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00305374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047434986", 
          "https://doi.org/10.1007/bf00305374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00394.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048637158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00394.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048637158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.2002.5653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048819224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.2002.5653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048819224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1047-8477(90)90111-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051948913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-0269fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053332957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1999.87.2.634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074506336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1999.87.5.1705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074550461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074747890", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2001.90.4.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074783248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075344134", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081884239", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1995.78.5.1969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082449365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082555983", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-09", 
    "datePublishedReg": "2009-09-01", 
    "description": "We reported recently that peroxisome proliferator-activated receptor beta (PPARbeta) activation promotes a calcineurin-dependent exercise-like remodelling characterised by increased numbers of oxidative fibres and capillaries. As physical exercise also induces myonuclear accretion, we investigated whether PPARbeta activation alters myonuclear density. Transgenic muscle-specific PPARbeta over-expression induced 14% increase of myonuclear density. Pharmacological PPARbeta activation promoted rapid and massive myonuclear accretion (20% increase after 48 h), which is dependent upon calcineurin/nuclear factor of activated T cells signalling pathway. In vivo bromodeoxyuridine labelling and proliferating cell nuclear antigen immunodetection revealed that PPARbeta activation did not promote cell proliferation, suggesting that the PPARbeta-promoted myonuclear accretion involves fusion of pre-existing muscle precursor cells to myofibres rather than cell division. Finally, we showed that in skeletal muscle, ageing led to a down-regulation of PPARbeta accompanied by decrease of both oxidative fibre number and myonuclear density. PPARbeta pharmacological activation counteracts, at least in part, the ageing-driven muscle remodelling.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00424-009-0676-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1005222", 
        "issn": [
          "0031-6768", 
          "1432-2013"
        ], 
        "name": "Pfl\u00fcgers Archiv - European Journal of Physiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "458"
      }
    ], 
    "name": "Peroxisome proliferator-activated receptor \u03b2 activation promotes myonuclear accretion in skeletal muscle of adult and aged mice", 
    "pagination": "901-913", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6d187e58d5a19a9c0b85b1cdc14036ad3b73bb9bf320239a38deb45066fe5946"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19415321"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0154720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00424-009-0676-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022899108"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00424-009-0676-9", 
      "https://app.dimensions.ai/details/publication/pub.1022899108"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13078_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00424-009-0676-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9'


 

This table displays all metadata directly associated to this object as RDF triples.

351 TRIPLES      21 PREDICATES      97 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00424-009-0676-9 schema:about N125868229b224af397ae03da7e6e7c0e
2 N13a9fcde7ef74bfc9648d733c1a1e678
3 N1a8357d4ab3f4e0eb66fc84d5cdf458c
4 N3d79418109994807ad31ebccfcca9f0a
5 N41dad4cc76644282a18f11bc2b4a4117
6 N58ab7af796f14dc192d1f9dfe941dcf3
7 N6127b5ab46e748abaa5c8970149df3aa
8 N672631773e084f31a749933bb004146c
9 N71aa0dcdcb6b490ca38ad97621b58dac
10 N77f3b49770b6406196bfe156ab843180
11 N7c940f15d14842fa986b13c039fe54e4
12 N8b92903413c443f198227d4a38fda2fd
13 N8f9d0b063b274ee7bf99fa962acee889
14 N92ff5779b7cd446d93840b9db2bfe946
15 N9c648bfaea934dbeabe88d199a921e21
16 N9cc675a80ce14f09b9e613913a520466
17 Na482621baae84c19a87a3c892ca4a046
18 Na50bb796d9be4754ab0e2590533050a4
19 Na57bad78e61d401b80ba33cb2043665d
20 Na950bac962774cd2ab3f196b9907a8da
21 Nb9d5f474847d44b3a80fad4d696165fd
22 Ne0a189d57d034c61b71a9014d28780e5
23 Nf9447283010f49f6a19cfa8fb802c63f
24 anzsrc-for:06
25 anzsrc-for:0601
26 schema:author N4b1c8356a2c24d5ca24dbda63d92978d
27 schema:citation sg:pub.10.1007/bf00305374
28 sg:pub.10.1007/bf00318695
29 sg:pub.10.1007/bf01923439
30 https://app.dimensions.ai/details/publication/pub.1074747890
31 https://app.dimensions.ai/details/publication/pub.1075344134
32 https://app.dimensions.ai/details/publication/pub.1081884239
33 https://app.dimensions.ai/details/publication/pub.1082555983
34 https://doi.org/10.1002/dmrr.656
35 https://doi.org/10.1002/jemt.1070300504
36 https://doi.org/10.1002/mus.880170607
37 https://doi.org/10.1006/excr.2002.5653
38 https://doi.org/10.1016/0014-4827(61)90450-5
39 https://doi.org/10.1016/1047-8477(90)90111-o
40 https://doi.org/10.1016/j.bbadis.2004.11.011
41 https://doi.org/10.1016/j.cardiores.2005.10.019
42 https://doi.org/10.1016/j.cell.2005.08.021
43 https://doi.org/10.1016/j.cellsig.2007.03.003
44 https://doi.org/10.1016/j.jmb.2007.06.091
45 https://doi.org/10.1016/s0014-5793(00)01554-4
46 https://doi.org/10.1016/s0092-8674(03)00269-1
47 https://doi.org/10.1016/s0960-894x(03)00207-5
48 https://doi.org/10.1034/j.1399-0004.2000.570103.x
49 https://doi.org/10.1046/j.0001-6772.2003.01238.x
50 https://doi.org/10.1046/j.1365-201x.1999.00619.x
51 https://doi.org/10.1073/pnas.091021198
52 https://doi.org/10.1083/jcb.9.2.493
53 https://doi.org/10.1091/mbc.e05-01-0055
54 https://doi.org/10.1093/nar/27.19.e27
55 https://doi.org/10.1096/fj.03-0269fje
56 https://doi.org/10.1111/j.1365-2990.1993.tb00451.x
57 https://doi.org/10.1139/h96-014
58 https://doi.org/10.1146/annurev.biochem.75.103004.142622
59 https://doi.org/10.1152/ajpcell.00532.2005
60 https://doi.org/10.1152/ajpendo.00581.2007
61 https://doi.org/10.1152/jappl.1995.78.5.1969
62 https://doi.org/10.1152/jappl.1999.87.2.634
63 https://doi.org/10.1152/jappl.1999.87.5.1705
64 https://doi.org/10.1152/jappl.2001.90.4.1407
65 https://doi.org/10.1152/japplphysiol.00394.2005
66 https://doi.org/10.1152/japplphysiol.00913.2005
67 https://doi.org/10.1152/japplphysiol.01227.2005
68 https://doi.org/10.1161/01.atv.0000252790.70572.0c
69 https://doi.org/10.1242/jcs.02602
70 https://doi.org/10.1249/00005768-198910001-00010
71 https://doi.org/10.1677/jme.1.01499
72 schema:datePublished 2009-09
73 schema:datePublishedReg 2009-09-01
74 schema:description We reported recently that peroxisome proliferator-activated receptor beta (PPARbeta) activation promotes a calcineurin-dependent exercise-like remodelling characterised by increased numbers of oxidative fibres and capillaries. As physical exercise also induces myonuclear accretion, we investigated whether PPARbeta activation alters myonuclear density. Transgenic muscle-specific PPARbeta over-expression induced 14% increase of myonuclear density. Pharmacological PPARbeta activation promoted rapid and massive myonuclear accretion (20% increase after 48 h), which is dependent upon calcineurin/nuclear factor of activated T cells signalling pathway. In vivo bromodeoxyuridine labelling and proliferating cell nuclear antigen immunodetection revealed that PPARbeta activation did not promote cell proliferation, suggesting that the PPARbeta-promoted myonuclear accretion involves fusion of pre-existing muscle precursor cells to myofibres rather than cell division. Finally, we showed that in skeletal muscle, ageing led to a down-regulation of PPARbeta accompanied by decrease of both oxidative fibre number and myonuclear density. PPARbeta pharmacological activation counteracts, at least in part, the ageing-driven muscle remodelling.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N17f9c1a489f047c191b3b7a4b19608aa
79 Na10f3b60ba5b46afb3685c0247185327
80 sg:journal.1005222
81 schema:name Peroxisome proliferator-activated receptor β activation promotes myonuclear accretion in skeletal muscle of adult and aged mice
82 schema:pagination 901-913
83 schema:productId N20973d9581cd424db0f7d58f70dbd387
84 N25f9b179536e457f9930c59bdf9410c0
85 N44da393780ac463bb8fe2c91267b19f0
86 N8a565e2e7b4a402cb9bbeab2e81fd285
87 N9e1871c92ecb4d439ee87a4b4b9b8f73
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022899108
89 https://doi.org/10.1007/s00424-009-0676-9
90 schema:sdDatePublished 2019-04-11T14:27
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Ncf24dfdbc9204442be5cd128c65060ec
93 schema:url http://link.springer.com/10.1007/s00424-009-0676-9
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0901093fea1d4a62b74b518e3d5974b3 rdf:first sg:person.01262116511.39
98 rdf:rest N78dd0e66945b4325ba476d9f0ab1e65a
99 N125868229b224af397ae03da7e6e7c0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cell Nucleus
101 rdf:type schema:DefinedTerm
102 N13a9fcde7ef74bfc9648d733c1a1e678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Thiazoles
104 rdf:type schema:DefinedTerm
105 N17f9c1a489f047c191b3b7a4b19608aa schema:issueNumber 5
106 rdf:type schema:PublicationIssue
107 N1a8357d4ab3f4e0eb66fc84d5cdf458c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aging
109 rdf:type schema:DefinedTerm
110 N1dbe8c329f2f4f39a8754d3d2ecd0564 rdf:first sg:person.01306674653.24
111 rdf:rest N1e170df6bda746ecac4c5cb737a516ab
112 N1e170df6bda746ecac4c5cb737a516ab rdf:first sg:person.0765410632.65
113 rdf:rest N0901093fea1d4a62b74b518e3d5974b3
114 N20973d9581cd424db0f7d58f70dbd387 schema:name doi
115 schema:value 10.1007/s00424-009-0676-9
116 rdf:type schema:PropertyValue
117 N25f9b179536e457f9930c59bdf9410c0 schema:name pubmed_id
118 schema:value 19415321
119 rdf:type schema:PropertyValue
120 N390b994f0e96409cbb05b3a893800c38 rdf:first sg:person.01344236736.51
121 rdf:rest rdf:nil
122 N3d79418109994807ad31ebccfcca9f0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Muscle Fibers, Fast-Twitch
124 rdf:type schema:DefinedTerm
125 N41dad4cc76644282a18f11bc2b4a4117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 N44da393780ac463bb8fe2c91267b19f0 schema:name dimensions_id
129 schema:value pub.1022899108
130 rdf:type schema:PropertyValue
131 N450d500da5a14a62974bf57d731d8d94 rdf:first sg:person.01340322655.48
132 rdf:rest N52c554b0fb0b44438eabead99be2be9e
133 N4b1c8356a2c24d5ca24dbda63d92978d rdf:first sg:person.0666746036.03
134 rdf:rest Nf3e899830b7346cd815808ac4f856b27
135 N52c554b0fb0b44438eabead99be2be9e rdf:first sg:person.0637737663.80
136 rdf:rest N1dbe8c329f2f4f39a8754d3d2ecd0564
137 N58ab7af796f14dc192d1f9dfe941dcf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mice, Inbred C57BL
139 rdf:type schema:DefinedTerm
140 N6127b5ab46e748abaa5c8970149df3aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 N672631773e084f31a749933bb004146c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Muscle, Skeletal
145 rdf:type schema:DefinedTerm
146 N71aa0dcdcb6b490ca38ad97621b58dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice, Transgenic
148 rdf:type schema:DefinedTerm
149 N77f3b49770b6406196bfe156ab843180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name NFATC Transcription Factors
151 rdf:type schema:DefinedTerm
152 N78dd0e66945b4325ba476d9f0ab1e65a rdf:first sg:person.01263111703.63
153 rdf:rest N390b994f0e96409cbb05b3a893800c38
154 N7c940f15d14842fa986b13c039fe54e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Succinate Dehydrogenase
156 rdf:type schema:DefinedTerm
157 N8a565e2e7b4a402cb9bbeab2e81fd285 schema:name nlm_unique_id
158 schema:value 0154720
159 rdf:type schema:PropertyValue
160 N8b92903413c443f198227d4a38fda2fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Muscle Fibers, Skeletal
162 rdf:type schema:DefinedTerm
163 N8f9d0b063b274ee7bf99fa962acee889 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Calcineurin Inhibitors
165 rdf:type schema:DefinedTerm
166 N92ff5779b7cd446d93840b9db2bfe946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name PPAR-beta
168 rdf:type schema:DefinedTerm
169 N9c648bfaea934dbeabe88d199a921e21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cell Division
171 rdf:type schema:DefinedTerm
172 N9cc675a80ce14f09b9e613913a520466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cyclosporine
174 rdf:type schema:DefinedTerm
175 N9e1871c92ecb4d439ee87a4b4b9b8f73 schema:name readcube_id
176 schema:value 6d187e58d5a19a9c0b85b1cdc14036ad3b73bb9bf320239a38deb45066fe5946
177 rdf:type schema:PropertyValue
178 Na10f3b60ba5b46afb3685c0247185327 schema:volumeNumber 458
179 rdf:type schema:PublicationVolume
180 Na482621baae84c19a87a3c892ca4a046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Male
182 rdf:type schema:DefinedTerm
183 Na50bb796d9be4754ab0e2590533050a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Citrate (si)-Synthase
185 rdf:type schema:DefinedTerm
186 Na57bad78e61d401b80ba33cb2043665d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Proliferating Cell Nuclear Antigen
188 rdf:type schema:DefinedTerm
189 Na950bac962774cd2ab3f196b9907a8da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Satellite Cells, Skeletal Muscle
191 rdf:type schema:DefinedTerm
192 Nb9d5f474847d44b3a80fad4d696165fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Calcineurin
194 rdf:type schema:DefinedTerm
195 Ncf24dfdbc9204442be5cd128c65060ec schema:name Springer Nature - SN SciGraph project
196 rdf:type schema:Organization
197 Ne0a189d57d034c61b71a9014d28780e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cell Fusion
199 rdf:type schema:DefinedTerm
200 Nf3e899830b7346cd815808ac4f856b27 rdf:first sg:person.01240134742.71
201 rdf:rest N450d500da5a14a62974bf57d731d8d94
202 Nf9447283010f49f6a19cfa8fb802c63f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice, Inbred Strains
204 rdf:type schema:DefinedTerm
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biochemistry and Cell Biology
210 rdf:type schema:DefinedTerm
211 sg:journal.1005222 schema:issn 0031-6768
212 1432-2013
213 schema:name Pflügers Archiv - European Journal of Physiology
214 rdf:type schema:Periodical
215 sg:person.01240134742.71 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
216 schema:familyName Rousseau
217 schema:givenName A. S.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240134742.71
219 rdf:type schema:Person
220 sg:person.01262116511.39 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
221 schema:familyName Sibille
222 schema:givenName B.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262116511.39
224 rdf:type schema:Person
225 sg:person.01263111703.63 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
226 schema:familyName Grimaldi
227 schema:givenName P. A.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263111703.63
229 rdf:type schema:Person
230 sg:person.01306674653.24 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
231 schema:familyName Murdaca
232 schema:givenName J.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306674653.24
234 rdf:type schema:Person
235 sg:person.01340322655.48 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
236 schema:familyName Wagner
237 schema:givenName N.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340322655.48
239 rdf:type schema:Person
240 sg:person.01344236736.51 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
241 schema:familyName Lopez
242 schema:givenName P.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344236736.51
244 rdf:type schema:Person
245 sg:person.0637737663.80 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
246 schema:familyName Gaudel
247 schema:givenName C.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637737663.80
249 rdf:type schema:Person
250 sg:person.0666746036.03 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
251 schema:familyName Giordano
252 schema:givenName C.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666746036.03
254 rdf:type schema:Person
255 sg:person.0765410632.65 schema:affiliation https://www.grid.ac/institutes/grid.10737.32
256 schema:familyName Jehl-Piétri
257 schema:givenName C.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765410632.65
259 rdf:type schema:Person
260 sg:pub.10.1007/bf00305374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047434986
261 https://doi.org/10.1007/bf00305374
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/bf00318695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015659644
264 https://doi.org/10.1007/bf00318695
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/bf01923439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038604665
267 https://doi.org/10.1007/bf01923439
268 rdf:type schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1074747890 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1075344134 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1081884239 schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1082555983 schema:CreativeWork
273 https://doi.org/10.1002/dmrr.656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019133445
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/jemt.1070300504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020953383
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/mus.880170607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034011343
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1006/excr.2002.5653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048819224
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/0014-4827(61)90450-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008777421
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/1047-8477(90)90111-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1051948913
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.bbadis.2004.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004349661
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.cardiores.2005.10.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013725097
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.cell.2005.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033912783
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.cellsig.2007.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005946233
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.jmb.2007.06.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002687554
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0014-5793(00)01554-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002098966
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0092-8674(03)00269-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014706912
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0960-894x(03)00207-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038763252
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1034/j.1399-0004.2000.570103.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012258360
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1046/j.0001-6772.2003.01238.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024726786
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1046/j.1365-201x.1999.00619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023076372
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.091021198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006226204
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1083/jcb.9.2.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010893613
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1091/mbc.e05-01-0055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007677840
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/nar/27.19.e27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022152428
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1096/fj.03-0269fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1053332957
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1111/j.1365-2990.1993.tb00451.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547491
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1139/h96-014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045972121
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1146/annurev.biochem.75.103004.142622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018598309
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1152/ajpcell.00532.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009514323
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1152/ajpendo.00581.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045415755
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1152/jappl.1995.78.5.1969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082449365
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1152/jappl.1999.87.2.634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074506336
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1152/jappl.1999.87.5.1705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074550461
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1152/jappl.2001.90.4.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074783248
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1152/japplphysiol.00394.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048637158
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1152/japplphysiol.00913.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031153233
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1152/japplphysiol.01227.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010992692
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/01.atv.0000252790.70572.0c schema:sameAs https://app.dimensions.ai/details/publication/pub.1004162314
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1242/jcs.02602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017517525
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1249/00005768-198910001-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013191294
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1677/jme.1.01499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046520091
348 rdf:type schema:CreativeWork
349 https://www.grid.ac/institutes/grid.10737.32 schema:alternateName Nice Sophia Antipolis University
350 schema:name INSERM U907, Université de Nice-Sophia Antipolis, Faculté de Médecine, 28 avenue de Valombrose, 06107, Nice, France
351 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...