Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-13

AUTHORS

Hideyuki Yoshitomi, Nozomu Sakai, Shingo Kagawa, Shigetsugu Takano, Atsuhiko Ueda, Atsushi Kato, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyzaki, Masayuki Ohtsuka

ABSTRACT

PurposePancreatic body/tail cancer commonly invades the hepatic artery or celiac artery, making surgical resection difficult. Distal pancreatectomy with celiac axis resection (DP-CAR) has recently been performed to achieve curative resection of these tumors. However, the safety and efficacy remain unclear. This study aimed to clarify the efficacy and safety of DP-CAR, mainly focusing on the combination with neoadjuvant therapy (NAT).MethodsWe retrospectively reviewed 31 consecutive patients with pancreatic ductal adenocarcinoma who underwent DP-CAR between 2010 and 2016. Data from 7 patients who underwent DP-CAR without NAT were used as a reference (upfront surgery, US).ResultsGemcitabine + S-1 (GS) (n = 17) and gemcitabine + albumin-bound paclitaxel (GnP) (n = 8) were frequently used as NAT. DP-CAR following NAT was performed safely with 1 death, resulting in a mortality rate of 3%. The median survival time (MST) in the NAT group was 38.6 months, while that in the US group was 15.6 months. The NAT group had a high R0 resection rate (74%), while only 1 of 7 cases in the US group achieved R0 resection. Within the NAT group, patients treated with GS showed favorable overall survival with 39.5 months of MST, while that of patients treated with GnP was 19.8 months.ConclusionThe combination of NAT and DP-CAR was feasible and safe for pancreatic body/tail cancer invading the celiac artery and/or hepatic artery. This strategy should be further assessed for the optimal regimen and duration of NAT in prospective studies. More... »

PAGES

451-458

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-019-01775-0

DOI

http://dx.doi.org/10.1007/s00423-019-01775-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112731583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30868241


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Celiac Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshitomi", 
        "givenName": "Hideyuki", 
        "id": "sg:person.01245062664.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245062664.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakai", 
        "givenName": "Nozomu", 
        "id": "sg:person.0737651177.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737651177.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kagawa", 
        "givenName": "Shingo", 
        "id": "sg:person.0613501053.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613501053.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takano", 
        "givenName": "Shigetsugu", 
        "id": "sg:person.01266546053.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Atsuhiko", 
        "id": "sg:person.01270771753.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270771753.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415958.4", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
            "Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Atsushi", 
        "id": "sg:person.01354163205.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354163205.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furukawa", 
        "givenName": "Katsunori", 
        "id": "sg:person.01013120705.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013120705.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takayashiki", 
        "givenName": "Tsukasa", 
        "id": "sg:person.01344552466.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344552466.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuboki", 
        "givenName": "Satoshi", 
        "id": "sg:person.0621146366.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621146366.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415958.4", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
            "Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyzaki", 
        "givenName": "Masaru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtsuka", 
        "givenName": "Masayuki", 
        "id": "sg:person.0653527253.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11605-007-0143-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011654821", 
          "https://doi.org/10.1007/s11605-007-0143-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02803900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039627294", 
          "https://doi.org/10.1007/bf02803900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-018-6391-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101502968", 
          "https://doi.org/10.1245/s10434-018-6391-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-012-1839-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011292551", 
          "https://doi.org/10.1007/s11605-012-1839-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016985566", 
          "https://doi.org/10.1038/sj.bjc.6603168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-016-5493-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052184532", 
          "https://doi.org/10.1245/s10434-016-5493-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-014-2702-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003126711", 
          "https://doi.org/10.1007/s00268-014-2702-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-13", 
    "datePublishedReg": "2019-03-13", 
    "description": "PurposePancreatic body/tail cancer commonly invades the hepatic artery or celiac artery, making surgical resection difficult. Distal pancreatectomy with celiac axis resection (DP-CAR) has recently been performed to achieve curative resection of these tumors. However, the safety and efficacy remain unclear. This study aimed to clarify the efficacy and safety of DP-CAR, mainly focusing on the combination with neoadjuvant therapy (NAT).MethodsWe retrospectively reviewed 31 consecutive patients with pancreatic ductal adenocarcinoma who underwent DP-CAR between 2010 and 2016. Data from 7 patients who underwent DP-CAR without NAT were used as a reference (upfront surgery, US).ResultsGemcitabine + S-1 (GS) (n\u2009=\u200917) and gemcitabine + albumin-bound paclitaxel (GnP) (n\u2009=\u20098) were frequently used as NAT. DP-CAR following NAT was performed safely with 1 death, resulting in a mortality rate of 3%. The median survival time (MST) in the NAT group was 38.6\u00a0months, while that in the US group was 15.6\u00a0months. The NAT group had a high R0 resection rate (74%), while only 1 of 7 cases in the US group achieved R0 resection. Within the NAT group, patients treated with GS showed favorable overall survival with 39.5\u00a0months of MST, while that of patients treated with GnP was 19.8\u00a0months.ConclusionThe combination of NAT and DP-CAR was feasible and safe for pancreatic body/tail cancer invading the celiac artery and/or hepatic artery. This strategy should be further assessed for the optimal regimen and duration of NAT in prospective studies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00423-019-01775-0", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6836139", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6822249", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7535501", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8428785", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5867309", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1371202", 
        "issn": [
          "1435-2443", 
          "1435-2451"
        ], 
        "name": "Langenbeck's Archives of Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "404"
      }
    ], 
    "keywords": [
      "body/tail cancer", 
      "median survival time", 
      "pancreatic body/tail cancer", 
      "neoadjuvant therapy", 
      "celiac axis resection", 
      "DP-CAR", 
      "tail cancer", 
      "NAT group", 
      "distal pancreatectomy", 
      "celiac artery", 
      "hepatic artery", 
      "en bloc celiac axis resection", 
      "higher R0 resection rate", 
      "US group", 
      "R0 resection rate", 
      "favorable overall survival", 
      "albumin-bound paclitaxel", 
      "pancreatic ductal adenocarcinoma", 
      "curative resection", 
      "resection rate", 
      "R0 resection", 
      "surgical resection", 
      "overall survival", 
      "optimal regimen", 
      "consecutive patients", 
      "prospective study", 
      "ductal adenocarcinoma", 
      "survival time", 
      "resection", 
      "mortality rate", 
      "patients", 
      "artery", 
      "cancer", 
      "months", 
      "pancreatectomy", 
      "therapy", 
      "efficacy", 
      "group", 
      "safety", 
      "ResultsGemcitabine", 
      "regimen", 
      "adenocarcinoma", 
      "gemcitabine", 
      "tumors", 
      "MethodsWe", 
      "paclitaxel", 
      "death", 
      "survival", 
      "study", 
      "borderline", 
      "duration", 
      "rate", 
      "combination", 
      "cases", 
      "GS", 
      "data", 
      "strategies", 
      "feasibility", 
      "time", 
      "reference", 
      "GNP"
    ], 
    "name": "Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable and unresectable pancreatic body/tail cancer", 
    "pagination": "451-458", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112731583"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00423-019-01775-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30868241"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00423-019-01775-0", 
      "https://app.dimensions.ai/details/publication/pub.1112731583"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_805.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00423-019-01775-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01775-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01775-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01775-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00423-019-01775-0'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      107 URIs      92 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00423-019-01775-0 schema:about N2273255f7a684631850b5cfeb363ce49
2 N2e6da8a6bded49958a23ca160c919930
3 N3c989691f1d7419fbec1b76e3d360f16
4 N4371d9439163475788951bf32b8ce2ba
5 N4553213008524d5e80fe078264a5ba91
6 N4a6d8e93da3042eaa436c2c0b1cebb12
7 N76252c5d739e4fd398b38452a0b0b58d
8 N7f72acec590b4e98b740960aea4e4c45
9 N9129346c945d4842b50486759991d4ca
10 N96b76856e79546be8bb9dd071e5704c5
11 Na41035938588495982a61edd87653d9c
12 Na89ec90145de4df793b4ca41794d7d13
13 Nb7787ace0ccf48888a0d1ab26e21963f
14 Ndb14aa8f055542ba9d28c47a14ced4b2
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N44be4d9cd5a14e529fe4d35d3d6be18a
18 schema:citation sg:pub.10.1007/bf02803900
19 sg:pub.10.1007/s00268-014-2702-0
20 sg:pub.10.1007/s11605-007-0143-x
21 sg:pub.10.1007/s11605-012-1839-0
22 sg:pub.10.1038/sj.bjc.6603168
23 sg:pub.10.1245/s10434-016-5493-8
24 sg:pub.10.1245/s10434-018-6391-z
25 schema:datePublished 2019-03-13
26 schema:datePublishedReg 2019-03-13
27 schema:description PurposePancreatic body/tail cancer commonly invades the hepatic artery or celiac artery, making surgical resection difficult. Distal pancreatectomy with celiac axis resection (DP-CAR) has recently been performed to achieve curative resection of these tumors. However, the safety and efficacy remain unclear. This study aimed to clarify the efficacy and safety of DP-CAR, mainly focusing on the combination with neoadjuvant therapy (NAT).MethodsWe retrospectively reviewed 31 consecutive patients with pancreatic ductal adenocarcinoma who underwent DP-CAR between 2010 and 2016. Data from 7 patients who underwent DP-CAR without NAT were used as a reference (upfront surgery, US).ResultsGemcitabine + S-1 (GS) (n = 17) and gemcitabine + albumin-bound paclitaxel (GnP) (n = 8) were frequently used as NAT. DP-CAR following NAT was performed safely with 1 death, resulting in a mortality rate of 3%. The median survival time (MST) in the NAT group was 38.6 months, while that in the US group was 15.6 months. The NAT group had a high R0 resection rate (74%), while only 1 of 7 cases in the US group achieved R0 resection. Within the NAT group, patients treated with GS showed favorable overall survival with 39.5 months of MST, while that of patients treated with GnP was 19.8 months.ConclusionThe combination of NAT and DP-CAR was feasible and safe for pancreatic body/tail cancer invading the celiac artery and/or hepatic artery. This strategy should be further assessed for the optimal regimen and duration of NAT in prospective studies.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N347fc173808e420984d8001404fb6a38
31 N5f944ee3b558451cbbdb29ae3c271654
32 sg:journal.1371202
33 schema:keywords DP-CAR
34 GNP
35 GS
36 MethodsWe
37 NAT group
38 R0 resection
39 R0 resection rate
40 ResultsGemcitabine
41 US group
42 adenocarcinoma
43 albumin-bound paclitaxel
44 artery
45 body/tail cancer
46 borderline
47 cancer
48 cases
49 celiac artery
50 celiac axis resection
51 combination
52 consecutive patients
53 curative resection
54 data
55 death
56 distal pancreatectomy
57 ductal adenocarcinoma
58 duration
59 efficacy
60 en bloc celiac axis resection
61 favorable overall survival
62 feasibility
63 gemcitabine
64 group
65 hepatic artery
66 higher R0 resection rate
67 median survival time
68 months
69 mortality rate
70 neoadjuvant therapy
71 optimal regimen
72 overall survival
73 paclitaxel
74 pancreatectomy
75 pancreatic body/tail cancer
76 pancreatic ductal adenocarcinoma
77 patients
78 prospective study
79 rate
80 reference
81 regimen
82 resection
83 resection rate
84 safety
85 strategies
86 study
87 surgical resection
88 survival
89 survival time
90 tail cancer
91 therapy
92 time
93 tumors
94 schema:name Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable and unresectable pancreatic body/tail cancer
95 schema:pagination 451-458
96 schema:productId N43431ceb41f843d1b03b7d642460bcce
97 N8c4d3e5e0eee40378e2de1ed33235fc3
98 Nc9009ff091ac4154976acf00aa1e6681
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112731583
100 https://doi.org/10.1007/s00423-019-01775-0
101 schema:sdDatePublished 2022-12-01T06:39
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher N6b35b75fb8754e6aad33a31653a6793b
104 schema:url https://doi.org/10.1007/s00423-019-01775-0
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N03a6f29237744ab690c6cf635ad08bec rdf:first sg:person.01354163205.16
109 rdf:rest N3c6bbbe0cb2b43a8b8d794487d1abc40
110 N2273255f7a684631850b5cfeb363ce49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Survival Rate
112 rdf:type schema:DefinedTerm
113 N2e6da8a6bded49958a23ca160c919930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 N347fc173808e420984d8001404fb6a38 schema:issueNumber 4
117 rdf:type schema:PublicationIssue
118 N3c6bbbe0cb2b43a8b8d794487d1abc40 rdf:first sg:person.01013120705.66
119 rdf:rest Nf84f13df71d94d44ad7b894dd3412da1
120 N3c989691f1d7419fbec1b76e3d360f16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Retrospective Studies
122 rdf:type schema:DefinedTerm
123 N43431ceb41f843d1b03b7d642460bcce schema:name pubmed_id
124 schema:value 30868241
125 rdf:type schema:PropertyValue
126 N4371d9439163475788951bf32b8ce2ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Celiac Artery
128 rdf:type schema:DefinedTerm
129 N44be4d9cd5a14e529fe4d35d3d6be18a rdf:first sg:person.01245062664.63
130 rdf:rest N58461d42d6ae4bcc8cf329e46f12b696
131 N4553213008524d5e80fe078264a5ba91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Pancreatic Neoplasms
133 rdf:type schema:DefinedTerm
134 N47c4889cb5bb4b9a8bf8da02db29dffe schema:affiliation grid-institutes:grid.415958.4
135 schema:familyName Miyzaki
136 schema:givenName Masaru
137 rdf:type schema:Person
138 N4a6d8e93da3042eaa436c2c0b1cebb12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Feasibility Studies
140 rdf:type schema:DefinedTerm
141 N58461d42d6ae4bcc8cf329e46f12b696 rdf:first sg:person.0737651177.83
142 rdf:rest N94dc065a966a49799cb36d9ad40b46bf
143 N5f944ee3b558451cbbdb29ae3c271654 schema:volumeNumber 404
144 rdf:type schema:PublicationVolume
145 N6b35b75fb8754e6aad33a31653a6793b schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N76252c5d739e4fd398b38452a0b0b58d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Pancreatectomy
149 rdf:type schema:DefinedTerm
150 N7f72acec590b4e98b740960aea4e4c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Neoadjuvant Therapy
152 rdf:type schema:DefinedTerm
153 N8c4d3e5e0eee40378e2de1ed33235fc3 schema:name dimensions_id
154 schema:value pub.1112731583
155 rdf:type schema:PropertyValue
156 N9129346c945d4842b50486759991d4ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antineoplastic Combined Chemotherapy Protocols
158 rdf:type schema:DefinedTerm
159 N94dc065a966a49799cb36d9ad40b46bf rdf:first sg:person.0613501053.29
160 rdf:rest N9faafd8e13044c17add4b209d6162b33
161 N96b76856e79546be8bb9dd071e5704c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 N9faafd8e13044c17add4b209d6162b33 rdf:first sg:person.01266546053.57
165 rdf:rest Nc0085300d7f541c4a98a6d53c0cfa5f3
166 Na0d0abea250e4df085aec084c1e8c8e9 rdf:first sg:person.0653527253.30
167 rdf:rest rdf:nil
168 Na41035938588495982a61edd87653d9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Chemotherapy, Adjuvant
170 rdf:type schema:DefinedTerm
171 Na89ec90145de4df793b4ca41794d7d13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aged
173 rdf:type schema:DefinedTerm
174 Nb7787ace0ccf48888a0d1ab26e21963f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Adenocarcinoma
176 rdf:type schema:DefinedTerm
177 Nc0085300d7f541c4a98a6d53c0cfa5f3 rdf:first sg:person.01270771753.50
178 rdf:rest N03a6f29237744ab690c6cf635ad08bec
179 Nc30f2824c27d476fba4df392ed06f2e7 rdf:first sg:person.0621146366.76
180 rdf:rest Ne3fefaf6ddf54d93950d6b183badc35c
181 Nc9009ff091ac4154976acf00aa1e6681 schema:name doi
182 schema:value 10.1007/s00423-019-01775-0
183 rdf:type schema:PropertyValue
184 Ndb14aa8f055542ba9d28c47a14ced4b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Female
186 rdf:type schema:DefinedTerm
187 Ne3fefaf6ddf54d93950d6b183badc35c rdf:first N47c4889cb5bb4b9a8bf8da02db29dffe
188 rdf:rest Na0d0abea250e4df085aec084c1e8c8e9
189 Nf84f13df71d94d44ad7b894dd3412da1 rdf:first sg:person.01344552466.53
190 rdf:rest Nc30f2824c27d476fba4df392ed06f2e7
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:grant.5867309 http://pending.schema.org/fundedItem sg:pub.10.1007/s00423-019-01775-0
198 rdf:type schema:MonetaryGrant
199 sg:grant.6822249 http://pending.schema.org/fundedItem sg:pub.10.1007/s00423-019-01775-0
200 rdf:type schema:MonetaryGrant
201 sg:grant.6836139 http://pending.schema.org/fundedItem sg:pub.10.1007/s00423-019-01775-0
202 rdf:type schema:MonetaryGrant
203 sg:grant.7535501 http://pending.schema.org/fundedItem sg:pub.10.1007/s00423-019-01775-0
204 rdf:type schema:MonetaryGrant
205 sg:grant.8428785 http://pending.schema.org/fundedItem sg:pub.10.1007/s00423-019-01775-0
206 rdf:type schema:MonetaryGrant
207 sg:journal.1371202 schema:issn 1435-2443
208 1435-2451
209 schema:name Langenbeck's Archives of Surgery
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01013120705.66 schema:affiliation grid-institutes:grid.136304.3
213 schema:familyName Furukawa
214 schema:givenName Katsunori
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013120705.66
216 rdf:type schema:Person
217 sg:person.01245062664.63 schema:affiliation grid-institutes:grid.136304.3
218 schema:familyName Yoshitomi
219 schema:givenName Hideyuki
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245062664.63
221 rdf:type schema:Person
222 sg:person.01266546053.57 schema:affiliation grid-institutes:grid.136304.3
223 schema:familyName Takano
224 schema:givenName Shigetsugu
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57
226 rdf:type schema:Person
227 sg:person.01270771753.50 schema:affiliation grid-institutes:grid.136304.3
228 schema:familyName Ueda
229 schema:givenName Atsuhiko
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270771753.50
231 rdf:type schema:Person
232 sg:person.01344552466.53 schema:affiliation grid-institutes:grid.136304.3
233 schema:familyName Takayashiki
234 schema:givenName Tsukasa
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344552466.53
236 rdf:type schema:Person
237 sg:person.01354163205.16 schema:affiliation grid-institutes:grid.415958.4
238 schema:familyName Kato
239 schema:givenName Atsushi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354163205.16
241 rdf:type schema:Person
242 sg:person.0613501053.29 schema:affiliation grid-institutes:grid.136304.3
243 schema:familyName Kagawa
244 schema:givenName Shingo
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613501053.29
246 rdf:type schema:Person
247 sg:person.0621146366.76 schema:affiliation grid-institutes:grid.136304.3
248 schema:familyName Kuboki
249 schema:givenName Satoshi
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621146366.76
251 rdf:type schema:Person
252 sg:person.0653527253.30 schema:affiliation grid-institutes:grid.136304.3
253 schema:familyName Ohtsuka
254 schema:givenName Masayuki
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30
256 rdf:type schema:Person
257 sg:person.0737651177.83 schema:affiliation grid-institutes:grid.136304.3
258 schema:familyName Sakai
259 schema:givenName Nozomu
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737651177.83
261 rdf:type schema:Person
262 sg:pub.10.1007/bf02803900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039627294
263 https://doi.org/10.1007/bf02803900
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s00268-014-2702-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003126711
266 https://doi.org/10.1007/s00268-014-2702-0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s11605-007-0143-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011654821
269 https://doi.org/10.1007/s11605-007-0143-x
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s11605-012-1839-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011292551
272 https://doi.org/10.1007/s11605-012-1839-0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/sj.bjc.6603168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016985566
275 https://doi.org/10.1038/sj.bjc.6603168
276 rdf:type schema:CreativeWork
277 sg:pub.10.1245/s10434-016-5493-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052184532
278 https://doi.org/10.1245/s10434-016-5493-8
279 rdf:type schema:CreativeWork
280 sg:pub.10.1245/s10434-018-6391-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101502968
281 https://doi.org/10.1245/s10434-018-6391-z
282 rdf:type schema:CreativeWork
283 grid-institutes:grid.136304.3 schema:alternateName Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
284 schema:name Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
285 rdf:type schema:Organization
286 grid-institutes:grid.415958.4 schema:alternateName Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan
287 schema:name Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
288 Digestive Diseases Center, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, 108-8329, Tokyo, Japan
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...