Radiologically occult metastatic pancreatic cancer: how can we avoid unbeneficial resection? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-11-28

AUTHORS

Atsushi Oba, Yosuke Inoue, Yoshihiro Ono, Shoichi Irie, Takafumi Sato, Yoshihiro Mise, Hiromichi Ito, Yu Takahashi, Akio Saiura

ABSTRACT

PurposeThis study aimed to clarify the key factors for minimizing unsuitable surgical interventions for patients with radiologically occult metastatic pancreatic cancer (ROMPC), defined as a distant metastasis detected during surgery or within 6 months after resection.MethodsThis study involved 502 patients planned to undergo curative resection for pancreatic cancer between 2008 and 2015. Patients were divided into ROMPC and non-ROMPC groups and evaluated preoperative factors associated with ROMPC.ResultsOverall survival (OS) was significantly lower in the ROMPC group (n = 145) than the non-ROMPC group (n = 357, median survival time [MST] 10.8 vs. 35.3 months, P < 0.001). In the ROMPC group, OS tended to be worse for patients who had pancreatectomies (n = 84) than those who did not (n = 61, MST 10.1 vs. 13.2 months, P = 0.057), and the next chemotherapy started significantly later in patients who had pancreatectomies (P < 0.001). Moreover, OS was significantly lower for patients with (n = 82) than without (n = 63) liver metastases (MST 9.7 vs. 13.0 months, respectively, P = 0.020). The best indicator for patients at higher risk of ROMPC was a combination of carbohydrate antigen 19-9 concentration ≥ 300 U/ml and tumor size ≥ 30 mm.ConclusionsIn the ROMPC group, patients who underwent pancreatectomy had a poorer prognosis than patients not undergoing pancreatectomy. Given that the liver was the most frequent distant metastatic site for ROMPC and had the poorest prognosis, establishing a strategy featuring new imaging modalities to detect radiologically occult liver metastases is necessary. More... »

PAGES

35-41

References to SciGraph publications

  • 2014-02-26. Usefulness of Contrast-Enhanced Intraoperative Ultrasound in Identifying Disappearing Liver Metastases from Colorectal Carcinoma After Chemotherapy in ANNALS OF SURGICAL ONCOLOGY
  • 2018-09-15. Prognostic factors for actual long-term survival in the era of multidisciplinary treatment for pancreatic ductal adenocarcinoma in LANGENBECK'S ARCHIVES OF SURGERY
  • 2019-01-16. Significance of neoadjuvant therapy for borderline resectable pancreatic cancer: a multicenter retrospective study in LANGENBECK'S ARCHIVES OF SURGERY
  • 2018-03-12. The Additional Value of Laparoscopic Ultrasound to Staging Laparoscopy in Patients with Suspected Pancreatic Head Cancer in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2012-03-13. Serum CA19-9 is a Significant Predictor among Preoperative Parameters for Early Recurrence after Resection of Pancreatic Adenocarcinoma in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2015-12. A clinical role of staging laparoscopy in patients with radiographically defined locally advanced pancreatic ductal adenocarcinoma in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2017-07-17. Reappraisal of Staging Laparoscopy for Patients with Pancreatic Adenocarcinoma: A Contemporary Analysis of 1001 Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2014-12-09. Postoperative Serum Albumin Level is a Marker of Incomplete Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2018-05-01. Therapeutic developments in pancreatic cancer: current and future perspectives in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00423-019-01846-2

    DOI

    http://dx.doi.org/10.1007/s00423-019-01846-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122984096

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31781919


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreas", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oba", 
            "givenName": "Atsushi", 
            "id": "sg:person.014215735464.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014215735464.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inoue", 
            "givenName": "Yosuke", 
            "id": "sg:person.0770623646.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770623646.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ono", 
            "givenName": "Yoshihiro", 
            "id": "sg:person.01240213665.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240213665.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
                "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Irie", 
            "givenName": "Shoichi", 
            "id": "sg:person.015027163676.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015027163676.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "Takafumi", 
            "id": "sg:person.013042551555.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013042551555.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
                "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mise", 
            "givenName": "Yoshihiro", 
            "id": "sg:person.0626665021.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Hiromichi", 
            "id": "sg:person.011406547173.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406547173.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Yu", 
            "id": "sg:person.01307772440.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307772440.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
                "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saiura", 
            "givenName": "Akio", 
            "id": "sg:person.0612301703.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s12957-016-0767-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020359853", 
              "https://doi.org/10.1186/s12957-016-0767-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-019-01754-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111442767", 
              "https://doi.org/10.1007/s00423-019-01754-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-3576-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034956453", 
              "https://doi.org/10.1245/s10434-014-3576-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41575-018-0005-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103687685", 
              "https://doi.org/10.1038/s41575-018-0005-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-018-1709-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106947924", 
              "https://doi.org/10.1007/s00423-018-1709-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-4280-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009858859", 
              "https://doi.org/10.1245/s10434-014-4280-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-018-3726-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101504811", 
              "https://doi.org/10.1007/s11605-018-3726-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-012-1859-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005915739", 
              "https://doi.org/10.1007/s11605-012-1859-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-017-5973-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090745985", 
              "https://doi.org/10.1245/s10434-017-5973-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-11-28", 
        "datePublishedReg": "2019-11-28", 
        "description": "PurposeThis study aimed to clarify the key factors for minimizing unsuitable surgical interventions for patients with radiologically occult metastatic pancreatic cancer (ROMPC), defined as a distant metastasis detected during surgery or within 6\u00a0months after resection.MethodsThis study involved 502 patients planned to undergo curative resection for pancreatic cancer between 2008 and 2015. Patients were divided into ROMPC and non-ROMPC groups and evaluated preoperative factors associated with ROMPC.ResultsOverall survival (OS) was significantly lower in the ROMPC group (n\u2009=\u2009145) than the non-ROMPC group (n\u2009=\u2009357, median survival time [MST] 10.8 vs. 35.3\u00a0months, P\u2009<\u20090.001). In the ROMPC group, OS tended to be worse for patients who had pancreatectomies (n\u2009=\u200984) than those who did not (n\u2009=\u200961, MST 10.1 vs. 13.2\u00a0months, P\u2009=\u20090.057), and the next chemotherapy started significantly later in patients who had pancreatectomies (P\u2009<\u20090.001). Moreover, OS was significantly lower for patients with (n\u2009=\u200982) than without (n\u2009=\u200963) liver metastases (MST 9.7 vs. 13.0\u00a0months, respectively, P\u2009=\u20090.020). The best indicator for patients at higher risk of ROMPC was a combination of carbohydrate antigen 19-9 concentration \u2265\u2009300\u00a0U/ml and tumor size \u2265\u200930\u00a0mm.ConclusionsIn the ROMPC group, patients who underwent pancreatectomy had a poorer prognosis than patients not undergoing pancreatectomy. Given that the liver was the most frequent distant metastatic site for ROMPC and had the poorest prognosis, establishing a strategy featuring new imaging modalities to detect radiologically occult liver metastases is necessary.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00423-019-01846-2", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1371202", 
            "issn": [
              "1435-2443", 
              "1435-2451"
            ], 
            "name": "Langenbeck's Archives of Surgery", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "405"
          }
        ], 
        "keywords": [
          "metastatic pancreatic cancer", 
          "pancreatic cancer", 
          "liver metastases", 
          "poor prognosis", 
          "occult liver metastases", 
          "carbohydrate antigen 19", 
          "distant metastatic sites", 
          "ResultsOverall survival", 
          "next chemotherapy", 
          "curative resection", 
          "preoperative factors", 
          "distant metastasis", 
          "metastatic sites", 
          "surgical intervention", 
          "tumor size", 
          "antigen 19", 
          "MethodsThis study", 
          "high risk", 
          "new imaging modality", 
          "patients", 
          "pancreatectomy", 
          "PurposeThis study", 
          "resection", 
          "metastasis", 
          "cancer", 
          "imaging modalities", 
          "prognosis", 
          "group", 
          "OS", 
          "chemotherapy", 
          "surgery", 
          "liver", 
          "months", 
          "survival", 
          "intervention", 
          "factors", 
          "modalities", 
          "ConclusionsIn", 
          "risk", 
          "study", 
          "good indicator", 
          "concentration", 
          "key factors", 
          "indicators", 
          "combination", 
          "strategies", 
          "sites", 
          "size"
        ], 
        "name": "Radiologically occult metastatic pancreatic cancer: how can we avoid unbeneficial resection?", 
        "pagination": "35-41", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1122984096"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00423-019-01846-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31781919"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00423-019-01846-2", 
          "https://app.dimensions.ai/details/publication/pub.1122984096"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_796.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00423-019-01846-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01846-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01846-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01846-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01846-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    261 TRIPLES      21 PREDICATES      96 URIs      78 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00423-019-01846-2 schema:about N01496f5601bc411887ff2f66e873e0fa
    2 N065f94224d1c4e21aa94b1e792f33027
    3 N0794f0e1c4f744a38d9957ea98aaec80
    4 N091d951e80e446ebb3d03a411cd9cd71
    5 N179df67221b34512b2f6b1949f71184c
    6 N202ccd8053aa487fa219305539343292
    7 N48095a67b51b4522bd893bae48491701
    8 N54d0e0fb5e8c48cbaf0dfd9c1603d2ff
    9 N5fdd366d9f634a3f9f8a1d9dae3c5747
    10 N95bf48585930473fbbcc5d1e665d9128
    11 Na548695e0c094af0bb4fb2372355f92c
    12 Nc9e52ad383b44ef2b0a127db96e96baf
    13 Ne11a75845a76431dabd1c6eee4b4e8d7
    14 anzsrc-for:11
    15 anzsrc-for:1103
    16 anzsrc-for:1112
    17 schema:author Nda9e7f8aa10c4d12ad4f1d5870617ff1
    18 schema:citation sg:pub.10.1007/s00423-018-1709-7
    19 sg:pub.10.1007/s00423-019-01754-5
    20 sg:pub.10.1007/s11605-012-1859-9
    21 sg:pub.10.1007/s11605-018-3726-9
    22 sg:pub.10.1038/s41575-018-0005-x
    23 sg:pub.10.1186/s12957-016-0767-y
    24 sg:pub.10.1245/s10434-014-3576-y
    25 sg:pub.10.1245/s10434-014-4280-7
    26 sg:pub.10.1245/s10434-017-5973-5
    27 schema:datePublished 2019-11-28
    28 schema:datePublishedReg 2019-11-28
    29 schema:description PurposeThis study aimed to clarify the key factors for minimizing unsuitable surgical interventions for patients with radiologically occult metastatic pancreatic cancer (ROMPC), defined as a distant metastasis detected during surgery or within 6 months after resection.MethodsThis study involved 502 patients planned to undergo curative resection for pancreatic cancer between 2008 and 2015. Patients were divided into ROMPC and non-ROMPC groups and evaluated preoperative factors associated with ROMPC.ResultsOverall survival (OS) was significantly lower in the ROMPC group (n = 145) than the non-ROMPC group (n = 357, median survival time [MST] 10.8 vs. 35.3 months, P < 0.001). In the ROMPC group, OS tended to be worse for patients who had pancreatectomies (n = 84) than those who did not (n = 61, MST 10.1 vs. 13.2 months, P = 0.057), and the next chemotherapy started significantly later in patients who had pancreatectomies (P < 0.001). Moreover, OS was significantly lower for patients with (n = 82) than without (n = 63) liver metastases (MST 9.7 vs. 13.0 months, respectively, P = 0.020). The best indicator for patients at higher risk of ROMPC was a combination of carbohydrate antigen 19-9 concentration ≥ 300 U/ml and tumor size ≥ 30 mm.ConclusionsIn the ROMPC group, patients who underwent pancreatectomy had a poorer prognosis than patients not undergoing pancreatectomy. Given that the liver was the most frequent distant metastatic site for ROMPC and had the poorest prognosis, establishing a strategy featuring new imaging modalities to detect radiologically occult liver metastases is necessary.
    30 schema:genre article
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N97524a6dd4fc40b0aeb310bd6a96277f
    33 Nb37ef552334f43ac88a74138da76480a
    34 sg:journal.1371202
    35 schema:keywords ConclusionsIn
    36 MethodsThis study
    37 OS
    38 PurposeThis study
    39 ResultsOverall survival
    40 antigen 19
    41 cancer
    42 carbohydrate antigen 19
    43 chemotherapy
    44 combination
    45 concentration
    46 curative resection
    47 distant metastasis
    48 distant metastatic sites
    49 factors
    50 good indicator
    51 group
    52 high risk
    53 imaging modalities
    54 indicators
    55 intervention
    56 key factors
    57 liver
    58 liver metastases
    59 metastasis
    60 metastatic pancreatic cancer
    61 metastatic sites
    62 modalities
    63 months
    64 new imaging modality
    65 next chemotherapy
    66 occult liver metastases
    67 pancreatectomy
    68 pancreatic cancer
    69 patients
    70 poor prognosis
    71 preoperative factors
    72 prognosis
    73 resection
    74 risk
    75 sites
    76 size
    77 strategies
    78 study
    79 surgery
    80 surgical intervention
    81 survival
    82 tumor size
    83 schema:name Radiologically occult metastatic pancreatic cancer: how can we avoid unbeneficial resection?
    84 schema:pagination 35-41
    85 schema:productId N04b1be6a3dab42aa88bd05c32ea04bc0
    86 N8449aaedf9a449c49abab5201efc2e20
    87 N9f8b9640bd184fd0a54bbcc008f2419a
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1122984096
    89 https://doi.org/10.1007/s00423-019-01846-2
    90 schema:sdDatePublished 2022-09-02T16:02
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nb491d8d920d24f59bf995c480957fba0
    93 schema:url https://doi.org/10.1007/s00423-019-01846-2
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N01496f5601bc411887ff2f66e873e0fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Middle Aged
    99 rdf:type schema:DefinedTerm
    100 N04b1be6a3dab42aa88bd05c32ea04bc0 schema:name dimensions_id
    101 schema:value pub.1122984096
    102 rdf:type schema:PropertyValue
    103 N065f94224d1c4e21aa94b1e792f33027 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Aged, 80 and over
    105 rdf:type schema:DefinedTerm
    106 N0794f0e1c4f744a38d9957ea98aaec80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Pancreatectomy
    108 rdf:type schema:DefinedTerm
    109 N091d951e80e446ebb3d03a411cd9cd71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Prognosis
    111 rdf:type schema:DefinedTerm
    112 N179df67221b34512b2f6b1949f71184c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Female
    114 rdf:type schema:DefinedTerm
    115 N202ccd8053aa487fa219305539343292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Male
    117 rdf:type schema:DefinedTerm
    118 N3811c970ab2240cdaebc27771ac3ded0 rdf:first sg:person.0770623646.53
    119 rdf:rest N6d3246e41d8e4d1093004f46de8f4247
    120 N443000ecf26a41a4b1cf7f0c8732f5c6 rdf:first sg:person.011406547173.21
    121 rdf:rest N479543169d9f4b2b9edac0466ec534ea
    122 N479543169d9f4b2b9edac0466ec534ea rdf:first sg:person.01307772440.53
    123 rdf:rest N8cbe014439f04af7a710661f2a0e2790
    124 N48095a67b51b4522bd893bae48491701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Liver Neoplasms
    126 rdf:type schema:DefinedTerm
    127 N54d0e0fb5e8c48cbaf0dfd9c1603d2ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Pancreas
    129 rdf:type schema:DefinedTerm
    130 N5fdd366d9f634a3f9f8a1d9dae3c5747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Pancreatic Neoplasms
    132 rdf:type schema:DefinedTerm
    133 N65ab1f0f70e644418ee5a30bb67f9293 rdf:first sg:person.0626665021.66
    134 rdf:rest N443000ecf26a41a4b1cf7f0c8732f5c6
    135 N6d3246e41d8e4d1093004f46de8f4247 rdf:first sg:person.01240213665.21
    136 rdf:rest Nd0647f19d7944e63b631e22a20e52c55
    137 N8449aaedf9a449c49abab5201efc2e20 schema:name pubmed_id
    138 schema:value 31781919
    139 rdf:type schema:PropertyValue
    140 N8cbe014439f04af7a710661f2a0e2790 rdf:first sg:person.0612301703.87
    141 rdf:rest rdf:nil
    142 N95bf48585930473fbbcc5d1e665d9128 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Adult
    144 rdf:type schema:DefinedTerm
    145 N97524a6dd4fc40b0aeb310bd6a96277f schema:volumeNumber 405
    146 rdf:type schema:PublicationVolume
    147 N9f8b9640bd184fd0a54bbcc008f2419a schema:name doi
    148 schema:value 10.1007/s00423-019-01846-2
    149 rdf:type schema:PropertyValue
    150 Na548695e0c094af0bb4fb2372355f92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Aged
    152 rdf:type schema:DefinedTerm
    153 Nb37ef552334f43ac88a74138da76480a schema:issueNumber 1
    154 rdf:type schema:PublicationIssue
    155 Nb491d8d920d24f59bf995c480957fba0 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 Nc9e52ad383b44ef2b0a127db96e96baf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Humans
    159 rdf:type schema:DefinedTerm
    160 Nce8a4a7cae2d4f9f8209afa539ffe558 rdf:first sg:person.013042551555.87
    161 rdf:rest N65ab1f0f70e644418ee5a30bb67f9293
    162 Nd0647f19d7944e63b631e22a20e52c55 rdf:first sg:person.015027163676.11
    163 rdf:rest Nce8a4a7cae2d4f9f8209afa539ffe558
    164 Nda9e7f8aa10c4d12ad4f1d5870617ff1 rdf:first sg:person.014215735464.23
    165 rdf:rest N3811c970ab2240cdaebc27771ac3ded0
    166 Ne11a75845a76431dabd1c6eee4b4e8d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Retrospective Studies
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical and Health Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Clinical Sciences
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Oncology and Carcinogenesis
    177 rdf:type schema:DefinedTerm
    178 sg:journal.1371202 schema:issn 1435-2443
    179 1435-2451
    180 schema:name Langenbeck's Archives of Surgery
    181 schema:publisher Springer Nature
    182 rdf:type schema:Periodical
    183 sg:person.011406547173.21 schema:affiliation grid-institutes:grid.486756.e
    184 schema:familyName Ito
    185 schema:givenName Hiromichi
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406547173.21
    187 rdf:type schema:Person
    188 sg:person.01240213665.21 schema:affiliation grid-institutes:grid.486756.e
    189 schema:familyName Ono
    190 schema:givenName Yoshihiro
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240213665.21
    192 rdf:type schema:Person
    193 sg:person.013042551555.87 schema:affiliation grid-institutes:grid.486756.e
    194 schema:familyName Sato
    195 schema:givenName Takafumi
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013042551555.87
    197 rdf:type schema:Person
    198 sg:person.01307772440.53 schema:affiliation grid-institutes:grid.486756.e
    199 schema:familyName Takahashi
    200 schema:givenName Yu
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307772440.53
    202 rdf:type schema:Person
    203 sg:person.014215735464.23 schema:affiliation grid-institutes:grid.486756.e
    204 schema:familyName Oba
    205 schema:givenName Atsushi
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014215735464.23
    207 rdf:type schema:Person
    208 sg:person.015027163676.11 schema:affiliation grid-institutes:grid.258269.2
    209 schema:familyName Irie
    210 schema:givenName Shoichi
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015027163676.11
    212 rdf:type schema:Person
    213 sg:person.0612301703.87 schema:affiliation grid-institutes:grid.258269.2
    214 schema:familyName Saiura
    215 schema:givenName Akio
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87
    217 rdf:type schema:Person
    218 sg:person.0626665021.66 schema:affiliation grid-institutes:grid.258269.2
    219 schema:familyName Mise
    220 schema:givenName Yoshihiro
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66
    222 rdf:type schema:Person
    223 sg:person.0770623646.53 schema:affiliation grid-institutes:grid.486756.e
    224 schema:familyName Inoue
    225 schema:givenName Yosuke
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770623646.53
    227 rdf:type schema:Person
    228 sg:pub.10.1007/s00423-018-1709-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106947924
    229 https://doi.org/10.1007/s00423-018-1709-7
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s00423-019-01754-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111442767
    232 https://doi.org/10.1007/s00423-019-01754-5
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s11605-012-1859-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005915739
    235 https://doi.org/10.1007/s11605-012-1859-9
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s11605-018-3726-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101504811
    238 https://doi.org/10.1007/s11605-018-3726-9
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/s41575-018-0005-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103687685
    241 https://doi.org/10.1038/s41575-018-0005-x
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/s12957-016-0767-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1020359853
    244 https://doi.org/10.1186/s12957-016-0767-y
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1245/s10434-014-3576-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034956453
    247 https://doi.org/10.1245/s10434-014-3576-y
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1245/s10434-014-4280-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009858859
    250 https://doi.org/10.1245/s10434-014-4280-7
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1245/s10434-017-5973-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090745985
    253 https://doi.org/10.1245/s10434-017-5973-5
    254 rdf:type schema:CreativeWork
    255 grid-institutes:grid.258269.2 schema:alternateName Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan
    256 schema:name Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan
    257 Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan
    258 rdf:type schema:Organization
    259 grid-institutes:grid.486756.e schema:alternateName Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan
    260 schema:name Department of Hepatobiliary Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan
    261 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...