Factors influencing hypertrophy of the left lateral liver lobe after portal vein embolization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

Maciej Malinowski, Victoria Stary, Johan F. Lock, Antje Schulz, Maximilian Jara, Daniel Seehofer, Bernhard Gebauer, Timm Denecke, Dominik Geisel, Peter Neuhaus, Martin Stockmann

ABSTRACT

PURPOSE: Portal vein embolization (PVE) before extended right hepatectomy leads to an increase of the future liver remnant (FLR) volume, but predictive factors for sufficient hypertrophy are still unclear. The purpose of this study was to investigate parameters influencing the growth of FLR. METHODS: Patients undergoing PVE prior hepatic resection were evaluated. PVE was done using polyvinyl alcohol particles only. Volumetric analysis was performed before embolization and before hepatectomy. Success of PVE was determined as percental growth of the future liver remnant. RESULTS: Seventy-seven patients were included, and three cohorts were formed according to the hypertrophy of FLR. FLR increased from 448.2 ± 187 to 475.5 ± 191 in the poor, from 315.3 ± 86 to 469.1 ± 142 in the moderate, and from 283.4 ± 68 to 400.4 ± 110 in the good hypertrophy group. More cases of recanalization of the portal vein were observed in patients with poor hypertrophy (p = 0.016). Small FLR before PVE predict higher growth of the FLR (p = 0.006). Duration between PVE and surgery differed significantly: 22 (poor) vs. 32 (good) days (p = 0.040). DISCUSSION: No recanalization, small initial FLR and longer time were assessed with better FLR hypertrophy. More sufficient PVE techniques and postponed hepatectomy might improve the outcome. Small initial FLR should not be a disclosure for curative hepatectomy. More... »

PAGES

237-246

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00423-014-1266-7

DOI

http://dx.doi.org/10.1007/s00423-014-1266-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011747194

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25559774


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