Clinical significance of lower perigastric lymph nodes dissection in Siewert type II/III adenocarcinoma of esophagogastric junction: a retrospective propensity score ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-18

AUTHORS

Zong-Lin Li, Lin-Yong Zhao, Wei-Han Zhang, Kai Liu, Hua-Yang Pang, Xiao-Long Chen, Xin-Zu Chen, Kun Yang, Jian-Kun Hu

ABSTRACT

PurposeThe optimal surgical procedure, whether total gastrectomy (TG) or proximal gastrectomy (PG), for Siewert type II/III adenocarcinoma of esophagogastric junction (AEG) has not been standardised, primarily because the optimal extent of lymph node (LN) dissection for AEG based on the metastatic rate of perigastric LNs remains under debate. The aim of this study was to investigate the metastatic incidence and prognostic significance of lower perigastric lymph nodes (LPLN), including No.4d, 5, 6 and 12a LN stations, in Siewert type II/III AEG.MethodsA total of 701 patients with Siewert type II/III AEG who received transabdominal open gastrectomy (425 patients with TG and 276 patients with PG) from 2010 to 2015 in West China Hospital were retrospectively included. Based on the clinicopathological information of TG patients, the risk factors of LPLN-positive patients were evaluated, and the metastatic incidence as well as the therapeutic value (TV) index of each LN station was assessed. Moreover, the 5-year overall survival (OS) rates between LPLN-positive and LPLN-negative groups were compared in TG patients, and the postoperative survival difference between TG and PG patients was also compared, using propensity score matching (PSM) method.ResultsTumour size (≥ 5 cm, OR = 1.481, p = 0.002) and pT stage (pT4, OR = 2.755, p = 0.024) were significant risk factors for patients with LPLN metastasis. For patients with tumour size more than 5 cm or pT4 stage, the metastatic rates of LPLN for Siewert type II, III and II/III AEG were 31.67%, 34.69% and 33.03%, whereas the TV indexes of LPLN for them were 5.76, 5.62 and 5.38, respectively. LPLN was a significant independent prognostic factor (HR = 1.422, p = 0.028), and positive LPLN was related to worse prognosis (p < 0.05). For patients with tumour size more than 5 cm or pT4 stage, TG patients were illustrated to have a better prognosis than PG patients, with 5-year OS rates of 58.9% vs 38.2% for Siewert type II AEG (χ2 = 4.159, p = 0.041), 68.9% vs 50.2% for Siewert type III AEG (χ2 = 5.630, p = 0.018) and 65.1% vs 40.3% for Siewert type II/III AEG (χ2 = 12.604, p < 0.001), respectively.ConclusionsLPLN metastasis is a poor prognostic factor for patients with Siewert II/III AEG. LPLN dissection may improve the long-term survival of patients with tumour size more than 5 cm or pT4 stage, and TG might be more suitable for this kind of cancer. More... »

PAGES

1-14

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-021-02380-w

DOI

http://dx.doi.org/10.1007/s00423-021-02380-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142677727

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34792614


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zong-Lin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Lin-Yong", 
        "id": "sg:person.015057113251.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015057113251.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Wei-Han", 
        "id": "sg:person.01006204242.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006204242.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Kai", 
        "id": "sg:person.012734705051.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012734705051.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pang", 
        "givenName": "Hua-Yang", 
        "id": "sg:person.011277602707.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011277602707.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiao-Long", 
        "id": "sg:person.016101103055.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016101103055.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xin-Zu", 
        "id": "sg:person.01112737343.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112737343.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Kun", 
        "id": "sg:person.0751500761.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751500761.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.412901.f", 
          "name": [
            "Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Jian-Kun", 
        "id": "sg:person.015160633665.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015160633665.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-018-6654-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105865531", 
          "https://doi.org/10.1245/s10434-018-6654-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-020-01042-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1124870346", 
          "https://doi.org/10.1007/s10120-020-01042-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-011-0042-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053291814", 
          "https://doi.org/10.1007/s10120-011-0042-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1362-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000439657", 
          "https://doi.org/10.1245/s10434-010-1362-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-018-3935-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107684280", 
          "https://doi.org/10.1007/s11605-018-3935-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-014-0364-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019805469", 
          "https://doi.org/10.1007/s10120-014-0364-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-013-3036-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042694816", 
          "https://doi.org/10.1245/s10434-013-3036-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-016-1422-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027841975", 
          "https://doi.org/10.1007/s00423-016-1422-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-014-0439-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014886010", 
          "https://doi.org/10.1007/s10120-014-0439-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-016-0663-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030513934", 
          "https://doi.org/10.1007/s10120-016-0663-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-11-18", 
    "datePublishedReg": "2021-11-18", 
    "description": "PurposeThe optimal surgical procedure, whether total gastrectomy (TG) or proximal gastrectomy (PG), for Siewert type II/III adenocarcinoma of esophagogastric junction (AEG) has not been standardised, primarily because the optimal extent of lymph node (LN) dissection for AEG based on the metastatic rate of perigastric LNs remains under debate. The aim of this study was to investigate the metastatic incidence and prognostic significance of lower perigastric lymph nodes (LPLN), including No.4d, 5, 6 and 12a LN stations, in Siewert type II/III AEG.MethodsA total of 701 patients with Siewert type II/III AEG who received transabdominal open gastrectomy (425 patients with TG and 276 patients with PG) from 2010 to 2015 in West China Hospital were retrospectively included. Based on the clinicopathological information of TG patients, the risk factors of LPLN-positive patients were evaluated, and the metastatic incidence as well as the therapeutic value (TV) index of each LN station was assessed. Moreover, the 5-year overall survival (OS) rates between LPLN-positive and LPLN-negative groups were compared in TG patients, and the postoperative survival difference between TG and PG patients was also compared, using propensity score matching (PSM) method.ResultsTumour size (\u2265\u20095\u00a0cm, OR\u2009=\u20091.481, p\u2009=\u20090.002) and pT stage (pT4, OR\u2009=\u20092.755, p\u2009=\u20090.024) were significant risk factors for patients with LPLN metastasis. For patients with tumour size more than 5\u00a0cm or pT4 stage, the metastatic rates of LPLN for Siewert type II, III and II/III AEG were 31.67%, 34.69% and 33.03%, whereas the TV indexes of LPLN for them were 5.76, 5.62 and 5.38, respectively. LPLN was a significant independent prognostic factor (HR\u2009=\u20091.422, p\u2009=\u20090.028), and positive LPLN was related to worse prognosis (p\u2009<\u20090.05). For patients with tumour size more than 5\u00a0cm or pT4 stage, TG patients were illustrated to have a better prognosis than PG patients, with 5-year OS rates of 58.9% vs 38.2% for Siewert type II AEG (\u03c72\u2009=\u20094.159, p\u2009=\u20090.041), 68.9% vs 50.2% for Siewert type III AEG (\u03c72\u2009=\u20095.630, p\u2009=\u20090.018) and 65.1% vs 40.3% for Siewert type II/III AEG (\u03c72\u2009=\u200912.604, p\u2009<\u20090.001), respectively.ConclusionsLPLN metastasis is a poor prognostic factor for patients with Siewert II/III AEG. LPLN dissection may improve the long-term survival of patients with tumour size more than 5\u00a0cm or pT4 stage, and TG might be more suitable for this kind of cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00423-021-02380-w", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1371202", 
        "issn": [
          "1435-2443", 
          "1435-2451"
        ], 
        "name": "Langenbeck's Archives of Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "Siewert type II/III AEG", 
      "Siewert type II/III adenocarcinoma", 
      "lymph node dissection", 
      "total gastrectomy", 
      "pT4 stage", 
      "TG patients", 
      "tumor size", 
      "proximal gastrectomy", 
      "node dissection", 
      "PG patients", 
      "prognostic factors", 
      "LN stations", 
      "esophagogastric junction", 
      "metastatic rate", 
      "risk factors", 
      "metastatic incidence", 
      "Siewert type II AEG", 
      "Siewert type III AEG", 
      "significant independent prognostic factor", 
      "propensity score", 
      "perigastric lymph node dissection", 
      "therapeutic value index", 
      "Siewert type II", 
      "type II AEG", 
      "type III AEG", 
      "retrospective propensity score", 
      "optimal surgical procedure", 
      "perigastric lymph nodes", 
      "overall survival rate", 
      "independent prognostic factor", 
      "poor prognostic factor", 
      "significant risk factors", 
      "West China Hospital", 
      "long-term survival", 
      "kinds of cancers", 
      "perigastric LN", 
      "open gastrectomy", 
      "LPLN metastasis", 
      "LPLN dissection", 
      "lymph nodes", 
      "OS rates", 
      "worse prognosis", 
      "better prognosis", 
      "prognostic significance", 
      "clinicopathological information", 
      "survival differences", 
      "China Hospital", 
      "clinical significance", 
      "surgical procedures", 
      "patients", 
      "survival rate", 
      "gastrectomy", 
      "optimal extent", 
      "dissection", 
      "adenocarcinoma", 
      "AEG", 
      "prognosis", 
      "metastasis", 
      "incidence", 
      "type II", 
      "scores", 
      "factors", 
      "hospital", 
      "TV index", 
      "cancer", 
      "rate", 
      "survival", 
      "index", 
      "total", 
      "significance", 
      "study", 
      "stage", 
      "group", 
      "aim", 
      "junction", 
      "differences", 
      "procedure", 
      "extent", 
      "size", 
      "Ln", 
      "nodes", 
      "information", 
      "method", 
      "debate", 
      "kind", 
      "value index", 
      "stations"
    ], 
    "name": "Clinical significance of lower perigastric lymph nodes dissection in Siewert type II/III adenocarcinoma of esophagogastric junction: a retrospective propensity score matched study", 
    "pagination": "1-14", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1142677727"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00423-021-02380-w"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34792614"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00423-021-02380-w", 
      "https://app.dimensions.ai/details/publication/pub.1142677727"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_891.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00423-021-02380-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-021-02380-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-021-02380-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-021-02380-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-021-02380-w'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      22 PREDICATES      121 URIs      103 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00423-021-02380-w schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nce5344fd19af48d3810d994e5ec2ade0
4 schema:citation sg:pub.10.1007/s00423-016-1422-3
5 sg:pub.10.1007/s10120-011-0042-4
6 sg:pub.10.1007/s10120-014-0364-0
7 sg:pub.10.1007/s10120-014-0439-y
8 sg:pub.10.1007/s10120-016-0663-8
9 sg:pub.10.1007/s10120-020-01042-y
10 sg:pub.10.1007/s11605-018-3935-2
11 sg:pub.10.1245/s10434-010-1362-z
12 sg:pub.10.1245/s10434-013-3036-0
13 sg:pub.10.1245/s10434-018-6654-8
14 schema:datePublished 2021-11-18
15 schema:datePublishedReg 2021-11-18
16 schema:description PurposeThe optimal surgical procedure, whether total gastrectomy (TG) or proximal gastrectomy (PG), for Siewert type II/III adenocarcinoma of esophagogastric junction (AEG) has not been standardised, primarily because the optimal extent of lymph node (LN) dissection for AEG based on the metastatic rate of perigastric LNs remains under debate. The aim of this study was to investigate the metastatic incidence and prognostic significance of lower perigastric lymph nodes (LPLN), including No.4d, 5, 6 and 12a LN stations, in Siewert type II/III AEG.MethodsA total of 701 patients with Siewert type II/III AEG who received transabdominal open gastrectomy (425 patients with TG and 276 patients with PG) from 2010 to 2015 in West China Hospital were retrospectively included. Based on the clinicopathological information of TG patients, the risk factors of LPLN-positive patients were evaluated, and the metastatic incidence as well as the therapeutic value (TV) index of each LN station was assessed. Moreover, the 5-year overall survival (OS) rates between LPLN-positive and LPLN-negative groups were compared in TG patients, and the postoperative survival difference between TG and PG patients was also compared, using propensity score matching (PSM) method.ResultsTumour size (≥ 5 cm, OR = 1.481, p = 0.002) and pT stage (pT4, OR = 2.755, p = 0.024) were significant risk factors for patients with LPLN metastasis. For patients with tumour size more than 5 cm or pT4 stage, the metastatic rates of LPLN for Siewert type II, III and II/III AEG were 31.67%, 34.69% and 33.03%, whereas the TV indexes of LPLN for them were 5.76, 5.62 and 5.38, respectively. LPLN was a significant independent prognostic factor (HR = 1.422, p = 0.028), and positive LPLN was related to worse prognosis (p < 0.05). For patients with tumour size more than 5 cm or pT4 stage, TG patients were illustrated to have a better prognosis than PG patients, with 5-year OS rates of 58.9% vs 38.2% for Siewert type II AEG (χ2 = 4.159, p = 0.041), 68.9% vs 50.2% for Siewert type III AEG (χ2 = 5.630, p = 0.018) and 65.1% vs 40.3% for Siewert type II/III AEG (χ2 = 12.604, p < 0.001), respectively.ConclusionsLPLN metastasis is a poor prognostic factor for patients with Siewert II/III AEG. LPLN dissection may improve the long-term survival of patients with tumour size more than 5 cm or pT4 stage, and TG might be more suitable for this kind of cancer.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf sg:journal.1371202
21 schema:keywords AEG
22 China Hospital
23 LN stations
24 LPLN dissection
25 LPLN metastasis
26 Ln
27 OS rates
28 PG patients
29 Siewert type II
30 Siewert type II AEG
31 Siewert type II/III AEG
32 Siewert type II/III adenocarcinoma
33 Siewert type III AEG
34 TG patients
35 TV index
36 West China Hospital
37 adenocarcinoma
38 aim
39 better prognosis
40 cancer
41 clinical significance
42 clinicopathological information
43 debate
44 differences
45 dissection
46 esophagogastric junction
47 extent
48 factors
49 gastrectomy
50 group
51 hospital
52 incidence
53 independent prognostic factor
54 index
55 information
56 junction
57 kind
58 kinds of cancers
59 long-term survival
60 lymph node dissection
61 lymph nodes
62 metastasis
63 metastatic incidence
64 metastatic rate
65 method
66 node dissection
67 nodes
68 open gastrectomy
69 optimal extent
70 optimal surgical procedure
71 overall survival rate
72 pT4 stage
73 patients
74 perigastric LN
75 perigastric lymph node dissection
76 perigastric lymph nodes
77 poor prognostic factor
78 procedure
79 prognosis
80 prognostic factors
81 prognostic significance
82 propensity score
83 proximal gastrectomy
84 rate
85 retrospective propensity score
86 risk factors
87 scores
88 significance
89 significant independent prognostic factor
90 significant risk factors
91 size
92 stage
93 stations
94 study
95 surgical procedures
96 survival
97 survival differences
98 survival rate
99 therapeutic value index
100 total
101 total gastrectomy
102 tumor size
103 type II
104 type II AEG
105 type III AEG
106 value index
107 worse prognosis
108 schema:name Clinical significance of lower perigastric lymph nodes dissection in Siewert type II/III adenocarcinoma of esophagogastric junction: a retrospective propensity score matched study
109 schema:pagination 1-14
110 schema:productId N9d90448d061b4d018866a8d901575712
111 Ne8cbbb2fa2fa4e18b78184e4e779e6c4
112 Nf39b7726ea0a444a93d824270bf5904d
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142677727
114 https://doi.org/10.1007/s00423-021-02380-w
115 schema:sdDatePublished 2022-05-20T07:38
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher Na4a19ef2bd674a58865173e16eb7f3e8
118 schema:url https://doi.org/10.1007/s00423-021-02380-w
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N43420a1424e84a4b89b9b60a0013f619 rdf:first sg:person.011277602707.46
123 rdf:rest Nc4d3d6f1b396406cb4eba04898ce4754
124 N508ee90c24974fa984bd38ff4e64d322 rdf:first sg:person.015057113251.56
125 rdf:rest Nc71a263926e64dc2a704f8dc79af562e
126 N61215d6c7cb44b839223b5b41d2af1e5 rdf:first sg:person.015160633665.09
127 rdf:rest rdf:nil
128 N6640b69cc9764758a85af895a970d08d rdf:first sg:person.01112737343.37
129 rdf:rest N9b47408ac35e4da5980e142a9a401214
130 N9b47408ac35e4da5980e142a9a401214 rdf:first sg:person.0751500761.58
131 rdf:rest N61215d6c7cb44b839223b5b41d2af1e5
132 N9d90448d061b4d018866a8d901575712 schema:name doi
133 schema:value 10.1007/s00423-021-02380-w
134 rdf:type schema:PropertyValue
135 Na4a19ef2bd674a58865173e16eb7f3e8 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 Nc4d3d6f1b396406cb4eba04898ce4754 rdf:first sg:person.016101103055.62
138 rdf:rest N6640b69cc9764758a85af895a970d08d
139 Nc71a263926e64dc2a704f8dc79af562e rdf:first sg:person.01006204242.10
140 rdf:rest Nf409ec4e1a7743bab81bc3bf8f36d5e9
141 Nce5344fd19af48d3810d994e5ec2ade0 rdf:first Nd717cf14aa7b4150a6a3fc84f2245e47
142 rdf:rest N508ee90c24974fa984bd38ff4e64d322
143 Nd717cf14aa7b4150a6a3fc84f2245e47 schema:affiliation grid-institutes:grid.412901.f
144 schema:familyName Li
145 schema:givenName Zong-Lin
146 rdf:type schema:Person
147 Ne8cbbb2fa2fa4e18b78184e4e779e6c4 schema:name dimensions_id
148 schema:value pub.1142677727
149 rdf:type schema:PropertyValue
150 Nf39b7726ea0a444a93d824270bf5904d schema:name pubmed_id
151 schema:value 34792614
152 rdf:type schema:PropertyValue
153 Nf409ec4e1a7743bab81bc3bf8f36d5e9 rdf:first sg:person.012734705051.89
154 rdf:rest N43420a1424e84a4b89b9b60a0013f619
155 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
156 schema:name Medical and Health Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
159 schema:name Oncology and Carcinogenesis
160 rdf:type schema:DefinedTerm
161 sg:journal.1371202 schema:issn 1435-2443
162 1435-2451
163 schema:name Langenbeck's Archives of Surgery
164 schema:publisher Springer Nature
165 rdf:type schema:Periodical
166 sg:person.01006204242.10 schema:affiliation grid-institutes:grid.412901.f
167 schema:familyName Zhang
168 schema:givenName Wei-Han
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006204242.10
170 rdf:type schema:Person
171 sg:person.01112737343.37 schema:affiliation grid-institutes:grid.412901.f
172 schema:familyName Chen
173 schema:givenName Xin-Zu
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112737343.37
175 rdf:type schema:Person
176 sg:person.011277602707.46 schema:affiliation grid-institutes:grid.412901.f
177 schema:familyName Pang
178 schema:givenName Hua-Yang
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011277602707.46
180 rdf:type schema:Person
181 sg:person.012734705051.89 schema:affiliation grid-institutes:grid.412901.f
182 schema:familyName Liu
183 schema:givenName Kai
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012734705051.89
185 rdf:type schema:Person
186 sg:person.015057113251.56 schema:affiliation grid-institutes:grid.412901.f
187 schema:familyName Zhao
188 schema:givenName Lin-Yong
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015057113251.56
190 rdf:type schema:Person
191 sg:person.015160633665.09 schema:affiliation grid-institutes:grid.412901.f
192 schema:familyName Hu
193 schema:givenName Jian-Kun
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015160633665.09
195 rdf:type schema:Person
196 sg:person.016101103055.62 schema:affiliation grid-institutes:grid.412901.f
197 schema:familyName Chen
198 schema:givenName Xiao-Long
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016101103055.62
200 rdf:type schema:Person
201 sg:person.0751500761.58 schema:affiliation grid-institutes:grid.412901.f
202 schema:familyName Yang
203 schema:givenName Kun
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751500761.58
205 rdf:type schema:Person
206 sg:pub.10.1007/s00423-016-1422-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027841975
207 https://doi.org/10.1007/s00423-016-1422-3
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/s10120-011-0042-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053291814
210 https://doi.org/10.1007/s10120-011-0042-4
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s10120-014-0364-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019805469
213 https://doi.org/10.1007/s10120-014-0364-0
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s10120-014-0439-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1014886010
216 https://doi.org/10.1007/s10120-014-0439-y
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s10120-016-0663-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030513934
219 https://doi.org/10.1007/s10120-016-0663-8
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s10120-020-01042-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1124870346
222 https://doi.org/10.1007/s10120-020-01042-y
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s11605-018-3935-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107684280
225 https://doi.org/10.1007/s11605-018-3935-2
226 rdf:type schema:CreativeWork
227 sg:pub.10.1245/s10434-010-1362-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000439657
228 https://doi.org/10.1245/s10434-010-1362-z
229 rdf:type schema:CreativeWork
230 sg:pub.10.1245/s10434-013-3036-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042694816
231 https://doi.org/10.1245/s10434-013-3036-0
232 rdf:type schema:CreativeWork
233 sg:pub.10.1245/s10434-018-6654-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105865531
234 https://doi.org/10.1245/s10434-018-6654-8
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.412901.f schema:alternateName Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China
237 schema:name Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan Province, No. 37 Guo Xue Xiang Street, 610041, Chengdu, China
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...