Peroxisome proliferator-activated receptor β activation promotes myonuclear accretion in skeletal muscle of adult and aged mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-09

AUTHORS

C. Giordano, A. S. Rousseau, N. Wagner, C. Gaudel, J. Murdaca, C. Jehl-Piétri, B. Sibille, P. A. Grimaldi, P. Lopez

ABSTRACT

We reported recently that peroxisome proliferator-activated receptor beta (PPARbeta) activation promotes a calcineurin-dependent exercise-like remodelling characterised by increased numbers of oxidative fibres and capillaries. As physical exercise also induces myonuclear accretion, we investigated whether PPARbeta activation alters myonuclear density. Transgenic muscle-specific PPARbeta over-expression induced 14% increase of myonuclear density. Pharmacological PPARbeta activation promoted rapid and massive myonuclear accretion (20% increase after 48 h), which is dependent upon calcineurin/nuclear factor of activated T cells signalling pathway. In vivo bromodeoxyuridine labelling and proliferating cell nuclear antigen immunodetection revealed that PPARbeta activation did not promote cell proliferation, suggesting that the PPARbeta-promoted myonuclear accretion involves fusion of pre-existing muscle precursor cells to myofibres rather than cell division. Finally, we showed that in skeletal muscle, ageing led to a down-regulation of PPARbeta accompanied by decrease of both oxidative fibre number and myonuclear density. PPARbeta pharmacological activation counteracts, at least in part, the ageing-driven muscle remodelling. More... »

PAGES

901-913

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-009-0676-9

DOI

http://dx.doi.org/10.1007/s00424-009-0676-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022899108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19415321


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