Effectiveness of anti-osteoporotic treatment after successful parathyroidectomy for primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-26

AUTHORS

Martin B. Niederle, Ursula Foeger-Samwald, Philipp Riss, Andreas Selberherr, Christian Scheuba, Peter Pietschmann, Bruno Niederle, Katharina Kerschan-Schindl

ABSTRACT

PurposeAfter successful surgery for primary hyperparathyroidism, bone mineral density (BMD) does not improve equally in all patients. As no trial has so far aimed to influence normalization of BMD, it was the goal of this investigation to determine whether pharmacological treatment is effective in improving regain of BMD after successful parathyroidectomy in patients with preoperatively diagnosed osteoporosis or osteopenia and to evaluate when treatment may be indicated.MethodsIn this randomized, placebo-controlled, double-blind trial, 52 patients were treated with strontium ranelate 2 g daily + 1000 mg calcium + 800 IU vitamin D (strontium group; SG) or with 1000 mg calcium + 800 IU vitamin D alone (placebo group; PG) for 1 year. The main outcome measures were BMD (lumbar spine, femoral neck, radius) and bone turnover markers.ResultsThe baseline characteristics were similar in both groups. Absolute BMD (1.007 ± 0.197 vs. 0.897 ± 0.137 g/cm2; p = 0.024) and both relative (9.94 vs. 3.94%; p < 0.001) and absolute (0.09 ± 0.06 vs. 0.03 ± 0.04 g/cm2; p < 0.001) changes in lumbar-spine BMD were significantly higher in the SG than in the PG. Compared to baseline, BMD significantly increased in both groups at the lumbar spine (p < 0.001 and p = 0.001, respectively) and femoral neck (both p < 0.001), whereas radius BMD only changed significantly in the SG. However, the proportion of patients with osteoporosis/osteopenia significantly declined only at the lumbar spine in the SG (from 69.0 to 37.9%; p = 0.034), whereas no decrease was found in the PG. No severe adverse events occurred.ConclusionsPostoperative anti-osteoporotic treatment can positively influence regain of BMD mainly in the lumbar spine and should be considered. Without treatment, most patients and especially those with low preoperative markers of bone turnover remained osteoporotic/osteopenic 1 year after surgery. More... »

PAGES

681-691

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-019-01815-9

DOI

http://dx.doi.org/10.1007/s00423-019-01815-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120608471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31451913


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Diseases, Metabolic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Remodeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperparathyroidism, Primary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoporosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parathyroidectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiophenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vitamin D", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
            "Department of Anesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niederle", 
        "givenName": "Martin B.", 
        "id": "sg:person.01256273177.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256273177.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foeger-Samwald", 
        "givenName": "Ursula", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riss", 
        "givenName": "Philipp", 
        "id": "sg:person.01107211310.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107211310.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selberherr", 
        "givenName": "Andreas", 
        "id": "sg:person.01365255052.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365255052.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheuba", 
        "givenName": "Christian", 
        "id": "sg:person.0617351314.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617351314.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pietschmann", 
        "givenName": "Peter", 
        "id": "sg:person.01167673472.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167673472.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niederle", 
        "givenName": "Bruno", 
        "id": "sg:person.0671724636.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724636.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerschan-Schindl", 
        "givenName": "Katharina", 
        "id": "sg:person.01357700254.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357700254.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10354-012-0125-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048696053", 
          "https://doi.org/10.1007/s10354-012-0125-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-012-1026-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036632064", 
          "https://doi.org/10.1007/s00423-012-1026-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.4248/br201302005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021063794", 
          "https://doi.org/10.4248/br201302005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12020-016-0931-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007203642", 
          "https://doi.org/10.1007/s12020-016-0931-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-08-26", 
    "datePublishedReg": "2019-08-26", 
    "description": "PurposeAfter successful surgery for primary hyperparathyroidism, bone mineral density (BMD) does not improve equally in all patients. As no trial has so far aimed to influence normalization of BMD, it was the goal of this investigation to determine whether pharmacological treatment is effective in improving regain of BMD after successful parathyroidectomy in patients with preoperatively diagnosed osteoporosis or osteopenia and to evaluate when treatment may be indicated.MethodsIn this randomized, placebo-controlled, double-blind trial, 52 patients were treated with strontium ranelate 2\u00a0g daily\u2009+\u20091000\u00a0mg calcium\u2009+\u2009800\u00a0IU vitamin D (strontium group; SG) or with 1000\u00a0mg calcium\u2009+\u2009800\u00a0IU vitamin D alone (placebo group; PG) for 1\u00a0year. The main outcome measures were BMD (lumbar spine, femoral neck, radius) and bone turnover markers.ResultsThe baseline characteristics were similar in both groups. Absolute BMD (1.007\u2009\u00b1\u20090.197 vs. 0.897\u2009\u00b1\u20090.137\u00a0g/cm2; p\u2009=\u20090.024) and both relative (9.94 vs. 3.94%; p\u2009<\u20090.001) and absolute (0.09\u2009\u00b1\u20090.06 vs. 0.03\u2009\u00b1\u20090.04\u00a0g/cm2; p\u2009<\u20090.001) changes in lumbar-spine BMD were significantly higher in the SG than in the PG. Compared to baseline, BMD significantly increased in both groups at the lumbar spine (p\u2009<\u20090.001 and p\u2009=\u20090.001, respectively) and femoral neck (both p\u2009<\u20090.001), whereas radius BMD only changed significantly in the SG. However, the proportion of patients with osteoporosis/osteopenia significantly declined only at the lumbar spine in the SG (from 69.0 to 37.9%; p\u2009=\u20090.034), whereas no decrease was found in the PG. No severe adverse events occurred.ConclusionsPostoperative anti-osteoporotic treatment can positively influence regain of BMD mainly in the lumbar spine and should be considered. Without treatment, most patients and especially those with low preoperative markers of bone turnover remained osteoporotic/osteopenic 1\u00a0year after surgery.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00423-019-01815-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1371202", 
        "issn": [
          "1435-2443", 
          "1435-2451"
        ], 
        "name": "Langenbeck's Archives of Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "404"
      }
    ], 
    "keywords": [
      "bone mineral density", 
      "anti-osteoporotic treatment", 
      "IU vitamin D", 
      "lumbar spine", 
      "successful parathyroidectomy", 
      "primary hyperparathyroidism", 
      "vitamin D", 
      "normalization of BMD", 
      "lumbar spine bone mineral density", 
      "radius bone mineral density", 
      "absolute bone mineral density", 
      "strontium ranelate 2", 
      "osteoporosis/osteopenia", 
      "double-blind trial", 
      "placebo-controlled trial", 
      "proportion of patients", 
      "severe adverse events", 
      "bone turnover markers", 
      "main outcome measures", 
      "turnover markers", 
      "baseline characteristics", 
      "adverse events", 
      "most patients", 
      "preoperative markers", 
      "pharmacological treatment", 
      "bone turnover", 
      "successful surgery", 
      "femoral neck", 
      "mineral density", 
      "outcome measures", 
      "patients", 
      "trials", 
      "parathyroidectomy", 
      "hyperparathyroidism", 
      "spine", 
      "osteopenia", 
      "treatment", 
      "surgery", 
      "markers", 
      "regain", 
      "calcium", 
      "osteoporosis", 
      "group", 
      "years", 
      "MethodsIn", 
      "neck", 
      "baseline", 
      "SG", 
      "pg", 
      "proportion", 
      "normalization", 
      "decrease", 
      "measures", 
      "events", 
      "turnover", 
      "changes", 
      "effectiveness", 
      "investigation", 
      "characteristics", 
      "goal", 
      "density"
    ], 
    "name": "Effectiveness of anti-osteoporotic treatment after successful parathyroidectomy for primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial", 
    "pagination": "681-691", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1120608471"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00423-019-01815-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31451913"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00423-019-01815-9", 
      "https://app.dimensions.ai/details/publication/pub.1120608471"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_803.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00423-019-01815-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01815-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01815-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01815-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01815-9'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      22 PREDICATES      105 URIs      93 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00423-019-01815-9 schema:about N146e161a1e224bbd9f8e97306317ff91
2 N16c8ad375ed44aa78bba2bba22ca986c
3 N220d89ad33b2438b838fbcf705f78157
4 N4b5b8d3f28204e4e814866e01fee35ad
5 N5a6319cb28a44769945454f493358713
6 N7dd5cf8e70854cc68f22bebd5cee6dda
7 N833ed81f00344f53bc01525ac62b9c5b
8 N9ae56226ef8345e3965531cd2bcecf5b
9 Nba6a4a2ff72e4d27aa061e3df13d6305
10 Nc80ab59cdc8d4b8693b7ef8165ea1901
11 Nccf954b4412a4af0b9f257bf8215be1a
12 Ne9e6410383cb49e6a67501e8e925343d
13 Nf4ddb3b370d74644a695951c261bf4b6
14 Nf6e5b75d7daa47e6bbae37e1c1eb3497
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N8726e46f84434fd9ac4335a61efed115
18 schema:citation sg:pub.10.1007/s00423-012-1026-5
19 sg:pub.10.1007/s10354-012-0125-9
20 sg:pub.10.1007/s12020-016-0931-8
21 sg:pub.10.4248/br201302005
22 schema:datePublished 2019-08-26
23 schema:datePublishedReg 2019-08-26
24 schema:description PurposeAfter successful surgery for primary hyperparathyroidism, bone mineral density (BMD) does not improve equally in all patients. As no trial has so far aimed to influence normalization of BMD, it was the goal of this investigation to determine whether pharmacological treatment is effective in improving regain of BMD after successful parathyroidectomy in patients with preoperatively diagnosed osteoporosis or osteopenia and to evaluate when treatment may be indicated.MethodsIn this randomized, placebo-controlled, double-blind trial, 52 patients were treated with strontium ranelate 2 g daily + 1000 mg calcium + 800 IU vitamin D (strontium group; SG) or with 1000 mg calcium + 800 IU vitamin D alone (placebo group; PG) for 1 year. The main outcome measures were BMD (lumbar spine, femoral neck, radius) and bone turnover markers.ResultsThe baseline characteristics were similar in both groups. Absolute BMD (1.007 ± 0.197 vs. 0.897 ± 0.137 g/cm2; p = 0.024) and both relative (9.94 vs. 3.94%; p < 0.001) and absolute (0.09 ± 0.06 vs. 0.03 ± 0.04 g/cm2; p < 0.001) changes in lumbar-spine BMD were significantly higher in the SG than in the PG. Compared to baseline, BMD significantly increased in both groups at the lumbar spine (p < 0.001 and p = 0.001, respectively) and femoral neck (both p < 0.001), whereas radius BMD only changed significantly in the SG. However, the proportion of patients with osteoporosis/osteopenia significantly declined only at the lumbar spine in the SG (from 69.0 to 37.9%; p = 0.034), whereas no decrease was found in the PG. No severe adverse events occurred.ConclusionsPostoperative anti-osteoporotic treatment can positively influence regain of BMD mainly in the lumbar spine and should be considered. Without treatment, most patients and especially those with low preoperative markers of bone turnover remained osteoporotic/osteopenic 1 year after surgery.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N40b6f590fb9e4623a59cb5b1b9b646c0
29 Nafabba67e355436587bb5b9213e6526c
30 sg:journal.1371202
31 schema:keywords IU vitamin D
32 MethodsIn
33 SG
34 absolute bone mineral density
35 adverse events
36 anti-osteoporotic treatment
37 baseline
38 baseline characteristics
39 bone mineral density
40 bone turnover
41 bone turnover markers
42 calcium
43 changes
44 characteristics
45 decrease
46 density
47 double-blind trial
48 effectiveness
49 events
50 femoral neck
51 goal
52 group
53 hyperparathyroidism
54 investigation
55 lumbar spine
56 lumbar spine bone mineral density
57 main outcome measures
58 markers
59 measures
60 mineral density
61 most patients
62 neck
63 normalization
64 normalization of BMD
65 osteopenia
66 osteoporosis
67 osteoporosis/osteopenia
68 outcome measures
69 parathyroidectomy
70 patients
71 pg
72 pharmacological treatment
73 placebo-controlled trial
74 preoperative markers
75 primary hyperparathyroidism
76 proportion
77 proportion of patients
78 radius bone mineral density
79 regain
80 severe adverse events
81 spine
82 strontium ranelate 2
83 successful parathyroidectomy
84 successful surgery
85 surgery
86 treatment
87 trials
88 turnover
89 turnover markers
90 vitamin D
91 years
92 schema:name Effectiveness of anti-osteoporotic treatment after successful parathyroidectomy for primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
93 schema:pagination 681-691
94 schema:productId N33f906932ee146dc8d54c5178bff2e3e
95 Nda0859e392b843e4bc90205fa30c35ec
96 Nfe861dfd34ef47d480314a77b107ec6d
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120608471
98 https://doi.org/10.1007/s00423-019-01815-9
99 schema:sdDatePublished 2022-05-10T10:22
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher Nc1f60467ca6441e78e1cf76f3689fb8f
102 schema:url https://doi.org/10.1007/s00423-019-01815-9
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0b9a5a9e46c0465e8166dedfbc0a643b schema:affiliation grid-institutes:grid.22937.3d
107 schema:familyName Foeger-Samwald
108 schema:givenName Ursula
109 rdf:type schema:Person
110 N146e161a1e224bbd9f8e97306317ff91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Hyperparathyroidism, Primary
112 rdf:type schema:DefinedTerm
113 N16c8ad375ed44aa78bba2bba22ca986c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Calcium
115 rdf:type schema:DefinedTerm
116 N220d89ad33b2438b838fbcf705f78157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Parathyroidectomy
118 rdf:type schema:DefinedTerm
119 N2c68387eb3f443939c055ce24d58f3c9 rdf:first sg:person.01107211310.34
120 rdf:rest Na0cc7f70cf564519abdd1dbdd0a04ce7
121 N31e2ba72cd5448c6a1ab5e54830f7e1b rdf:first sg:person.01167673472.64
122 rdf:rest N60128b51bb514ec196f3d9f0f9c78c7f
123 N33f906932ee146dc8d54c5178bff2e3e schema:name dimensions_id
124 schema:value pub.1120608471
125 rdf:type schema:PropertyValue
126 N40b6f590fb9e4623a59cb5b1b9b646c0 schema:issueNumber 6
127 rdf:type schema:PublicationIssue
128 N4b5b8d3f28204e4e814866e01fee35ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Thiophenes
130 rdf:type schema:DefinedTerm
131 N5a6319cb28a44769945454f493358713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Bone Diseases, Metabolic
133 rdf:type schema:DefinedTerm
134 N60128b51bb514ec196f3d9f0f9c78c7f rdf:first sg:person.0671724636.94
135 rdf:rest Nfa66932d74e149bc8006c7ce661b4f5d
136 N7dd5cf8e70854cc68f22bebd5cee6dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Bone Density
138 rdf:type schema:DefinedTerm
139 N833ed81f00344f53bc01525ac62b9c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Double-Blind Method
141 rdf:type schema:DefinedTerm
142 N8726e46f84434fd9ac4335a61efed115 rdf:first sg:person.01256273177.02
143 rdf:rest Nea460cfbebf44b7e9a89a9d67e875c3e
144 N9ae56226ef8345e3965531cd2bcecf5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Na0cc7f70cf564519abdd1dbdd0a04ce7 rdf:first sg:person.01365255052.76
148 rdf:rest Nc86cf967168c46a5803a8ae9714dbd3d
149 Nafabba67e355436587bb5b9213e6526c schema:volumeNumber 404
150 rdf:type schema:PublicationVolume
151 Nba6a4a2ff72e4d27aa061e3df13d6305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Osteoporosis
153 rdf:type schema:DefinedTerm
154 Nc1f60467ca6441e78e1cf76f3689fb8f schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 Nc80ab59cdc8d4b8693b7ef8165ea1901 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Bone Remodeling
158 rdf:type schema:DefinedTerm
159 Nc86cf967168c46a5803a8ae9714dbd3d rdf:first sg:person.0617351314.15
160 rdf:rest N31e2ba72cd5448c6a1ab5e54830f7e1b
161 Nccf954b4412a4af0b9f257bf8215be1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Male
163 rdf:type schema:DefinedTerm
164 Nda0859e392b843e4bc90205fa30c35ec schema:name doi
165 schema:value 10.1007/s00423-019-01815-9
166 rdf:type schema:PropertyValue
167 Ne9e6410383cb49e6a67501e8e925343d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Vitamin D
169 rdf:type schema:DefinedTerm
170 Nea460cfbebf44b7e9a89a9d67e875c3e rdf:first N0b9a5a9e46c0465e8166dedfbc0a643b
171 rdf:rest N2c68387eb3f443939c055ce24d58f3c9
172 Nf4ddb3b370d74644a695951c261bf4b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Middle Aged
174 rdf:type schema:DefinedTerm
175 Nf6e5b75d7daa47e6bbae37e1c1eb3497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Female
177 rdf:type schema:DefinedTerm
178 Nfa66932d74e149bc8006c7ce661b4f5d rdf:first sg:person.01357700254.33
179 rdf:rest rdf:nil
180 Nfe861dfd34ef47d480314a77b107ec6d schema:name pubmed_id
181 schema:value 31451913
182 rdf:type schema:PropertyValue
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
187 schema:name Clinical Sciences
188 rdf:type schema:DefinedTerm
189 sg:journal.1371202 schema:issn 1435-2443
190 1435-2451
191 schema:name Langenbeck's Archives of Surgery
192 schema:publisher Springer Nature
193 rdf:type schema:Periodical
194 sg:person.01107211310.34 schema:affiliation grid-institutes:grid.22937.3d
195 schema:familyName Riss
196 schema:givenName Philipp
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107211310.34
198 rdf:type schema:Person
199 sg:person.01167673472.64 schema:affiliation grid-institutes:grid.22937.3d
200 schema:familyName Pietschmann
201 schema:givenName Peter
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167673472.64
203 rdf:type schema:Person
204 sg:person.01256273177.02 schema:affiliation grid-institutes:grid.22937.3d
205 schema:familyName Niederle
206 schema:givenName Martin B.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256273177.02
208 rdf:type schema:Person
209 sg:person.01357700254.33 schema:affiliation grid-institutes:grid.22937.3d
210 schema:familyName Kerschan-Schindl
211 schema:givenName Katharina
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357700254.33
213 rdf:type schema:Person
214 sg:person.01365255052.76 schema:affiliation grid-institutes:grid.22937.3d
215 schema:familyName Selberherr
216 schema:givenName Andreas
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365255052.76
218 rdf:type schema:Person
219 sg:person.0617351314.15 schema:affiliation grid-institutes:grid.22937.3d
220 schema:familyName Scheuba
221 schema:givenName Christian
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617351314.15
223 rdf:type schema:Person
224 sg:person.0671724636.94 schema:affiliation grid-institutes:grid.22937.3d
225 schema:familyName Niederle
226 schema:givenName Bruno
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724636.94
228 rdf:type schema:Person
229 sg:pub.10.1007/s00423-012-1026-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036632064
230 https://doi.org/10.1007/s00423-012-1026-5
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s10354-012-0125-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048696053
233 https://doi.org/10.1007/s10354-012-0125-9
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s12020-016-0931-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007203642
236 https://doi.org/10.1007/s12020-016-0931-8
237 rdf:type schema:CreativeWork
238 sg:pub.10.4248/br201302005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021063794
239 https://doi.org/10.4248/br201302005
240 rdf:type schema:CreativeWork
241 grid-institutes:grid.22937.3d schema:alternateName Department of Anesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
242 Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
243 Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
244 Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
245 schema:name Department of Anesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
246 Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
247 Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
248 Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...