Effects of oxaliplatin-based chemotherapy on liver function—an analysis of impact and functional recovery using the LiMAx test View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Maximilian Jara, Jan Bednarsch, Maciej Malinowski, Johann Pratschke, Martin Stockmann

ABSTRACT

PURPOSE: Chemotherapy-associated liver injury of patients undergoing therapy for colorectal liver metastases stimulates concerns on surgical safety. No common guidelines for the optimal timing of liver surgery after the application of systemic chemotherapy (chemotherapy-free interval) have been established and effects on individual liver function remain unexplored. METHODS: Maximum liver function capacity (LiMAx) and indocyanine green plasma disappearance rate (ICG-PDR) were measured in 20 patients with colorectal cancer receiving adjuvant oxaliplatin-based chemotherapy (OBC) prior to the first and after the last treatment course as well as 4 and 8 weeks thereafter. RESULTS: Comparison of pre- and post-chemotherapy test results demonstrated a significant decrease of LiMAx to 73.2 % ± 19.0 % (p = 0.001) and ICG-PDR to 78.2 % ± 21.3 % (p = 0.001) after cessation of OBC. The dynamics of LiMAx indicate an interindividual effect on vulnerability to systemic chemotherapy with subsequent functional regeneration after 8 weeks (pre-OBC 530 ± 144 μg/kg/h vs. 4 weeks post-OBC 463 ± 111 μg/kg/; p = 0.012 and vs. 8 weeks post-OBC 494 ± 138 μg/kg/h; p = 0.134). An analysis of individual regeneration after chemotherapy yielded a highly different course of functional recovery with patients regaining pre-chemotherapy function within 4 weeks, whereas others still showed deterioration after 8 weeks after cessation of chemotherapy. DISCUSSION AND CONCLUSION: Enzymatic liver function (LiMAx) is significantly reduced after oxaliplatin-based chemotherapy and subsequently recovers within 8 weeks after cessation of chemotherapy. However, pace of regeneration appears to be highly different among patients suggesting patient individual chemotherapy-free interval monitored by LiMAx. More... »

PAGES

33-41

References to SciGraph publications

  • 2007-04. Safe liver resection following chemotherapy for colorectal metastases is a matter of timing in BRITISH JOURNAL OF CANCER
  • 2004-03. Measurement of indocyanine green plasma disappearance rate by two different dosages in INTENSIVE CARE MEDICINE
  • 2013-10. Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test in CRITICAL CARE
  • 2003-02. Assessment of Effective Hepatic Blood Flow in Critically Ill Patients by Noninvasive Pulse Dye-Densitometry in SURGERY TODAY
  • 2010-11. Cetuximab plus chronomodulated irinotecan, 5-fluorouracil, leucovorin and oxaliplatin as neoadjuvant chemotherapy in colorectal liver metastases: POCHER trial in BRITISH JOURNAL OF CANCER
  • 2005-02. Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2010-02. Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2010-10. Recovery of Liver Function After the Cessation of Preoperative Chemotherapy for Colorectal Liver Metastasis in ANNALS OF SURGICAL ONCOLOGY
  • 2011-02. Sinusoidal Obstruction Syndrome Impairs Long-Term Outcome of Colorectal Liver Metastases Treated with Resection after Neoadjuvant Chemotherapy in ANNALS OF SURGICAL ONCOLOGY
  • 2011-06. Evaluation of Chemotherapy-Associated Liver Injury in Patients with Colorectal Cancer Liver Metastases Using Indocyanine Green Clearance Testing in ANNALS OF SURGICAL ONCOLOGY
  • 2014-01. Evaluation of the Usefulness of the Indocyanine Green Clearance Test for Chemotherapy-Associated Liver Injury in Patients with Colorectal Cancer Liver Metastasis in ANNALS OF SURGICAL ONCOLOGY
  • 2012-12. Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity in LANGENBECK'S ARCHIVES OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00423-015-1352-5

    DOI

    http://dx.doi.org/10.1007/s00423-015-1352-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010681255

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26507639


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