A new methodological approach to assess cardiac work by pressure–volume and stress–length relations in patients with aortic valve stenosis and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

P. Alter, H. Rupp, M. B. Rominger, K. J. Klose, B. Maisch

ABSTRACT

In experimental animals, cardiac work is derived from pressure-volume area and analyzed further using stress-length relations. Lack of methods for determining accurately myocardial mass has until now prevented the use of stress-length relations in patients. We hypothesized, therefore, that not only pressure-volume loops but also stress-length diagrams can be derived from cardiac volume and cardiac mass as assessed by cardiac magnetic resonance imaging (CMR) and invasively measured pressure. Left ventricular (LV) volume and myocardial mass were assessed in seven patients with aortic valve stenosis (AS), eight with dilated cardiomyopathy (DCM), and eight controls using electrocardiogram (ECG)-gated CMR. LV pressure was measured invasively. Pressure-volume curves were calculated based on ECG triggering. Stroke work was assessed as area within the pressure-volume loop. LV wall stress was calculated using a thick-wall sphere model. Similarly, stress-length loops were calculated to quantify stress-length-based work. Taking the LV geometry into account, the normalization with regard to ventricular circumference resulted in "myocardial work." Patients with AS (valve area 0.73+/-0.18 cm(2)) exhibited an increased LV myocardial mass when compared with controls (P<0.05). LV wall stress was increased in DCM but not in AS. Stroke work of AS was unchanged when compared with controls (0.539+/-0.272 vs 0.621+/-0.138 Nm, not significant), whereas DCM exhibited a significant depression (0.367+/-0.157 Nm, P<0.05). Myocardial work was significantly reduced in both AS and DCM when compared with controls (129.8+/-69.6, 200.6+/-80.1, 332.2+/-89.6 Nm/m(2), P<0.05), also after normalization (7.40+/-5.07, 6.27+/-3.20, 14.6+/-4.07 Nm/m(2), P<0.001). It is feasible to obtain LV pressure-volume and stress-length diagrams in patients based on the present novel methodological approach of using CMR and invasive pressure measurement. Myocardial work was reduced in patients with DCM and noteworthy also in AS, while stroke work was reduced in DCM only. Most likely, deterioration of myocardial work is crucial for the prognosis. It is suggested to include these basic physiological procedures in the clinical assessment of the pump function of the heart. More... »

PAGES

627-636

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00424-007-0323-2

DOI

http://dx.doi.org/10.1007/s00424-007-0323-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031428248

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17721708


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aortic Valve Stenosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiac Catheterization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiomyopathy, Dilated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertrophy, Left Ventricular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Cine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Cardiovascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Mechanical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Pressure", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Internal Medicine\u2014Cardiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alter", 
        "givenName": "P.", 
        "id": "sg:person.01065373312.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065373312.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Internal Medicine\u2014Cardiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rupp", 
        "givenName": "H.", 
        "id": "sg:person.01177445163.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177445163.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Radiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rominger", 
        "givenName": "M. B.", 
        "id": "sg:person.01024561317.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024561317.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Radiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klose", 
        "givenName": "K. J.", 
        "id": "sg:person.0745120173.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745120173.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Philipp University of Marburg", 
          "id": "https://www.grid.ac/institutes/grid.10253.35", 
          "name": [
            "Internal Medicine\u2014Cardiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maisch", 
        "givenName": "B.", 
        "id": "sg:person.0630132362.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630132362.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/hrt.73.2.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000635662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-003-1018-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002087932", 
          "https://doi.org/10.1007/s00424-003-1018-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0702312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002471298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-4215(06)80305-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005692059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00363320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005971989", 
          "https://doi.org/10.1007/bf00363320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00363320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005971989", 
          "https://doi.org/10.1007/bf00363320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01907105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009805882", 
          "https://doi.org/10.1007/bf01907105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01907105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009805882", 
          "https://doi.org/10.1007/bf01907105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-6039-1_54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010674780", 
          "https://doi.org/10.1007/978-1-4684-6039-1_54"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.13.2.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011340295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)32101-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018563229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)32101-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018563229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.102.12.1388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021117692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y07-076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021992734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(69)86379-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023993459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00555.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025397523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.106.637827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025609171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-4215(07)60232-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026995154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.33.2.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027091312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.49.4.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028450760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2005.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029454750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1007181626766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030570861", 
          "https://doi.org/10.1023/a:1007181626766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032547270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00059-006-2911-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033395163", 
          "https://doi.org/10.1007/s00059-006-2911-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02443288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033626186", 
          "https://doi.org/10.1007/bf02443288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02443288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033626186", 
          "https://doi.org/10.1007/bf02443288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00059-004-2578-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035112554", 
          "https://doi.org/10.1007/s00059-004-2578-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.69.4.836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043609180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.67.6.1355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044651733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.1999.1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046257220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2005.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046685056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816090-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048607545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816090-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048607545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.63.1.204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048818015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01906378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050030533", 
          "https://doi.org/10.1007/bf01906378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01906378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050030533", 
          "https://doi.org/10.1007/bf01906378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051688608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.10.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051688608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00138.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052891311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/14.3.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059485829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/16.suppl_o.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059575246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.96.10.3681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063338154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1990.258.5.h1281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078683942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079477654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1988.255.3.h679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079732610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1980.238.6.h917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082324836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/6.3.14s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082818298"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-01", 
    "datePublishedReg": "2008-01-01", 
    "description": "In experimental animals, cardiac work is derived from pressure-volume area and analyzed further using stress-length relations. Lack of methods for determining accurately myocardial mass has until now prevented the use of stress-length relations in patients. We hypothesized, therefore, that not only pressure-volume loops but also stress-length diagrams can be derived from cardiac volume and cardiac mass as assessed by cardiac magnetic resonance imaging (CMR) and invasively measured pressure. Left ventricular (LV) volume and myocardial mass were assessed in seven patients with aortic valve stenosis (AS), eight with dilated cardiomyopathy (DCM), and eight controls using electrocardiogram (ECG)-gated CMR. LV pressure was measured invasively. Pressure-volume curves were calculated based on ECG triggering. Stroke work was assessed as area within the pressure-volume loop. LV wall stress was calculated using a thick-wall sphere model. Similarly, stress-length loops were calculated to quantify stress-length-based work. Taking the LV geometry into account, the normalization with regard to ventricular circumference resulted in \"myocardial work.\" Patients with AS (valve area 0.73+/-0.18 cm(2)) exhibited an increased LV myocardial mass when compared with controls (P<0.05). LV wall stress was increased in DCM but not in AS. Stroke work of AS was unchanged when compared with controls (0.539+/-0.272 vs 0.621+/-0.138 Nm, not significant), whereas DCM exhibited a significant depression (0.367+/-0.157 Nm, P<0.05). Myocardial work was significantly reduced in both AS and DCM when compared with controls (129.8+/-69.6, 200.6+/-80.1, 332.2+/-89.6 Nm/m(2), P<0.05), also after normalization (7.40+/-5.07, 6.27+/-3.20, 14.6+/-4.07 Nm/m(2), P<0.001). It is feasible to obtain LV pressure-volume and stress-length diagrams in patients based on the present novel methodological approach of using CMR and invasive pressure measurement. Myocardial work was reduced in patients with DCM and noteworthy also in AS, while stroke work was reduced in DCM only. Most likely, deterioration of myocardial work is crucial for the prognosis. It is suggested to include these basic physiological procedures in the clinical assessment of the pump function of the heart.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00424-007-0323-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1005222", 
        "issn": [
          "0031-6768", 
          "1432-2013"
        ], 
        "name": "Pfl\u00fcgers Archiv - European Journal of Physiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "455"
      }
    ], 
    "name": "A new methodological approach to assess cardiac work by pressure\u2013volume and stress\u2013length relations in patients with aortic valve stenosis and dilated cardiomyopathy", 
    "pagination": "627-636", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95b7b4a49a8b2e76e96822dceee05b715687811f2fdf1fe817d0209d21c83434"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17721708"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0154720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00424-007-0323-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031428248"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00424-007-0323-2", 
      "https://app.dimensions.ai/details/publication/pub.1031428248"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13104_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00424-007-0323-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00424-007-0323-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00424-007-0323-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00424-007-0323-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00424-007-0323-2'


 

This table displays all metadata directly associated to this object as RDF triples.

294 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00424-007-0323-2 schema:about N0fd184bce2214de1a6a829c3d14b9a34
2 N1e56351304614cad8b289febdd1105f5
3 N26bb2165f75241538b7fb12c293bb3d4
4 N506a2b64fdaa4ef682a6cc0f07972b7d
5 N6f0491b057da44aeba5abc18f9dc1fe5
6 N841f36cb284040f3938a2a9a31b9459e
7 N8cbc598f6da4416192c6c91ac2dbb82b
8 N8fe91e4d53954da1b3fe8e1cecff9d53
9 Na4745ddbcae34cd7b30bb09c9e418b53
10 Na4c5c6948f364a4d9b8099406722f197
11 Na64763f742404a75b45efb5a65707081
12 Nad12a2929c744ae8839331dcb2d32514
13 Nd02c4d5f0f4d4fe6a512be2a20409458
14 Nd4571a1fb58940a38584a94ab5ef80d1
15 Ne450e7b5535343da97e00969a2e9f80b
16 Nec68662815be456887c2f2e461300abc
17 Nfb3ac8f47eda42d1a8a50f2eff721d7a
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author Ndee1f219963d4fac8f976a1cb6b05e8e
21 schema:citation sg:pub.10.1007/978-1-4684-6039-1_54
22 sg:pub.10.1007/bf00363320
23 sg:pub.10.1007/bf01906378
24 sg:pub.10.1007/bf01907105
25 sg:pub.10.1007/bf02443288
26 sg:pub.10.1007/s00059-004-2578-0
27 sg:pub.10.1007/s00059-006-2911-x
28 sg:pub.10.1007/s00424-003-1018-y
29 sg:pub.10.1023/a:1007181626766
30 https://app.dimensions.ai/details/publication/pub.1079477654
31 https://doi.org/10.1006/jmcc.1999.1052
32 https://doi.org/10.1016/j.ahj.2005.06.016
33 https://doi.org/10.1016/j.bbrc.2005.10.195
34 https://doi.org/10.1016/j.cardiores.2005.03.023
35 https://doi.org/10.1016/s0006-3495(69)86379-4
36 https://doi.org/10.1016/s0140-6736(01)32101-3
37 https://doi.org/10.1016/s1567-4215(06)80305-x
38 https://doi.org/10.1016/s1567-4215(07)60232-x
39 https://doi.org/10.1038/sj.bjp.0702312
40 https://doi.org/10.1056/nejmoa043399
41 https://doi.org/10.1093/ajh/6.3.14s
42 https://doi.org/10.1093/cvr/14.3.142
43 https://doi.org/10.1093/eurheartj/16.suppl_o.107
44 https://doi.org/10.1097/00004872-199816090-00016
45 https://doi.org/10.1136/hrt.73.2.139
46 https://doi.org/10.1139/y07-076
47 https://doi.org/10.1152/ajpheart.00138.2005
48 https://doi.org/10.1152/ajpheart.00555.2003
49 https://doi.org/10.1152/ajpheart.1980.238.6.h917
50 https://doi.org/10.1152/ajpheart.1988.255.3.h679
51 https://doi.org/10.1152/ajpheart.1990.258.5.h1281
52 https://doi.org/10.1161/01.cir.102.12.1388
53 https://doi.org/10.1161/01.cir.63.1.204
54 https://doi.org/10.1161/01.cir.69.4.836
55 https://doi.org/10.1161/01.cir.96.10.3681
56 https://doi.org/10.1161/01.res.13.2.91
57 https://doi.org/10.1161/01.res.33.2.233
58 https://doi.org/10.1161/01.res.49.4.829
59 https://doi.org/10.1161/01.res.67.6.1355
60 https://doi.org/10.1161/circulationaha.106.637827
61 schema:datePublished 2008-01
62 schema:datePublishedReg 2008-01-01
63 schema:description In experimental animals, cardiac work is derived from pressure-volume area and analyzed further using stress-length relations. Lack of methods for determining accurately myocardial mass has until now prevented the use of stress-length relations in patients. We hypothesized, therefore, that not only pressure-volume loops but also stress-length diagrams can be derived from cardiac volume and cardiac mass as assessed by cardiac magnetic resonance imaging (CMR) and invasively measured pressure. Left ventricular (LV) volume and myocardial mass were assessed in seven patients with aortic valve stenosis (AS), eight with dilated cardiomyopathy (DCM), and eight controls using electrocardiogram (ECG)-gated CMR. LV pressure was measured invasively. Pressure-volume curves were calculated based on ECG triggering. Stroke work was assessed as area within the pressure-volume loop. LV wall stress was calculated using a thick-wall sphere model. Similarly, stress-length loops were calculated to quantify stress-length-based work. Taking the LV geometry into account, the normalization with regard to ventricular circumference resulted in "myocardial work." Patients with AS (valve area 0.73+/-0.18 cm(2)) exhibited an increased LV myocardial mass when compared with controls (P<0.05). LV wall stress was increased in DCM but not in AS. Stroke work of AS was unchanged when compared with controls (0.539+/-0.272 vs 0.621+/-0.138 Nm, not significant), whereas DCM exhibited a significant depression (0.367+/-0.157 Nm, P<0.05). Myocardial work was significantly reduced in both AS and DCM when compared with controls (129.8+/-69.6, 200.6+/-80.1, 332.2+/-89.6 Nm/m(2), P<0.05), also after normalization (7.40+/-5.07, 6.27+/-3.20, 14.6+/-4.07 Nm/m(2), P<0.001). It is feasible to obtain LV pressure-volume and stress-length diagrams in patients based on the present novel methodological approach of using CMR and invasive pressure measurement. Myocardial work was reduced in patients with DCM and noteworthy also in AS, while stroke work was reduced in DCM only. Most likely, deterioration of myocardial work is crucial for the prognosis. It is suggested to include these basic physiological procedures in the clinical assessment of the pump function of the heart.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N577a2e27f46e4883aff41c4ed851c749
68 Ne774272a24df4aa9b136a907d6f8d2c9
69 sg:journal.1005222
70 schema:name A new methodological approach to assess cardiac work by pressure–volume and stress–length relations in patients with aortic valve stenosis and dilated cardiomyopathy
71 schema:pagination 627-636
72 schema:productId N29520c4a851c46308c6f25802e6969f9
73 N3cf03b4fa30a4669b5017935faad9bbb
74 N42f516c7e48d484985deed20c5b1d620
75 N8ebc7b52664b4e93aa95fbd53150b7ab
76 Ne60d484fbbdf401f8b2c8692ce6fa669
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031428248
78 https://doi.org/10.1007/s00424-007-0323-2
79 schema:sdDatePublished 2019-04-11T14:33
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N2cc05839a47a44c19a461bfebf39c5b5
82 schema:url http://link.springer.com/10.1007/s00424-007-0323-2
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N0057392259da421cb4b60ba79e225829 rdf:first sg:person.01024561317.02
87 rdf:rest Nbf7cdc1e8ae942698680c526806c83a7
88 N0fd184bce2214de1a6a829c3d14b9a34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Stress, Mechanical
90 rdf:type schema:DefinedTerm
91 N1010471c9f784c6c849cdae2b7d4f320 rdf:first sg:person.0630132362.75
92 rdf:rest rdf:nil
93 N1e56351304614cad8b289febdd1105f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Predictive Value of Tests
95 rdf:type schema:DefinedTerm
96 N26bb2165f75241538b7fb12c293bb3d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Case-Control Studies
98 rdf:type schema:DefinedTerm
99 N29520c4a851c46308c6f25802e6969f9 schema:name doi
100 schema:value 10.1007/s00424-007-0323-2
101 rdf:type schema:PropertyValue
102 N2cc05839a47a44c19a461bfebf39c5b5 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N37d145a56c584d14b1224d77f24f1839 rdf:first sg:person.01177445163.00
105 rdf:rest N0057392259da421cb4b60ba79e225829
106 N3cf03b4fa30a4669b5017935faad9bbb schema:name readcube_id
107 schema:value 95b7b4a49a8b2e76e96822dceee05b715687811f2fdf1fe817d0209d21c83434
108 rdf:type schema:PropertyValue
109 N42f516c7e48d484985deed20c5b1d620 schema:name pubmed_id
110 schema:value 17721708
111 rdf:type schema:PropertyValue
112 N506a2b64fdaa4ef682a6cc0f07972b7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Heart Function Tests
114 rdf:type schema:DefinedTerm
115 N577a2e27f46e4883aff41c4ed851c749 schema:issueNumber 4
116 rdf:type schema:PublicationIssue
117 N6f0491b057da44aeba5abc18f9dc1fe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Feasibility Studies
119 rdf:type schema:DefinedTerm
120 N841f36cb284040f3938a2a9a31b9459e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Myocardial Contraction
122 rdf:type schema:DefinedTerm
123 N8cbc598f6da4416192c6c91ac2dbb82b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cardiac Catheterization
125 rdf:type schema:DefinedTerm
126 N8ebc7b52664b4e93aa95fbd53150b7ab schema:name nlm_unique_id
127 schema:value 0154720
128 rdf:type schema:PropertyValue
129 N8fe91e4d53954da1b3fe8e1cecff9d53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cardiomyopathy, Dilated
131 rdf:type schema:DefinedTerm
132 Na4745ddbcae34cd7b30bb09c9e418b53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Hypertrophy, Left Ventricular
134 rdf:type schema:DefinedTerm
135 Na4c5c6948f364a4d9b8099406722f197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Prospective Studies
137 rdf:type schema:DefinedTerm
138 Na64763f742404a75b45efb5a65707081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Electrocardiography
140 rdf:type schema:DefinedTerm
141 Nad12a2929c744ae8839331dcb2d32514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Aortic Valve Stenosis
143 rdf:type schema:DefinedTerm
144 Nbf7cdc1e8ae942698680c526806c83a7 rdf:first sg:person.0745120173.71
145 rdf:rest N1010471c9f784c6c849cdae2b7d4f320
146 Nd02c4d5f0f4d4fe6a512be2a20409458 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Ventricular Pressure
148 rdf:type schema:DefinedTerm
149 Nd4571a1fb58940a38584a94ab5ef80d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Models, Cardiovascular
151 rdf:type schema:DefinedTerm
152 Ndee1f219963d4fac8f976a1cb6b05e8e rdf:first sg:person.01065373312.37
153 rdf:rest N37d145a56c584d14b1224d77f24f1839
154 Ne450e7b5535343da97e00969a2e9f80b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Magnetic Resonance Imaging, Cine
156 rdf:type schema:DefinedTerm
157 Ne60d484fbbdf401f8b2c8692ce6fa669 schema:name dimensions_id
158 schema:value pub.1031428248
159 rdf:type schema:PropertyValue
160 Ne774272a24df4aa9b136a907d6f8d2c9 schema:volumeNumber 455
161 rdf:type schema:PublicationVolume
162 Nec68662815be456887c2f2e461300abc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Blood Pressure
164 rdf:type schema:DefinedTerm
165 Nfb3ac8f47eda42d1a8a50f2eff721d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
172 schema:name Cardiorespiratory Medicine and Haematology
173 rdf:type schema:DefinedTerm
174 sg:journal.1005222 schema:issn 0031-6768
175 1432-2013
176 schema:name Pflügers Archiv - European Journal of Physiology
177 rdf:type schema:Periodical
178 sg:person.01024561317.02 schema:affiliation https://www.grid.ac/institutes/grid.10253.35
179 schema:familyName Rominger
180 schema:givenName M. B.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024561317.02
182 rdf:type schema:Person
183 sg:person.01065373312.37 schema:affiliation https://www.grid.ac/institutes/grid.10253.35
184 schema:familyName Alter
185 schema:givenName P.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065373312.37
187 rdf:type schema:Person
188 sg:person.01177445163.00 schema:affiliation https://www.grid.ac/institutes/grid.10253.35
189 schema:familyName Rupp
190 schema:givenName H.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177445163.00
192 rdf:type schema:Person
193 sg:person.0630132362.75 schema:affiliation https://www.grid.ac/institutes/grid.10253.35
194 schema:familyName Maisch
195 schema:givenName B.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630132362.75
197 rdf:type schema:Person
198 sg:person.0745120173.71 schema:affiliation https://www.grid.ac/institutes/grid.10253.35
199 schema:familyName Klose
200 schema:givenName K. J.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745120173.71
202 rdf:type schema:Person
203 sg:pub.10.1007/978-1-4684-6039-1_54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010674780
204 https://doi.org/10.1007/978-1-4684-6039-1_54
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/bf00363320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005971989
207 https://doi.org/10.1007/bf00363320
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/bf01906378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050030533
210 https://doi.org/10.1007/bf01906378
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/bf01907105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009805882
213 https://doi.org/10.1007/bf01907105
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/bf02443288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033626186
216 https://doi.org/10.1007/bf02443288
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s00059-004-2578-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035112554
219 https://doi.org/10.1007/s00059-004-2578-0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s00059-006-2911-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033395163
222 https://doi.org/10.1007/s00059-006-2911-x
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s00424-003-1018-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1002087932
225 https://doi.org/10.1007/s00424-003-1018-y
226 rdf:type schema:CreativeWork
227 sg:pub.10.1023/a:1007181626766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030570861
228 https://doi.org/10.1023/a:1007181626766
229 rdf:type schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1079477654 schema:CreativeWork
231 https://doi.org/10.1006/jmcc.1999.1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046257220
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.ahj.2005.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029454750
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.bbrc.2005.10.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051688608
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.cardiores.2005.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046685056
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0006-3495(69)86379-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023993459
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0140-6736(01)32101-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018563229
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s1567-4215(06)80305-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005692059
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s1567-4215(07)60232-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026995154
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1038/sj.bjp.0702312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002471298
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1056/nejmoa043399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032547270
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/ajh/6.3.14s schema:sameAs https://app.dimensions.ai/details/publication/pub.1082818298
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1093/cvr/14.3.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059485829
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/eurheartj/16.suppl_o.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059575246
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00004872-199816090-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048607545
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1136/hrt.73.2.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000635662
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1139/y07-076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021992734
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1152/ajpheart.00138.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052891311
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1152/ajpheart.00555.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025397523
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajpheart.1980.238.6.h917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082324836
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajpheart.1988.255.3.h679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079732610
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpheart.1990.258.5.h1281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078683942
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1161/01.cir.102.12.1388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021117692
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/01.cir.63.1.204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048818015
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1161/01.cir.69.4.836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043609180
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1161/01.cir.96.10.3681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338154
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/01.res.13.2.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011340295
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1161/01.res.33.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027091312
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.res.49.4.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028450760
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.res.67.6.1355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044651733
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/circulationaha.106.637827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025609171
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.10253.35 schema:alternateName Philipp University of Marburg
292 schema:name Internal Medicine—Cardiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany
293 Radiology, Philipps University, Baldingerstrasse, 35033, Marburg, Germany
294 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...